Alternatively activated macrophages in infection and autoimmunity

Fairweather, DeLisa; Cihakova, Daniela

doi:10.1016/j.jaut.2009.09.012

Cited by 290Immune cells in cancerCardiac Fibrosis and RemodelingPhagocytosis and Immune Regulation

Alternatively activated macrophages in infection and autoimmunity

Open access

Fairweather, DeLisa, Cihakova, Daniela·2009·Journal of Autoimmunity

DOI 10.1016/j.jaut.2009.09.012PMC PMC2783278

Open this paper in CoChat — free account

Abstract

Macrophages are innate immune cells that play an important role in activation of the immune response and wound healing. Pathogens that require T helper-type 2 (Th2) responses for effective clearance, such as parasitic worms, are strong inducers of alternatively activated or M2 macrophages. However, infections such as bacteria and viruses that require Th1-type responses may induce M2 as a strategy to evade the immune system. M2 are particularly efficient at scavenging self tissues following injury through receptors like the mannose receptor and scavenger receptor-A. Thus, M2 may increase autoimmune disease by presenting self tissue to T cells. M2 may also exacerbate immune complex (IC)-mediated pathology and fibrosis, a hallmark of autoimmune disease in women, due to the release of profibrotic factors such as interleukin-1beta, transforming growth factor-beta, fibronectin and matrix metalloproteinases. We have found that M2 comprise anywhere from 30% to 70% of the infiltrate during acute viral or experimental autoimmune myocarditis, and shifts in M2 populations correlate with increased IC deposition, fibrosis and chronic autoimmune pathology. Thus, women may be at an increased risk of M2-mediated autoimmunity due to estrogen's ability to increase Th2 responses.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jaut.2009.09.012

