Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose–response meta‐analysis of randomized controlled trials
Abstract
Accumulating evidence regarding the effect of artichoke on lipid profile is equivocal. We updated a previous meta‐analysis on the effect of artichoke extract supplementation on lipid profile and performed dose–response analysis. We searched PubMed, Scopus, Web of Science, and Cochrane Library from inception to June 2021 using relevant keywords. Papers from identified articles were collected. Two researchers rated the certainty in the estimates using the GRADE approach. Combining 15 effect sizes from 14 studies based on the random‐effects analysis, we found that artichoke significantly reduced TG (weighed mean difference [WMD]: −17.01 mg/dl, 95% CI: −23.88, −10.13, p = .011), TC (WMD: −17.01 mg/dl, 95% CI: −23.88, −10.13, p < .001), and LDL‐C (WMD: −17.48 mg/dl, 95%CI: −25.44, −9.53, p < .001). No significant effect of artichoke on HDL‐C level was detected (WMD: 0.78 mg/dl, 95%CI: −0.93, 2.49, p = .371). Combining the two effect sizes revealed that artichoke juice supplementation significantly reduced TG (WMD: −3.34 mg/dl, 95%CI: −5.51, −1.17, p = .003), TC (WMD: −18.04 mg/dl, 95%CI: −20.30, −15.78, p < .001), LDL‐C (WMD: −1.75 mg/dl, 95%CI: −3.02, −0.48, p = .007), and HDL‐C levels (WMD: −4.21 mg/dl, 95%CI: −5.49, −2.93, p < .001). In conclusion, we found that artichoke supplementation may favor CVD prevention by acting in improving the lipid profile.
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Lipid disturbances such as high LDL-C, hypertriglyceridemia, and low HDL-C are well-known risk factors for cardiovascular disease.
“Lipid disturbances, such as high LDL-C, hypertriglyceridemia, and low HDL-C, are well-known risk factors for cardiovascular disease [11–14].”
From Ketogenic diet-induced changes in adult lipid metabolism: a comprehensive systematic review and meta-regression of randomized controlled trials (2026) · cites this paper as [14]
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- Authors
- Shahinfar, H., Bazshahi, E., Amini, M. R., Payandeh, N., Pourreza, S., Noruzi, Z., & Shab‐Bidar, S.
- Affiliations
- Iran University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Corresponding author
- Shab‐Bidar, Sakineh
- ORCID
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2021-09-27
- Volume
- 35
- Issue
- 12
- Pages
- 6607-6623
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W3204178112
- Cited by
- 18
- References
- 69
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 4
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Cynara cardunculus studies
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- artichoke leaf extract, lipid profile, triglycerides, total cholesterol, LDL cholesterol, HDL cholesterol, dose-response relationship, cardiovascular disease prevention, dietary supplementation
- MeSH terms
- Lipids, Plant Extracts, Randomized Controlled Trials as Topic, Dietary Supplements, Cynara scolymus
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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