Mangiferin, a natural xanthone, protects murine liver in Pb(II) induced hepatic damage and cell death via MAP kinase, NF-κB and mitochondria dependent pathways

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

Tissue sulfhydryl groups

Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,824 · see citing works

Antioxidant Determinations by the Use of a Stable Free Radical

Blois, M. S. (1958) · Nature · doi:10.1038/1811199a0 · Cited by 13,180 · see citing works

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061 · see citing works

The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

Nash, T. (1953) · Biochemical Journal · doi:10.1042/bj0550416 · Cited by 4,358 · see citing works

A fluorometric method for determination of oxidized and reduced glutathione in tissues

Hissin, P. J., & Hilf, R. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90326-2 · Cited by 4,106 · see citing works

[42] Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal

Esterbauer, H., & Cheeseman, K. H. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86134-h · Cited by 3,360 · see citing works

The Relative Antioxidant Activities of Plant-Derived Polyphenolic Flavonoids

Rice-Evans, C. A., Miller, N. J., Bolwell, P., Bramley, P. M., & Pridham, J. B. (1995) · Free Radical Research · doi:10.3109/10715769509145649 · Cited by 2,160 · see citing works

Toxic Metals and Oxidative Stress Part I: Mechanisms Involved in Me-tal induced Oxidative Damage

Nuran Ercal, B. S. P., Hande Gurer-Orhan, B. S. P., & Nukhet Aykin-Burns, B. S. P. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013394831 · Cited by 1,944 · see citing works

TISSUE SULPHYDRYL GROUPS

Ellman, G. L. (1959) · Cited by 1,422 · see citing works

Toxicological profile for lead

(2020) · doi:10.15620/cdc:95222 · Cited by 1,337 · see citing works

The Nitric Oxide-Scavenging Properties of Ginkgo Biloba Extract EGb 761

Marcocci, L., Maguire, J. J., Droy-Lefaix, M. T., & Packer, L. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1764 · Cited by 1,053 · see citing works

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

Sellins, K. S., & Cohen, J. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.10.3199 · Cited by 919 · see citing works

Can antioxidants be beneficial in the treatment of lead poisoning?

Gürer-Orhan, H., & Nuran Ercal, A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00413-5 · Cited by 612 · see citing works

Lead Toxicity: Current Concerns

Goyer, R. A. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.93100177 · Cited by 568 · see citing works

Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.

Uchida, K., & Stadtman, E. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53264-6 · Cited by 513 · see citing works

Low level lead exposure and oxidative stress: Current opinions

Ahamed, M., & Siddiqui, M. K. J. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.04.024 · Cited by 469 · see citing works

Antioxidant effects of α tocopherol, ascorbic acid and l-methionine on lead induced oxidative stress to the liver, kidney and brain in rats

Patra, R. C., Swarup, D., & Dwivedi, S. K. (2001) · Toxicology · doi:10.1016/s0300-483x(01)00345-6 · Cited by 432 · see citing works

New and evolving concepts in the neurotoxicology of lead☆

White, L. D., Cory‐Slechta, D. A., Gilbert, M. E., Tiffany‐Castiglioni, E., Zawia, N. H., Virgolini, M. B., Rossi‐George, A., Lasley, S. M., Qian, Y., & Basha, R. M. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.08.001 · Cited by 404 · see citing works

Tumor Necrosis Factor-α-induced IKK Phosphorylation of NF-κB p65 on Serine 536 Is Mediated through the TRAF2, TRAF5, and TAK1 Signaling Pathway

Sakurai, H., Suzuki, S., Kawasaki, N., Nakano, H., Okazaki, T., CHINO, A., Doi, T., & Saiki, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301598200 · Cited by 374 · see citing works

Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes

LeBel, C. P., & Bondy, S. C. (1990) · Neurochemistry International · doi:10.1016/0197-0186(90)90025-o · Cited by 313 · see citing works

Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice

Martı́nez-Sánchez, G., Re, L., Giuliani, A., Sellés, A. J. N., Pérez-Davison, G., & León-Fernández, O. S. (2000) · Pharmacological Research · doi:10.1006/phrs.2000.0727 · Cited by 302 · see citing works

Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone

Guha, S., Ghosal, S., & Chattopadhyay, U. (2009) · Chemotherapy · doi:10.1159/000239478 · Cited by 275 · cited 1× · see citing works

Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice

Makare, N., Bodhankar, S., & Rangari, V. (2001) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00326-9 · Cited by 258 · see citing works

Flavonoids from Emblica officinalis and Mangifera indica—effectiveness for dyslipidemia

Anila, L., & Vijayalakshmi, N. R. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00361-0 · Cited by 250 · see citing works

The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects

Bode, A. M., & Dong, Z. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00215-3 · Cited by 237 · see citing works

Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats

Muruganandan, S., Gupta, S., Kataria, M., Lal, J., & Gupta, P. K. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00069-0 · Cited by 216 · see citing works

The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats

Yoshimi, N., Matsunaga, K., Katayama, M., Yamada, Y., Kuno, T., Qiao, Z., Hara, A., Yamahara, J., & Mori, H. (2001) · Cancer Letters · doi:10.1016/s0304-3835(00)00678-9 · Cited by 215 · see citing works

Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders

Manna, P., Sinha, M., & Sil, P. C. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-33 · Cited by 202 · see citing works

In vitro assessment of the toxicity of metal compounds

Christie, N. T., & Costa, M. (1984) · Biological Trace Element Research · doi:10.1007/bf02916931 · Cited by 198 · see citing works

Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid

Manna, P., Das, J., Ghosh, J., & Sil, P. C. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.02.025 · Cited by 189 · see citing works

Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2–NFκB pathways

Das, J., Ghosh, J., Roy, A., & Sil, P. C. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.01.015 · Cited by 173 · see citing works

