A pilot randomized controlled trial of liraglutide 3.0 mg for binge eating disorder
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Objective: To assess the efficacy of liraglutide 3.0 mg, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, for binge eating disorder (BED). Methods: Adults with a body mass index (BMI) ≥ 27 kg/m 2 enrolled in a pilot, 17‐week double‐blind, randomized controlled trial of liraglutide 3.0 mg/day for BED. The primary outcome was number of objective binge episodes (OBEs)/week. Binge remission, weight change, and psychosocial variables were secondary outcomes. Mixed effect models were used for continuous variables, and generalized estimating equations were used for remission rates. Results: Participants ( n = 27) were 44.2 ± 10.6 years; BMI = 37.9 ± 11.8 kg/m 2 ; 63% women; and 59% White and 41% Black. At baseline, the liraglutide group ( n = 13) reported 4.7 ± 0.7 OBEs/week, compared with 3.0 ± 0.7 OBEs/week for the placebo group, p = 0.07. At week 17, OBEs/week decreased by 4.0 ± 0.6 in liraglutide participants and by 2.5 ± 0.5 in placebo participants ( p = 0.37, mean difference = 1.2, 95% confidence interval 1.3, 2.0). BED remission rates of 44% and 36%, respectively, did not differ. Percent weight loss was significantly greater in the liraglutide versus the placebo group (5.2 ± 1.0% vs. 0.9 ± 0.7%, p = 0.005). Conclusion: Participants in both groups reported reductions in OBEs, with the liraglutide group showing clinically meaningful weight loss. A pharmacy medication dispensing error was a significant limitation of this study. Further research on liraglutide and other GLP‐1 agonists for BED is warranted.
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In a 17-week pilot RCT, liraglutide 3.0 mg led to greater weight loss (-5.2% vs −0.9%, p=0.005) but no significant difference in binge remission or reduction in binge episodes compared to placebo.
“In a 17-week pilot RCT, liraglutide 3.0 mg led to greater weight loss (–5.2% vs. − 0.9%, p = 0.005) but no significant difference in binge remission or reduction in binge episodes compared to placebo.”
From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [138]
The Results (Table 3 and “Binge-eating outcomes”) support the 17-week comparison: weight loss differed significantly (p = 0.005), while reductions in binge episodes and remission rates did not. The Results report 5.1% weight loss with liraglutide, however, rather than the claimed 5.2%; the placebo figure is 0.9%. (LLM, conf=0.88)
Experimental — accuracy not yet measuredBoth groups in that trial showed improvements in binge eating episodes.
“Both groups showed improvements in binge eating episodes, highlighting the need for further research in BED [138].”
From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [138]
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Standard Binge Eating Treatments Are Not Effective for My Patient
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Binge-Eating Disorder: General Information
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- Authors
- Allison, K. C., Chao, A. M., Bruzas, M. B., McCuen‐Wurst, C., Jones, E., McAllister, C., Gruber, K., Berkowitz, R. I., Wadden, T. A., & Tronieri, J. S.
- Affiliations
- University of Pennsylvania (US)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Allison, Kelly C.
- Venue
- Obesity Science & Practice
- Publisher
- Wiley
- Published
- 2022-07-26
- Volume
- 9
- Issue
- 2
- Pages
- 127-136
- ISSN
- 2055-2238 (ISSN-L)
- PMC
- PMC10073825
- OpenAlex
- W4282044710
- Cited by
- 75
- References
- 38
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 19 · 2023: 7 · 2022: 1
- FWCI
- 12.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Obesity Science & Practice (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Novo Nordisk (Investigator Initiated Study)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- liraglutide, binge eating disorder, GLP-1 receptor agonists, weight loss, obesity
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