Cites

123 of 123 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In preclinical animal models for myocarditis, monocytes and macrophages were predominant populations in heart infiltrates.
“in preclinical animal models for myocarditis, monocytes and macrophages were predominant populations in the heart infiltrates”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [114]
M1s are pro-inflammatory and microbicidal; M2s are immunomodulatory, reparative, and poorly microbicidal.
“In general, M1s or classically activated MΦs are pro-inflammatory and microbicidal, whereas M2s or alternatively activated MΦs are immunomodulatory, reparative, and poorly microbicidal [7–12].”
From Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds (2013) · cites this paper as [7]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Macrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160 · see citing works
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745 · see citing works
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300 · see citing works
Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation
Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960 · see citing works
The complex role of estrogens in inflammation
Straub, R. H. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0001 · Cited by 1,950 · see citing works
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
Yu, H., Kortylewski, M., & Pardoll, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1995 · Cited by 1,809 · see citing works
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer
Ostrand‐Rosenberg, S., & Sinha, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802740 · Cited by 1,733 · see citing works
Epidemiology and estimated population burden of selected autoimmune diseases in the United States
Jacobson, D. L., Gange, S. J., Rose, N. R., & Graham, N. M. H. (1997) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1997.4412 · Cited by 1,667 · see citing works
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
Monney, L., Sabatos, C. A., Gaglia, J. L., Ryu, A., Waldner, H., Chernova, T., Manning, S., Greenfield, E. A., Coyle, A. J., Sobel, R. A., et al. (2002) · Nature · doi:10.1038/415536a · Cited by 1,648 · see citing works
Altered macrophage differentiation and immune dysfunction in tumor development
Sica, A., & Bronte, V. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31422 · Cited by 1,239 · see citing works
C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
Dempsey, P. W., Allison, M. E. D., Akkaraju, S., Goodnow, C. C., & Fearon, D. T. (1996) · Science · doi:10.1126/science.271.5247.348 · Cited by 1,197 · see citing works
Protective immune mechanisms in helminth infection
Anthony, R. M., Rutitzky, L., Urban, J., Stadecker, M., & Gause, W. (2007) · Nature reviews. Immunology · doi:10.1038/nri2199 · Cited by 976 · see citing works
Active Caspase-1 Is a Regulator of Unconventional Protein Secretion
Keller, M., Rüegg, A., Werner, S., & Beer, H. (2008) · Cell · doi:10.1016/j.cell.2007.12.040 · Cited by 851 · see citing works
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
Maruyama, K., Ii, M., Cursiefen, C., Jackson, D. G., Keino, H., Tomita, M., van Rooijen, N., Takenaka, H., D'Amore, P. A., Stein‐Streilein, J., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23874 · Cited by 712 · see citing works
Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy.
Lassmann, H., Brück, W., & Lucchinetti, C. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(00)01909-2 · Cited by 691 · see citing works
Androgens and Cardiovascular Disease
Liu, P. Y., Death, A. K., & Handelsman, D. J. (2003) · Endocrine Reviews · doi:10.1210/er.2003-0005 · Cited by 690 · see citing works
Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
El Kasmi, K. C., Qualls, J. E., Pesce, J. T., Smith, A. M., Thompson, R. W., Henao-Tamayo, M., Basaraba, R. J., König, T., Schleicher, U., Koo, M.-S., et al. (2008) · Nature Immunology · doi:10.1038/ni.1671 · Cited by 646 · see citing works
Sex Differences in Autoimmune Disease from a Pathological Perspective
Fairweather, D., Frisancho-Kiss, S., & Rose, N. R. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071008 · Cited by 629 · see citing works
Self-citation
The macrophage: Past, present and future
Gordon, S. (2007) · European Journal of Immunology · doi:10.1002/eji.200737638 · Cited by 625 · see citing works
Complement: a unique innate immune sensor for danger signals
GASQUE, P. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.06.011 · Cited by 552 · see citing works
Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells
Gabrilovich, D. I., Velders, M. P., Sotomayor, E. M., & Kast, W. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5398 · Cited by 538 · see citing works
Macrophages as APC and the Dendritic Cell Myth
Hume, D. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.5829 · Cited by 504 · see citing works
Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10
Bogdan, C., Paik, J., Yoram Vodovotz, B., & Nathan, C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50091-0 · Cited by 502 · see citing works
Antiviral immune responses: triggers of or triggered by autoimmunity?
Münz, C., Lünemann, J. D., Getts, M. T., & Miller, S. D. (2009) · Nature reviews. Immunology · doi:10.1038/nri2527 · Cited by 480 · see citing works
Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease
Sinha, P., Clements, V. K., & Ostrand‐Rosenberg, S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.636 · Cited by 461 · see citing works
STAT1 Signaling Regulates Tumor-Associated Macrophage-Mediated T Cell Deletion
Kusmartsev, S. A., & Gabrilovich, D. I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4880 · Cited by 444 · see citing works
Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer
O'Neill, L. A. J., Bryant, C. E., & Doyle, S. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001073 · Cited by 426 · see citing works
Immunotoxicology and immunopharmacology
(1986) · Food and Chemical Toxicology · doi:10.1016/0278-6915(86)90331-5 · Cited by 425 · see citing works
CD11b+Ly-6Chi Suppressive Monocytes in Experimental Autoimmune Encephalomyelitis
Zhu, B., Bandô, Y., Xiao, S., Yang, K., Anderson, A. C., Kuchroo, V. K., & Khoury, S. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5228 · Cited by 370 · see citing works
Classical and alternative activation of mononuclear phagocytes: Picking the best of both worlds for tumor promotion
Ginderachter, J. A. V., Movahedi, K., Ghassabeh, G. H., Meerschaut, S., Beschin, A., Raes, G., & BAETSELIER, P. D. (2006) · Immunobiology · doi:10.1016/j.imbio.2006.06.002 · Cited by 370 · see citing works
Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program
Chieppa, M., Bianchi, G., Doni, A., Prete, A. D., Sironi, M., Laškarin, G., Monti, P., Piemonti, L., Biondi, A., Mantovani, A., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4552 · Cited by 368 · see citing works
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans
Santo, C. D., Salio, M., Masri, S. H., Lee, L. Y.-H., Dong, T., Speak, A. O., Porubský, Š., Booth, S., Veerapen, N., Besra, G. S., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36264 · Cited by 352 · see citing works
CNS-Derived Interleukin-4 Is Essential for the Regulation of Autoimmune Inflammation and Induces a State of Alternative Activation in Microglial Cells
Ponomarev, E. D., Maresz, K., Tan, Y., & Dittel, B. N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1922-07.2007 · Cited by 339 · see citing works
The Macrophage Mannose Receptor Induces IL-17 in Response to Candida albicans
van de Veerdonk, F. L., Marijnissen, R. J., Kullberg, B. J., Koenen, H. J. P. M., Cheng, S., Joosten, I., van den Berg, W. B., Williams, D. L., van der Meer, J. W. M., Joosten, L. A. B., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.02.006 · Cited by 338 · see citing works
Gender as risk factor for autoimmune diseases
Gleicher, N., & Barad, D. H. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2006.12.004 · Cited by 337 · see citing works
C-type lectins and phagocytosis
Kerrigan, A. M., & Brown, G. D. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.003 · Cited by 325 · see citing works
Complement Regulatory Proteins
(1999) · Elsevier eBooks · doi:10.1016/b978-0-125-06965-6.x5000-4 · Cited by 294 · see citing works
Estrogen, A Double-Edged Sword: Modulation of TH1- and TH2-Mediated Inflammations by Differential Regulation of TH1 / TH2 Cytokine Production
Salem, M. L. (2004) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010043483944 · Cited by 289 · see citing works
Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages
Sierra, J. R., Corso, S., Caione, L., Cepero, V., Conrotto, P., Cignetti, A., Piacibello, W., Kumanogoh, A., Kikutani, H., Comoglio, P. M., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072602 · Cited by 281 · see citing works
Infection with a Helminth Parasite Prevents Experimental Colitis via a Macrophage-Mediated Mechanism
Smith, P., Mangan, N. E., Walsh, C. M., Fallon, R. E., McKenzie, A. N. J., van Rooijen, N., & Fallon, P. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4557 · Cited by 279 · see citing works
Complement in human diseases: Lessons from complement deficiencies
Botto, M., Kirschfink, M., Macor, P., Pickering, M. C., Würzner, R., & Tedesco, F. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.04.029 · Cited by 264 · see citing works
Modulation of adaptive immunity with Toll-like receptors
Manicassamy, S., & Pulendran, B. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.05.005 · Cited by 255 · see citing works
Gene expression profiling of peripheral blood from patients with untreated new‐onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
