Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis

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Nutraceutical Combinations in Hypercholesterolemia: Evidence from Randomized, Placebo-Controlled Clinical Trials

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A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Effect of a Dietary Supplement Containing Dry Artichoke and Bergamot Extracts on Metabolic and Vascular Risk Factors in Individuals with Suboptimal Cholesterol Levels

Fogacci, F., Giovannini, M., Micoli, A. D., Fiorini, G., Grandi, E., Borghi, C., & Cicero, A. F. G. (2024) · Nutrients · doi:10.3390/nu16111587 · Cited by 10 · see citing works

Efficacy, side effects, adherence, affordability, and procurement of dietary supplements for treating hypercholesterolemia: a narrative review

von Känel-Cordoba, I., Wirnitzer, K., Weiss, K., Nikolaidis, P. Τ., Devrim-Lanpir, A., Hill, L., Rosemann, T. J., & Knechtle, B. (2024) · Journal of Health Population and Nutrition · doi:10.1186/s41043-024-00679-0 · Cited by 9 · see citing works

Artichoke and bergamot extracts: a new opportunity for the management of dyslipidemia and related risk factors

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Totum-070, a Polyphenol-Rich Plant Extract, Prevents Hypercholesterolemia in High-Fat Diet-Fed Hamsters by Inhibiting Intestinal Cholesterol Absorption

Langhi, C., Vallier, M., Otero, Y. F., Maura, M., Joubioux, F. L., Groult, H., Achour, O., Pebriana, R. B., Giera, M. A., Guigas, B., et al. (2023) · Nutrients · doi:10.3390/nu15245056 · Cited by 9 · see citing works

The effects of supplementation with Cynara scolymus L. on anthropometric indices: А systematic review and dose-response meta-analysis of clinical trials

Hemati, N., Venkatakrishnan, K., Yarmohammadi, S., Moradi, M., Moravejolahkami, A. R., Hadi, A., Moradi, S., Aneva, I. Y., & Farzaei, M. H. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102612 · Cited by 9 · see citing works

Effect of Pycnogenol on Blood Pressure: Findings From a PRISMA Compliant Systematic Review and Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled, Clinical Studies

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Comparative effect of nutraceuticals on lipid profile: a protocol for systematic review and network meta-analysis

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The effects of a novel nutraceutical combination on low-density lipoprotein cholesterol and other markers of cardiometabolic health in adults with hypercholesterolaemia: A randomised double-blind placebo-controlled trial

Stonehouse, W., Benassi-Evans, B., & Louise, J. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119177 · Cited by 8 · see citing works

Three arms, double-blind, non-inferiority, randomized clinical study testing the lipid-lowering effect of a novel dietary supplement containing red yeast rice and artichoke extracts compared to Armolipid Plus® and placebo

Cicero, A. F. G., Fogacci, F., Tocci, G., D’Addato, S., Grandi, E., Banach, M., & Borghi, C. (2023) · Archives of Medical Science · doi:10.5114/aoms/167969 · Cited by 9 · see citing works

Natural Killer Response and Lipo-Metabolic Profile in Adults with Low HDL-Cholesterol and Mild Hypercholesterolemia: Beneficial Effects of Artichoke Leaf Extract Supplementation

Rondanelli, M., Castellazzi, A. M., Riva, A., Allegrini, P., Faliva, M. A., Peroni, G., Naso, M., Nichetti, M., Tagliacarne, S. C., Valsecchi, C., et al. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/2069701 · Cited by 8 · see citing works

Anti-Aging Effect of Cynara cardunculus L. var. Cynara scolymus L. Extract in D-Galactose-Induced Skin Aging Model in Rats

Sukoyan, G. V., Tsivtsivadze, E. E., Golovach, V. V., Kezeli, T. T., & Demina, N. (2018) · Pharmacology &amp Pharmacy · doi:10.4236/pp.2018.910032 · Cited by 8 · see citing works

Differential effect of high fat diet (HFD) on the cardiac muscle of adult and aged female mice and the possible protective role of artichoke treatment: Histomorphometric and ultrastructural study

Dawood, A. F. A., & Hareedy, H. (2019) · Journal of Medical Histology/Journal of Medical Histology · doi:10.21608/jmh.2019.11528.1053 · Cited by 7 · see citing works

Anti-hypertensive Effects of Artichoke Supplementation in Adults: A Systematic Review and Dose-response Meta-analysis of Randomized Controlled Trials