Evaluation of the in vitro antioxidant activity of Mangifera indica L. extract (Vimang)

Mart�nez, G., Delgado, R., P�rez, G., Garrido, G., Sellés, A. J. N., & León, O. S. (2000) · Phytotherapy Research · doi:10.1002/1099-1573(200009)14:6 · Cited by 163 · see citing works

Influence of age, exercise, and dietary restriction on oxidative stress in rats

Kim, J. D., McCarter, R., & Yu, B. (1996) · Aging Clinical and Experimental Research · doi:10.1007/bf03339566 · Cited by 158 · see citing works

Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin

Leiro, J. M., Arranz, J. A., Yáñez, M., Ubeira, F. M., Sanmartín, M. L., & Orallo, F. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.03.002 · Cited by 152 · see citing works

Antihyperglycaemic effect of Mangifera indica in rat

Aderibigbe, A., EMUDIANUGHE, T. S., & Lawal, B. A. (1999) · Phytotherapy Research · doi:10.1002/(sici)1099-1573(199909)13:6 · Cited by 148 · see citing works

In vitro assessment of the toxicity of metal compounds

Heck, J. D., & Costa, M. (1982) · Biological Trace Element Research · doi:10.1007/bf02783248 · Cited by 148 · see citing works

Signal transduction pathways: targets for chemoprevention of skin cancer

Bode, A. M., & Dong, Z. (2000) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00029-2 · Cited by 130 · see citing works

Evaluation of anti-diarrhoeal activity in seed extracts of Mangifera indica

Sairam, K., Hemalatha, S., Kumar, A., Srinivasan, T., Ganesh, J., Shankar, M., & Venkataraman, S. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00250-7 · Cited by 127 · see citing works

Protection of arsenic-induced testicular oxidative stress by arjunolic acid

Manna, P., Sinha, M., & Sil, P. C. (2008) · Redox Report · doi:10.1179/135100008x259169 · Cited by 113 · see citing works

Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway

Ghosh, J., Das, J., Manna, P., & Sil, P. C. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.09.010 · Cited by 109 · see citing works

Anthelminthic and antiallergic activities of <i>Mangifera indica</i> L. stem bark components Vimang and mangiferin

García, D., Escalante, M., Delgado, R., Ubeira, F. M., & Leiro, J. (2003) · Phytotherapy Research · doi:10.1002/ptr.1343 · Cited by 109 · see citing works

The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties

Bhattacharjee, R., & Sil, P. C. (2006) · Phytotherapy Research · doi:10.1002/ptr.1933 · Cited by 98 · see citing works

Anti-oxidative Effect of a Protein from Cajanus indicus L against Acetaminophen-induced Hepato-nephro Toxicity

Ghosh, A., & Sil, P. C. (2007) · BMB Reports · doi:10.5483/bmbrep.2007.40.6.1039 · Cited by 95 · see citing works

Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways

Manna, P., Sinha, M., & Sil, P. C. (2008) · Toxicology · doi:10.1016/j.tox.2008.12.008 · Cited by 94 · see citing works

Protective role of Tinospora cordifolia against lead-induced hepatotoxicity

Sharma, V. K., & Pandey, D. (2010) · Toxicology International · doi:10.4103/0971-6580.68343 · Cited by 94 · see citing works

A microtiter plate assay for superoxide using MTT reduction method.

Madesh, M., & Balasubramanian, K. A. (1997) · PubMed · Cited by 92 · see citing works

Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties

Bhattacharjee, R., & Sil, P. C. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2006.10.029 · Cited by 92 · see citing works

SILYMARIN EFFECTS ON INTRACELLULAR CALCUIM AND CYTOTOXICITY: A STUDY IN PERFUSED RAT HEPATOCYTES AFTER OXIDATIVE STRESS INJURY

Farghali, H. (2000) · Pharmacological Research · doi:10.1006/phrs.1999.0575 · Cited by 90 · see citing works

Liver sinusoidal endothelial cells represents an important blood clearance system in pigs

Nedredal, G. I., Elvevold, K., Ytrebø, L. M., Olsen, R. F., Revhaug, A., & Smedsrød, B. H. (2003) · Comparative Hepatology · doi:10.1186/1476-5926-2-1 · Cited by 88 · see citing works

The Critical Role of Mitochondrial Energetic Impairment in the Toxicity of Nimesulide to Hepatocytes

Mingatto, F. E., Rodrigues, T., Pigoso, A. A., Uyemura, S. A., Curti, C., & dos Santos, A. C. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.038620 · Cited by 85 · see citing works

Lead Activates Nuclear Transcription Factor -κB, Activator Protein-1, and Amino-Terminal c-Jun Kinase in Pheochromocytoma Cells

Ramesh, G. T., Manna, S. K., Aggarwal, B. B., & Jadhav, A. L. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8624 · Cited by 84 · see citing works

Protective effect of arjunolic acid against arsenic‐induced oxidative stress in mouse brain

Sinha, M., Manna, P., & Sil, P. C. (2008) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.20209 · Cited by 84 · see citing works

Apoptosis commitment – translating survival signals into decisions on mitochondria

Keeble, J. A., & Gilmore, A. P. (2007) · Cell Research · doi:10.1038/cr.2007.101 · Cited by 78 · see citing works

N-Acetyl-L-Cysteine Affords Protection against Lead-Induced Cytotoxicity and Oxidative Stress in Human Liver Carcinoma (HepG2) Cells

Yedjou, C. G., & Tchounwou, P. B. (2007) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph2007040007 · Cited by 75 · see citing works

Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo.

