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Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence

Heidari, Zinat, Daei, Maryam, Boozari, Motahareh, Jamialahmadi, Tannaz, Sahebkar, Amirhossein·2022·Phytotherapy Research
DOI 10.1002/ptr.7350
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Abstract

This systematic review was designed to determine the clinical efficacy and safety of curcumin supplementation for pediatric patients based on clinical trials in children. We systematically searched electronic databases including PubMed, EMBASE, Web of Science, and Scopus for all studies that investigated curcumin administration in the pediatric population without any time frame limitation. Finally, we identified 16 studies for this review. Clinical efficacy and safety of curcumin were assessed in children with inflammatory and immune disorders (including asthma, inflammatory bowel disease (IBD), and juvenile idiopathic arthritis (JIA)), metabolic disorders, autosomal dominant polycystic kidney disease (ADPKD), cystic fibrosis (CF), tetralogy of Fallot (TOF), and infectious diseases. Curcumin was administered in a wide range of doses (45 mg–4,000 mg daily) and durations (2–48 weeks). Overall, curcumin was well tolerated in all studies and improved the severity of inflammatory and immune disorders and metabolic diseases. However, more studies are needed to clarify the role of curcumin supplementation among children with ADPKD, CF, TOF, and infectious diseases. Because of substantial heterogeneity in methodological quality, design, outcomes, dose, duration of intake, formulations, and study populations across studies, no quantitative analysis was performed. Additional large‐scale, randomized, placebo‐controlled clinical trials are needed to confirm the results of the conducted studies.

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Research works printed but not linked: 120

