Effects of exercise training on Fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: A systematic review and Meta-analysis
Open accessAbstract
BACKGROUND: Elevated levels of fetuin-A are associated with increased risks of metabolic syndrome, type 2 diabetes and nonalcoholic fatty liver disease. This meta-analysis investigated whether exercise interventions can reduce fetuin-A in adults. METHODS: We searched clinical trials that objectively assessed fetuin-A and included study arms with exercise intervention. The pre-intervention and post-intervention data were used for meta-analysis. The effect sizes were calculated as standardized mean differences or changes in fetuin-A and expressed as Hedges' g using random-effects models. RESULTS: The overall Hedges' g for fetuin-A in all included interventions was - 0.640 (95%CI - 1.129 to - 0.151; n = 9), but this effect was not observed in obese (g = - 0.096; 95%CI, - 0.328 to 0.135) and type 2 diabetes/dysglycemia (g = - 0.56; 95%CI, - 1.348 to 0.236) individuals. Additionally, the random-effects meta-regression analysis showed that there was not a greater decrease in fetuin-A in individuals who achieved greater body mass index reductions (regression coefficient = 0.065; 95%CI, - 0.185 to 0.315). CONCLUSION: Supervised exercise is associated with reductions in fetuin-A levels in adults and elderly. However, the results of the present meta-analysis should be interpreted with caution because of the variety of type of exercises and individual obesity related-disorders involve. Therefore, additional high-quality randomized controlled trials describing the effect of supervised exercise interventions on fetuin-A in adults are still needed. .
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Modulation of fetuin A by exercise partially depends on pre-existing metabolic status.
“Regarding exercise, a recent meta-analysis found decreased fetuin A levels following completion of aerobic exercise regimes of varying frequency and duration (e.g., 1–12 weeks, 3–5 sessions per week of 40–70 min each) and intensity (e.g., 60–85% maximum heart rate), except in patients with T2DM, suggesting that modulation of fetuin A by exercise partially depends on the pre-existing metabolic stat”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [138]
The Results (Additional analysis; page unavailable) and Discussion report no significant fetuin-A reduction in the type 2 diabetes/dysglycemia subgroup, which supports the suggestion that response may vary with metabolic status. But the obese subgroup also showed no significant reduction, and the Discussion says it is unclear whether the divergent findings are due to health status rather than other factors. The source therefore does not establish metabolic status as an explanation or support diabetes as the sole exception. (LLM, conf=0.86)
Experimental — accuracy not yet measuredA recent meta-analysis found decreased fetuin A levels following completion of aerobic exercise regimes of varying frequency and duration and intensity, except in patients with T2DM.
“Regarding exercise, a recent meta-analysis found decreased fetuin A levels following completion of aerobic exercise regimes of varying frequency and duration (e.g., 1–12 weeks, 3–5 sessions per week of 40–70 min each) and intensity (e.g., 60–85% maximum heart rate), except in patients with T2DM, suggesting that modulation of fetuin A by exercise partially depends on the pre-existing metabolic stat”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [138]
The Results (Synthesis of results) report an overall reduction in fetuin-A after supervised exercise, and the Results (Study selection) describe varied exercise durations, frequencies, and intensities. The Results (Additional analysis) found no statistically significant reduction in the type 2 diabetes/dysglycemia subgroup, but also found none in the obesity subgroup. Thus, presenting T2DM as the sole exception overstates the findings. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
