The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Notch signalling in T‐cell lymphoblastic leukaemia/lymphoma and other haematological malignancies
Open accessAbstract
Notch receptors participate in a highly conserved signalling pathway that regulates normal development and tissue homeostasis in a context‐ and dose‐dependent manner. Deregulated Notch signalling has been implicated in many diseases, but the clearest example of a pathogenic role is found in T‐cell lymphoblastic leukaemia/lymphoma (T‐LL), in which the majority of human and murine tumours have acquired mutations that lead to aberrant increases in Notch1 signalling. Remarkably, it appears that the selective pressure for Notch mutations is virtually unique among cancers to T‐LL, presumably reflecting a special context‐dependent role for Notch in normal T‐cell progenitors. Nevertheless, there are some recent reports suggesting that Notch signalling has subtle, yet important roles in other forms of haematological malignancy as well. Here, we review the role of Notch signalling in various blood cancers, focusing on T‐LL with an eye towards targeted therapeutics. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutations in NOTCH1 cause aortic valve disease
Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature · doi:10.1038/nature03940 · Cited by 1,509
Direct inhibition of the NOTCH transcription factor complex
Moellering, R. E., Cornejo, M., Davis, T. N., Bianco, C. D., Aster, J. C., Blacklow, S. C., Kung, A. L., Gilliland, D. G., Verdine, G. L., & Bradner, J. E. (2009) · Nature · doi:10.1038/nature08543 · Cited by 752
Self-citationIkaros DNA-Binding Proteins Direct Formation of Chromatin Remodeling Complexes in Lymphocytes
Kim, J., Sif, S., Jones, B., Jackson, A., Koipally, J., Heller, E., Winandy, S., Viel, A., Sawyer, A., Ikeda, T., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80034-5 · Cited by 587
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
Maser, R. S., Choudhury, B., Campbell, P. J., Feng, B., Wong, K.-K., Protopopov, A., O’Neil, J., Gutierrez, A., Ivanova, E., Perna, I., et al. (2007) · Nature · doi:10.1038/nature05886 · Cited by 377
Self-citationPredominant Interaction of Both Ikaros and Helios with the NuRD Complex in Immature Thymocytes
Sridharan, R., & Smale, S. T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702541200 · Cited by 130
Cited by
Comprehensive genomic characterization of squamous cell lung cancers
The Cancer Genome Atlas Research Network (2012) · Nature · doi:10.1038/nature11404 · Cited by 3,994
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
Ntziachristos, P., Tsirigos, A., Vlierberghe, P. V., Nedjic, J., Trimarchi, T., Flaherty, M. S., Ferres-Marco, D., da Ros, V., Tang, Z., Siegle, J., et al. (2012) · Nature Medicine · doi:10.1038/nm.2651 · Cited by 526
Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
Rossi, D., Rasi, S., Fabbri, G., Spina, V., Fangazio, M., Forconi, F., Marasca, R., Laurenti, L., Bruscaggin, A., Cerri, M., et al. (2012) · Blood · doi:10.1182/blood-2011-09-379966 · Cited by 462
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Leigh, I. M., Collisson, E. A., Gordon, P. B., Jakkula, L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114669108 · Cited by 462
Self-citationDevelopmental gene networks: a triathlon on the course to T cell identity
Yui, M. A., & Rothenberg, E. V. (2014) · Nature Reviews Immunology · doi:10.1038/nri3702 · Cited by 342
Kiel, M. J., Velusamy, T., Betz, B. L., Zhao, L., Weigelin, H. G., Chiang, M. Y., Huebner-Chan, D. R., Bailey, N. G., Yang, D. T., Bhagat, G., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120910 · Cited by 284
Targeting Transcription Factors in Cancer
Bhagwat, A. S., & Vakoc, C. R. (2015) · Trends in Cancer · doi:10.1016/j.trecan.2015.07.001 · Cited by 276
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
Mayle, A., Yang, L., Rodriguez, B., Zhou, T., Chang, E., Curry, C. V., Challen, G. A., Li, W., Wheeler, D., Rebel, V. I., et al. (2015) · Blood · doi:10.1182/blood-2014-08-594648 · Cited by 235
Cell competition is a tumour suppressor mechanism in the thymus
Martins, V. C., Busch, K., Juraeva, D., Blum, C., Ludwig, C., Rasche, V., Lasitschka, F., Mastitsky, S. E., Brors, B., Hielscher, T., et al. (2014) · Nature · doi:10.1038/nature13317 · Cited by 231
Papayannidis, C., DeAngelo, D. J., Stock, W., Huang, B., Shaik, M. N., Cesari, R., Zheng, X., Reynolds, J. M., English, P. A., Ozeck, M., et al. (2015) · Blood Cancer Journal · doi:10.1038/bcj.2015.80 · Cited by 122
Self-citationFine-tuning of the intracellular canonical Notch signaling pathway
Borggrefe, T., & Liefke, R. (2012) · Cell Cycle · doi:10.4161/cc.11.2.18995 · Cited by 102
The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells
Geimer Le Lay, A.-S., Oravecz, A., Mastio, J., Jung, C., Marchal, P., Ebel, C., Dembélé, D., Jost, B., Le Gras, S., Thibault, C., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2004545 · Cited by 74
Metadata
- Authors
- Aster, J. C., Blacklow, S. C., & Pear, W. S.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2010-10-21
- Volume
- 223
- Issue
- 2
- Pages
- 263-274
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2037290810
- Cited by
- 163
- References
- 5
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