Amini, M. R., Sheikhhossein, F., Alvani, M., Shoura, S. M. S., Sohrabnavi, A., Heidarian, E., & Hekmatdoost, A. (2022) · Clinical Nutrition Research · doi:10.7762/cnr.2022.11.3.214 · Cited by 6 · see citing works

The effect of artichoke leaf extract supplementation on lipid profile of chronic kidney disease patients; a double-blind, randomized clinical trial

Gatmiri, S. M., Khadem, E., Fakhrian, T., Kamalinejad, M., Hosseini, H., Ghorat, F., Alamdari, A., & Naderi, N. (2019) · Journal of Renal Injury Prevention · doi:10.15171/jrip.2019.42 · Cited by 6 · see citing works

Citrus bergamia Extract, a Natural Approach for Cholesterol and Lipid Metabolism Management: A Randomized, Double-Blind Placebo-Controlled Clinical Trial

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Promising new fixed combination for the treatment of diseases of the hepatobiliar system: Substantiation of pharmacotherapeutic properties and pharmaceutical quality profile

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Metabolomics of Artichoke Bud Extract in Spontaneously Hypertensive Rats

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Artichoke and cardiometabolic health: A systematic and meta-analytic synthesis of current evidence

Jafari, A., Karimi, M. A., Mahmoudinezhad, M., Razavi, F., Mardani, H., & Musazadeh, V. (2025) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2025.103328 · Cited by 4 · see citing works

Effect of Cynara scolymus L. on Cardiometabolic Outcomes: An Updated Meta-analysis of Randomized Controlled Trials and Meta-regression

Phimarn, W., Sungthong, B., & Wichiyo, K. (2024) · Pharmacognosy Magazine · doi:10.1177/09731296231217557 · Cited by 4 · see citing works

ENGİNAR (CYNARA SCOLYMUS): BESİN DEĞERİ VE OLASI SAĞLIK ETKİLERİ

KILIÇTAŞ, Ş. (2020) · Uluslararası Sosyal Bilimler Akademi Dergisi · doi:10.47994/usbad.788581 · Cited by 4 · see citing works

Production of Vegetables and Artichokes Is Associated with Lower Cardiovascular Mortality: An Ecological Study

Arnedo-Pena, A., Puig‐Barberà, J., Bellido-Blasco, J. B., Romeu-Garcia, M., Pac-Sa, M. R., & Guillén‐Grima, F. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186583 · Cited by 3 · see citing works

Hepatoprotective effects of silibinin and chlorogenic acid standardised extract to alleviate the fatty liver syndrome and improve blood indices in caged-laying hens after the peak of production

Guerrini, A., Muscatello, L. V., del Zozzo, F., Harper, V., Fiorini, L., Archetti, I., Serra, V., Carlu, C., Chabrillat, T., & Tedesco, D. E. A. (2025) · Veterinary and Animal Science · doi:10.1016/j.vas.2025.100522 · Cited by 2 · see citing works

Polymer encapsulation of Cynara Scolymus L. extract using supercritical fluid expansion into an aqueous solution (ESSAS): Optimization of conditions, identification of compounds using LC-HRMS, and investigation of antioxidant properties

Nasrollahi, H., & Raofie, F. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.147118 · Cited by 2 · see citing works

Bioavailable human metabolites from TOTUM-448 (plant-based formulation) maintain liver cell functionality in a hyperlipidic context that drives MASLD onset

Wauquier, F., Chavanelle, V., Bouchard‐Mercier, A., Boutin-Wittrant, L., Otero, Y. F., Krisa, S., Valls, J., Joubioux, F. L., Pereira, B., Roux, V., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-32556-z · Cited by 2 · see citing works

Nutraceuticals and Lipid Management

Sachinidis, A. G., Nikolić, D., Stoian, A. P., Toth, P. P., & Rizzo, M. (2020) · Contemporary cardiology · doi:10.1007/978-3-030-56514-5_10 · Cited by 2 · see citing works

The effect of plant-based dietary supplements on weight reduction and the regulation of metabolism

Mizera, K. M., & Mizera, J. (2022) · Journal of Education Health and Sport · doi:10.12775/jehs.2022.12.10.031 · Cited by 1 · see citing works

Anxiolytic-Like Effect of Hydroalcoholic Extract of Cynara Scolymus L. in Male Mice: An Experimental Study

