IL‐1β induces thymic stromal lymphopoietin and an atopic dermatitis‐like phenotype in reconstructed healthy human epidermis
Abstract
Atopic dermatitis (AD) is a common skin inflammatory disease characterized by the production of thymic stromal lymphopoietin (TSLP) and marked T H 2 polarization. Recent studies suggest that IL‐1β contributes to the development of AD skin inflammation. Here, we have investigated the impact of IL‐1β signalling on the epidermal homeostasis of both healthy subjects and AD patients [with functional filaggrin (FLG) alleles], with particular attention to TSLP production and keratinocyte differentiation. In healthy reconstructed human epidermis (RHE), IL‐1β promoted (i) robust secretion of TSLP in an NF‐κB‐dependent manner and (ii) a significant decrease in the expression of filaggrin and other proteins of the epidermal differentiation complex. These effects were prevented by treatment of RHE with the anti‐IL‐1β mAb canakinumab and by the IL‐1 receptor antagonist anakinra. Interestingly, RHE generated from AD donors behaved like that of healthy individuals and showed comparable responses to IL‐1β signals. Collectively, our results suggest that IL‐1β may be an early key mediator for the acquisition of an AD phenotype through induction of TSLP and alteration of the epidermal homeostasis. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Inhibition of FLG expression by keratinocyte-derived cytokines including TNF-α, TSLP, IL-1β, IL-33, and IL-25 has been documented.
“Inhibition of FLG expression by keratinocyte-derived cytokines including TNF-α (37), thymic stromal lymphopoietin (TSLP) (38), IL-1β (39), IL-33 (40), and IL-25 (41) has been documented.”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [39]
Cites
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
Soumelis, V., Reche, P. A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M. F., Ho, S., Antonenko, S. V., Lauerma, A., et al. (2002) · Nature Immunology · doi:10.1038/ni805 · Cited by 2,186 · see citing works
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960 · see citing works
Weidinger, S., & Novak, N. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00149-x · Cited by 1,908 · see citing works
Leung, D. Y. M., & Bieber, T. R. M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12193-9 · Cited by 1,149 · see citing works
The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch
Wilson, S. R., Thé, L., Batia, L. M., Beattie, K., Katibah, G. E., McClain, S. P., Pellegrino, M., Estandian, D., & Bautista, D. M. (2013) · Cell · doi:10.1016/j.cell.2013.08.057 · Cited by 989 · see citing works
Gittler, J. K., Shemer, A., Suárez-Fariñas, M., Fuentes-Duculan, J., Gulewicz, K. J., Wang, C. Q. F., Mitsui, H., Cardinale, I., de Guzman Strong, C., Krueger, J. G., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.07.012 · Cited by 981 · see citing works
Boniface, K., Bernard, F.-X., Garcia, M., Gurney, A. L., Lecron, J.-C., & Morel, F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3695 · Cited by 864 · see citing works
Allakhverdi, Z., Comeau, M. R., Jessup, H. K., Yoon, B. P., Brewer, A. W., Chartier, S., Paquette, N., Ziegler, S. F., Sarfati, M., & Delespesse, G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062211 · Cited by 787 · see citing works
Sensing the outside world: TSLP regulates barrier immunity
Ziegler, S. F., & Artis, D. (2010) · Nature Immunology · doi:10.1038/ni.1852 · Cited by 558 · see citing works
Suárez-Fariñas, M., Dhingra, N., Gittler, J., Shemer, A., Cardinale, I., de Guzman Strong, C., Krueger, J. G., & Guttman-Yassky, E. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.046 · Cited by 483 · see citing works
Cytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L. C., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.012 · Cited by 473 · see citing works
Suárez‐Fariñas, M., Tintle, S. J., Shemer, A., Chiricozzi, A., Nograles, K. E., Cardinale, I. R., Duan, S., Bowcock, A. M., Krueger, J. G., & Guttman‐Yassky, E. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.12.1124 · Cited by 466 · see citing works
Craven, R. R., Gao, X., Allen, I. C., Gris, D., Wardenburg, J. B., McElvania, E., Ting, J. P. ‐., & Duncan, J. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007446 · Cited by 433 · see citing works
The multifunctional role of filaggrin in allergic skin disease
McAleer, M. A., & Irvine, A. D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.668 · Cited by 413 · see citing works
Willart, M. A. M., Deswarte, K., Pouliot, P., Braun, H., Beyaert, R., Lambrecht, B. N., & Hammad, H. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112691 · Cited by 409 · see citing works
van Smeden, J., & Bouwstra, J. A. (2016) · Current Problems in Dermatology · doi:10.1159/000441540 · Cited by 366 · see citing works