  1. 10.1002/jcp.25778 · DOI · Paper page
  2. Abidi A., 2014, Evaluation of efficacy of curcumin as an add‐on therapy in patients of bronchial asthma, Journal of Clinical and Diagnostic Research, 8, Hc19‐24
  3. 10.3390/ph13070153 · DOI · Paper page
  4. Ailioaie C., 2018, FRI0726‐HPR study on the efficacy of curcumin therapy in early stages of juvenile oligoarthritis, Annals of the Rheumatic Diseases, 77, 1810
  5. Ailioaie L. M., 2018, FRI0728‐HPR cost‐reducing and improving quality of life in juvenile arthritis by blue laser and ultrabioavailable curcumin, Annals of the Rheumatic Diseases, 77, 1811
  6. 10.3389/fphar.2019.00649 · DOI
  7. 10.1016/j.jtcme.2016.05.005 · DOI · Paper page
  8. 10.1089/jmf.2017.3930 · DOI
  9. American Autoimmune Related Diseases Association (AARDA), 2011, The Cost Burden of Autoimmune Disease: The Latest Front in the War on Healthcare Spending
  10. 10.1007/s00431-019-03464-y · DOI
  11. 10.2174/1389201021666200305115101 · DOI
  12. 10.1902/jop.2016.150722 · DOI
  13. 10.1007/s12035-018-1169-7 · DOI
  14. 10.1016/j.phrs.2018.12.014 · DOI
  15. 10.1074/jbc.M412972200 · DOI
  16. 10.1038/cmi.2010.11 · DOI
  17. 10.1002/ibd.20348 · DOI
  18. 10.1016/j.diabet.2020.01.003 · DOI
  19. 10.1002/jcp.28103 · DOI
  20. 10.1016/j.intimp.2006.11.006 · DOI · Paper page
  21. 10.1021/mp900138a · DOI
  22. 10.3390/molecules25153469 · DOI
  23. Chandan S., 2020, Curcumin use in ulcerative colitis: Is it ready for prime time? A systematic review and meta‐analysis of clinical trials, Annals of Gastroenterology, 33, 53
  24. 10.1002/ptr.4639 · DOI · Paper page
  25. 10.1248/bpb.b18-00928 · DOI
  26. 10.3389/fped.2018.00431 · DOI
  27. 10.1542/peds.2016-1209 · DOI
  28. 10.1016/j.phymed.2009.01.004 · DOI
  29. 10.3390/nu12010118 · DOI
  30. 10.1016/j.phymed.2012.09.018 · DOI
  31. 10.3748/wjg.v19.i48.9256 · DOI · Paper page
  32. 10.30881/prmij.00010 · DOI
  33. 10.3390/nu10070855 · DOI · Paper page
  34. 10.3390/molecules20023020 · DOI
  35. 10.1016/j.exger.2012.10.008 · DOI
  36. 10.1016/j.ejphar.2010.12.008 · DOI
  37. 10.2174/1381612822666161006151605 · DOI
  38. 10.1016/j.prp.2019.152556 · DOI · Paper page
  39. 10.5812/ijem.18081 · DOI
  40. Golombick T. Diamond T. H. Manoharan A. &Ramakrishna R.(2015).The effect of curcumin (as Meriva) on absolute lymphocyte count (ALC) NK cells and T cell populations in patients with stage 0/1 chronic lymphocytic leukemia. · DOI
  41. 10.1186/1743-7075-5-17 · DOI · Paper page
  42. 10.3748/wjg.v19.i46.8552 · DOI
  43. 10.1007/978-3-030-64872-5_11 · DOI
  44. 10.1136/bmj.d5928 · DOI · Paper page
  45. 10.1016/j.ejphar.2010.09.065 · DOI
  46. 10.1124/mol.108.046169 · DOI
  47. Ismail N. A., 2016, Impact of curcumin intake on gluco‐insulin homeostasis, leptin and adiponectin in obese subjects, Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7, 1891
  48. Ismail N. A., 2014, Effect of oral curcumin administration on insulin resistance, serum resistin and fetuin‐a in obese children: Randomized placebo‐controlled study, Research Journal of Pharmaceutical, Biological and Chemical Sciences, 5, 887
  49. 10.1002/ptr.5591 · DOI · Paper page
  50. 10.1186/s12986-019-0331-1 · DOI
  51. 10.3748/wjg.v12.i24.3848 · DOI
  52. 10.1016/j.intimp.2010.04.006 · DOI
  53. Kanai M., 2014, Therapeutic applications of curcumin for patients with pancreatic cancer, World Journal of Gastroenterology, 20, 9384
  54. 10.1016/S0014-2999(99)00690-1 · DOI
  55. 10.5578/mb.3902 · DOI
  56. 10.1097/MD.0000000000019052 · DOI
  57. 10.4110/in.2017.17.1.25 · DOI · Paper page
  58. Kim G.‐Y. Kim K.‐H. Lee S.‐H. Yoon M.‐S. Lee H.‐J. Moon D.‐O. …Park Y.‐M.(2005).Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF‐κB as potential targets 174(12) 8116–8124. · DOI · Paper page
  59. Korth‐Bradley J. M., 2018, The path to perfect pediatric posology — Drug development, Pediatrics, 58, S48
  60. Krivosikova M., 2009, B cell activating factor, its role in autoimmunity, and targeting in autoimmune diseases, Bratislavske Lekarske Listy, 110, 137
  61. 10.4103/0250-474X.65012 · DOI
  62. 10.1101/cshperspect.a001651 · DOI · Paper page
  63. 10.1667/RR1522.1 · DOI
