Ginger (Zingiber officinaleRosc.) and its bioactive components are potential resources for health beneficial agents

Vegetables, Fruit, and Cancer Prevention

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A Review of 12 Commonly Used Medicinal Herbs

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Ginger — chemistry, technology, and quality evaluation: Part 1

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Pharmacokinetics of 6-Gingerol, 8-Gingerol, 10-Gingerol, and 6-Shogaol and Conjugate Metabolites in Healthy Human Subjects

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Ginger for nausea and vomiting in pregnancy: Randomized, double-masked, placebo-controlled trial

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Update on the Chemopreventive Effects of Ginger and its Phytochemicals

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Pharmacological studies on Ginger. I. Pharmacological actions of pungent constituents, (6)-gingerol and (6)-shogaol.

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Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients

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[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A4 Hydrolase

Jeong, C.-H., Bode, A. M., Pugliese, A., Cho, Y.-Y., Kim, H.-G., Shim, J.-H., Jeon, Y.-J., Li, H., Jiang, H., & Dong, Z. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0491 · Cited by 238

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger ( Zingiber officinale Roscoe)

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The effect of ginger ( Zingiber officinale ) on glycemic markers in patients with type 2 diabetes

Shidfar, F., Rajab, A., Rahideh, T., Khandouzi, N., Hosseini, S., & Shidfar, S. (2015) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2014-0021 · Cited by 186

Pharmacological Basis for the Medicinal Use of Ginger in Gastrointestinal Disorders

Ghayur, M. N., & Gilani, A. H. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-2957-2 · Cited by 183

A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting

Viljoen, E., Visser, J., Koen, N., & Musekiwa, A. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-20 · Cited by 176

Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways

Ghayur, M. N., Gilani, A. H., Afridi, M. B., & Houghton, P. J. (2005) · Vascular Pharmacology · doi:10.1016/j.vph.2005.07.003 · Cited by 174

6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice

Wei, C.-K., Tsai, Y.-H., Korinek, M., Hung, P.-H., El-Shazly, M., Cheng, Y.-B., Wu, Y.-C., Hsieh, T.-J., & Chang, F.-R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010168 · Cited by 168

Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting

Zick, S. M., Ruffin, M. T., Lee, J., Normolle, D. P., Siden, R., Alrawi, S., & Brenner, D. E. (2009) · Supportive Care in Cancer · doi:10.1007/s00520-008-0528-8 · Cited by 167

Anti‐emetic effect of ginger powder versus placebo as an add‐on therapy in children and young adults receiving high emetogenic chemotherapy

Pillai, A. K., Sharma, K. K., Gupta, Y. K., & Bakhshi, S. (2011) · Pediatric Blood & Cancer · doi:10.1002/pbc.22778 · Cited by 164

Anti‐obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high‐fat diet

Saravanan, G., Ponmurugan, P., Deepa, M. A., & Senthilkumar, B. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6642 · Cited by 161

Ginger — chemistry, technology, and quality evaluation: Part 2

Govindarajan, V. S., & Connell, D. (1983) · C R C Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398209527348 · Cited by 159

Effect of a ginger extract on pregnancy‐induced nausea: A randomised controlled trial

Willetts, K. E., Ekangaki, A., & Eden, J. (2003) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1046/j.0004-8666.2003.00039.x · Cited by 158

6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-α mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes

Isa, Y., Miyakawa, Y., Yanagisawa, M., Goto, T., Kang, M., Kawada, T., Morimitsu, Y., Kubota, K., & Tsuda, T. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.046 · Cited by 156

Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review

Marx, W., Ried, K., McCarthy, A. L., Vitetta, L., Sali, A., McKavanagh, D., & Isenring, L. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.865590 · Cited by 152

6-Gingerol protects intestinal barrier from ischemia/reperfusion-induced damage via inhibition of p38 MAPK to NF-κB signalling

Li, Y., Xu, B., Xu, M. Q., Chen, D., Xiong, Y., Lian, M., Sun, Y., Tang, Z., Wang, L., Jiang, C., et al. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.01.026 · Cited by 152

Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high‐fat diet‐fed mice

Suk, S., Kwon, G. T., Lee, E., Jang, W. J., Yang, H. S., Kim, J. H., Thimmegowda, N. R., Chung, M., Kwon, J. Y., Yang, S., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700139 · Cited by 151

6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia

Moon, M., Kim, H. G., Choi, J. G., Oh, H., Lee, P. K. J., Ha, S. K., Kim, S. Y., Park, Y., Huh, Y., & Oh, M. S. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.121 · Cited by 150

6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF-κB Signaling

Saha, A., Blando, J. M., Silver, E. S., Beltrán, L., Sessler, J. L., & DiGiovanni, J. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0420 · Cited by 150

Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis

Funk, J. L., Frye, J. B., Oyarzo, J. N., Chen, J., Zhang, H., & Timmermann, B. N. (2016) · PharmaNutrition · doi:10.1016/j.phanu.2016.02.004 · Cited by 150

Anti‐invasion effects of 6‐shogaol and 6‐gingerol, two active components in ginger, on human hepatocarcinoma cells

Weng, C., Wu, C., Huang, H., Ho, C., & Yen, G. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000108 · Cited by 147

Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol

Ho, S.-C., Chang, K., & Lin, C. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.06.010 · Cited by 146

Cytotoxic and apoptotic activities of diarylheptanoids and gingerol-related compounds from the rhizome of Chinese ginger

Wei, Q., Ma, J., Cai, Y.-J., Li, Y., & Liu, Z. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.05.043 · Cited by 141

Isolation of Novel Glucosides Related to Gingerdiol from Ginger and Their Antioxidative Activities

Sekiwa, Y., Kubota, K., & Kobayashi, A. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990674x · Cited by 139

Gastrointestinal motility enhancing effect of ginger and its active constituents.

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Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger

Peng, F., Tao, Q., Wu, X., Dou, H., Spencer, S. D., Mang, C.-Y., Xu, L., Sun, L., Zhao, Y., Li, H., et al. (2012) · Fitoterapia · doi:10.1016/j.fitote.2011.12.028 · Cited by 132

Protective effects of phenolics rich extract of ginger against Aflatoxin B1-induced oxidative stress and hepatotoxicity

Vipin, A. V., Raksha, R. K., Kurrey, N. K., Anu Appaiah, K. A., & Venkateswaran, G. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.107 · Cited by 130

Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway

Misawa, K., Hashizume, K., Yamamoto, M., Minegishi, Y., Hase, T., & Shimotoyodome, A. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.04.014 · Cited by 127

Reversal of cisplatin-induced delay in gastric emptying in rats by ginger (Zingiber officinale)

Sharma, S., & Gupta, Y. K. (1998) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00053-1 · Cited by 126

6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation

Park, G., Kim, H. G., Ju, M. S., Ha, S. K., Park, Y., Kim, S. Y., & Oh, M. S. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.57 · Cited by 121

Antiemetic efficacy of ginger (Zingiber officinale) against cisplatin-induced emesis in dogs

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Is drop-out from obesity treatment a predictable and preventable event?

Colombo, O., Ferretti, V. V., Ferraris, C., Trentani, C., Vinai, P., Villani, S., & Tagliabue, A. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-13 · Cited by 119

Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans

Yu, Y., Zick, S. M., Li, X., et al. (2011) · The AAPS Journal · doi:10.1208/s12248-011-9286-5 · Cited by 117

Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy

Portnoi, G., Chng, L.-A., Karimi-Tabesh, L., Koren, G., Tan, M. P., & Einarson, A. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/s0002-9378(03)00649-5 · Cited by 117

Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-Gingerol in cervical cancer cells

Rastogi, N., Duggal, S., Singh, S. K., Porwal, K., Srivastava, V. K., Maurya, R., Bhatt, M. L. B., & Mishra, D. P. (2015) · Oncotarget · doi:10.18632/oncotarget.6383 · Cited by 116

Protective effect of dietary ginger on antioxidant enzymes and oxidative damage in experimental diabetic rat tissues

