Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic?

Hallmarks of Cancer: The Next Generation

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The limited in vitro lifetime of human diploid cell strains

Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766 · see citing works

Exosomes: composition, biogenesis and function

Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355 · see citing works

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works

Membrane vesicles as conveyors of immune responses

Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works

Exosomes: Extracellular organelles important in intercellular communication

Mathivanan, S., Ji, H. L., & Simpson, R. J. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.06.006 · Cited by 2,539 · see citing works

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

Engelman, J. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2664 · Cited by 2,445 · see citing works

The microenvironment of the tumour–host interface

Liotta, L. A., & Kohn, E. C. (2001) · Nature · doi:10.1038/35077241 · Cited by 2,322 · see citing works

Stromal fibroblasts in cancer initiation and progression

Bhowmick, N. A., Neilson, E. G., & Moses, H. L. (2004) · Nature · doi:10.1038/nature03096 · Cited by 2,291 · see citing works

Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

Hennessy, B. T., Smith, D. L., Ram, P. T., Lu, Y., & Mills, G. B. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1902 · Cited by 2,183 · see citing works

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

Al-Nedawi, K. N. I., Meehan, B., Micallef, J., Lhotak, V., May, L. L., Guha, A., & Rak, J. W. (2008) · Nature Cell Biology · doi:10.1038/ncb1725 · Cited by 2,037 · see citing works

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

Wolfers, J., Lozier, A., Raposo, G., Régnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,643 · see citing works

Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

Ratajczak, J., Miękus, K., Kucia, M., Zhang, J., Reca, R., Dvořák, P., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404132 · Cited by 1,630 · see citing works

The self-tuning neuron: synaptic scaling of excitatory synapses

Turrigiano, G. G. (2008) · Cell · doi:10.1016/j.cell.2008.10.008 · Cited by 1,533 · see citing works

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V. C., Borràs, F. E., Breakefield, X., Budnik, V., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001450 · Cited by 1,367 · see citing works

Alzheimer’s disease β-amyloid peptides are released in association with exosomes

Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., & Simons, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603838103 · Cited by 1,343 · see citing works

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311 · see citing works

Exosomes with Immune Modulatory Features Are Present in Human Breast Milk

Admyre, C., Johansson, S. M., Qazi, K. R., Filén, J., Lahesmaa, R., Norman, M., Neve, E. P. A., Scheynius, A., & Gabrielsson, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1969 · Cited by 1,222 · see citing works

Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., & Vekrellis, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5699-09.2010 · Cited by 1,115 · see citing works

Exosomes: proteomic insights and diagnostic potential

Simpson, R. J., Lim, J. W., Moritz, R. L., & Mathivanan, S. (2009) · Expert Review of Proteomics · doi:10.1586/epr.09.17 · Cited by 1,113 · see citing works

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

Arslan, F., Lai, R. C., Smeets, M. B., Akeroyd, L., Choo, A. B. H., Aguor, E. N. E., Timmers, L., van Rijen, H. V. M., Doevendans, P. A., Pasterkamp, G., et al. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.01.002 · Cited by 1,108 · see citing works

Molecular Characterization of Dendritic Cell-Derived Exosomes

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PI3K-PKB/Akt PathwayPreprint

Hemmings, B. A., & Restuccia, D. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011189 · Cited by 1,054 · see citing works

Active Wnt proteins are secreted on exosomes

Gross, J. C., Chaudhary, V., Bartscherer, K., & Boutros, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2574 · Cited by 1,025 · see citing works

Cells release prions in association with exosomes

Février, B., Vilette, D., Archer, F., Loew, D., Faigle, W., Vidal, M., Laude, H., & Raposo, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308413101 · Cited by 998 · see citing works

Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

Saman, S., Kim, W., Raya, M., Visnick, Y., Miro, S., Saman, S., Jackson, B., McKee, A. C., Alvarez, V. E., Lee, N. C. Y., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277061 · Cited by 985 · see citing works

Malignant effusions and immunogenic tumour-derived exosomes

André, F., Schartz, N. E. C., Movassagh, M., Flament, C., Pautier, P., Morice, P., Pomel, C., Lhommé, C., Escudier, B. J., Chevalier, T. L., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09552-1 · Cited by 953 · see citing works

Exosomes are released by cultured cortical neurones

Fauré, J., Lachenal, G., Court, M., Hirrlinger, J., Chatellard-Causse, C., Blot, B., Grange, J., Schoehn, G., Goldberg, Y., Boyer, V., et al. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.12.003 · Cited by 896 · see citing works

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

Webber, J. P., Steadman, R., Mason, M. D., Tabi, Z., & Clayton, A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1722 · Cited by 850 · see citing works

Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration

Maness, P. F., & Schachner, M. (2006) · Nature Neuroscience · doi:10.1038/nn1827 · Cited by 850 · see citing works

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

Alvarez‐Erviti, L., Seow, Y., Schapira, A. H. V., Gardiner, C., Sargent, I. L., Wood, M. J. A., & Cooper, J. A. D. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.029 · Cited by 741 · see citing works

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

Taelman, V. F., Dobrowolski, R., Plouhinec, J.-L., Fuentealba, L. C., Vorwald, P. P., Gumper, I., Sabatini, D. D., & Robertis, E. M. D. (2010) · Cell · doi:10.1016/j.cell.2010.11.034 · Cited by 715 · see citing works

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

Nazarenko, I. A., Rana, S., Baumann, A., McAlear, J., Hellwig, A., Trendelenburg, M. F., Lochnit, G., Preissner, K. T., & Zöller, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2470 · Cited by 686 · see citing works

Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.

Dvorak, H. F., Nagy, J. A., Dvorák, J., & Dvořàk, A. M. (1988) · PubMed Central · Cited by 679 · see citing works

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

Al-Nedawi, K. N. I., Meehan, B., Kerbel, R. S., ALLISON, A. C., & Rak, J. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804543106 · Cited by 666 · see citing works

Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma

Kalra, H., Adda, C. G., Liem, M. K., Ang, C., Mechler, Á., Simpson, R. J., Hulett, M. D., & Mathivanan, S. (2013) · PROTEOMICS · doi:10.1002/pmic.201300282 · Cited by 625 · see citing works

Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

Lachenal, G. M., Pernet‐Gallay, K., Chivet, M., Hemming, F. J., Belly, A., Bodon, G., Blot, B., Haase, G., Goldberg, Y., & Sadoul, R. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.004 · Cited by 595 · see citing works

Proteomics Analysis of A33 Immunoaffinity-purified Exosomes Released from the Human Colon Tumor Cell Line LIM1215 Reveals a Tissue-specific Protein Signature

Mathivanan, S., Lim, J. W. E., Tauro, B. J., Ji, H. L., Moritz, R. L., & Simpson, R. J. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900152-mcp200 · Cited by 593 · see citing works

Human tumor virus utilizes exosomes for intercellular communication

Meckes, D. G., Shair, K. H. Y., Marquitz, A. R., Kung, C.-P., Edwards, R. H., & Raab‐Traub, N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014194107 · Cited by 542 · see citing works

Human Tumor-Derived Exosomes Selectively Impair Lymphocyte Responses to Interleukin-2

Clayton, A., Mitchell, J. P., Court, J., Mason, M. D., & Tabi, Z. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3456 · Cited by 519 · see citing works

Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

Beckler, M. D., Higginbotham, J. N., Franklin, J. L., Ham, A. L., Halvey, P. J., Imasuen, I., Whitwell, C. A., Li, M., Liebler, D. C., & Coffey, R. J. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.022806 · Cited by 514 · see citing works

Proteomics, transcriptomics and lipidomics of exosomes and ectosomes

Choi, D., Kim, D., Kim, Y., & Gho, Y. S. (2013) · PROTEOMICS · doi:10.1002/pmic.201200329 · Cited by 513 · see citing works

Cancer and the tumor microenvironment: a review of an essential relationship

Mbeunkui, F., & Johann, D. J. (2008) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-008-0881-9 · Cited by 476 · see citing works

Senescence-Associated Exosome Release from Human Prostate Cancer Cells

Lehmann, B. D., Paine, M. S., Brooks, A. M., McCubrey, J. A., Renegar, R. H., Wang, R., & Terrian, D. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6538 · Cited by 464 · see citing works

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

Grad, L. I., Yerbury, J. J., Turner, B. J., Guest, W., Pokrishevsky, E., O’Neill, M. A., Yanai, A., Silverman, J. M., Zeineddine, R., Corcoran, L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312245111 · Cited by 433 · see citing works

Proteomic and immunologic analyses of brain tumor exosomes

Graner, M. W., Álzate, Ó., Dechkovskaia, A. M., Keene, J. D., Sampson, J. H., Mitchell, D. A., & Bigner, D. D. (2008) · The FASEB Journal · doi:10.1096/fj.08-122184 · Cited by 430 · see citing works

Packaging of prions into exosomes is associated with a novel pathway of PrP processing

Vella, L. J., Sharples, R., Lawson, V., Masters, C. L., Cappai, R., & Hill, A. F. (2007) · The Journal of Pathology · doi:10.1002/path.2145 · Cited by 426 · see citing works