Chatterjee, M., & Sil, P. C. (2006) · PubMed · Cited by 67 · see citing works

A 43kDa protein from the herb Cajanus indicus L. protects thioacetamide induced cytotoxicity in hepatocytes

Sarkar, K., & Sil, P. C. (2006) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.11.003 · Cited by 61 · see citing works

Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-κB pathway: Role of a novel plant protein

Ghosh, A., & Sil, P. C. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.09.006 · Cited by 59 · see citing works

D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-κB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin

Ghosh, M., Das, J., & Sil, P. C. (2011) · Free Radical Research · doi:10.3109/10715762.2011.644240 · Cited by 57 · see citing works

Lead exposure activates nuclear factor kappa B, activator protein-1, c-Jun N-terminal kinase and caspases in the rat brain

Ramesh, G. T., Manna, S. K., Aggarwal, B. B., & Jadhav, A. L. (2001) · Toxicology Letters · doi:10.1016/s0378-4274(01)00395-2 · Cited by 57 · see citing works

Protective effect of the fruits of Terminalia arjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway

Ghosh, J., Das, J., Manna, P., & Sil, P. C. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.05.062 · Cited by 49 · see citing works

Hepatocytes are protected by herb Phyllanthus niruri protein isolate against thioacetamide toxicity

Sarkar, M. K., & Sil, P. C. (2007) · Pathophysiology · doi:10.1016/j.pathophys.2007.08.001 · Cited by 47 · see citing works

Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress

Chatterjee, M., Sarkar, K., & Sil, P. C. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.02.003 · Cited by 45 · see citing works

Prevention of tertiary butyl hydroperoxide induced oxidative impairment and cell death by a novel antioxidant protein molecule isolated from the herb, Phyllanthus niruri

Sarkar, M. K., & Sil, P. C. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.05.014 · Cited by 45 · see citing works

THE PROTECTIVE EFFECT OF SESAMOL AGAINST MITOCHONDRIAL OXIDATIVE STRESS AND HEPATIC INJURY IN ACETAMINOPHEN-OVERDOSED RATS

Chandrasekaran, V. R. M., Hsu, D.-Z., & Liu, M.-Y. (2009) · Shock · doi:10.1097/shk.0b013e31818ede6f · Cited by 44 · see citing works

Evaluation of antibacterial activity of Mangifera indica on anaerobic dental microglora based on in vivo studies.

Bairy, I., Reeja, S., Siddharth, Rao, P. S., Bhat, M., & Shivananda, P. G. (2002) · PubMed · Cited by 42 · see citing works

A new xanthone C-glucoside, position isomer of Mangiferin, from Bunge

Aritomi, M., & Kawasaki, T. (1969) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)97704-4 · Cited by 42 · see citing works

Purification and characterisation of a novel antioxidant protein molecule from Phyllanthus niruri

Sarkar, M. K., Kinter, M. T., Mazumder, B., & Sil, P. C. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.11.022 · Cited by 42 · see citing works

A Protein from Cajanus indicus Spreng Protects Liver and Kidney against Mercuric Chloride-Induced Oxidative Stress

Ghosh, A., & Sil, P. C. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1651 · Cited by 39 · see citing works

Purification and Characterization of a 43 kD Hepatoprotective Protein from the Herb Cajanus indicus L.

Sarkar, K., Ghosh, A., Kinter, M. T., Mazumder, B., & Sil, P. C. (2006) · The Protein Journal · doi:10.1007/s10930-006-9030-7 · Cited by 38 · see citing works

A 43 kD Protein Isolated from the Herb Cajanus indicus L Attenuates Sodium Fluoride-induced Hepatic and Renal Disorders in Vivo

Manna, P., Sinha, M., & Sil, P. C. (2007) · BMB Reports · doi:10.5483/bmbrep.2007.40.3.382 · Cited by 36 · see citing works

Kupffer cells promote lead nitrate-induced hepatocyte apoptosis via oxidative stress

Pagliara, P., Carlà, E. C., Caforio, S., Chionna, A., Massa, S., Abbro, L., & Dini, L. (2003) · Comparative Hepatology · doi:10.1186/1476-5926-2-8 · Cited by 31 · see citing works

Attenuation of cadmium chloride induced cytotoxicity in murine hepatocytes by a protein isolated from the leaves of the herb Cajanus indicus L.

Sinha, M., Manna, P., & Sil, P. C. (2007) · Archives of Toxicology · doi:10.1007/s00204-007-0176-7 · Cited by 30 · see citing works

Preventive and curative role of a 43kD protein from the leaves of the herb L on thioacetamide-induced hepatotoxicity in vivo

SARKAR, K., Ghosh, A., & Sil, P. C. (2005) · Hepatology Research · doi:10.1016/j.hepres.2005.06.007 · Cited by 29 · see citing works

Biochemical Aspects of Lead Exposure in Silver Jewelry Workers in Western Maharastra (India)

Patil, A. J., V.R. Bhagwat, Patil, J. A., Dongre, N., Ambekar, J. G., & Das, K. K. (2006) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp.2006.17.4.213 · Cited by 28 · see citing works

Protective role ofPhyllanthus niruri against nimesulide induced hepatic damage

Chatterjee, M., & Sil, P. C. (2007) · Indian Journal of Clinical Biochemistry · doi:10.1007/bf02912892 · Cited by 26 · see citing works

Pulse radiolysis studies of mangiferin: A C-glycosyl xanthone isolated from Mangifera indica

Mishra, B., Priyadarsini, K. I., Sudheerkumar, M., Unnikrishhnan, M. K., & Mohan, H. (2005) · Radiation Physics and Chemistry · doi:10.1016/j.radphyschem.2005.05.015 · Cited by 23 · see citing works

Traditional extract of Pithecellobium dulce fruits protects mice against CCl4 induced renal oxidative impairments and necrotic cell death

Pal, P. B., Pal, S., Manna, P., & Sil, P. C. (2012) · Pathophysiology · doi:10.1016/j.pathophys.2012.02.001 · Cited by 19 · see citing works

