The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Computational pathology definitions, best practices, and recommendations for regulatory guidance: a white paper from the Digital Pathology Association
Open accessAbstract
In this white paper, experts from the Digital Pathology Association (DPA) define terminology and concepts in the emerging field of computational pathology, with a focus on its application to histology images analyzed together with their associated patient data to extract information. This review offers a historical perspective and describes the potential clinical benefits from research and applications in this field, as well as significant obstacles to adoption. Best practices for implementing computational pathology workflows are presented. These include infrastructure considerations, acquisition of training data, quality assessments, as well as regulatory, ethical, and cyber‐security concerns. Recommendations are provided for regulators, vendors, and computational pathology practitioners in order to facilitate progress in the field. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
LeCun, Y., Bengio, Y., & Hinton, G. (2015) · Nature · doi:10.1038/nature14539 · Cited by 84,126
Grad-CAM: Visual Explanations from Deep Networks via Gradient-Based Localization
Selvaraju, R. R., Cogswell, M., Das, A., Vedantam, R., Parikh, D., & Batra, D. (2017) · 2017 IEEE International Conference on Computer Vision (ICCV) · doi:10.1109/iccv.2017.74 · Cited by 24,513
"Why Should I Trust You?": Explaining the Predictions of Any Classifier
Ribeiro, M. T., Singh, S., & Guestrin, C. (2016) · Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining · doi:10.1145/2939672.2939778 · Cited by 17,555
A survey on deep learning in medical image analysis
Litjens, G., Kooi, T., Bejnordi, B. E., Setio, A. A. A., Ciompi, F., Ghafoorian, M., van der Laak, J. A. W. M., van Ginneken, B., & Sánchez, C. I. (2017) · Medical Image Analysis · doi:10.1016/j.media.2017.07.005 · Cited by 15,332
Deep learning in medical image analysis
Shen, D., Wu, G., & Suk, H.-I. (2017) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071516-044442 · Cited by 4,968
Ehteshami Bejnordi, B., Veta, M., Johannes van Diest, P., van Ginneken, B., Karssemeijer, N., Litjens, G., van der Laak, J. A. W. M., and the CAMELYON16 Consortium, Hermsen, M., Manson, Q. F., et al. (2017) · JAMA · doi:10.1001/jama.2017.14585 · Cited by 3,293
Self-citationOpportunities and obstacles for deep learning in biology and medicine
Ching, T., Himmelstein, D. S., Beaulieu-Jones, B. K., Kalinin, A. A., Do, B. T., Way, G. P., Ferrero, E., Agapow, P.-M., Zietz, M., Hoffman, M. M., et al. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0387 · Cited by 2,310
The practical implementation of artificial intelligence technologies in medicine
He, J., Baxter, S. L., Xu, J., Xu, J., Zhou, X., & Zhang, K. (2019) · Nature Medicine · doi:10.1038/s41591-018-0307-0 · Cited by 2,246
Mitosis Detection in Breast Cancer Histology Images with Deep Neural Networks
Cireşan, D. C., Giusti, A., Gambardella, L. M., & Schmidhuber, J. (2013) · Lecture Notes in Computer Science · doi:10.1007/978-3-642-40763-5_51 · Cited by 1,536
Image analysis and machine learning in digital pathology: challenges and opportunities
Madabhushi, A., & Lee, G. (2016) · Medical Image Analysis · doi:10.1016/j.media.2016.06.037 · Cited by 1,093
Cited by
Deep learning in histopathology: the path to the clinic
van der Laak, J., Litjens, G., & Ciompi, F. (2021) · Nature Medicine · doi:10.1038/s41591-021-01343-4 · Cited by 902
Self-citationAI applications to medical images: From machine learning to deep learning
Castiglioni, I., Rundo, L., Codari, M., Di Leo, G., Salvatore, C., Interlenghi, M., Gallivanone, F., Cozzi, A., D'Amico, N. C., & Sardanelli, F. (2021) · Physica Medica · doi:10.1016/j.ejmp.2021.02.006 · Cited by 710
Digital pathology and artificial intelligence in translational medicine and clinical practice
Baxi, V., Edwards, R., Montalto, M., & Saha, S. (2022) · Modern Pathology · doi:10.1038/s41379-021-00919-2 · Cited by 592
A foundation model for clinical-grade computational pathology and rare cancers detection