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

Sheldon, H., Heikamp, E., Turley, H., Dragovic, R., Thomas, P. H., Oon, C. E., Leek, R., Edelmann, M. J., Kessler, B. M., Sainson, R. C. A., et al. (2010) · Blood · doi:10.1182/blood-2009-08-239228 · Cited by 409 · see citing works

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

Korkut, C., Ataman, B., Ramachandran, P., Ashley, J., Barria, R., Gherbesi, N., & Budnik, V. (2009) · Cell · doi:10.1016/j.cell.2009.07.051 · Cited by 396 · see citing works

Proteomics Analysis of Bladder Cancer Exosomes

Welton, J. L., Khanna, S., Giles, P. J., Brennan, P., Brewis, I. A., Staffurth, J. N., Mason, M. D., & Clayton, A. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m000063-mcp201 · Cited by 387 · see citing works

Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines

Pukrop, T., Klemm, F., Hagemann, T., Gradl, D., Schulz, M., Siemes, S., Trümper, L. H. P., & Binder, C. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509703103 · Cited by 362 · see citing works

Amphiregulin exosomes increase cancer cell invasion

Higginbotham, J. N., Demory Beckler, M., Gephart, J. D., Franklin, J. L., Bogatcheva, G., Kremers, G.-J., Piston, D. W., Ayers, G. D., McConnell, R. E., Tyska, M. J., et al. (2011) · Current Biology · doi:10.1016/j.cub.2011.03.043 · Cited by 360 · see citing works

Proteomic Analysis of Exosomes Secreted by Human Mesothelioma Cells

Hegmans, J. P., Bard, M. P. L., Hemmes, A., Luider, T. M., Kleijmeer, M. J., Prins, J., Zitvogel, L., Burgers, S. A., Hoogsteden, H. C., & Lambrecht, B. N. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63739-x · Cited by 350 · see citing works

CD44v6 Dependence of Premetastatic Niche Preparation by Exosomes

Jung, T., Castellana, D., Klingbeil, P., Hernández, I. C., Vitacolonna, M., Orlicky, D. J., Roffler, S. R., Brodt, P., & Zöller, M. (2009) · Neoplasia · doi:10.1593/neo.09822 · Cited by 341 · see citing works

Lactadherin promotes VEGF-dependent neovascularization

Silvestre, J., Théry, C., Hamard, G., Boddaert, J., Aguilar, B. A., Delcayre, A. X., Houbron, C., Tamarat, R., Blanc‐Brude, O., Heeneman, S., et al. (2005) · Nature Medicine · doi:10.1038/nm1233 · Cited by 320 · see citing works

Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models

Suetsugu, A., Honma, K., Saji, S., Moriwaki, H., Ochiya, T., & Hoffman, R. M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.007 · Cited by 314 · see citing works

Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity

Danzer, K. M., Ruf, W. P., Putcha, P., Joyner, D., Hashimoto, T., Glabe, C. C., Hyman, B. T., & McLean, P. J. (2010) · The FASEB Journal · doi:10.1096/fj.10-164624 · Cited by 309 · see citing works

Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation

Qu, J.-L., Qu, X.-J., Zhao, M.-F., Teng, Y.-E., Zhang, Y., Hou, K., Jiang, Y.-H., Yang, X., & Liu, Y.-P. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.04.006 · Cited by 303 · see citing works

Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation

McCready, J., Sims, J. D., Chan, D. W., & Jay, D. G. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-294 · Cited by 298 · see citing works

Mechanism of Evenness Interrupted (Evi)-Exosome Release at Synaptic Boutons

Koles, K., Nunnari, J. N., Korkut, C., Barría, R., Brewer, C. K., Li, Y., Leszyk, J., Zhang, B., & Budnik, V. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.342667 · Cited by 284 · see citing works

Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases

Masyuk, A. I., Masyuk, T. V., & LaRusso, N. F. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.028 · Cited by 283 · see citing works

Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion

Mineo, M., Garfield, S. H., Taverna, S., Flugy, A. M., Leo, G. D., Alessandro, R., & Kohn, E. C. (2011) · Angiogenesis · doi:10.1007/s10456-011-9241-1 · Cited by 267 · see citing works

Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin.

