The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Zebrafish heart regeneration: 15 years of discoveries
Open accessAbstract
Cardiovascular disease is the leading cause of death worldwide. Compared to other organs such as the liver, the adult human heart lacks the capacity to regenerate on a macroscopic scale after injury. As a result, myocardial infarctions are responsible for approximately half of all cardiovascular related deaths. In contrast, the zebrafish heart regenerates efficiently upon injury through robust myocardial proliferation. Therefore, deciphering the mechanisms that underlie the zebrafish heart's endogenous regenerative capacity represents an exciting avenue to identify novel therapeutic strategies for inducing regeneration of the human heart. This review provides a historical overview of adult zebrafish heart regeneration. We summarize 15 years of research, with a special focus on recent developments from this fascinating field. We discuss experimental findings that address fundamental questions of regeneration research. What is the origin of regenerated muscle? How is regeneration controlled from a genetic and molecular perspective? How do different cell types interact to achieve organ regeneration? Understanding natural models of heart regeneration will bring us closer to answering the ultimate question: how can we stimulate myocardial regeneration in humans?
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Citations
Cites
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130
Efficient genome editing in zebrafish using a CRISPR-Cas system
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Transient Regenerative Potential of the Neonatal Mouse Heart
Porrello, E. R., Mahmoud, A. I., Simpson, E., Hill, J. A., Richardson, J. A., Olson, E. N., & Sadek, H. A. (2011) · Science · doi:10.1126/science.1200708 · Cited by 2,545
Mammalian heart renewal by pre-existing cardiomyocytes
Senyo, S. E., Steinhauser, M. L., Pizzimenti, C. L., Yang, V. K., Cai, L., Wang, M., Wu, T.-D., Guerquin-Kern, J.-L., Lechene, C. P., & Lee, R. T. (2013) · Nature · doi:10.1038/nature11682 · Cited by 1,343
Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., & Belmonte, J. C. I. (2010) · Nature · doi:10.1038/nature08899 · Cited by 1,333
High-throughput functional genomics using CRISPR-Cas9
Shalem, O., Sanjana, N. E., & Zhang, F. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3899 · Cited by 1,233
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
Zhou, B., Ma, Q., Rajagopal, S., Wu, S. M., Domian, I., Rivera-Feliciano, J., Jiang, D., von Gise, A., Ikeda, S., Chien, K. R., et al. (2008) · Nature · doi:10.1038/nature07060 · Cited by 1,019
Apoptosis in human acute myocardial infarction.
Saraste, A., Pulkki, K., Kallajoki, M., Henriksen, K., Parvinen, M., & Voipio-Pulkki, L.-M. (1997) · Circulation · doi:10.1161/01.cir.95.2.320 · Cited by 825 · cited 2×
“As in humanMI (Itoh et al., 1995; Saraste et al., 1997), cryoinjury results in rapid cardiomyocyte enucleation, while the sarcomeric apparatus remains relatively intact for a few days (González-Rosa et al.”
BackgroundNerve dependence in tissue, organ, and appendage regeneration
Kumar, A., & Brockes, J. P. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.003 · Cited by 290
Cited by
Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise
Schüttler, D., Clauss, S., Weckbach, L. T., & Brunner, S. (2019) · Cells · doi:10.3390/cells8101128 · Cited by 117
Myocardial regeneration: Role of epicardium and implicated genes
Saifi, O., Ghandour, B., Jaalouk, D., Refaat, M., & Mahfouz, R. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-05075-0 · Cited by 10
Metadata
- Authors
- González‐Rosa, J. M., Burns, C. E., & Burns, C. G.
- Venue
- Regeneration
- Publisher
- Wiley
- Published
- 2017-06
- Volume
- 4
- Issue
- 3
- Pages
- 105-123
- ISSN
- 2052-4412 (ISSN-L)
- OpenAlex
- W2748775553
- Cited by
- 188
- References
- 9
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
