Cited by 75Eating Disorders and BehaviorsPharmacology and Obesity TreatmentRegulation of Appetite and Obesity

A pilot randomized controlled trial of liraglutide 3.0 mg for binge eating disorder

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Allison, Kelly C., Chao, Ariana M., Bruzas, Maija B., McCuen‐Wurst, Courtney, Jones, Elizabeth, McAllister, Cooper, Gruber, Kathryn, Berkowitz, Robert I. +2 more·2023·Obesity Science & Practice

Abstract

Objective: To assess the efficacy of liraglutide 3.0 mg, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, for binge eating disorder (BED). Methods: Adults with a body mass index (BMI) ≥ 27 kg/m 2 enrolled in a pilot, 17‐week double‐blind, randomized controlled trial of liraglutide 3.0 mg/day for BED. The primary outcome was number of objective binge episodes (OBEs)/week. Binge remission, weight change, and psychosocial variables were secondary outcomes. Mixed effect models were used for continuous variables, and generalized estimating equations were used for remission rates. Results: Participants ( n = 27) were 44.2 ± 10.6 years; BMI = 37.9 ± 11.8 kg/m 2 ; 63% women; and 59% White and 41% Black. At baseline, the liraglutide group ( n = 13) reported 4.7 ± 0.7 OBEs/week, compared with 3.0 ± 0.7 OBEs/week for the placebo group, p = 0.07. At week 17, OBEs/week decreased by 4.0 ± 0.6 in liraglutide participants and by 2.5 ± 0.5 in placebo participants ( p = 0.37, mean difference = 1.2, 95% confidence interval 1.3, 2.0). BED remission rates of 44% and 36%, respectively, did not differ. Percent weight loss was significantly greater in the liraglutide versus the placebo group (5.2 ± 1.0% vs. 0.9 ± 0.7%, p = 0.005). Conclusion: Participants in both groups reported reductions in OBEs, with the liraglutide group showing clinically meaningful weight loss. A pharmacy medication dispensing error was a significant limitation of this study. Further research on liraglutide and other GLP‐1 agonists for BED is warranted.

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  • In a 17-week pilot RCT, liraglutide 3.0 mg led to greater weight loss (-5.2% vs −0.9%, p=0.005) but no significant difference in binge remission or reduction in binge episodes compared to placebo.

    “In a 17-week pilot RCT, liraglutide 3.0 mg led to greater weight loss (–5.2% vs. − 0.9%, p = 0.005) but no significant difference in binge remission or reduction in binge episodes compared to placebo.”

    From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [138]

    The Results (Table 3 and “Binge-eating outcomes”) support the 17-week comparison: weight loss differed significantly (p = 0.005), while reductions in binge episodes and remission rates did not. The Results report 5.1% weight loss with liraglutide, however, rather than the claimed 5.2%; the placebo figure is 0.9%. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • Both groups in that trial showed improvements in binge eating episodes.

    “Both groups showed improvements in binge eating episodes, highlighting the need for further research in BED [138].”

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Authors
Allison, K. C., Chao, A. M., Bruzas, M. B., McCuen‐Wurst, C., Jones, E., McAllister, C., Gruber, K., Berkowitz, R. I., Wadden, T. A., & Tronieri, J. S.
Affiliations
  • University of Pennsylvania (US)
  • Children's Hospital of Philadelphia (US)
Corresponding author
Allison, Kelly C.
Venue
Obesity Science & Practice
Publisher
Wiley
Published
2022-07-26
Volume
9
Issue
2
Pages
127-136
ISSN
2055-2238 (ISSN-L)
OpenAlex
W4282044710
Cited by
75
References
38
Citations by year
2026: 20 · 2025: 28 · 2024: 19 · 2023: 7 · 2022: 1
FWCI
12.56
Type
journal article
Language
en
Open access
Locations
  • Obesity Science & Practice (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Novo Nordisk (Investigator Initiated Study)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
liraglutide, binge eating disorder, GLP-1 receptor agonists, weight loss, obesity

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