Shanmugam, K. R., Korivi, M., Nishanth, K., Kuo, C., & Reddy, K. S. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.07.104 · Cited by 111

Beneficial effects of ginger ( Zingiber officinale ) on carbohydrate metabolism in streptozotocin-induced diabetic rats

Nafiu, B. A., Cho, M. M., Win, N. N., Zaman, R., & Rahman, M. T. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511006635 · Cited by 104

Ginger improves cognitive function via NGF-induced ERK/CREB activation in the hippocampus of the mouse

Lim, S., Moon, M., Oh, H., Kim, H. G., Kim, S. Y., & Oh, M. S. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.05.009 · Cited by 104

Cyclic diarylheptanoids from rhizomes of Zingiber officinale

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Plasma pharmacokinetics and tissue distribution of [6]‐gingerol in rats

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Biological activities of ginger against cadmium-induced renal toxicity

Gabr, S. A., Alghadir, A. H., & Ghoniem, G. A. (2017) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.08.008 · Cited by 99

Assessment of anti-cancerous potential of 6-gingerol (Tongling White Ginger) and its synergy with drugs on human cervical adenocarcinoma cells

Zhang, F., Zhang, J.-G., Qu, J., Zhang, Q., Prasad, C., & Wei, Z. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.02.038 · Cited by 98

Metabolism of [6]-gingerol in rats

Nakazawa, T., & Ohsawa, K. (2002) · Life Sciences · doi:10.1016/s0024-3205(01)01551-x · Cited by 97

The safety of a ginger extract in the rat

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A randomized comparison of ginger and vitamin B6 in the treatment of nausea and vomiting of pregnancy.

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Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells

Park, G. H., Park, J. H., Song, H. M., Eo, H. J., Kim, M. K., Lee, J. W., Lee, M. H., Cho, K.-H., Lee, J. R., Cho, H. J., et al. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-408 · Cited by 93

Constituents of Zingiberaceae. I. Diarylheptanoids from the rhizomes of ginger (Zingiber officinale Roscoe).

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6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest

Lin, C.-B., Lin, C.-C., & Tsay, G. J. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/326096 · Cited by 90

6-Gingerol prevents adipogenesis and the accumulation of cytoplasmic lipid droplets in 3T3-L1 cells

Tzeng, T., & Liu, I.-M. (2013) · Phytomedicine · doi:10.1016/j.phymed.2012.12.006 · Cited by 90

Conjugation of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 with intracellular glutathione and enhancement of its antiproliferative activity by glutathione depletion.

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Safety of ginger use in pregnancy: results from a large population-based cohort study

Heitmann, K., Nordeng, H., & Holst, L. (2012) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-012-1331-5 · Cited by 86

The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats

Murata, P., Kase, Y., Ishige, A., Sasaki, H., Kurosawa, S., & Nakamura, T. (2002) · Life Sciences · doi:10.1016/s0024-3205(01)01552-1 · Cited by 84

Effect of variety and location on the total fat, fatty acids and squalene content of amaranth

Berganza, B. E., Moran, A. W., Rodríguez, G. M., Coto, N. M., Santamaría, M., & Bressani, R. (2003) · Plant Foods for Human Nutrition · doi:10.1023/b:qual.0000041143.24454.0a · Cited by 83

Ginger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells

Wang, Y., Wang, S., Song, R., Cai, J., Xu, J., Tang, X., & Li, N. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.10.169 · Cited by 83

Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats.

