The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models: HESPERIDIN AND HESPERETIN AS ANTIOXIDANT AND ANTI-INFLAMMATORY AGENTS
Abstract
Inflammation and oxidative stress are two major causes of various life-threatening diseases. Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species that have numerous biological properties, particularly antioxidant and anti-inflammatory. New findings showed that the antioxidant activity of Hsd/Hst was not only limited to its radical scavenging activity, but it augmented the antioxidant cellular defenses via the ERK/Nrf2 signaling pathway as well. Various in vitro and in vivo studies have been conducted to evaluate Hsd, its metabolites, or its synthetic derivatives at reducing inflammatory targets including NF-κB, iNOS, and COX-2, and the markers of chronic inflammation. In this review, new findings regarding the molecular targets of Hsd and Hst in the reduction of oxidative stress are discussed. Also, in the anti-inflammatory section, we provide a summary of significant investigations concerning the mechanisms of action based on the studied inflammation models.
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Cites
Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956
Oxidative stress and cancer: Have we moved forward?
Halliwell, B. (2007) · Biochemical Journal · doi:10.1042/bj20061131 · Cited by 1,302
Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms
Li, R., Li, J., Cai, L., Hu, C.-M., & Zhang, L. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.2.0011 · Cited by 84
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Arroyave-Ospina, J. C., Wu, Z., Geng, Y., & Moshage, H. (2021) · Antioxidants · doi:10.3390/antiox10020174 · Cited by 527
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Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health
Mahmoud, A. M., Hernández Bautista, R. J., Sandhu, M. A., & Hussein, O. E. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5484138 · Cited by 298
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Metadata
- Authors
- Parhiz, H., Roohbakhsh, A., Soltani, F., Rezaee, R., & Iranshahi, M.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2014-11-13
- Volume
- 29
- Issue
- 3
- Pages
- 323-331
- ISSN
- 0951-418X (ISSN-L)
- OpenAlex
- W1736515909
- Cited by
- 908
- References
- 3
- FWCI
- 37.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models: HESPERIDIN AND HESPERETIN AS ANTIOXIDANT AND ANTI-INFLAMMATORY AGENTS. https://app.cochat.ai/papers/10.1002/ptr.5256
- The paper
- Parhiz, H., Roohbakhsh, A., Soltani, F., Rezaee, R., & Iranshahi, M. (2015). Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models: HESPERIDIN AND HESPERETIN AS ANTIOXIDANT AND ANTI-INFLAMMATORY AGENTS. Phytotherapy Research. https://doi.org/10.1002/ptr.5256
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