Attenuation of Acetaminophen-Induced Hepatotoxicity In Vivo and In Vitro by a 43-kD Protein Isolated from the HerbCajanus indicusL

Sarkar, K., & Sil, P. C. (2007) · Toxicology Mechanisms and Methods · doi:10.1080/15376510601031919 · Cited by 18 · see citing works

Protein Isolate from the HerbPhyllanthus niruriModulates Carbon Tetrachloride-Induced Cytotoxicity in Hepatocytes

Bhattacharjee, R., & Sil, P. C. (2006) · Toxicology Mechanisms and Methods · doi:10.1080/15376510600970034 · Cited by 18 · see citing works

Cajanus indicus leaf protein: Beneficial role in experimental organ pathophysiology. A review

Sarkar, K., & Sil, P. C. (2011) · Pathophysiology · doi:10.1016/j.pathophys.2011.05.001 · Cited by 10 · see citing works

Protein isolate from the herb, Phyllanthus niruri, protects liver from acetaminophen induced toxicity

Bhattacharjee, R., & Sil, P. C. (2006) · Biomedical Research-tokyo · Cited by 8 · see citing works

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

Sinha, K., Das, J., Pal, P. B., & Sil, P. C. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1034-4 · Cited by 1,622 · see citing works

Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus

Tangvarasittichai, S. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i3.456 · Cited by 1,238 · see citing works

Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction

Paithankar, J. G., Saini, S., Dwivedi, S., Sharma, A., & Chowdhuri, D. K. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128350 · Cited by 603 · see citing works

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

Ghosh, S., Banerjee, S., & Sil, P. C. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.05.022 · Cited by 501 · see citing works

Protective effect of curcumin against heavy metals-induced liver damage

García‐Niño, W. R., & Pedraza‐Chaverrí, J. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.04.016 · Cited by 388 · see citing works

Graphene Quantum Dots from Mangifera indica : Application in Near-Infrared Bioimaging and Intracellular Nanothermometry

Kumawat, M. K., Thakur, M., Gurung, R. B., & Srivastava, R. (2016) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.6b01893 · Cited by 368 · see citing works

Mangiferin: A natural miracle bioactive compound against lifestyle related disorders

Imran, M., Arshad, M. S., Butt, M. S., Kwon, J.-H., Arshad, M. U., & Sultan, M. T. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0449-y · Cited by 366 · see citing works

Mangiferin attenuates diabetic nephropathy by inhibiting oxidative stress mediated signaling cascade, TNFα related and mitochondrial dependent apoptotic pathways in streptozotocin-induced diabetic rats

Pal, P. B., Sinha, K., & Sil, P. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107220 · Cited by 185 · see citing works

Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential

Saha, S., Sadhukhan, P., & Sil, P. C. (2016) · BioFactors · doi:10.1002/biof.1292 · Cited by 159 · see citing works

Study of the synergistic effect of Mangifera indica leaves extract and zinc ions on the mild steel corrosion inhibition in simulated seawater: Computational and electrochemical studies

Ramezanzadeh, M., Bahlakeh, G., & Ramezanzadeh, B. (2019) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2019.111387 · Cited by 145 · see citing works

Mangiferin: An effective therapeutic agent against several disorders (Review)

Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works

An update on oxidative stress-mediated organ pathophysiology

Rashid, K., Sinha, K., & Sil, P. C. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.09.026 · Cited by 139 · see citing works

Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation

Dou, W., Zhang, J., Ren, G., Ding, L., Sun, A., Deng, C., Wu, X., Wei, X., Mani, S., & Wang, Z. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.08.025 · Cited by 135 · see citing works

Mitochondrial Redox Dysfunction and Environmental Exposures

Caito, S. W., & Aschner, M. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6289 · Cited by 94 · see citing works

Nrf2/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation

Wang, Z., Guo, S., Wang, J., Shen, Y., Zhang, J., & Wu, Q. (2017) · Scientific Reports · doi:10.1038/s41598-017-12160-6 · Cited by 92 · see citing works

Mangiferin as New Potential Anti-Cancer Agent and Mangiferin-Integrated Polymer Systems—A Novel Research Direction

Morozkina, S. N., Nhung Vu, T. H., Generalova, Y. E., Snetkov, P. P., & Uspenskaya, M. V. (2021) · Biomolecules · doi:10.3390/biom11010079 · Cited by 82 · see citing works

Mangiferin Ameliorates Cisplatin Induced Acute Kidney Injury by Upregulating Nrf-2 via the Activation of PI3K and Exhibits Synergistic Anticancer Activity With Cisplatin

Sadhukhan, P., Saha, S., Dutta, S., & Sil, P. C. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00638 · Cited by 81 · see citing works

Mangiferin attenuates oxidative stress induced renal cell damage through activation of PI3K induced Akt and Nrf-2 mediated signaling pathways

Saha, S., Sadhukhan, P., Sinha, K., Agarwal, N., & Sil, P. C. (2016) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2016.01.011 · Cited by 80 · see citing works

Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets

Rajendran, P., Rengarajan, T., Nandakumar, N., Divya, H., & Nishigaki, I. (2014) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2014.931431 · Cited by 71 · see citing works

Mangiferin modulation of metabolism and metabolic syndrome

Fomenko, E. V., & Chi, Y. (2016) · BioFactors · doi:10.1002/biof.1309 · Cited by 69 · see citing works

Iron oxide nanoparticles mediated cytotoxicity via PI3K/AKT pathway: Role of quercetin

Sarkar, A., & Sil, P. C. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.06.003 · Cited by 68 · see citing works

Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Tsai, M.-H., Liu, J., Chiang, Y., Hu, S. C., Hsu, L.-F., Lin, Y., Lin, Z., Lee, H.-C., Chen, M.-C., Huang, C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16058 · Cited by 68 · see citing works