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity
Brydges, S. D., Mueller, J. L., McGeough, M. D., Pena, C. A., Misaghi, A., Gandhi, C., Putnam, C. D., Boyle, D. L., Firestein, G. S., Horner, A. A., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.005 · Cited by 339 · see citing works
Lee, H., & Ziegler, S. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607305104 · Cited by 338 · see citing works
Muñoz-Planillo, R., Franchi, L., Miller, L. S., & Núñez, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900729 · Cited by 335 · see citing works
Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis
Nomura, I., Gao, B., Boguniewicz, M., Darst, M. A., Travers, J. B., & Leung, D. Y. M. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.08.049 · Cited by 332 · see citing works
Guttman‐Yassky, E., Nograles, K. E., & Krueger, J. G. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.054 · Cited by 312 · see citing works
IL-31 regulates differentiation and filaggrin expression in human organotypic skin models
Cornelissen, C., Marquardt, Y., Czaja, K., Wenzel, J., Frank, J., Lüscher‐Firzlaff, J., Lüscher, B., & Baron, J. M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.10.042 · Cited by 292 · see citing works
Kežić, S., O’Regan, G. M., Lutter, R., Jakaša, I., Koster, E. S., Saunders, S. P., Caspers, P. J., Kemperman, P. M. J. H., Puppels, G. J., Sandilands, A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.989 · Cited by 276 · see citing works
Bogiatzi, S. I., Fernandez, I., Bichet, J.-C., Marloie-Provost, M.-A., Volpe, E., Sastre‐Garau, X., & Soumelis, V. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3373 · Cited by 272 · see citing works
Hijnen, D., Knol, E. F., Gent, Y. Y. J., Giovannone, B., Beijn, S. J. P., Kupper, T. S., Bruijnzeel-Koomen, C. A. F. M., & Clark, R. A. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.456 · Cited by 272 · see citing works
Hijnen, D., de Bruin-Weller, M. S., Oosting, B., Lebre, M. C., de Jong, E. C., Bruijnzeel-Koomen, C. A. F. M., & Knol, E. F. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.12.007 · Cited by 268 · see citing works
TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms
Takai, T. (2012) · Allergology International · doi:10.2332/allergolint.11-rai-0395 · Cited by 255 · see citing works
TSLP acts on infiltrating effector T cells to drive allergic skin inflammation
He, R., Oyoshi, M. K., Garibyan, L., Kumar, L., Ziegler, S. F., & Geha, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801532105 · Cited by 250 · see citing works
Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin
Pellerin, L., Henry, J., Hsu, C.-Y., Balica, S., Jean-Decoster, C., Méchin, M.-C., Hansmann, B., Rodriguez, E., Weindinger, S., Schmitt, A.-M., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1566 · Cited by 239 · see citing works
The cutaneous innate immune response in patients with atopic dermatitis
Kuo, I., Yoshida, T., Benedetto, A. D., & Beck, L. A. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1563 · Cited by 232 · see citing works
Leyva-Castillo, J. M., Hener, P., Jiang, H., & Li, M. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.239 · Cited by 231 · see citing works
IL-25 in Atopic Dermatitis: A Possible Link between Inflammation and Skin Barrier Dysfunction?
Hvid, M., Vestergaard, C., Kemp, K., Christensen, G. B., Deleuran, B. W., & Deleuran, M. S. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.277 · Cited by 219 · see citing works
Mechanism of HBD-3 deficiency in atopic dermatitis
Howell, M. D., Boguniewicz, M., Pastore, S., Novak, N., Bieber, T., Girolomoni, G., & Leung, D. Y. M. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.08.008 · Cited by 208 · see citing works
Pastore, S., Fanales‐Belasio, E., Albanesi, C., Chinni, L. M., Giannetti, A., & Girolomoni, G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119496 · Cited by 205 · see citing works
Overview of the interleukin-1 family of ligands and receptors
Dinarello, C. A. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.001 · Cited by 198 · see citing works
Vu, A. T., Baba, T., Chen, X., Lê, T. A., Kinoshita, H., Xie, Y., Kamijo, S., Hiramatsu, K., Ikeda, S., Ogawa, H., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.002 · Cited by 186 · see citing works
Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes
Dai, X., Sayama, K., Tohyama, M., Shirakata, Y., Hanakawa, Y., Tokumaru, S., Yang, L., Hirakawa, S., & Hashimoto, K. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.12.006 · Cited by 173 · see citing works
Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis
Rebane, A., Zimmermann, M., Aab, A., Baurecht, H., Koreck, A., Karelson, M., Abram, K., Metsalu, T., Pihlap, M., Meyer, N., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.02.020 · Cited by 162 · see citing works