Fall, N., Barnes, M., Thornton, S., Luyrink, L., Olson, J., Ilowite, N. T., Gottlieb, B. S., Griffin, T., Sherry, D. D., Thompson, S., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22981 · Cited by 245 · see citing works
IL-12 Receptor β1 and Toll-Like Receptor 4 Increase IL-1β- and IL-18-Associated Myocarditis and Coxsackievirus Replication
Fairweather, D., Yusung, S., Frisancho, S., Barrett, M., Gatewood, S., Steele, R., & Rose, N. R. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4731 · Cited by 229 · see citing works
Self-citation
Chapter 4 Pathogenesis of Myocarditis and Dilated Cardiomyopathy
Cihakova, D., & Rose, N. R. (2008) · Advances in Immunology · doi:10.1016/s0065-2776(08)00604-4 · Cited by 223 · see citing works
Cutting Edge: Cross-Regulation by TLR4 and T cell Ig Mucin-3 Determines Sex Differences in Inflammatory Heart Disease
Frisancho-Kiss, S., Davis, S. E., Nyland, J. F., Frisancho, J. A., Cihakova, D., Barrett, M. A., Rose, N. R., & Fairweather, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6710 · Cited by 212 · see citing works
Self-citation
Complement evasion strategies of pathogens—Acquisition of inhibitors and beyond
Blom, A. M., Hallström, T., & Riesbeck, K. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.04.025 · Cited by 212 · see citing works
Coxsackievirus-induced myocarditis in mice: A model of autoimmune disease for studying immunotoxicity
Fairweather, D., & Rose, N. R. (2007) · Methods · doi:10.1016/j.ymeth.2006.07.009 · Cited by 208 · see citing works
Self-citation
Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells
Sohn, J.-H., Bora, P. S., Suk, H.-J., Molina, H. D., Kaplan, H. J., & Bora, N. S. (2003) · Nature Medicine · doi:10.1038/nm814 · Cited by 199 · see citing works
Interferon-γ Protects against Chronic Viral Myocarditis by Reducing Mast Cell Degranulation, Fibrosis, and the Profibrotic Cytokines Transforming Growth Factor-β1, Interleukin-1β, and Interleukin-4 in the Heart
Fairweather, D., Frisancho-Kiss, S., Yusung, S. A., Barrett, M. A., Davis, S. E., Gatewood, S. J. L., Njoku, D. B., & Rose, N. R. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63241-5 · Cited by 198 · see citing works
Self-citation
Complement receptors CD21 and CD35 in humoral immunity
Roozendaal, R., & Carroll, M. C. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00556.x · Cited by 188 · see citing works
Decreased expression of the C3b/C4b receptor (CR1) and the C3d receptor (CR2) on B lymphocytes and of CR1 on neutrophils of patients with systemic lupus erythematosus
Wilson, J. G., Ratnoff, W. D., Schur, P. H., & Fearon, D. T. (1986) · Arthritis & Rheumatism · doi:10.1002/art.1780290606 · Cited by 181 · see citing works
Immunosuppression during acute Trypanosoma cruzi infection: involvement of Ly6G (Gr1+)CD11b+ immature myeloid suppressor cells
Goni, O., Alcaide, P., & Fresno, M. (2002) · International Immunology · doi:10.1093/intimm/dxf076 · Cited by 179 · see citing works
Granulocyte colony-stimulating factor and neutrophils—forgotten mediators of inflammatory disease
Eyles, J. L., Roberts, A. W., Metcalf, D., & Wicks, I. P. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0291 · Cited by 179 · see citing works
Experimental Autoimmune Myocarditis in A/J mice Is an Interleukin-4-Dependent Disease with a Th2 Phenotype
Afanasyeva, M., Wang, Y., Kaya, Z., Park, S., Zilliox, M. J., Schofield, B. H., Hill, S. L., & Rose, N. R. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61685-9 · Cited by 175 · see citing works
Contribution of the innate immune system to autoimmune myocarditis: a role for complement
Kaya, Z., Afanasyeva, M., Wang, Y., Dohmen, K. M., Schlichting, J., Tretter, T., Fairweather, D., Holers, V. M., & Rose, N. R. (2001) · Nature Immunology · doi:10.1038/90686 · Cited by 175 · see citing works
Self-citation
CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation
Ehirchiou, D., Xiong, Y., Xu, G., Chen, W., Shi, Y., & Zhang, L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062292 · Cited by 175 · see citing works
The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues
Allavena, P., Sica, A., Vecchi, A., Locati, M., Sozzani, S., & Mantovani, A. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.17714.x · Cited by 172 · see citing works
The Schistosome Oligosaccharide Lacto- <i>N</i> -neotetraose Expands Gr1+ Cells That Secrete Anti-inflammatory Cytokines and Inhibit Proliferation of Naive CD4+ Cells: A Potential Mechanism for Immune Polarization in Helminth Infections
Terrazas, L. I., Walsh, K. L., Piskorska, D., McGuire, E., & Harn, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.5294 · Cited by 169 · see citing works
The murine complement receptor gene family. IV. Alternative splicing of Cr2 gene transcripts predicts two distinct gene products that share homologous domains with both human CR2 and CR1.
Kurtz, C. B., O’Toole, E., Christensen, S. M., & Weis, J. H. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3581 · Cited by 168 · see citing works
