Cited by 38Cancer survivorship and careCancer, Stress, Anesthesia, and Immune ResponseNatural Compounds in Disease Treatment

Role of natural products in breast cancer related symptomology: Targeting chronic inflammation

Andrijauskaite, Kristina, Wargovich, Michael J.·2022·Seminars in Cancer Biology

Abstract

Breast cancer is the most common cancer in women worldwide. There have been many advancements in the treatment of breast cancer leading to an increased population of patients living with this disease. Accumulating evidence suggests that cancer diagnosis and aftermath experienced stress could not only affect the quality of life of cancer patients, but it could also influence their disease outcome. The magnitude of stress experienced by breast cancer patients is often compared to the post-traumatic stress disorder-like symptoms suggested to be mediated by the chronic inflammation including NF-κB, AKt, p53 and other inflammatory pathways. Here, we describe the symptomology of PTSD-like symptoms in breast cancer patients and argue that they may in fact be caused by or maintained through aspects of chronic inflammation mediated by the pro-inflammatory markers. Evidence exists that natural products that might attenuate or lessen the effects of chronic inflammation abound in the diet. We summarize some possible agents that might abate the genesis of symptoms experienced by breast cancer patients while mitigating the effect of inflammation.

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Crossref · 10.1016/j.semcancer.2020.08.011

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Authors
Andrijauskaite, K., & Wargovich, M. J.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Venue
Seminars in Cancer Biology
Publisher
Elsevier BV
Published
2022-05
Volume
80
Pages
370-378
ISSN
1044-579X (ISSN-L)
OpenAlex
W3083163755
Cited by
38
References
175
Citations by year
2026: 4 · 2025: 6 · 2024: 10 · 2023: 10 · 2022: 3 · 2021: 5
FWCI
0.48
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Cancer Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
UT Health San Antonio Mays Cancer Center
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords
breast cancer, chronic inflammation, natural products, cancer-related stress, NF-κB, Akt signaling, p53, pro-inflammatory markers, diet, quality of life, symptom management
MeSH terms
Biological Products, Breast Neoplasms, Female, Humans, Inflammation, Quality of Life, Stress Disorders, Post-Traumatic

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