Wang, Z., Hasegawa, J., Wang, X., Matsuda, A., Tokuda, T., Miura, N., & Watanabe, T. (2011) · PubMed · Cited by 80

10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity

Joo, J., Hong, S. S., Cho, Y., & Seo, D. W. (2015) · Oncology Reports · doi:10.3892/or.2015.4405 · Cited by 80

The Roman and Islamic spice trade: New archaeological evidence

van der Veen, M., & Morales, J. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.09.036 · Cited by 79

[10]-Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells

Ryu, M. J., & Chung, H. S. (2014) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-014-9806-6 · Cited by 78

Protein and Ginger for the Treatment of Chemotherapy-Induced Delayed Nausea

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Larvicidal activities of ginger (Zingiber officinale) against Angiostrongylus cantonensis

Lin, R., Chen, C., Chung, L.-Y., et al. (2010) · Acta Tropica · doi:10.1016/j.actatropica.2009.12.007 · Cited by 77

Characterization and identification of diarylheptanoids in ginger ( Zingiber officinale Rosc.) using high‐performance liquid chromatography/electrospray ionization mass spectrometry

Jiang, H., Timmermann, B. N., & Gang, D. R. (2007) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.2858 · Cited by 77

Effect of aswagandha, ginger and mulberry on hyperglycemia and hyperlipidemia

Andallu, B., Radhika, B., & Suryakantham, V. (2003) · Plant Foods for Human Nutrition · doi:10.1023/b:qual.0000040352.23559.04 · Cited by 74

Determination of 6‐gingerol in ginger (Zingiber officinale) using high‐performance thin‐layer chromatography

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Inhibitory Effect of [6]-Gingerol on Melanogenesis in B16F10 Melanoma Cells and a Possible Mechanism of Action

Huang, H., Chiu, S.-H., & Chang, T. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100851 · Cited by 71

Zingiber officinale extract exhibits antidiabetic potential via modulating glucose uptake, protein glycation and inhibiting adipocyte differentiation: an in vitro study

Rani, M. P., Krishna, M. S., Padmakumari, K. P., Raghu, K. G., & Sundaresan, A. (2012) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5567 · Cited by 71

10-Gingerol, a Phytochemical Derivative from “Tongling White Ginger”, Inhibits Cervical Cancer: Insights into the Molecular Mechanism and Inhibitory Targets

Zhang, F., Thakur, K., Hu, F., Zhang, J., & Wei, Z. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b00095 · Cited by 71

Anti-diabetic and anti-oxidant effects of Zingiber officinale on alloxan-induced and insulin-resistant diabetic male rats.

Iranloye, B. O., Arikawe, A. P., Rotimi, G., & Sogbade, A. O. (2011) · PubMed · Cited by 69

Gingerol, a novel cardiotonic agent, activates the Ca2+-pumping ATPase in skeletal and cardiac sarcoplasmic reticulum

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Synthesis of a New [6]-Gingerol Analogue and Its Protective Effect with Respect to the Development of Metabolic Syndrome in Mice Fed a High-Fat Diet

Okamoto, M., Irii, H., Tahara, Y., Ishii, H., Hirao, A., Udagawa, H., Hiramoto, M., Yasuda, K., Takanishi, A., Shibata, S., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200662c · Cited by 65

Protective effects of ginger against aspirin-induced gastric ulcers in rats

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Inhibition of Angiotensin-1-Converting Enzyme Activity by Two Varieties of Ginger ( Zingiber officinale ) in Rats Fed a High Cholesterol Diet

Akinyemi, A. J., Ademiluyi, A. O., & Oboh, G. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0264 · Cited by 62

A Bioactive Constituent of Ginger, 6-Shogaol, Prevents Adipogenesis and Stimulates Lipolysis in 3T3-L1 Adipocytes

Suk, S., Seo, S. G., Yu, J. G., Yang, H. S., Jeong, E., Jang, Y. J., Yaghmoor, S., Ahmed, Y. M., Yousef, J. M., Abualnaja, K. O., et al. (2015) · Journal of Food Biochemistry · doi:10.1111/jfbc.12191 · Cited by 62

6-Gingerdiols as the Major Metabolites of 6-Gingerol in Cancer Cells and in Mice and Their Cytotoxic Effects on Human Cancer Cells

Lv, L., Chen, H., Soroka, D. N., Chen, X. L., Leung, T., & Sang, S. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf303879b · Cited by 57

6-Shogaol has anti-amyloidogenic activity and ameliorates Alzheimer’s disease via CysLT1R-mediated inhibition of cathepsin B