Nutraceuticals: An emerging therapeutic approach against the pathogenesis of Alzheimer’s disease

Sadhukhan, P., Saha, S., Dutta, S., Mahalanobish, S., & Sil, P. C. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.11.028 · Cited by 66 · see citing works

Nephroprotective activity of natural products against chemical toxicants: The role of Nrf2/ARE signaling pathway

Molaei, E., Molaei, A., Abedi, F., Hayes, A. W., & Karimi, G. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2320 · Cited by 65 · see citing works

Mitochondrion: a sensitive target for Pb exposure

Han, Q., Zhang, W. K., Guo, J., Zhu, Q., Chen, H., Xia, Y., & Zhu, G. (2021) · The Journal of Toxicological Sciences · doi:10.2131/jts.46.345 · Cited by 64 · see citing works

Mangiferin Has an Additive Effect on the Apoptotic Properties of Hesperidin in Cyclopia sp. Tea Extracts

Bartoszewski, R., Hering, A., Marszałł, M., Stefanowicz‐Hajduk, J., Bartoszewska, S., Kapoor, N., Kochan, K., & Ochocka, J. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092128 · Cited by 63 · see citing works

Mangiferin alleviates arsenic induced oxidative lung injury via upregulation of the Nrf2-HO1 axis

Mahalanobish, S., Saha, S., Dutta, S., & Sil, P. C. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.02.022 · Cited by 60 · see citing works

Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats

Lwin, O. M., Giribabu, N., Kilari, E. K., & Salleh, N. (2020) · Journal of Dermatological Treatment · doi:10.1080/09546634.2020.1721419 · Cited by 59 · see citing works

Mangiferin attenuates contusive spinal cord injury in rats through the regulation of oxidative stress, inflammation and the Bcl-2 and Bax pathway

LUO, Y., Fu, C., Wang, Z., ZHANG, Z., Wang, H., & Liu, Y. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4274 · Cited by 59 · see citing works

Mangiferin and naringenin affect the photostability and phototoxicity of sunscreens containing avobenzone

Kawakami, C. M., & Gaspar, L. R. (2015) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2015.08.014 · Cited by 57 · see citing works

Mangiferin Alleviates Ovalbumin-Induced Allergic Rhinitis via Nrf2/HO-1/NF-κB Signaling Pathways

Piao, C. H., Fan, Y. J., Nguyen, T. V., Song, C. H., & Chai, O. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103415 · Cited by 56 · see citing works

Mangiferin ameliorates placental oxidative stress and activates PI3K/Akt/mTOR pathway in mouse model of preeclampsia

Huang, J., Zheng, L., Wang, F., Yuan, S., Kong, H., & Xin, H. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01220-7 · Cited by 55 · see citing works

In-vitro catalytic, antimicrobial and antioxidant activities of bioengineered copper quantum dots using Mangifera indica (L.) leaf extract

Rani, H., Singh, S. P., Yadav, T. P., Khan, M. S., Ansari, M. I., & Singh, A. K. (2019) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2019.122052 · Cited by 54 · see citing works

Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells

Xia, Z., Zhang, H., Xu, D., Lao, Y., Fu, W., Tan, H., Cao, P., Yang, L., & Xu, H. (2015) · Molecules · doi:10.3390/molecules200611387 · Cited by 51 · see citing works

The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice

Zhang, Z., Gao, X., Guo, M., Jiang, H., Cao, Y., & Zhang, N. (2016) · Biological Trace Element Research · doi:10.1007/s12011-016-0731-2 · Cited by 51 · see citing works

Spectroscopic Studies on Dual Role of Natural Flavonoids in Detoxification of Lead Poisoning: Bench-to-Bedside Preclinical Trial

Adhikari, A., Darbar, S., Chatterjee, T., Das, M., Polley, N., Bhattacharyya, M., Bhattacharya, S. S., Pal, D., & Pal, S. K. (2018) · ACS Omega · doi:10.1021/acsomega.8b02046 · Cited by 49 · see citing works

The role of inflammation in cadmium nephrotoxicity: NF-κB comes into view

Hassanein, E. H. M., Mohamed, W. R., Ahmed, O. S., Abdel‐Daim, M. M., & Sayed, A. M. M. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120971 · Cited by 48 · see citing works

Evaluation of Lead Hepatotoxicity; Histological, Histochemical and Ultrastructural Study

Hegazy, A. M., & Fouad, U. A. (2014) · Forensic Medicine and Anatomy Research · doi:10.4236/fmar.2014.23013 · Cited by 48 · see citing works

Xanthones from mangosteen (Garcinia mangostana): multi-targeting pharmacological properties.

Jindarat, S. (2014) · PubMed · Cited by 47 · see citing works

Mangiferin: the miraculous xanthone with diverse pharmacological properties

Dutta, T., Das, T., Gopalakrishnan, A. V., Saha, S. C., Ghorai, M., Nandy, S., Kumar, M., Radha, Ghosh, A., Mukerjee, N., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02373-6 · Cited by 45 · see citing works

Mangiferin attenuates cisplatin-induced acute kidney injury in rats mediating modulation of MAPK pathway

Sahu, A. K., Verma, V. K., Mutneja, E., Malik, S., Nag, T. C., Dinda, A. K., Arya, D. S., & Bhatia, J. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3420-y · Cited by 45 · see citing works

Protective effect of arjunolic acid against atorvastatin induced hepatic and renal pathophysiology via MAPK, mitochondria and ER dependent pathways

Pal, S., Sarkar, A., Pal, P. B., & Sil, P. C. (2015) · Biochimie · doi:10.1016/j.biochi.2015.02.016 · Cited by 40 · see citing works

Systematic Development and Validation of a Thin-Layer Densitometric Bioanalytical Method for Estimation of Mangiferin Employing Analytical Quality by Design (AQbD) Approach

