Anthelminthic and antiallergic activities of Mangifera indica L. stem bark components Vimang and mangiferin
Abstract
This study investigated the antiallergic and anthelmintic properties of Vimang (an aqueous extract of Mangifera indica family stem bark) and mangiferin (the major polyphenol present in Vimang) administered orally to mice experimentally infected with the nematode, Trichinella spiralis. Treatment with Vimang or mangiferin (500 or 50 mg per kg body weight per day, respectively) throughout the parasite life cycle led to a significant decline in the number of parasite larvae encysted in the musculature; however, neither treatment was effective against adults in the gut. Treatment with Vimang or mangiferin likewise led to a significant decline in serum levels of specific anti-Trichinella IgE, throughout the parasite life cycle. Finally, oral treatment of rats with Vimang or mangiferin, daily for 50 days, inhibited mast cell degranulation as evaluated by the passive cutaneous anaphylaxis test (sensitization with infected mouse serum with a high IgE titre, then stimulation with the cytosolic fraction of T. spiralis muscle larvae). Since IgE plays a key role in the pathogenesis of allergic diseases, these results suggest that Vimang and mangiferin may be useful in the treatment of diseases of this type.
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Oral mangiferin (50 mg/kg) reduces the number of parasitic larvae in Trichinella spiralis infection.
“Oral mangiferin (50 mg/kg) suppresses the growth of nematode Trichinella spiralis throughout the parasitic life cycle, by inhibiting mast cell degranulation, decreasing the serum levels of specific anti-Trichinella IgE and reducing the number of parasitic larvae (114).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [114]
Oral mangiferin (50 mg/kg) suppresses the growth of nematode Trichinella spiralis throughout the parasitic life cycle.
“Oral mangiferin (50 mg/kg) suppresses the growth of nematode Trichinella spiralis throughout the parasitic life cycle, by inhibiting mast cell degranulation, decreasing the serum levels of specific anti-Trichinella IgE and reducing the number of parasitic larvae (114).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [114]
Oral mangiferin (50 mg/kg) decreases serum levels of specific anti-Trichinella IgE.
“Oral mangiferin (50 mg/kg) suppresses the growth of nematode Trichinella spiralis throughout the parasitic life cycle, by inhibiting mast cell degranulation, decreasing the serum levels of specific anti-Trichinella IgE and reducing the number of parasitic larvae (114).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [114]
Oral mangiferin (50 mg/kg) inhibits mast cell degranulation in Trichinella spiralis infection.
“Oral mangiferin (50 mg/kg) suppresses the growth of nematode Trichinella spiralis throughout the parasitic life cycle, by inhibiting mast cell degranulation, decreasing the serum levels of specific anti-Trichinella IgE and reducing the number of parasitic larvae (114).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [114]
Cites
Guha, S., Ghosal, S., & Chattopadhyay, U. (2009) · Chemotherapy · doi:10.1159/000239478 · Cited by 275 · see citing works
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Mangiferin: A natural miracle bioactive compound against lifestyle related disorders
Imran, M., Arshad, M. S., Butt, M. S., Kwon, J.-H., Arshad, M. U., & Sultan, M. T. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0449-y · Cited by 366 · see citing works
Pal, P. B., Sinha, K., & Sil, P. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107220 · Cited by 185 · see citing works
Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works
“Oral mangiferin (50 mg/kg) suppresses the growth of nematode Trichinella spiralis throughout the parasitic life cycle, by inhibiting mast cell degranulation, decreasing the serum levels of specific anti‑ Trichinella IgE and reducing the number of parasitic larvae (114).”
Pal, P. B., Sinha, K., & Sil, P. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056894 · Cited by 98 · see citing works
Morozkina, S. N., Nhung Vu, T. H., Generalova, Y. E., Snetkov, P. P., & Uspenskaya, M. V. (2021) · Biomolecules · doi:10.3390/biom11010079 · Cited by 82 · see citing works
Antidiabetic activity of mango peel extract and mangiferin in alloxan-induced diabetic rats
Mistry, J., Biswas, M., Sarkar, S., & Ghosh, S. (2023) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-023-00472-6 · Cited by 48 · see citing works
- Authors
- García, D., Escalante, M., Delgado, R., Ubeira, F. M., & Leiro, J.
- Affiliations
- Universidade de Santiago de Compostela (ES)
- Corresponding author
- Leiro, J.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2003-12
- Volume
- 17
- Issue
- 10
- Pages
- 1203-1208
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2019348905
- Cited by
- 109
- References
- 1
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 4 · 2014: 13 · 2013: 7 · 2012: 2
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondo de Investigación Sanitaria (Ministerio de Sanidad y Consumo, Spain) (0010787)
- Xunta de Galicia, Spain (PGID-T99MAR20301)
- Agencia Española de Cocperacion Internacional (AECI), Spain
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- mango, Vimang, mangiferin, anthelmintic activity, anti-allergic activity, Trichinella spiralis, trichinellosis, IgE, mast cell degranulation, polyphenols, stem bark extract, parasitic nematodes, allergic diseases
- MeSH terms
- Administration, Oral, Anaphylaxis, Animals, Anthelmintics, Antibodies, Helminth, Dose-Response Relationship, Drug, Larva, Male, Phytotherapy, Mice, Inbred BALB C, Plant Extracts, Trichinellosis, Trichinella spiralis, Plant Stems, Anti-Allergic Agents, Mangifera, Xanthones, Mice, Rats
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