Na, J., Song, K., Lee, J.-W., Kim, S., & Kwon, J. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.026 · Cited by 57

Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice

Hagl, S., Berressem, D., Grewal, R., Sus, N., Frank, J., & Eckert, G. P. (2015) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000040 · Cited by 56

Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery

Wang, C., Qi, L., & Yuan, C. (2015) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x15500767 · Cited by 55

Anthelmintic constituents from ginger (Zingiber officinale) against Hymenolepis nana

Lin, R., Chen, C., Lu, C.-M., Ma, Y.-H., Chung, L.-Y., Wang, J.-J., Lee, J., & Yen, C. (2014) · Acta Tropica · doi:10.1016/j.actatropica.2014.07.009 · Cited by 53

[6]-Gingerol: A Novel AT1 Antagonist for the Treatment of Cardiovascular Disease

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Pharmacognostic studies on ginger and related drugs—part 1: five sulfonated compounds from Zingiberis rhizome (Shokyo)

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Pharmacokinetics of (6)-Gingerol after Intravenous Administration in Rats.

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[6]‐Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKα2‐Mediated AS160–Rab5 Pathway and AMPK‐Mediated Insulin Sensitizing Effects

Lee, J. O., Kim, N., Lee, H. J., Moon, J. W., Lee, S. K., Kim, S. J., Kim, J. K., Park, S. H., & Kim, H. S. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25100 · Cited by 51

Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats

Iwami, M., Shiina, T., Hirayama, H., Shima, T., Takewaki, T., & Shimizu, Y. (2010) · Journal of Natural Medicines · doi:10.1007/s11418-010-0463-0 · Cited by 47

Acute administration of ginger (Zingiber officinale rhizomes) extract on timed intravenous pentylenetetrazol infusion seizure model in mice

Hosseini, A., & Mirazi, N. (2014) · Epilepsy Research · doi:10.1016/j.eplepsyres.2014.01.008 · Cited by 47

Effect of [10]-Gingerol on [Ca2+]i and Cell Death in Human Colorectal Cancer Cells

Chen, C., Li, Y., & Kuo, S. (2009) · Molecules · doi:10.3390/molecules14030959 · Cited by 46

[8]-Gingerol inhibits melanogenesis in murine melanoma cells through down-regulation of the MAPK and PKA signal pathways

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Ginger extract diminishes chronic fructose consumption-induced kidney injury through suppression of renal overexpression of proinflammatory cytokines in rats

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Ginger and 6-shogaol protect intestinal tight junction and enteric dopaminergic neurons against 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine in mice

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Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis

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[6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway

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Ginger Protects the Liver against the Toxic Effects of Xenobiotic Compounds: Preclinical Observations

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Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats

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6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation

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Nine New Gingerols from the Rhizoma of Zingiber officinale and Their Cytotoxic Activities

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Ginger ingredients inhibit the development of diethylnitrosoamine induced premalignant phenotype in rat chemical hepatocarcinogenesis model

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6‐Gingerol Activates PI3K/Akt and Inhibits Apoptosis to Attenuate Myocardial Ischemia/Reperfusion Injury

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Zingiberis rhizoma mediated enhancement of the pharmacological effect of aconiti lateralis radix praeparata against acute heart failure and the underlying biological mechanisms

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(S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+]i

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Inhibitory effect of galanolactone isolated from Zingiber officinale roscoe extract on adipogenesis in 3T3-L1 cells

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Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

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Non-volatile pungent compounds isolated from Zingiber officinale and their mechanisms of action

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Effect of gingerol on colonic motilityviainhibition of calcium channel currents in rats

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Pathway and single gene analyses of inhibited Caco‐2 differentiation by ascorbate‐stabilized quercetin suggest enhancement of cellular processes associated with development of colon cancer

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Ameliorative effect of 10-gingerol on drug induced hepatotoxicity in albino rats

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Ameliorating the effect of Zingiber officinale (ginger) hydroethanolic extract on scopolamine-induced memory impairment in adult male rats

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Ginger for treating nausea and vomiting: an overview of systematic reviews and meta-analyses

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