Kim, C. W., Lee, H. M., Lee, T. H., Kang, C., Kleinman, H. K., & Gho, Y. S. (2002) · PubMed · Cited by 265 · see citing works

Inhibition of γ‐secretase causes increased secretion of amyloid precursor protein C‐terminal fragments in association with exosomes

Sharples, R. A., Vella, L. J., Nisbet, R. M., Naylor, R., Perez, K. A., Barnham, K. J., Masters, C. L., & Hill, A. F. (2008) · The FASEB Journal · doi:10.1096/fj.07-9357com · Cited by 253 · see citing works

Modulation of B-cell exosome proteins by gamma herpesvirus infection

Meckes, D. G., Gunawardena, H. P., DeKroon, R. M., Heaton, P. R., Edwards, R. H., Özgür, S., Griffith, J. D., Damania, B., & Raab‐Traub, N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303906110 · Cited by 243 · see citing works

The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor

Miller, W. E., Earp, H. S., & Raab‐Traub, N. (1995) · Journal of Virology · doi:10.1128/jvi.69.7.4390-4398.1995 · Cited by 236 · see citing works

The role of exosomes in the processing of proteins associated with neurodegenerative diseases

Vella, L. J., Sharples, R. A., Nisbet, R. M., Cappai, R., & Hill, A. F. (2007) · European Biophysics Journal · doi:10.1007/s00249-007-0246-z · Cited by 235 · see citing works

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

Kong, S. M. Y., Chan, B. K. K., Park, J., Hill, K. J., Aitken, J. B., Cottle, L., Farghaian, H., Cole, A. R., Lay, P. A., Sue, C. M., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu099 · Cited by 233 · see citing works

Body Fluid Exosomes Promote Secretion of Inflammatory Cytokines in Monocytic Cells via Toll-like Receptor Signaling*

Bretz, N. P., Ridinger, J., Rupp, A.-K., Rimbach, K., Keller, S., Rupp, C., Marmé, F., Umansky, L., Umansky, V., Eigenbrod, T., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.512806 · Cited by 231 · see citing works

Ionizing Radiation and Glioblastoma Exosomes: Implications in Tumor Biology and Cell Migration

Arscott, W. T., Tandle, A. T., Zhao, S., Shabason, J. E., Gordon, I. K., Schlaff, C. D., Zhang, G., Tofilon, P. J., & Camphausen, K. A. (2013) · Translational Oncology · doi:10.1593/tlo.13640 · Cited by 229 · see citing works

Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis

Gomes, C., Keller, S., Altevogt, P., & Costa, J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.09.024 · Cited by 228 · see citing works

Systemic Induction of the Angiogenesis Switch by the Tetraspanin D6.1A/CO-029

Gesierich, S., Berezovskiy, I., Ryschich, E., & Zöller, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0391 · Cited by 225 · see citing works

Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis

Taverna, S., Flugy, A. M., Saieva, L., Kohn, E. C., Santoro, A., Meraviglia, S., Leo, G. D., & Alessandro, R. (2011) · International Journal of Cancer · doi:10.1002/ijc.26217 · Cited by 206 · see citing works

Alkalizing Drugs Induce Accumulation of Amyloid Precursor Protein By-products in Luminal Vesicles of Multivesicular Bodies

Vingtdeux, V., Hamdane, M., Loyens, A., Gelé, P., Drobeck, H., Bégard, S., Galas, M., Delacourte, A., Beauvillain, J., Buée, L., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609475200 · Cited by 195 · see citing works

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

Alvarez‐Erviti, L., Couch, Y., Richardson, J. C., Cooper, J. A. D., & Wood, M. J. A. (2011) · Neuroscience Research · doi:10.1016/j.neures.2010.12.020 · Cited by 193 · see citing works

Tumor–Stroma Interaction: Revealing Fibroblast-Secreted Exosomes as Potent Regulators of Wnt-Planar Cell Polarity Signaling in Cancer Metastasis

Luga, V., & Wrana, J. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1791 · Cited by 180 · see citing works

Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine

Gao, X., & Hannoush, R. N. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1392 · Cited by 167 · see citing works

Human tumor nanoparticles induce apoptosis of pancreatic cancer cells

Ristorcelli, E., Béraud, E., Verrando, P., Villard, C., Lafitte, D., Sbarra, V., Lombardo, D., & Vérine, A. (2008) · The FASEB Journal · doi:10.1096/fj.07-102855 · Cited by 152 · see citing works

Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins

Putz, U., Howitt, J. A., Lackovic, J., Foot, N. J., Kumar, S., Silke, J., & Tan, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804120200 · Cited by 151 · see citing works

Exosomes and the MICA-NKG2D system in cancer

Clayton, A., & Tabi, Z. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.03.003 · Cited by 149 · see citing works

Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

Shi, J., Yao, D., Liu, W., Wang, N., Lv, H., Zhang, G., Ji, M., Li, X., He, N., Shi, B., et al. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-50 · Cited by 145 · see citing works

Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles

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Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma

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