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A role for quercetin in coronavirus disease 2019 (COVID‐19)
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Several months ago, an outbreak of pneumonia of unknown aetiology was detected in Wuhan City (China) and the aetiological agent of the atypical pneumonia was isolated by the Chinese authorities as novel coronavirus (2019‐nCoV or SARS‐CoV‐2). The WHO announced this new disease was to be known as “COVID‐19.” When looking for new antiviral compounds, knowledge of the main viral proteins is fundamental. The major druggable targets of SARS‐CoV‐2 include 3‐chymotrypsin‐like protease (3CLpro), papain‐like protease (PLpro), RNA‐dependent RNA polymerase, and spike (S) protein. Quercetin inhibits 3CLpro and PLpro with a docking binding energy corresponding to −6.25 and −4.62 kcal/mol, respectively. Quercetin has a theoretical, but significant, capability to interfere with SARS‐CoV‐2 replication, with the results showing this to be the fifth best compound out of 18 candidates. On the basis of the clinical COVID‐19 manifestations, the multifaceted aspect of quercetin as both antiinflammatory and thrombin‐inhibitory actions, should be taken into consideration.
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Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148
La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
Martínez González, M. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,463
Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001316 · Cited by 16,575
Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1
van Doremalen, N., Bushmaker, T., Morris, D. H., Holbrook, M. G., Gamble, A., Williamson, B. N., Tamin, A., Harcourt, J. L., Thornburg, N. J., Gerber, S. I., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2004973 · Cited by 9,951
Lauer, S. A., Grantz, K. H., Bi, Q., Jones, F. K., Zheng, Q., Meredith, H. R., Azman, A. S., Reich, N. G., & Lessler, J. (2020) · Annals of Internal Medicine · doi:10.7326/m20-0504 · Cited by 5,970
Temporal dynamics in viral shedding and transmissibility of COVID-19
He, X., Lau, E. H. Y., Wu, P., Deng, X., Wang, J., Hao, X., Lau, Y. C., Wong, J. Y., Guan, Y., Tan, X., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0869-5 · Cited by 4,247
Hui, D. S., I Azhar, E., Madani, T. A., Ntoumi, F., Kock, R., Dar, O., Ippolito, G., Mchugh, T. D., Memish, Z. A., Drosten, C., et al. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.01.009 · Cited by 3,809
Computational protein–ligand docking and virtual drug screening with the AutoDock suite
Forli, S., Huey, R., Pique, M. E., Sanner, M. F., Goodsell, D. S., & Olson, A. J. (2016) · Nature Protocols · doi:10.1038/nprot.2016.051 · Cited by 2,811
Overviews of biological importance of quercetin: A bioactive flavonoid
Parasuraman, S., Anand David, A., & Arulmoli, R. (2016) · Pharmacognosy Reviews · doi:10.4103/0973-7847.194044 · Cited by 1,610
Discovering drugs to treat coronavirus disease 2019 (COVID-19)
Dong, L., Hu, S., & Gao, J. (2020) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2020.01012 · Cited by 1,390
Zhang, W., Zhao, Y., Zhang, F., Wang, Q., Li, T., Liu, Z., Wang, J., Qin, Y., Zhang, X., Yan, X., et al. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108393 · Cited by 1,266
Dabeek, W. M., & Marra, M. V. (2019) · Nutrients · doi:10.3390/nu11102288 · Cited by 827
Inhibition of SARS-CoV 3CL protease by flavonoids
Jo, S., Kim, S., Shin, D. H., & Kim, M.-S. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2019.1690480 · Cited by 685
Interspecies transmission and emergence of novel viruses: lessons from bats and birds
Chan, J. F.-W., To, K. K.-W., Tse, H., Jin, D.-Y., & Yuen, K.-Y. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.05.005 · Cited by 616
Zhang, D.-H., Wu, K.-L., Zhang, X., Deng, S.-Q., & Peng, B. (2020) · Journal of Integrative Medicine · doi:10.1016/j.joim.2020.02.005 · Cited by 482
Natural product-derived phytochemicals as potential agents against coronaviruses: A review
Mani, J. S., Johnson, J. B., Steel, J. C., Broszczak, D. A., Neilsen, P. M., Walsh, K. B., & Naiker, M. (2020) · Virus Research · doi:10.1016/j.virusres.2020.197989 · Cited by 450
Quercetin: A Versatile Flavonoid
Lakhanpal, P., & Rai, D. K. (2007) · Internet Journal of Medical Update - EJOURNAL · doi:10.4314/ijmu.v2i2.39851 · Cited by 366
Accurate calculation of the absolute free energy of binding for drug molecules
Aldeghi, M., Heifetz, A., Bodkin, M. J., Knapp, S., & Biggin, P. C. (2016) · Chemical Science · doi:10.1039/c5sc02678d · Cited by 347
Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris
Nguyen, T. T. H., Woo, H.-J., Kang, H.-K., Nguyen, V. D., Kim, Y.-M., Kim, D.-W., Ahn, S.-A., Xia, Y., & Kim, D. (2012) · Biotechnology Letters · doi:10.1007/s10529-011-0845-8 · Cited by 347
Zeng, Q.-L., Yu, Z.-J., Gou, J.-J., Li, G.-M., Ma, S.-H., Zhang, G.-F., Xu, J.-H., Lin, W.-B., Cui, G.-L., Zhang, M.-M., et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa228 · Cited by 330
The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase
Lung, J., Lin, Y., Yang, Y., Chou, Y., Shu, L., Cheng, Y., Liu, H. T., & Wu, C. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25761 · Cited by 295
Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics
Cassidy, L., Fernandez, F., Johnson, J. B., Naiker, M., Owoola, A. G., & Broszczak, D. A. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.102294 · Cited by 275
Chiow, K. H., Phoon, M. C., Putti, T., Tan, B. K. H., & Chow, V. T. (2016) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2015.12.002 · Cited by 272
Khaerunnisa, S., Kurniawan, H., Awaluddin, R., Suhartati, S., & Soetjipto, S. (2020) · doi:10.20944/preprints202003.0226.v1 · Cited by 256
Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors
Jo, S., Kim, H., Kim, S., Shin, D. H., & Kim, M. (2019) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13604 · Cited by 242
Cheng, S.-C., Huang, W.-C., S. Pang, J.-H., Wu, Y.-H., & Cheng, C.-Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122957 · Cited by 235
Polyphenols in the treatment of autoimmune diseases
Khan, H., Sureda, A., Belwal, T., Çetinkaya, S., Süntar, İ., Tejada, S., Devkota, H. P., Ullah, H., & Aschner, M. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.05.001 · Cited by 220
Beneficial Effects of Quercetin on Obesity and Diabetes
P. Portillo, M. (2011) · The Open Nutraceuticals Journal · doi:10.2174/1876396001104010189 · Cited by 210
Smith, M., & Smith, J. C. (2020) · ChemRxiv · doi:10.26434/chemrxiv.11871402.v4 · Cited by 206
Luo, E., Zhang, D., Luo, H., Liu, B., Keming, Z., Zhao, Y., Bian, Y., & Wang, Y. (2020) · Chinese Medicine · doi:10.1186/s13020-020-00317-x · Cited by 173
Data Resources for the Computer-Guided Discovery of Bioactive Natural Products
Chen, Y., Kops, C. D. B., & Kirchmair, J. (2017) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.7b00341 · Cited by 167
Heinz, S. A., Henson, D. A., Austin, M. D., Jin, F., & Nieman, D. C. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.05.001 · Cited by 155
Tomé‐Carneiro, J., & Visioli, F. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.10.018 · Cited by 138
Smith, M. D., & Smith, J. C. (2020) · ChemRxiv · doi:10.26434/chemrxiv.11871402 · Cited by 130
Song, J. H., Shim, J. K., & Choi, H. J. (2011) · Virology Journal · doi:10.1186/1743-422x-8-460 · Cited by 73
Quercetin Blocks Ebola Virus Infection by Counteracting the VP24 Interferon-Inhibitory Function
Fanunza, E., Iampietro, M., Distinto, S., Corona, A., Quartu, M., Maccioni, E., Horvat, B., & Tramontano, E. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00530-20 · Cited by 68
SARS‐CoV protease inhibitors design using virtual screening method from natural products libraries
Liu, B., & Zhou, J. (2005) · Journal of Computational Chemistry · doi:10.1002/jcc.20186 · Cited by 39
TONEY, J. H., Navas, S., Weiss, S. R., & Koeller, A. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm034137m · Cited by 37
Cited by
Di Pierro, F., Derosa, G., Maffioli, P., Bertuccioli, A., Togni, S., Riva, A., Allegrini, P., Khan, A., Khan, S., Khan, B. A., et al. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s318720 · Cited by 182
Self-citationDi Pierro, F., Iqtadar, S., Khan, A., Ullah Mumtaz, S., Masud Chaudhry, M., Bertuccioli, A., Derosa, G., Maffioli, P., Togni, S., Riva, A., et al. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s318949 · Cited by 180
Self-citationZeng, J., Bao, T., Yang, K., Zhu, X., Wang, S., Xiang, W., Ge, A., Zeng, L., & Ge, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1047550 · Cited by 175
Parisi, G. F., Carota, G., Castruccio Castracani, C., Spampinato, M., Manti, S., Papale, M., Di Rosa, M., Barbagallo, I., & Leonardi, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052465 · Cited by 43
Metadata
- Authors
- Derosa, G., Maffioli, P., D'Angelo, A., & Di Pierro, F.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2020-10-09
- Volume
- 35
- Issue
- 3
- Pages
- 1230-1236
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W3091854037
- Cited by
- 303
- References
- 40
- FWCI
- 27.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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