Vorontsov, E., Bozkurt, A., Casson, A., Shaikovski, G., Zelechowski, M., Severson, K., Zimmermann, E., Hall, J., Tenenholtz, N., Fusi, N., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03141-0 · Cited by 572
Artificial intelligence and computational pathology
Cui, M., & Zhang, D. Y. (2021) · Laboratory Investigation · doi:10.1038/s41374-020-00514-0 · Cited by 544
Artificial intelligence (AI) and big data in cancer and precision oncology
Dlamini, Z., Francies, F. Z., Hull, R., & Marima, R. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.08.019 · Cited by 398
Artificial intelligence for digital and computational pathology
Song, A. H., Jaume, G., Williamson, D. F. K., Lu, M. Y., Vaidya, A., Miller, T. R., & Mahmood, F. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00096-8 · Cited by 356
Digital Pathology: Advantages, Limitations and Emerging Perspectives
Jahn, S. W., Plass, M., & Moinfar, F. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113697 · Cited by 348
Digital pathology and computational image analysis in nephropathology
Barisoni, L., Lafata, K. J., Hewitt, S. M., Madabhushi, A., & Balis, U. G. J. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-0321-6 · Cited by 264
A Graph-Transformer for Whole Slide Image Classification
Zheng, Y., Gindra, R. H., Green, E. J., Burks, E. J., Betke, M., Beane, J. E., & Kolachalama, V. B. (2022) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2022.3176598 · Cited by 255
A population-level digital histologic biomarker for enhanced prognosis of invasive breast cancer
Amgad, M., Hodge, J. M., Elsebaie, M. A. T., Bodelon, C., Puvanesarajah, S., Gutman, D. A., Siziopikou, K. P., Goldstein, J. A., Gaudet, M. M., Teras, L. R., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02643-7 · Cited by 137
Biopsy-Free in Vivo Virtual Histology of Skin Using Deep Learning
Li, J., Garfinkel, J., Zhang, X., Wu, D., Zhang, Y., de Haan, K., Wang, H., Liu, T., Bai, B., Rivenson, Y., et al. (2021) · Light: Science & Applications · doi:10.1038/s41377-021-00674-8 · Cited by 109
Brancato, V., Esposito, G., Coppola, L., Cavaliere, C., Mirabelli, P., Scapicchio, C., Borgheresi, R., Neri, E., Salvatore, M., & Aiello, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04891-8 · Cited by 106
Explainability and causability in digital pathology
Plass, M., Kargl, M., Kiehl, T., Regitnig, P., Geißler, C., Evans, T., Zerbe, N., Carvalho, R., Holzinger, A., & Müller, H. (2023) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.322 · Cited by 99
Turner, O. C., Aeffner, F., Bangari, D. S., High, W., Knight, B., Forest, T., Cossic, B., Himmel, L. E., Rudmann, D. G., Bawa, B., et al. (2020) · Toxicologic Pathology · doi:10.1177/0192623319881401 · Cited by 64
Self-citationYang, P., Yin, X., Lu, H., Hu, Z., Zhang, X., Jiang, R., & Lv, H. (2022) · Medical Image Analysis · doi:10.1016/j.media.2022.102539 · Cited by 50
Banff Digital Pathology Working Group: Going Digital in Transplant Pathology
Farris, A. B., Moghe, I., Wu, S., Hogan, J., Cornell, L. D., Alexander, M. P., Kers, J., Demetris, A. J., Levenson, R. M., Tomaszewski, J., et al. (2020) · American Journal of Transplantation · doi:10.1111/ajt.15850 · Cited by 48
One label is all you need: Interpretable AI-enhanced histopathology for oncology
Tavolara, T. E., Su, Z., Gurcan, M. N., & Niazi, M. K. K. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.09.006 · Cited by 28
A review of current systems for annotation of cell and tissue images in digital pathology
Korzynska, A., Roszkowiak, L., Zak, J., & Siemion, K. (2021) · Biocybernetics and Biomedical Engineering · doi:10.1016/j.bbe.2021.04.012 · Cited by 26
Kulkarni Kale, U., & Vemulapalli, G. (2025) · The Cancer Journal · doi:10.1097/ppo.0000000000000799 · Cited by 1
Metadata
- Authors
- Abels, E., Pantanowitz, L., Aeffner, F., Zarella, M. D., van der Laak, J., Bui, M. M., Vemuri, V. N., Parwani, A. V., Gibbs, J., Agosto‐Arroyo, E., Beck, A. H., & Kozlowski, C.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2019-09-03
- Volume
- 249
- Issue
- 3
- Pages
- 286-294
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2964756323
- Cited by
- 459
- References
- 55
- FWCI
- 19.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
