Mangiferin Attenuates Renal Fibrosis Through Down-Regulation of Osteopontin in Diabetic Rats: EFFECTS OF MANGIFERIN ON RENAL FIBROSIS IN DIABETES
Abstract
This study was designed to investigate the effects of mangiferin on renal fibrosis, osteopontin production, and inflammation in the kidney of diabetic rats. Diabetes was induced through the single administration of streptozotocin (55 mg/kg, i.p.). Diabetic rats were treated with mangiferin (15, 30, and 60 mg/kg/day, i.g.) for 9 weeks. The kidney was fixed in 10% formalin for glomerulus fibrosis examination using Masson trichrome staining. Kidney and blood were obtained for assays of the associated biochemical parameters. Chronic mangiferin treatment prevented renal glomerulus fibrosis evidenced by decreases in Mason-stained positive area of glomeruli, protein expression of type IV collagen, and α-smooth muscle actin in the kidney of diabetic rats, in comparison with decreases in mRNA and protein expression of osteopontin as well as protein expression of cyclooxygenase 2 and NF-кB p65 subunit in the renal cortex of diabetic rats. Moreover, mangiferin reduced the levels of interleukin 1β in both the serum and the kidney of diabetic rats. Our findings demonstrate that mangiferin prevents the renal glomerulus fibrosis of diabetic rats, which is realized through the suppression of osteopontin overproduction and inflammation likely via inactivation of NF-кB.
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Mangiferin (15, 30 and 60 mg/kg/day for 9 weeks) effectively attenuated renal fibrosis through inhibition of osteopontin overproduction and inflammation in a STZ-induced rat diabetic model.
“Furthermore, mangiferin (15, 30 and 60 mg/kg/day for 9 weeks) effectively attenuated renal fibrosis through the inhibition of osteopontin overproduction and inflammation in a STZ-induced rat diabetic model (36).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [36]
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Mangiferin: A natural miracle bioactive compound against lifestyle related disorders
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“Furthermore, mangiferin (15, 30 and 60 mg/kg/day for 9 weeks) effectively attenuated renal fibrosis through the inhibition of osteopontin overproduction and inflammation in a STZ‑induced rat diabetic model (36).”
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- Authors
- Zhu, X., Cheng, Y.-Q., Du, L., Li, Y., Zhang, F., Guo, H., Liu, Y.-W., & Yin, X.-X.
- Affiliations
- Xuzhou Medical College (CN)
- Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy; Xuzhou Medical College; Xuzhou 221004 Jiangsu China
- Corresponding author
- Liu, Yao-Wu
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2014-11-07
- Volume
- 29
- Issue
- 2
- Pages
- 295-302
- ISSN
- 0951-418X (ISSN-L)
- OpenAlex
- W1916263719
- Cited by
- 66
- References
- 3
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 11 · 2021: 6 · 2020: 13 · 2019: 6 · 2018: 7 · 2017: 1 · 2016: 4
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jiangsu Province (BK2011208)
- Zhen Xing Project of XZMC, China
- Priority Academic Program Development of Jiangsu Higher Education Institutions, China
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- mangiferin, renal fibrosis, osteopontin, diabetic nephropathy, glomerular fibrosis, NF-κB, cyclooxygenase-2, IL-1β, renal inflammation, type IV collagen, alpha-smooth muscle actin, streptozotocin-induced diabetes, renal protection
- MeSH terms
- Actins, Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Fibrosis, Inflammation, Kidney Diseases, Kidney Glomerulus, Male, RNA, Messenger, Streptozocin, Down-Regulation, Rats, Sprague-Dawley, Collagen Type IV, Xanthones, Rats, Cyclooxygenase 2, Transcription Factor RelA, Osteopontin, Interleukin-1beta
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