Systematic review and meta‐analysis of objective and subjective quality of life among pediatric, adolescent, and young adult bone tumor survivors
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Background: Pediatric, adolescent, and young adult survivors of bone sarcomas are at risk for poor quality of life (QOL). We conducted a systematic review and meta‐analysis to summarize the literature describing QOL in this population and differences in QOL based on local control procedures. Procedure: Included studies described ≥5 patients <25 years old who had completed local control treatment for bone sarcoma, defined QOL as a main outcome, and measured it with a validated instrument. Data extraction and quality assessments were conducted with standardized tools. Meta‐analyses compared QOL based on surgical procedure (limb‐sparing vs. amputation) and were stratified by assessment type (objective physical function, clinician‐assessed disability, patient‐reported disability, and patient‐reported QOL). Effect sizes were reported as the standard mean difference when multiple instruments were used within a comparison and weighted mean difference otherwise. All were weighted by inverse variance and modeled with random effects. Results: Twenty‐two of 452 unique manuscripts were included in qualitative syntheses, eight of which were included in meta‐analyses. Manuscripts were heterogeneous with respect to included patient populations (age, tumor type, time since treatment) and QOL instruments. Prospective studies suggested that QOL improves over time, and that female sex and older age at diagnosis are associated with poor QOL. Meta‐analyses showed no differences in outcomes between patients who underwent limb‐sparing versus amputation for local control. Conclusion: QOL studies among children and AYAs with bone sarcoma are remarkably diverse, making it difficult to detect trends in patient outcomes. Future research should focus on standardized QOL instruments and interpretations. Pediatr Blood Cancer 2015;62:1616–1629. © 2015 Wiley Periodicals, Inc.
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Few studies have investigated the health-related quality of life of osteosarcoma survivors.
“Few studies have investigated the health-related quality of life (HRQoL) of osteosarcoma survivors 177 .”
From Osteosarcoma (2022) · cites this paper as [177]
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- Authors
- Stokke, J., Sung, L., Gupta, A., Lindberg, A., & Rosenberg, A. R.
- Affiliations
- Seattle Children's Hospital (US)
- Hospital for Sick Children (CA)
- University of Toronto (CA)
- Venue
- Pediatric Blood & Cancer
- Publisher
- Wiley
- Published
- 2015-03-27
- Volume
- 62
- Issue
- 9
- Pages
- 1616-1629
- ISSN
- 1545-5009 (ISSN-L)
- 1545-5017
- PMC
- PMC4515170
- OpenAlex
- W1791980580
- Cited by
- 77
- References
- 55
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 6 · 2023: 4 · 2022: 10 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 1
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pediatric Blood & Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (KL2TR000421)
- National Cancer Institute (L40 CA170049)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- quality of life, bone sarcoma, childhood cancer survivors, adolescent and young adult cancer survivors, limb-sparing surgery, amputation, physical function, disability, patient-reported outcomes, sex differences, age at diagnosis
- MeSH terms
- Adolescent, Age Factors, Amputation, Surgical, Bone Neoplasms, Child, Child, Preschool, Cross-Sectional Studies, Female, Persons with Disabilities, Humans, Male, Prospective Studies, Quality of Life, Surveys and Questionnaires, Sarcoma, Survivors, Recovery of Function, Limb Salvage, Young Adult, Self Report
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