The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
BCL‐2 expression in adult and embryonic non‐haematopoietic tissues
Abstract
The B‐cell leukaemia/lymphoma‐2 (bcl‐2) proto‐oncogene is unusual as its product appears to provide survival advantage to B cells by blocking apoptosis. In this study, the expression of bcl‐2 has been examined in normal nonhaematopoietic tissues, embryos, and psoriatic skin by immunohistochemical staining. Bcl‐2 protein expression is mainly observed in cell populations with a long life and/or proliferating ability such as duct cells in exocrine glands, basal keratinocytes, cells at the bottom of colon crypts, and neurons. In the skin of both adult and embryo and also embryonic kidney and cartilage, bcl‐2 expression was observed in cells which were undergoing morphological transition from undifferentiated stem cells to committed precursor cells. The finding of bcl‐2 expression in the terminal differentiated syncytial trophoblast, but not cytotrophoblast, and in some cells responsive to hormone stimulation such as in the endometrium and myometrium suggests that the gene expression may be related too hormone responsiveness. As no bci‐2 localization was seen in the benign hyperproliferative skin condition psoriasis, this does not suggest a straightforward link to proliferation. These observations support the view that the bcl‐2 gene may have an important role in cell development, maturation, and the path to terminal differentiation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
Hockenbery, D., Nuñez, G., Milliman, C., Schreiber, R. D., & Korsmeyer, S. J. (1990) · Nature · doi:10.1038/348334a0 · Cited by 3,720
Tsujimoto, Y., Finger, L. R., Yunis, J., Nowell, P. C., & Croce, C. M. (1984) · Science · doi:10.1126/science.6093263 · Cited by 1,769
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252
Bakhshi, A., Jensen, J. P., Goldman, P., Wright, J. J., McBride, O. W., Epstein, A. L., & Korsmeyer, S. J. (1985) · Cell · doi:10.1016/s0092-8674(85)80070-2 · Cited by 1,179
Henderson, S., Rowe, M., Gregory, C., Croom-Carter, D., Wang, F., Longnecker, R., Kieff, E., & Rickinson, A. (1991) · Cell · doi:10.1016/0092-8674(91)90007-l · Cited by 1,168
Cleary, M. L., & Sklar, J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.21.7439 · Cited by 924
Nuñez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., & Korsmeyer, S. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3602 · Cited by 899
Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.
Pezzella, F., Tse, A. G. D., Cordell, J. L., Pulford, K. A. F., Gatter, K. C., & Mason, D. Y. (1990) · Europe PMC (PubMed Central) · Cited by 595
Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.
Graninger, W. B., Seto, M., Boutain, B., Goldman, P., & Korsmeyer, S. J. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113235 · Cited by 281
Nuñez, G., Hockenbery, D., McDonnell, T. J., Sorensen, C. M., & Korsmeyer, S. J. (1991) · Nature · doi:10.1038/353071a0 · Cited by 211
Cited by
Bcl-2 and the regulation of programmed cell death
Reed, J. (1994) · The Journal of cell biology · doi:10.1083/jcb.124.1.1 · Cited by 2,305
Sex steroidal regulation of uterine leiomyoma growth and apoptosis
Maruo, T. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh019 · Cited by 294
bcl-2: Role in epithelial differentiation and oncogenesis
Lu, Q.-L., Abel, P., Foster, C. S., & Lalani, E.-N. (1996) · Human Pathology · doi:10.1016/s0046-8177(96)90362-7 · Cited by 265
Self-citationUckan, D. (1997) · Molecular Human Reproduction · doi:10.1093/molehr/3.8.655 · Cited by 206
Simpson, J. L., Bischoff, F. Z., Kamat, A., Buster, J. E., & Carson, S. A. (2003) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(02)00051-7 · Cited by 83
Metadata
- Authors
- Lu, Q., Poulsom, R., Wong, L., & Hanby, A. M.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 1993-04
- Volume
- 169
- Issue
- 4
- Pages
- 431-437
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2022273331
- Cited by
- 261
- References
- 13
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: BCL‐2 expression in adult and embryonic non‐haematopoietic tissues. https://app.cochat.ai/papers/10.1002/path.1711690408
- The paper
- Lu, Q., Poulsom, R., Wong, L., & Hanby, A. M. (1993). BCL‐2 expression in adult and embryonic non‐haematopoietic tissues. The Journal of Pathology. https://doi.org/10.1002/path.1711690408
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
