Mechanism of protective action of mangiferin on suppression of inflammatory response and lysosomal instability in rat model of myocardial infarction
Abstract
Lysosomal instability has been suggested as a major factor in the development of cellular injury during myocardial necrosis through the formation of inflammatory mediators. The present study was designed to investigate the effect of mangiferin on lysosomal hydrolases and TNF-alpha production during isoproterenol (ISPH) induced myocardial necrosis in rats. The rats given ISPH (200 mg/kg body weight twice, subcutaneous) for 2 days showed a significant increase in plasma TNF-alpha production, serum and heart lysosomal hydrolases activity. ISPH administration to rats resulted in decreased stability of the membranes, which was reflected by the lowered activity of cathepsin-D and beta-glucuronidase in mitochondrial, nuclear, lysosomal and microsomal fractions. Pretreatment with mangiferin (100 mg/kg body weight, intraperitoneally) for 28 days, significantly prevented the alterations and restored the enzyme activities to near-normal status. These findings demonstrate that mangiferin could preserve lysosomal integrity through decrease in the inflammatory process and hence establish the cardioprotective effect of mangiferin.
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Mangiferin prevents free radical-mediated lipid peroxidation and increases lysosomal instability, thus alleviating MI injury.
“In addition, mangiferin has been reported to prevent free radical-mediated lipid peroxidation and increase lysosomal instability, thus alleviating MI injury (79).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [79]
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The aging myocardium: roles of mitochondrial damage and lysosomal degradation
Terman, A., & Brunk, U. T. (2005) · Heart, Lung and Circulation · doi:10.1016/j.hlc.2004.12.023 · Cited by 80 · see citing works
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Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential
Saha, S., Sadhukhan, P., & Sil, P. C. (2016) · BioFactors · doi:10.1002/biof.1292 · Cited by 159 · see citing works
Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works
“In addition, mangiferin has been reported to prevent free radical-mediated lipid peroxidation and increase lysosomal instability, thus alleviating MI injury (79).”
Hou, J., Zheng, D., Fung, G., Deng, H., Chen, L., Liang, J., Jiang, Y., & Hu, Y. (2016) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0073 · Cited by 89 · see citing works
Morozkina, S. N., Nhung Vu, T. H., Generalova, Y. E., Snetkov, P. P., & Uspenskaya, M. V. (2021) · Biomolecules · doi:10.3390/biom11010079 · Cited by 82 · see citing works
Prado, Y., Merino, N., Acosta, J., Herrera, J. A., Luque, Y., Hernández, I., Prado, E., Garrido, G., Delgado, R., & Rodeiro, I. (2015) · Journal of Pharmacy & Pharmacognosy Research · doi:10.56499/jppres14.050_3.1.13 · Cited by 38 · see citing works
Recent Formulation Advances of Mangiferin
Barakat, S., Nasr, M., Ahmed, R. F., Badawy, S., & Mortada, N. (2022) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-022-00297-z · Cited by 28 · see citing works
- Authors
- Prabhu, S., Narayan, S., & Devi, C. S. S.
- Affiliations
- University of Madras (IN)
- Corresponding author
- Prabhu, S.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2009-01-26
- Volume
- 23
- Issue
- 6
- Pages
- 756-760
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2101571251
- Cited by
- 32
- References
- 1
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- mangiferin, myocardial infarction, lysosomal enzymes, TNF-α, inflammation, isoproterenol-induced cardiotoxicity, cathepsin D, beta-glucuronidase, cardioprotection, membrane stability
- MeSH terms
- Animals, Cardiotonic Agents, Disease Models, Animal, Hydrolases, Isoproterenol, Lysosomes, Male, Phytotherapy, Myocardial Infarction, Myocardium, Plant Extracts, Tumor Necrosis Factor-alpha, Rats, Wistar, Xanthones, Rats
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