Khurana, R. K., Rao, S., Beg, S., Katare, O. P., & Singh, B. (2016) · Journal of Chromatographic Science · doi:10.1093/chromsci/bmw001 · Cited by 39 · see citing works

Chlorogenic Acid Ameliorates Lead-Induced Renal Damage in Mice

Zhang, T., Chen, S., Chen, L., Zhang, L., Meng, F., Sha, S., Ai, C., & Tai, J. (2018) · Biological Trace Element Research · doi:10.1007/s12011-018-1508-6 · Cited by 39 · see citing works

The Effect of Mangiferin Against Brain Damage Caused by Oxidative Stress and Inflammation Induced by Doxorubicin

Siswanto, S., Arozal, W., Juniantito, V., Grace, A., Agustini, F. D., & Nafrialdi, N. (2016) · HAYATI Journal of Biosciences · doi:10.1016/j.hjb.2016.02.001 · Cited by 39 · see citing works

Neuroprotective effects of two selenium-containing peptides, TSeMMM and SeMDPGQQ, derived from selenium-enriched rice protein hydrolysates on Pb2+-induced oxidative stress in HT22 cells

Wu, J., Li, P., Shi, Y., Fang, Y., Zhu, Y., Fan, F., Pei, F., Xia, J., Xie, M., & Hu, Q. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110932 · Cited by 37 · see citing works

Mangiferin exerts neuroprotective activity against lead-induced toxicity and oxidative stress via Nrf2 pathway

Li, H.-W., Lan, T.-J., Yun, C.-X., Yang, K.-D., Du, Z.-C., Luo, X.-F., Hao, E.-W., & Deng, J.-G. (2020) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2019.12.002 · Cited by 37 · see citing works

The multifaceted role of mangiferin in health and diseases: a review

Jangra, A., Arora, M. K., Kisku, A., & Sharma, S. (2020) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-020-00471-5 · Cited by 37 · see citing works

HIV-TAT mediated protein transduction of Cu/Zn-superoxide dismutase-1 (SOD1) protects skin cells from ionizing radiation

Gu, Q., Feng, T., Cao, H., Tang, Y., Ge, X., Luo, J., Xue, J., Wu, J., Yang, H., Zhang, S., et al. (2013) · Radiation Oncology · doi:10.1186/1748-717x-8-253 · Cited by 36 · see citing works

Umbilical Cord MSCs Reverse D-Galactose-Induced Hepatic Mitochondrial Dysfunction via Activation of Nrf2/HO-1 Pathway

Yan, W., Li, D., Chen, T., Tian, G., Zhou, P., & Ju, X. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00777 · Cited by 32 · see citing works

Harmonization of Mangiferin on methylmercury engendered mitochondrial dysfunction

Das, S., Paul, A., Mumbrekar, K. D., & Rao, B. S. S. (2016) · Environmental Toxicology · doi:10.1002/tox.22265 · Cited by 31 · see citing works

Cadmium (Cd2+) exposure differentially elicits both cell proliferation and cell death related responses in SK-RC-45

Sinha, K., Pal, P. B., & Sil, P. C. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.11.011 · Cited by 29 · see citing works

Selected Plant-Derived Polyphenols as Potential Therapeutic Agents for Peripheral Artery Disease: Molecular Mechanisms, Efficacy and Safety

Froldi, G., & Ragazzi, E. (2022) · Molecules · doi:10.3390/molecules27207110 · Cited by 27 · see citing works

In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin

Kaurav, M., Kanoujia, J., Gupta, M., Goyal, P., Pant, S., Rai, S., Sahu, K. K., Bhatt, P., & Ghai, R. (2023) · Phytomedicine Plus · doi:10.1016/j.phyplu.2023.100445 · Cited by 27 · see citing works

Novel one pot synthesis and spectroscopic characterization of a folate-Mn 3 O 4 nanohybrid for potential photodynamic therapeutic application

Mondal, S., Adhikari, A., Das, M., Darbar, S., Alharbi, A., Ahmed, S. A., Bhattacharya, S. S., Pal, D., & Pal, S. K. (2019) · RSC Advances · doi:10.1039/c9ra06835j · Cited by 26 · see citing works

Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma

Jain, D., Murti, Y., Khan, W. U., Hossain, R., Hossain, M. N., Agrawal, K. K., Ashraf, R. A., Islam, M. T., Janmeda, P., Taheri, Y., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9068850 · Cited by 24 · see citing works

Protein and Peptides for Elderly Health

Shang, N., Chalamaiah, M., Bandara, N., & Wu, J. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.03.003 · Cited by 24 · see citing works

Mangiferin offers protection against deleterious effects of pharmaceuticals, heavy metals, and environmental chemicals

Naraki, K., Rezaee, R., Mashayekhi‐Sardoo, H., Hayes, A. W., & Karimi, G. (2020) · Phytotherapy Research · doi:10.1002/ptr.6864 · Cited by 22 · see citing works

In vitrostudies on mangiferin protection against cadmium-induced human renal endothelial damage and cell death via the MAP kinase and NF-κB pathways

Rajendran, P., Rengarajan, T., Nishigaki, Y., Palaniswami, R., & Nishigaki, I. (2015) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2015.1019137 · Cited by 22 · see citing works

γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction

Wang, A., Li, D., Wang, S., Zhou, F., Li, P., Wang, Y., & Lin, L. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.11.047 · Cited by 22 · see citing works

Investigating the inflammatory effect of microplastics in cigarette butts on peripheral blood mononuclear cells

Soltani, M., Shahsavani, A., Hopke, P. K., Bakhtiarvand, N. A., Abtahi, M., Rahmatinia, M., & Kermani, M. (2025) · Scientific Reports · doi:10.1038/s41598-024-84784-4 · Cited by 21 · see citing works

Mangiferin for the Management of Liver Diseases: A Review

Li, L., Dong, Y., Liu, X., & Wang, M. (2023) · Foods · doi:10.3390/foods12132469 · Cited by 20 · see citing works

Mangosteen (Garcinia mangostana L.)