Zhang, K., Shan, L., Rahman, M. S., Unruh, H. W., Halayko, A. J., & GOUNNI, A. S. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00045.2007 · Cited by 161 · see citing works
Alteration of Tight Junction Proteins Is an Early Event in Psoriasis
Kirschner, N., Poetzl, C., Driesch, P. V. D., Wladykowski, E., Moll, I., Behne, M. J., & Brandner, J. M. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080973 · Cited by 158 · see citing works
Fornasa, G., Tsilingiri, K., Caprioli, F., Botti, F., Mapelli, M., Meller, S., Kislat, A., Homey, B., Sabatino, A. D., Sonzogni, A., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.04.011 · Cited by 145 · see citing works
Chemokines induce eosinophil degranulation through CCR-3
Fujisawa, T., Kato, Y., Nagase, H., et al. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.108311 · Cited by 139 · see citing works
Nagarkar, D. R., Poposki, J. A., Comeau, M. R., Biyasheva, A., Avila, P. C., Schleimer, R. P., & Kato, A. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.04.019 · Cited by 132 · see citing works
Kinoshita, H., Takai, T., Lê, T. A., Kamijo, S., Wang, X. L., Ushio, H., Hara, M., Kawasaki, J., Vu, A. T., Ogawa, T., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.10.008 · Cited by 131 · see citing works
Sensitization via Healthy Skin Programs Th2 Responses in Individuals with Atopic Dermatitis
Newell, L., Polak, M. E., Perera, J., Owen, C. L., Boyd, P., Pickard, C., Howarth, P. H., Healy, E., Holloway, J. W., Friedmann, P. S., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.148 · Cited by 122 · see citing works
Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis
Takaoka, A., Arai, I., Sugimoto, M., Yamaguchi, A., Tanaka, M., & Nakaike, S. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.04.040 · Cited by 120 · see citing works
Omori‐Miyake, M., Yamashita, M., Tsunemi, Y., Kawashima, M., & Yagi, J. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.503 · Cited by 120 · see citing works
Skin-Infiltrating CD8+ T Cells Initiate Atopic Dermatitis Lesions
Hennino, A., Vocanson, M., Toussaint, Y., Rodet, K., Bénetière, J., Schmitt, A.-M., Ariès, M.-F., Bérard, F., Rozières, A., & Nicolas, J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5571 · Cited by 119 · see citing works
Self-citationEpidermal Barrier in Atopic Dermatitis
Kim, B. E., & Leung, D. Y. (2012) · Allergy, Asthma and Immunology Research · doi:10.4168/aair.2012.4.1.12 · Cited by 114 · see citing works
The contribution of keratinocytes to the pathogenesis of atopic dermatitis.
Pastore, S., Mascia, F., & Girolomoni, G. (2006) · PubMed · Cited by 104 · see citing works
Therapeutic implications of a barrier-based pathogenesis of atopic dermatitis
Elias, P. M., & Wakefield, J. S. (2011) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-010-8231-1 · Cited by 103 · see citing works
Xie, Y., Takai, T., Chen, X., Okumura, K., & Ogawa, H. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2012.03.007 · Cited by 101 · see citing works
TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis
Morizane, S., Yamasaki, K., Kajita, A., Ikeda, K., Zhan, M., Aoyama, Y., Gallo, R. L., & Iwatsuki, K. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.03.006 · Cited by 101 · see citing works
Zepter, K., Häffner, A. C., Soohoo, L., Luca, D. D., Tang, H. P., Fisher, P. B., Chavinson, J., & Elmets, C. A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.12.6203 · Cited by 94 · see citing works
Yokouchi, M., Kubo, A., Kawasaki, H., Yoshida, K., Ishii, K., Furuse, M., & Amagai, M. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.11.007 · Cited by 90 · see citing works
Altered claudin expression is a feature of chronic plaque psoriasis
Watson, R. E. B., Poddar, R., Walker, J., McGuill, I., Hoare, L. M., Griffiths, C. E. M., & O’Neill, C. A. (2007) · The Journal of Pathology · doi:10.1002/path.2200 · Cited by 85 · see citing works
Basophil Responses to Chemokines Are Regulated by Both Sequential and Cooperative Receptor Signaling
Heinemann, Á., Hartnell, A., Stubbs, V. E. L., Murakami, K., Soler, D. F., LaRosa, G. J., Askenase, P. W., Williams, T. J., & Sabroe, I. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.12.7224 · Cited by 80 · see citing works
Hennino, A., Jean, C., Giordano‐Labadie, F., Debeer, S. O. S., Vanbervliet, B., Rozières, A., Schmitt, A.-M., & Nicolas, J. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.022 · Cited by 69 · see citing works
Self-citationMa, P., Bian, F., Wang, Z., et al. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3074 · Cited by 66 · see citing works
IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis
