How well will stacked transgenic pest/herbicide resistances delay pests from evolving resistance?
Abstract
Resistance has evolved to single transgenic traits engineered into crops for arthropod and herbicide resistances, and can be expected to evolve to the more recently introduced pathogen resistances. Combining transgenes against the same target pest is being promoted as the solution to the problem. This solution will work if used pre-emptively, but where resistance has evolved to one member of a stack, resistance should easily evolve for the second gene in most cases. We propose and elaborate criteria that could be used to evaluate the value of stacked traits for pest resistance management. Stacked partners must: target the same pest species; be in a tandem construct to preclude segregation; be synchronously expressed in the same tissues; have similar tissue persistence; target pest species that are still susceptible to at least two stacked partners. Additionally, transgene products must not be degraded in the same manner, and there should be a lack of cross-resistance to stacked transgenes or to their products. With stacked herbicide resistance transgenes, both herbicides must be used and have the same persistence. If these criteria are followed, and integrated with other pest management practices, resistance may be considerably delayed. © 2016 Society of Chemical Industry.
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Pyramid events, current Bt varieties expressing two or more insecticidal genes, are more effective in controlling target pests and help to slow down the evolution of resistance.
“These so-called pyramid events are more effective in controlling the target pests and help to slow down the evolution of resistance (Gressel et al., 2017;Huang, 2015;Que et al., 2010;Zhao et al. 2005).”
From Genetically engineered crops help support conservation biological control (2019) · cites this paper as Gressel et al., 2017
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Genetically engineered crops help support conservation biological control
Romeis, J., Naranjo, S. E., Meissle, M., & Shelton, A. M. (2019) · Biological Control · doi:10.1016/j.biocontrol.2018.10.001 · Cited by 231 · see citing works
- Authors
- Gressel, J., Gassmann, A. J., & Owen, M. D.
- Affiliations
- Weizmann Institute of Science (IL)
- Iowa State University (US)
- Corresponding author
- Gressel, Jonathan
- Venue
- Pest Management Science
- Publisher
- Wiley
- Published
- 2016-10-20
- Volume
- 73
- Issue
- 1
- Pages
- 22-34
- ISSN
- 1526-498X (ISSN-L)
- 1526-4998
- OpenAlex
- W2511681954
- Cited by
- 50
- References
- 94
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 8 · 2017: 6
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pest Management Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
- Keywords
- genetically modified crops, pest resistance management, herbicide resistance, cross-resistance, transgene persistence, tissue-specific gene expression, integrated pest management, pathogen resistance
- MeSH terms
- Animals, Insecticide Resistance, Pest Control, Biological, Time Factors, Crops, Agricultural, Transgenes, Evolution, Molecular, Plants, Genetically Modified
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