A basic introduction to fixed-effect and random-effects models for meta-analysis
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2010) · Research Synthesis Methods · doi:10.1002/jrsm.12 · Cited by 6,793 · see citing works
Armijo‐Olivo, S., Stiles, C. R., Hagen, N. A., Biondo, P. D., & Cummings, G. G. (2012) · Journal of Evaluation in Clinical Practice · doi:10.1111/j.1365-2753.2010.01516.x · Cited by 1,539 · see citing works
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works
Randomized versus historical controls for clinical trials
Sacks, H., Chalmers, T. C., & Smith, H. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90815-4 · Cited by 834 · see citing works
Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease
Pedersen, B. K. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12781 · Cited by 617 · see citing works
Causes and Metabolic Consequences of Fatty Liver
Stefan, N., Kantartzis, K., & Häring, H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0009 · Cited by 529 · see citing works
Stefan, N., Hennige, A. M., Staiger, H., Machann, J., Schick, F., Kröber, S. M., Machicao, F. E., Fritsche, A., & Häring, H. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1938 · Cited by 475 · see citing works
Physical Inactivity and Obesity: A Vicious Circle
Pietiläinen, K. H., Kaprio, J., Borg, P., Plasqui, G., Yki‐Järvinen, H., Kujala, U. M., Rose, R. J., Westerterp, K. R., & Rissanen, A. (2008) · Obesity · doi:10.1038/oby.2007.72 · Cited by 388 · see citing works
Association Between Human Fetuin-A and the Metabolic Syndrome
Ix, J. H., Shlipak, M. G., Brandenburg, V. M., Ali, S., Ketteler, M., & Whooley, M. A. (2006) · Circulation · doi:10.1161/circulationaha.105.588723 · Cited by 316 · see citing works
Plasma Fetuin-A Levels and the Risk of Myocardial Infarction and Ischemic Stroke
Weikert, C., Stefan, N., Schulze, M. B., Pischon, T., Berger, K., Joost, H., Häring, H., Boeing, H., & Fritsche, A. (2008) · Circulation · doi:10.1161/circulationaha.108.814418 · Cited by 310 · see citing works
Fetuin, a New Globulin Isolated from Serum
Pedersen, K. O. (1944) · Nature · doi:10.1038/154575a0 · Cited by 289 · see citing works
Fetuin-A Induces Cytokine Expression and Suppresses Adiponectin Production
Hennige, A. M., Staiger, H., Wicke, C., Machicao, F., Fritsche, A., Häring, H.-U., & Stefan, N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001765 · Cited by 282 · see citing works
Church, T. S., Kuk, J. L., Ross, R., Priest, E. L., Biltoff, E., & Blair, S. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.019 · Cited by 268 · see citing works
Srinivas, P. R., Wagner, A. S., Reddy, L. V. K., Deutsch, D. D., Leon, M. A., Goustin, A. S., & Grunberger, G. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.11.7906861 · Cited by 243 · see citing works
Fetuin-A: a multifunctional protein.
Mori, K., Emoto, M., & Inaba, M. (2011) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/187221411799015372 · Cited by 220 · see citing works
Metabolic adaptation in obesity and type ii diabetes: myokines, adipokines and hepatokines
Oh, K.-J., Lee, D., Kim, W., Han, B., Lee, S., & Bae, K.-H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010008 · Cited by 210 · see citing works
Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies
Haukeland, J. W., Dahl, T. B., Yndestad, A., Gladhaug, I. P., Løberg, E. M., Haaland, T., Konopski, Z., Wium, C., Aasheim, E. T., Johansen, O. E., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0864 · Cited by 186 · see citing works
Fetuin-A: A novel link between obesity and related complications
Trepanowski, J. F., Mey, J., & Varady, K. A. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.203 · Cited by 161 · see citing works
