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Azole fungicides – understanding resistance mechanisms in agricultural fungal pathogens

Price, Claire L, Parker, Josie E, Warrilow, Andrew GS, Kelly, Diane E, Kelly, Steven L·2015·Pest Management Science

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Abstract

Plant fungal pathogens can have devastating effects on a wide range of crops, including cereals and fruit (such as wheat and grapes), causing losses in crop yield, which are costly to the agricultural economy and threaten food security. Azole antifungals are the treatment of choice; however, resistance has arisen against these compounds, which could lead to devastating consequences. Therefore, it is important to understand how these fungicides are used and how the resistance arises in order to tackle the problem fully. Here, we give an overview of the problem and discuss the mechanisms that mediate azole resistance in agriculture (point mutations in the CYP51 amino acid sequence, overexpression of the CYP51 enzyme and overexpression of genes encoding efflux pump proteins). © 2015 Society of Chemical Industry

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See all 321

Authors: Price, C. L., Parker, J. E., Warrilow, A. G., Kelly, D. E., & Kelly, S. L.
Venue: Pest Management Science
Publisher: Wiley
Published: 2015-05-20
Volume: 71
Issue: 8
Pages: 1054-1058
ISSN: 1526-498X (ISSN-L)
1526-4998
DOI: 10.1002/ps.4029
OpenAlex: W1792060583
Cited by: 321
References: 45
FWCI: 20.24
Type: journal article
Language: en
Open access: closed

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Azole fungicides – understanding resistance mechanisms in agricultural fungal pathogens

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