EL-Kenawy, A. E.-M., Hassan, S. M. A., & Osman, H.-E. H. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812491-8.00045-x · Cited by 20 · see citing works

Systematic Review of Chemical Compounds with Immunomodulatory Action Isolated from African Medicinal Plants

Nikiema, W. A., Ouédraogo, M., Ouedraogo, W. P., Fofana, S., Ouédraogo, B. H. A., Delma, T. E., BELEM, A., Abdoulaye, G. M., Sawadogo, A. S., Ouédraogo, R., et al. (2024) · Molecules · doi:10.3390/molecules29092010 · Cited by 18 · see citing works

Activation of Heme Oxygenase-1 by Mangiferin in Human Retinal Pigment Epithelial Cells Contributes to Blocking Oxidative Damage

Park, C., Cha, H., Hwangbo, H., Bang, E., Kim, H., Yun, S. J., Moon, S., Kim, W., Kim, G., Lee, S., et al. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2023.175 · Cited by 17 · see citing works

A geniposide-phospholipid complex ameliorates posthyperuricemia chronic kidney disease induced by inflammatory reactions and oxidative stress

Wang, M.-X., Wang, M., Liu, C., Chen, J., Liu, J.-S., Guo, X., Zhang, M.-Q., Zhang, J., Sun, J., & Liao, Z. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175157 · Cited by 17 · see citing works

Plant-Derived Food Grade Substances (PDFGS) Active Against Respiratory Viruses: A Systematic Review of Non-clinical Studies

Umeoguaju, F. U., Ephraim-Emmanuel, B. C., Patrick-Iwuanyanwu, K. C., Zelikoff, J. T., & Orisakwe, O. E. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.606782 · Cited by 16 · see citing works

Molecular docking studies of α-mangostin, γ-mangostin, and xanthone on peroxisome proliferator-activated receptor gamma diphenyl peptidase-4 enzyme, and aldose reductase enzyme as an antidiabetic drug candidate

Mahmudah, R., Adnyana, I. K., & Sukandar, E. Y. (2021) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/japtr.japtr_255_20 · Cited by 16 · see citing works

Mangiferin mitigates methotrexate-induced liver injury and suppresses hepatic stellate cells activation in rats: Imperative role of Nrf2/NF-κB/NLRP3 signaling axis

El-Sayed, N. M., Menze, E. T., Tadros, M. G., & Hanna, D. M. F. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119296 · Cited by 15 · see citing works

Mangiferin alleviates endoplasmic reticulum stress in acute liver injury by regulating the miR-20a/miR-101a-Nrf2 axis

Li, S., Jin, S., Chen, W., Yu, J., Fang, P., Zhou, G., Li, J., Jin, L., Chen, Y., Chen, P., et al. (2020) · The Journal of Biochemistry · doi:10.1093/jb/mvaa056 · Cited by 14 · see citing works

Color integration in biomass-derived carbon dots to realize one-step white light

Hui, S., Li, C., Ke, X., Cai, Y., Qian, S., Wu, L., Deng, Y., Sai, L., & Xu, X. (2023) · Green Chemistry Letters and Reviews · doi:10.1080/17518253.2023.2214178 · Cited by 14 · see citing works

Hepatoprotective effect of avicularin on lead-induced steatosis, oxidative stress, and inflammation in mice associated with the MAPK/HSP60/NLRP3 and SREBP1c pathway

Qiu, T., Shi, J.-X., Cheng, C., Jiang, H., Ruan, H.-N., Li, J., & Liu, C.-M. (2023) · Toxicology Research · doi:10.1093/toxres/tfad028 · Cited by 13 · see citing works

Anti-Oxidative Effect of Genistein and Mangiferin on Sodium Fluoride Induced Oxidative Insult of Renal Cells: A Comparative Study

Sadhukhan, P., Saha, S., & Sil, P. C. (2016) · Biomarkers · Cited by 13 · see citing works

Betaine, heavy metal protection, oxidative stress, and the liver

Ommati, M. M., & Heidari, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819092-0.00038-8 · Cited by 12 · see citing works

IL1β/ TNFα/COX-2/VEGF axis responsible for effective healing potential of C-glucoside xanthone (mangiferin) based ointment in immunocompromised rats

Yadav, V. P., Shukla, A. K., Choudhury, S., Singh, R., Anand, M., & Prabhu, S. N. (2022) · Cytokine · doi:10.1016/j.cyto.2022.156012 · Cited by 11 · see citing works

Impact of plant extracts on hepatic redox metabolism upon lead exposure: a systematic review of preclinical in vivo evidence

Destro, A. L. F., Mattosinhos, P. D. S., Novaes, R. D., Sarandy, M. M., Gonçalves, R. V., & Freitas, M. B. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-28620-8 · Cited by 10 · see citing works

Beneficial Upshots of Naturally Occurring Antioxidant Compounds against Neurological Disorders

Saha, S., Sadhukhan, P., & Sil, P. C. (2017) · Wiley eBooks · doi:10.1002/9783527803781.ch3 · Cited by 9 · see citing works

Pb( NO 3 ) 2 induces cell apoptosis through triggering of reactive oxygen species accumulation and disruption of mitochondrial function via SIRT3 / SOD2 pathways

Lin, H., Lee, H., Shen, T., Ho, M., Lee, Y., Wang, I., Lin, C., & Chang, Y. (2023) · Environmental Toxicology · doi:10.1002/tox.24019 · Cited by 8 · see citing works

Rationalization of a traditional liver medicine using systems biology approach and its evaluation in preclinical trial

