Role of natural products in breast cancer related symptomology: Targeting chronic inflammation
Abstract
Breast cancer is the most common cancer in women worldwide. There have been many advancements in the treatment of breast cancer leading to an increased population of patients living with this disease. Accumulating evidence suggests that cancer diagnosis and aftermath experienced stress could not only affect the quality of life of cancer patients, but it could also influence their disease outcome. The magnitude of stress experienced by breast cancer patients is often compared to the post-traumatic stress disorder-like symptoms suggested to be mediated by the chronic inflammation including NF-κB, AKt, p53 and other inflammatory pathways. Here, we describe the symptomology of PTSD-like symptoms in breast cancer patients and argue that they may in fact be caused by or maintained through aspects of chronic inflammation mediated by the pro-inflammatory markers. Evidence exists that natural products that might attenuate or lessen the effects of chronic inflammation abound in the diet. We summarize some possible agents that might abate the genesis of symptoms experienced by breast cancer patients while mitigating the effect of inflammation.
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About 50% to 60% of patients with breast cancer perceive cancer diagnosis and treatment as a severe threat to life and physical health.
“In this regard, studies show that about 50% to 60% of patients with breast cancer perceive cancer diagnosis and treatment as a severe threat to life and physical health.”
From Acceptance and commitment therapy for demoralization syndrome and cancer-related trauma: A randomized clinical trial study (2021) · cites this paper as [7]
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- Authors
- Andrijauskaite, K., & Wargovich, M. J.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 80
- Pages
- 370-378
- ISSN
- 1044-579X (ISSN-L)
- OpenAlex
- W3083163755
- Cited by
- 38
- References
- 175
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 10 · 2023: 10 · 2022: 3 · 2021: 5
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Cancer Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- UT Health San Antonio Mays Cancer Center
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- breast cancer, chronic inflammation, natural products, cancer-related stress, NF-κB, Akt signaling, p53, pro-inflammatory markers, diet, quality of life, symptom management
- MeSH terms
- Biological Products, Breast Neoplasms, Female, Humans, Inflammation, Quality of Life, Stress Disorders, Post-Traumatic
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