Intradialytic exercise training reduces oxidative stress and epicardial fat: a pilot study
Wilund, K. R., Tomayko, E. J., Wu, P.-T., Chung, H. R., Vallurupalli, S., Lakshminarayanan, B., & Fernhall, B. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq106 · Cited by 152 · see citing works
Yang, S. J., Hong, H. C., Choi, H. Y., Yoo, H. J., Cho, G. J., Hwang, T. G., Baik, S. H., Choi, D. S., Kim, S. M., & Choi, K. M. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04078.x · Cited by 148 · see citing works
Winn, N. C., Liu, Y., Rector, R. S., Parks, E. J., Ibdah, J. A., & Kanaley, J. A. (2017) · Metabolism · doi:10.1016/j.metabol.2017.08.012 · Cited by 136 · see citing works
Fetuin-null mice are protected against obesity and insulin resistance associated with aging
Mathews, S. T., Rakhade, S. N., Zhou, X., Parker, G. C., Coscina, D. V., & Grunberger, G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.071 · Cited by 129 · see citing works
Elevated Fetuin-A Concentrations in Morbid Obesity Decrease after Dramatic Weight Loss
Brix, J. M., Stingl, H., Höllerl, F., Schernthaner, G.-H., Kopp, H.-P., & Schernthaner, G. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0148 · Cited by 112 · see citing works
Hepatokines: unlocking the multi-organ network in metabolic diseases
Iroz, A., Couty, J.-P., & Postic, C. (2015) · Diabetologia · doi:10.1007/s00125-015-3634-4 · Cited by 111 · see citing works
Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials
García‐Hermoso, A., Ceballos-Ceballos, R., Poblete-Aro, C., Hackney, A. C., Mota, J. A. P. S., & Ramírez‐Vélez, R. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.230 · Cited by 89 · see citing works
Plasma Levels of Fetuin-A and Hepatic Enzymes and Risk of Type 2 Diabetes in Women in the U.S.
Sun, Q., Cornelis, M. C., Manson, J. E., & Hu, F. B. (2012) · Diabetes · doi:10.2337/db12-0372 · Cited by 87 · see citing works
Fetuin-A and the cardiovascular system
Mori, K., Emoto, M., & Inaba, M. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394317-0.00010-8 · Cited by 86 · see citing works
Exercise-induced lowering of fetuin-A may increase hepatic insulin sensitivity
Malin, S. K., del Rincon, J. P., Huang, H., & Kirwan, J. P. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000338 · Cited by 85 · see citing works
Salsalate and adiponectin ameliorate hepatic steatosis by inhibition of the hepatokine fetuin-A
Jung, T. W., Youn, B., Choi, H. Y., Lee, S. Y., Hong, H. C., Yang, S. J., Yoo, H. J., Kim, B., Baik, S. H., & Choi, K. M. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.034 · Cited by 82 · see citing works
Effects of pioglitazone on serum fetuin-A levels in patients with type 2 diabetes mellitus
Mori, K., Emoto, M., Araki, T., Yokoyama, H., Lee, E., Teramura, M., Koyama, H., Shoji, T., Inaba, M., & Nishizawà, Y. (2008) · Metabolism · doi:10.1016/j.metabol.2008.04.019 · Cited by 77 · see citing works
Guo, R., Liong, E. C., So, K., Fung, M., & Tipoe, G. L. (2015) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(15)60355-1 · Cited by 74 · see citing works
Implication of hepatokines in metabolic disorders and cardiovascular diseases
Jung, T. W., Yoo, H. J., & Choi, K. M. (2016) · BBA Clinical · doi:10.1016/j.bbacli.2016.03.002 · Cited by 71 · see citing works
Ou, H., Yang, Y., Wu, H., Wu, J., Lu, F., & Chang, C. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2414 · Cited by 69 · see citing works
Malin, S. K., Mulya, A., Fealy, C. E., Haus, J. M., Pagadala, M. R., Scelsi, A. R., Huang, H., Flask, C. A., McCullough, A. J., & Kirwan, J. P. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00237.2013 · Cited by 68 · see citing works
González‐Ruíz, K., Ramírez‐Vélez, R., Correa‐Bautista, J. E., Peterson, M. D., & García‐Hermoso, A. (2017) · Childhood Obesity · doi:10.1089/chi.2017.0027 · Cited by 68 · see citing works