Paydar, E., & Alimohammadi, S. (2023) · مجله علمی دانشگاه علوم پزشکی رفسنجان · doi:10.61186/jrums.22.8.805 · Cited by 1 · see citing works

Role of Artichoke Leaf Extract as Antioxidant in Nonalcoholic Fatty Liver Disease of Adult Male Albino Rats

ZOAIR, M. D. M. A. Z. H. M., Abdelhay, O., & El-Said, Z. H. (2023) · Benha Medical Journal · doi:10.21608/bmfj.2023.243831.1931 · Cited by 1 · see citing works

Effect of Artichoke Extract on Hypercholesterolemic Status of Bile Duct Ligation Rat Model

Adawi, A. I., & PEKER, T. (2022) · Academic Journal of Research and Scientific Publishing · doi:10.52132/ajrsp.e.2022.39.3 · Cited by 1 · see citing works

Fall 69: Prävention – 49 Jahre, ♀, DM Typ 2, Senkung des kardiovaskulären Risikos

Sulaj, A., & Zemva, J. (2018) · Springer eBooks · doi:10.1007/978-3-662-55972-7_69

Mit Pflanzenstoffen gegen erhöhtes Cholesterin

Schmiedel, V. (2018) · Zeitschrift für Komplementärmedizin · doi:10.1055/a-0718-7196

Characterization, Electrochemical Detection, Biological Evaluation and Molecular Modelling of 1,5-Di- O -caffeoylquinic Acid from Artichoke ( Cynara scolymus L.) Head Extract

Jamshidi, M., Ranjbar, A., Khazalpour, S., Dastan, D., Vakili-Azghandi, M., Torabi, S., Amani, A., Alizadeh, H., & Sedaghat, M. (2021) · Journal of The Electrochemical Society · doi:10.1149/1945-7111/abdb45

Nutraceuticals and Cardiovascular Disease

Chianetta, R., Sachinidis, A. G., Nikolić, D., Luzzu, L. M., Stoian, A. P., Toth, P. P., & Rizzo, M. (2021) · Contemporary cardiology · doi:10.1007/978-3-030-62632-7_5

Therapeutic Potential of the Plants Ailanthus Excelsus, Allium Sativum, and Cymbopogon Flexuosus in the Treatment of Hyperlipidemia and Oxidative Stress: An Overview

Agrawal, A., Dubey, S., & Sharma, S. (2025) · Current Chemical Biology · doi:10.2174/0122127968366669250703194520

Cynara scolymus in Modern Medicine: The Healing Power of Phytochemicals and Cynarin’s Role in Cancer Therapy

Sonali, & Goel, R. (2025) · International Journal of Newgen Research in Pharmacy & Healthcare · doi:10.61554/ijnrph.v3i1.2025.150

Intérêt des extraits d’artichaut dans l’amélioration du profil cardiométabolique

Bard, J. (2026) · Pratiques en nutrition · doi:10.1016/j.pranut.2026.01.009

Artichoke as a novel substrate for kombucha fermentation: Fermentation characteristics, functional properties, and sensory evaluation

Do, A. D., Nguyen, L. B. X., La, H. V., & Van, T. P. (2026) · Czech Journal of Food Sciences · doi:10.17221/90/2024-cjfs

Cholesterinsenkung durch Phytotherapie? Kurzer Blick auf eine zu Recht häufig gestellte Patientenfrage

Stange, R. (2026) · Zeitschrift für Komplementärmedizin · doi:10.1055/a-2923-7647

A Look At Non-Statin Lipid-Lowering Pharmacological Therapy

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Harvest Time Influences Inulin and Phenolic Accumulation of Globe Artichoke ( Cynara cardunculus L.)

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Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose–response meta‐analysis of randomized controlled trials

Shahinfar, H., Bazshahi, E., Amini, M. R., Payandeh, N., Pourreza, S., Noruzi, Z., & Shab‐Bidar, S. (2021) · Phytotherapy Research · doi:10.1002/ptr.7247 · Cited by 18 · see citing works

The effect of artichoke on lipid profile: A review of possible mechanisms of action

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Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial

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Efficacy of Artichoke Dry Extract in Patients with Hyperlipoproteinemia

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EFFECT OF CYNARA SCOLYMUS L. (ARTICHOKE) EXTRACT ON LIPID PROFILE OF HYPERLIPIDEMIC MALE RATS

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