Kim, S. J., Kim, H. J., Yang, H. S., Kim, E., Huh, I., & Yang, J.-M. (2011) · Annals of Dermatology · doi:10.5021/ad.2011.23.4.468 · Cited by 66 · see citing works
Limat, A., & Hunziker, T. (2002) · Cells Tissues Organs · doi:10.1159/000065615 · Cited by 52 · see citing works
Landheer, J., Giovannone, B., Mattson, J. D., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.07.051 · Cited by 45 · see citing works
Cytokines as therapeutic targets in skin inflammation
Wittmann, M., McGonagle, D., & Werfel, T. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.008 · Cited by 42 · see citing works
Profiling and metaanalysis of epidermal keratinocytes responses to epidermal growth factor
Blumenberg, M. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-85 · Cited by 38 · see citing works
Niebuhr, M., Heratizadeh, A., Wichmann, K., Satzger, I., & Werfel, T. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01277.x · Cited by 38 · see citing works
Li, J., Leyva-Castillo, J. M., Hener, P., Eisenmann, A., Zaafouri, S., Jonca, N., Serre, G., Birling, M., & Li, M. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.01.013 · Cited by 30 · see citing works
Guiraud, B., Hernandez-Pigeon, H., Ceruti, I., et al. (2014) · International Journal of Cosmetic Science · doi:10.1111/ics.12150 · Cited by 27 · see citing works
Self-citationSimon, D., & Lang, K. K. (2011) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32834cad0a · Cited by 26 · see citing works
Nutan, F., Kanwar, A. J., & Parsad, D. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04133.x · Cited by 23 · see citing works
Antagonistic effect of the inflammasome on thymic stromal lymphopoietin expression in the skin
Schuepbach‐Mallepell, S., Philippe, V., Brüggen, M., Watanabe, H., Roques, S., Baldeschi, C., & Gaide, O. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.06.033 · Cited by 23 · see citing works
Analysis of Gene Expression in Atopic Dermatitis Using a Microabrasive Method
Bianchi, P., Ribet, V., Casas, C., Lejeune, O., Schmitt, A.-M., & Redoules, D. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.306 · Cited by 22 · see citing works
Yoshikawa, Y., Sasahara, Y., Takeuchi, K., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14023215 · Cited by 22 · see citing works
Vos, J. B., Datson, N. A., van Kampen, A. H. C., et al. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-9 · Cited by 19 · see citing works
Nisticò, S. P., Paolillo, N., Minella, D., Piccirilli, S., Rispoli, V., Giardina, E., Biancolella, M., Chimenti, S., Novelli, G., & Nisticò, G. (2010) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201002300410 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Particulate matter causes skin barrier dysfunction.
Kim, B. E., Kim, J., Goleva, E., Berdyshev, E., Lee, J., Vang, K. A., Lee, U. H., Han, S., Leung, S., Hall, C. F., et al. (2021) · JCI insight · doi:10.1172/jci.insight.145185 · Cited by 173 · see citing works
“stromal lymphopoietin (TSLP) (38), IL-1beta (39), IL-33 (40), and IL-25 (41) has been documented.”
Alarmin cytokines as central regulators of cutaneous immunity
Hasegawa, T., Oka, T., & Demehri, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.876515 · Cited by 70 · see citing works
- Authors
- Bernard, M., Carrasco, C., Laoubi, L., Guiraud, B., Rozières, A., Goujon, C., Duplan, H., Bessou‐Touya, S., Nicolas, J., Vocanson, M., & Galliano, M.
- Affiliations
- Lyon 1 Université (FR)
- Pierre Fabre (France) (FR)
- Hôpital Lyon Sud (FR)
- Corresponding author
- Vocanson, Marc
- Galliano, Marie‐Florence
- ORCID
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2017-04-06
- Volume
- 242
- Issue
- 2
- Pages
- 234-245
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2588105665
- Cited by
- 66
- References
- 74
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 7 · 2023: 8 · 2022: 11 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 1 · 2017: 1
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pathology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Association Nationale de la Recherche et de la Technologie
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- IL-1β, thymic stromal lymphopoietin, atopic dermatitis, reconstructed human epidermis, filaggrin, keratinocyte differentiation, epidermal homeostasis, NF-κB signaling, canakinumab, anakinra, epidermal differentiation complex, skin inflammation
- MeSH terms
- Filaggrin Proteins, Thymic Stromal Lymphopoietin, Adult, Antibodies, Monoclonal, Cell Differentiation, Dermatitis, Atopic, Epidermis, Female, Homeostasis, Humans, Intermediate Filament Proteins, Male, Middle Aged, Phenotype, Cytokines, NF-kappa B, Interleukin-1beta, Interleukin 1 Receptor Antagonist Protein, Young Adult, Antibodies, Monoclonal, Humanized
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