Lee-Ødegård, S., Norheim, F., Gulseth, H. L., Langleite, T. M., Kolnes, K. J., Tangen, D. S., Stadheim, H. K., Gilfillan, G. D., Holen, T., Birkeland, K. I., et al. (2017) · Physiological Reports · doi:10.14814/phy2.13183 · Cited by 59 · see citing works
Sex-Specific Association of Fetuin-A With Type 2 Diabetes in Older Community-Dwelling Adults
Laughlin, G. A., Barrett-Connor, E. L., Cummins, K. M., Daniels, L. B., Wassel, C. L., & Ix, J. H. (2013) · Diabetes Care · doi:10.2337/dc12-1870 · Cited by 51 · see citing works
Chattopadhyay, M., Mukherjee, S., Chatterjee, S. K., Chattopadhyay, D., Das, S., Majumdar, S. S., Mukhopadhyay, S., Mukherjee, S., & Bhattarcharya, S. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.10.005 · Cited by 42 · see citing works
Zhang, L., Liu, T., Teng, Y., Yao, X., Zhao, T., Lin, L., Jin, Q., & Jin, Y. (2017) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-115904 · Cited by 37 · see citing works
Plasma fetuin-A concentrations in young and older high- and low-active men
Jenkins, N. T., McKenzie, J. A., Hagberg, J. M., & Witkowski, S. (2010) · Metabolism · doi:10.1016/j.metabol.2010.01.026 · Cited by 33 · see citing works
Mukhopadhyay, S., & Bhattacharya, S. (2016) · Diabetologia · doi:10.1007/s00125-016-3866-y · Cited by 30 · see citing works
Aroner, S. A., St-Jules, D. E., Mukamal, K. J., Katz, R., Shlipak, M. G., Criqui, M. H., Kestenbaum, B. R., Siscovick, D. S., de Boer, I. H., Jenny, N. S., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.03.029 · Cited by 28 · see citing works
Laugsand, L. E., Ix, J. H., Bartz, T. M., Djoussé, L., Kizer, J. R., Tracy, R. P., Dehghan, A., Rexrode, K. M., López, O. L., Rimm, E. B., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.08.031 · Cited by 24 · see citing works
Schultes, B., Frick, J. E., Ernst, B., Stefan, N., & Fritsche, A. (2010) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0030-1253418 · Cited by 23 · see citing works
König, D., Zdzieblik, D., Deibert, P., Berg, A., Gollhofer, A., & Büchert, M. (2015) · Nutrients · doi:10.3390/nu7125500 · Cited by 23 · see citing works
Xu, X. J., Valentine, R. J., & Ruderman, N. B. (2014) · Current Obesity Reports · doi:10.1007/s13679-014-0095-x · Cited by 22 · see citing works
Blumenthal, J. B., Gitterman, A., Ryan, A. S., & Prior, S. J. (2017) · Journal of Diabetes Research · doi:10.1155/2017/1492581 · Cited by 20 · see citing works
Association of Human Fetuin-A rs4917 Polymorphism with Obesity in 2 Cohorts
Temesszentandrási, G., Vörös, K., Böröcz, Z., Kaszás, E., Prohászka, Z., Falus, A., Cseh, K., & Kalabay, L. (2015) · Journal of Investigative Medicine · doi:10.1097/jim.0000000000000151 · Cited by 12 · see citing works
Explaining heterogeneity in meta-analysis: a comparison of methods
Thompson, S. G., & Sharp, S. J. (1999) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19991030)18:20
Flagged first, then by citations
Cited by
Sorted by citations
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works
Bourebaba, L., & Marycz, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122033 · Cited by 123 · see citing works
Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence
Heidari, Z., Daei, M., Boozari, M., Jamialahmadi, T., & Sahebkar, A. (2021) · Phytotherapy Research · doi:10.1002/ptr.7350 · Cited by 80 · see citing works
García-Hermoso, A., Ramírez-Vélez, R., Díez, J., González, A., & Izquierdo, M. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.11.003 · Cited by 80 · see citing works
Self-citationNewly discovered endocrine functions of the liver
Rhyu, J., & Yu, R. (2021) · World Journal of Hepatology · doi:10.4254/wjh.v13.i11.1611 · Cited by 62 · see citing works
Fetuin-A in Metabolic syndrome: A systematic review and meta-analysis
Pan, X., Wen, S. W., Bestman, P. L., Kaminga, A. C., Acheampong, K., & Liu, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229776 · Cited by 52 · see citing works