Adhikari, A., Darbar, S., Das, M., Mondal, S., Bhattacharya, S. S., Pal, D., & Pal, S. K. (2019) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2019.107196 · Cited by 8 · see citing works

Evaluation of the Antidiabetic Potential of Xanthone-Rich Extracts from Gentiana dinarica and Gentiana utriculosa

Јovanović, J. A., Krstić‐Milošević, D., Vinterhalter, B., Dinić, S., Grdović, N., Uskoković, A. S., Rajić, J., Đorđević, M., Sarić, A., Vidaković, M., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169066 · Cited by 7 · see citing works

Cyclopia intermedia (Honeybush) Induces Uncoupling Protein 1 and Peroxisome Proliferator-Activated Receptor Alpha Expression in Obese Diabetic Female db/db Mice

Jack, B. U., Ramharack, P., Malherbe, C. J., Gabuza, K., Joubert, E., & Pheiffer, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043868 · Cited by 6 · see citing works

Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight into vascular dysfunction and hepatic steatosis

Alsaedi, A. Q., Nader, M. A., El-Kashef, D. H., & Abdelmageed, M. E. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1572758 · Cited by 5 · see citing works

Effects of food-borne docosahexaenoic acid supplementation on bone lead mobilisation, mitochondrial function and serum metabolomics in pre-pregnancy lead-exposed lactating rats

Lu, A.-X., Lin, Y., Li, J., Liu, J., Yan, C., & Zhang, L. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122613 · Cited by 5 · see citing works

Uranium and Lead Intoxication Hazards Induce Hepatotoxicity In Rats; Biochemical, Histochemical And Histopathological Studies

Sarhan, H. (2021) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2021.82995.4079 · Cited by 4 · see citing works

Phytochemicals and Human Health

Sinha, K., Chowdhury, S., & Sil, P. C. (2018) · Springer eBooks · doi:10.1007/978-981-13-1123-9_10 · Cited by 4 · see citing works

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Dai, Y., Huang, Q., Tan, M., Wang, Z., Jiang, C., Liu, Z., Zhang, S., & Song, S. (2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2026.5736 · Cited by 3 · see citing works

Lead-induced Hepatotoxicity in Rat Hepatocytes: a Transcriptomic Network Analysis Reveals Key Molecular Insights

Li, X., & Yang, B. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04902-9 · Cited by 3 · see citing works

Protective effect of mangiferin on doxorubicin-induced liver damage in animal model

Husna, F., Arozal, W., Yusuf, H., & Safarianti, S. (2021) · Journal of Research in Pharmacy · doi:10.29228/jrp.102 · Cited by 3 · see citing works

Dopamine impairs functional integrity of rat hepatocytes through nuclear factor kappa B activity modulation: An in vivo, ex vivo, and in vitro study

Sun, C., Kao, Y. H., Lee, P., Wu, M., Chen, K., Lin, Y., Tsai, M., & Chen, P. (2015) · Liver Transplantation · doi:10.1002/lt.24346 · Cited by 3 · see citing works

Beneficial Effect of Naturally Occurring Antioxidants against Oxidative Stress–Mediated Organ Dysfunctions

Pal, P. B., Ghosh, S., & Sil, P. C. (2014) · Wiley eBooks · doi:10.1002/9783527684403.ch8 · Cited by 3 · see citing works

Role of Oxidative Stress, Mitochondrial Dysfunction, and Autophagy in Cardiovascular Disease: Its Pathogenesis and Amelioration by Different Small Natural Molecules

Chatterjee, S., Hossain, U., & Sil, P. C. (2019) · Springer eBooks · doi:10.1007/978-981-13-8946-7_19 · Cited by 2 · see citing works

Influences of Mangiferin on Lipid Metabolism Pathway in Hight Fat Diet-and Streptozotocin-induced Model in Rat

Chang, C., Chen, Y.-F., & Lin, Y. (2017) · Cited by 1 · see citing works

Drug-metabolizing enzymes and oxidative stress

Hussain, M., Fatima, M., Shaukat, S., Barkat, M. Q., Alqahtani, T., Alqahtani, A., Mei, L., Shi, W., & Wu, X. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-95120-3.00010-5 · Cited by 1 · see citing works

EVALUATION OF PROTECTIVE ROLE OF SALACIA OBLONGA AND MANGIFERIN IN TOBACCO SMOKE AND GLUCOSE-INDUCED TOXIC CONDITIONS

Basu, S. (2015) · University

Hepatoprotective potential of Salacia oblonga root against antitubercular drug-induced hepatotoxicity: An in vivo approach

Qidwai, S., Ahmad, A., Shariq, M., Islam, A., & Khushtar, M. (2025) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2025.103874

Cryoprotectant effects of mangiferin on the quality of frozen-thawed boar sperm

Zhang, M., Luo, Z., Weipu, M., Zhang, G., & Gu, P. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1706051

Mangiferin mitigates mercuric chloride-induced hepatotoxicity: targeting Nrf2, NF-κB, NLRP3, and ER stress

Hassan, H. E., Hazem, S. H., & Zaghloul, M. S. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05709-8

Antiviral potential of mangiferin, a natural plant polyphenol compound

Li, Y., Yang, J., Xu, G., & Cao, Z. (2026) · Natural Product Research · doi:10.1080/14786419.2026.2748465

Mangiferin exerts neuroprotective activity against lead-induced toxicity and oxidative stress via Nrf2 pathway

Li, H.-W., Lan, T.-J., Yun, C.-X., Yang, K.-D., Du, Z.-C., Luo, X.-F., Hao, E.-W., & Deng, J.-G. (2020) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2019.12.002 · Cited by 37 · see citing works

Protective effects of sinomenine hydrochloride on lead-induced oxidative stress, inflammation, and apoptosis in mouse liver

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