  64. 10.1016/j.phrs.2016.11.017 · DOI · Paper page
  65. 10.1152/ajprenal.00419.2010 · DOI
  66. 10.1016/j.autrev.2011.02.001 · DOI
  67. 10.1097/MD.0000000000019052 · DOI
  68. 10.1016/j.jep.2019.111882 · DOI
  69. 10.3389/fendo.2021.669448 · DOI
  70. Institute of Medicine, 2000, Rational therapeutics for infants and children: Workshop summary
  71. 10.1038/nrrheum.2011.68 · DOI · Paper page
  72. Miserocchi E. Giuffrè C. Cicinelli M. V. Marchese A. Gattinara M. Modorati G. &Bandello F.(2020).Oral phospholipidic curcumin in juvenile idiopathic arthritis‐associated uveitis 30(6) 1390–1396.https://doi.org/10.1177/1120672119892804 · DOI
  73. Moghadamtousi S. Z., 2014, A review on antibacterial, antiviral, and antifungal activity of curcumin, BioMed Research International, 2014, 186864
  74. 10.1016/j.phrs.2020.104765 · DOI
  75. 10.1002/jcp.28122 · DOI · Paper page
  76. 10.1038/hr.2011.180 · DOI
  77. 10.1016/j.conctc.2020.100635 · DOI
  78. 10.1007/s40272-014-0084-2 · DOI
  79. 10.1016/j.ijrobp.2006.03.025 · DOI
  80. 10.1016/j.intimp.2011.12.009 · DOI
  81. 10.1007/s13105-013-0244-9 · DOI
  82. 10.1016/j.jclinepi.2021.02.003 · DOI · Paper page
  83. 10.1055/s-0044-101752 · DOI
  84. 10.1038/s41598-019-41106-3 · DOI
  85. 10.3389/fcell.2021.663535 · DOI
  86. 10.1053/j.ackd.2010.01.003 · DOI
  87. 10.3390/nu11081837 · DOI · Paper page
  88. 10.1111/ijcp.14280 · DOI
  89. Rafeey M., 2020, Effects of curcumin supplementation on quality of life of cystic fibrosis patients, International Journal of Pediatrics, 8, 11169
  90. 10.1111/j.1365-2249.2010.04232.x · DOI
  91. 10.1186/1472-6882-10-57 · DOI
  92. 10.1016/j.jad.2020.09.091 · DOI
  93. 10.1155/2020/8405370 · DOI
  94. 10.1590/1516-3180.2018.0454120419 · DOI
  95. 10.1002/ptr.6370 · DOI
  96. 10.1002/jcp.27404 · DOI
  97. 10.1111/j.1365-2249.2006.03257.x · DOI
  98. 10.15420/ecr.2019.17.2 · DOI
  99. 10.1016/j.bbrc.2008.07.051 · DOI
  100. Soetikno V., 2011, Curcumin ameliorates macrophage infiltration by inhibiting NF‐κB activation and proinflammatory cytokines in streptozotocin induced‐diabetic nephropathy, Nutrition and Metabolism, 8, 1
  101. Somashekara M., 2020, A phase IV clinical study to evaluate the efficacy and safety of Bresol and Septilin tablets in combination for chronic allergic rhinitis and recurrent bacterial sinusitis along with impact on immune system, Annals of Medical and Health Sciences Research, 10, 912
  102. 10.1017/S1047951115000360 · DOI
  103. 10.1097/MPG.0b013e318276977d · DOI
  104. 10.2174/1381612824666180828162053 · DOI
  105. 10.1186/s13063-021-05224-6 · DOI
  106. 10.2174/1389201017666160721123109 · DOI
  107. 10.2500/aap.2016.37.3920 · DOI
  108. 10.1038/nri1937 · DOI · Paper page
  109. 10.3390/ijms20051033 · DOI · Paper page
  110. 10.1371/journal.pone.0121313 · DOI · Paper page
  111. 10.1016/j.intimp.2008.01.008 · DOI
  112. 10.1053/j.ajkd.2007.09.010 · DOI
  113. 10.3390/nu11051004 · DOI
  114. 10.1002/ptr.6738 · DOI · Paper page
  115. 10.1155/2013/636053 · DOI · Paper page
  116. 10.1016/j.intimp.2006.02.013 · DOI
  117. 10.3389/fphys.2014.00094 · DOI
  118. 10.1002/cbdv.202000171 · DOI · Paper page
  119. 10.1159/000430126 · DOI
  120. 10.1155/2019/4927430 · DOI

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Metadata

Authors
Heidari, Z., Daei, M., Boozari, M., Jamialahmadi, T., & Sahebkar, A.
Affiliations
  • Department of Clinical Pharmacy, Faculty of Pharmacy Mashhad University of Medical Sciences Mashhad Iran
  • Department of Clinical Pharmacy, Faculty of Pharmacy Alborz University of Medical Sciences Alborz Iran
  • Department of Pharmacognosy, Faculty of Pharmacy Mashhad University of Medical Sciences Mashhad Iran
  • Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran
  • Applied Biomedical Research Center Mashhad University of Medical Sciences Mashhad Iran
ORCID
Sahebkar, Amirhossein
Venue
Phytotherapy Research
Publisher
Wiley
Published
2021-12-14
Volume
36
Issue
4
Pages
1442-1458
ISSN
  • 0951-418X
  • 1099-1573
DOI
10.1002/ptr.7350
Cited by
80
References
4
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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