Memarian, E., Hart, L. M. ‘., Slieker, R. C., Lemmers, R. F. H., van der Heijden, A. A. W. A., Rutters, F., Nijpels, G., Schoep, E., Lieverse, A. G., Sijbrands, E. J. G., et al. (2021) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2021-002345 · Cited by 36 · see citing works
Ramanjaneya, M., Bensila, M., Bettahi, I., Jerobin, J., Samra, T. A., Aye, M. M., Alkasem, M., Siveen, K. S., Sathyapalan, T., Skarulis, M. C., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.568500 · Cited by 34 · see citing works
Saberi, S., Askaripour, M., Khaksari, M., Rajizadeh, M. A., Bejeshk, M. A., Akhbari, M. R., Jafari, E., & Khoramipour, K. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27749 · Cited by 24 · see citing works
Udoy, I. A., & Hassan, O. (2025) · Symmetry · doi:10.3390/sym17030469 · Cited by 30 · see citing works
Selvaraju, V., Babu, J. R., & Geetha, T. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155843 · Cited by 22 · see citing works
Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest
Ward, K., Mulder, E. R., Frings‐Meuthen, P., O’Gorman, D. J., & Cooper, D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.573581 · Cited by 13 · see citing works
Mastrototaro, L., & Roden, M. (2023) · PROTEOMICS · doi:10.1002/pmic.202300078 · Cited by 12 · see citing works
Exercise and inactivity as modifiers of β cell function and type 2 diabetes risk
Hall, L. G., Thyfault, J. P., & Johnson, J. D. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00472.2022 · Cited by 14 · see citing works
Pulido-Gil, J. M., Sánchez‐Oliva, D., López-Gajardo, M. Á., Ponce-Bordón, J. C., & García‐Calvo, T. (2022) · Cultura Ciencia y Deporte · doi:10.12800/ccd.v17i52.1792 · Cited by 12 · see citing works
Pàmies, A., Vallvé, J.-C., & Paredes, S. (2025) · Biomedicines · doi:10.3390/biomedicines13040870 · Cited by 10 · see citing works
Tammam, M. A., Aly, O., Pereira, F., Mahdy, A., & El‐Demerdash, A. (2024) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2024.100175 · Cited by 8 · see citing works
Eswar, S., Rajagopalan, B., Ete, K., & Gattem, S. N. R. (2024) · JMA Journal · doi:10.31662/jmaj.2024-0104 · Cited by 6 · see citing works
Garcia, J. A., Sundara, N., Tabor, G., Gay, V. C., & Leong, T. W. (2019) · SeGAH ... IEEE ... International Conference on Serious Games and Applications for Health/IEEE International Conference on Serious Games and Applications for Health · doi:10.1109/segah.2019.8882471 · Cited by 6 · see citing works
Interaction of fetuin-A with obesity related insulin resistance and diabetes mellitus
Öner-İyidoğan, Y., & Koçak, H. (2024) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2024-0235 · Cited by 6 · see citing works
Choi, N. G., DiNitto, D. M., Sullivan, J. E., & Choi, B. Y. (2020) · Journal of Aging and Physical Activity · doi:10.1123/japa.2019-0338 · Cited by 4 · see citing works
Enríquez-Rodríguez, C. J., Pascual-Guàrdia, S., Casadevall, C., Caguana-Vélez, O. A., Rodriguez, D. A., Barreiro, E., & Gea, J. (2024) · Cells · doi:10.3390/cells13100866 · Cited by 4 · see citing works
Błaszczyk, J. W. (2025) · Metabolites · doi:10.3390/metabo15060404 · Cited by 3 · see citing works
Jemal, M., Waritu, N. C., Baylie, T., Sinamaw, D., Mengistu, E. F., Osman, E. E., Baye, G., Tegegne, B. A., Amare, G. A., Teffera, Z. H., et al. (2025) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223251389795 · Cited by 3 · see citing works
Fadieienko, G. D., Kushnir, I. Е., Chernova, V. M., Solomentseva, Т. А., Nikiforova, Y. V., & Kurinna, O. G. (2022) · Modern Gastroenterology · doi:10.30978/mg-2022-5-5 · Cited by 3 · see citing works
How Exercise Affects Exerkines in Metabolic Syndrome
Babaei, P., & Yadegari, F. (2025) · Hormone and Metabolic Research · doi:10.1055/a-2720-5398 · Cited by 2 · see citing works
Hepatokines modulation in obesity: which exercise training model is better in men with obesity?
Ataeinosrat, A., Abednatanzi, H., Hajesfandiari, S., Nasser, M. N. A., Dara, M. M., Farzanegi, P., Nahand, M. S., Almaqhawi, A., Karimi, N., Bagherzadeh-Rahmani, B., et al. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1560453 · Cited by 3 · see citing works
Investigaciones realizadas en Colombia relacionadas con actividad física y obesidad 2010-2020
Roldán-Aguilar, E. E., Vergara-Ramos, G., & Jaramillo-Osorno, A. F. (2022) · Revista Politécnica · doi:10.33571/rpolitec.v18n36a5 · Cited by 2 · see citing works
Khabiri, P., Rahimi, R., Rashidi, I., & Nedaei, S. E. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.09.004 · Cited by 2 · see citing works
Diabetes mellitus: An overview
Sonia, T. A., & Sharma, C. P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30272-5.00007-x · Cited by 1 · see citing works
Torabi, M., & Mirzaei, B. (2022) · Journal of Sport and Exercise Physiology · doi:10.52547/joeppa.15.3.81 · Cited by 1 · see citing works
The Relationship Between Urinary System Stone Disease and Serum Fetuin-A Glycoprotein
Yavuz, A., & Arısan, S. (2025) · Endouroloji Bulteni · doi:10.54233/endourolbull-1621723
Hazrati, F., Safarzade, A., Talebi-Garakani, E., & Hamedchaman, N. (2025) · Research Square · doi:10.21203/rs.3.rs-7285688/v1
Bernard, D., Sultan, A., & Bouzakri, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178182
Lionardi, S. K., Prihadi, J. C., Hengky, A., Secodiningrat, R. H. P. S., Widjanarko, N. D., Alvianto, S., & Lionardi, S. (2025) · Journal of Clinical Urology · doi:10.1177/20514158251364038
Hazrati, F., Safarzade, A., Talebi-Garakani, E., & Hamedchaman, N. (2025) · Nutrire · doi:10.1186/s41110-025-00376-w
- Authors
- Ramírez-Vélez, R., García-Hermoso, A., Hackney, A. C., & Izquierdo, M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Lipids in Health and Disease
- Published
- 2019-01-22
- Volume
- 18
- Issue
- 1
- Pages
- 23-23
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC6343360
- OpenAlex
- W2918805195
- Cited by
- 37
- References
- 53
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 2
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Academica-e (Universidad Pública de Navarra) (acceptedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- UNC Libraries
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- fetuin-A, exercise training, obesity, type 2 diabetes, cardiovascular disease, metabolic syndrome, non-alcoholic fatty liver disease, body mass index reduction, supervised exercise, older adults
- MeSH terms
- Adult, Aged, Diabetes Mellitus, Type 2, Humans, Middle Aged, Obesity, Regression Analysis, Risk Factors, Exercise, Randomized Controlled Trials as Topic, Publication Bias, alpha-2-HS-Glycoprotein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