Reciprocal Antagonism Between Estrogen Receptor and NF-κB Activity In Vivo
Evans, M. J., Eckert, A., Lai, K., Adelman, S. J., & Harnish, D. C. (2001) · Circulation Research · doi:10.1161/hh2101.098543 · Cited by 164 · see citing works
A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis
Mordue, D. G., & Sibley, L. D. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403164 · Cited by 163 · see citing works
Cell damage and autoimmunity: A critical appraisal
Mackay, I. R., Leskovsek, N. V., & Rose, N. R. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.11.009 · Cited by 162 · see citing works
17β-Estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells
Bengtsson, A. K., Ryan, E. J., Giordano, D., Magaletti, D. M., & Clark, E. A. (2004) · Blood · doi:10.1182/blood-2003-10-3380 · Cited by 161 · see citing works
Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice
Takahashi, K., Kozono, Y., Waldschmidt, T. J., Berthiaume, D., Quigg, R. J., Baron, A., & Holers, V. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.3.1557 · Cited by 160 · see citing works
Autoimmune thyroiditis and ROS
Burek, C. L., & Rose, N. R. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2008.04.006 · Cited by 156 · see citing works
Viruses as adjuvants for autoimmunity: evidence from Coxsackievirus‐induced myocarditis
Fairweather, D., Frisancho‐Kiss, S., & Rose, N. R. (2005) · Reviews in Medical Virology · doi:10.1002/rmv.445 · Cited by 155 · see citing works
Self-citation
TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis
Drage, M. G., Pecora, N., Hise, A. G., Febbraio, M., Silverstein, R. L., Golenbock, D. T., Boom, W. H., & Harding, C. V. (2009) · Cellular Immunology · doi:10.1016/j.cellimm.2009.03.008 · Cited by 153 · see citing works
Critical Role for Monocyte Chemoattractant Protein-1 and Macrophage Inflammatory Protein-1α in Induction of Experimental Autoimmune Myocarditis and Effective Anti–Monocyte Chemoattractant Protein-1 Gene Therapy
Göser, S., Öttl, R., Brodner, A., Dengler, T. J., Torzewski, J., Egashira, K., Rose, N. R., Katus, H. A., & Kaya, Z. (2005) · Circulation · doi:10.1161/circulationaha.105.572396 · Cited by 152 · see citing works
Interleukin-13 Protects Against Experimental Autoimmune Myocarditis by Regulating Macrophage Differentiation
Čiháková, D., Barin, J. G., Afanasyeva, M., Kimura, M., Fairweather, D., Berg, M. G., Talor, M. V., Baldeviano, G. C., Frisancho‐Kiss, S., Gabrielson, K. L., et al. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070207 · Cited by 147 · see citing works
Self-citation
A Schistosome-Expressed Immunomodulatory Glycoconjugate Expands Peritoneal Gr1+ Macrophages That Suppress Naive CD4+ T Cell Proliferation Via an IFN-γ and Nitric Oxide-Dependent Mechanism
Atochina, O., Daly‐Engel, T. S., Piskorska, D., McGuire, E., & Harn, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4293 · Cited by 144 · see citing works
Gonadectomy of male BALB/c mice increases Tim-3+ alternatively activated M2 macrophages, Tim-3+ T cells, Th2 cells and Treg in the heart during acute coxsackievirus-induced myocarditis
Frisancho-Kiss, S., Coronado, M. J., Frisancho, J. A., Lau, V. M., Rose, N. R., Klein, S. L., & Fairweather, D. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.12.002 · Cited by 143 · see citing works
Self-citation
Estrogen and brain inflammation: Effects on microglial expression of MHC, costimulatory molecules and cytokines
Dimayuga, F. O., Reed, J. L., Carnero, G. A., Wang, C., Dimayuga, E. R., Smith, V. D., Perger, A., Wilson, M. E., Keller, J. N., & Bruce‐Keller, A. J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.12.016 · Cited by 142 · see citing works
CD11b+ Monocytes Abrogate Th17 CD4+ T Cell-Mediated Experimental Autoimmune Myocarditis
Valaperti, A., Marty, R. R., Kania, G., Germano, D., Mauermann, N., Dirnhofer, S., Leimenstoll, B. M., Błyszczuk, P., Dong, C., Mueller, C. E., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2686 · Cited by 137 · see citing works
CD80+Gr-1+ Myeloid Cells Inhibit Development of Antifungal Th1 Immunity in Mice with Candidiasis
Mencacci, A., Montagnoli, C., Bacci, A., Cenci, E., Pitzurra, L., Spreca, A., Köpf, M., Sharpe, A. H., & Romani, L. R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3180 · Cited by 136 · see citing works
Role of Immature Myeloid Gr-1+ Cells in the Development of Antitumor Immunity
Li, Q., Pan, P., Gu, P., Xu, D., & Chen, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1715 · Cited by 135 · see citing works
The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity
Shoenfeld, Y., Selmi, C. F., Zimlichman, E., & Gershwin, M. E. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.08.004 · Cited by 135 · see citing works
About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-α gene (ESR1) in breast cancer
Lacroix, M., & Leclercq, G. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.02.021 · Cited by 134 · see citing works
Cutting Edge: T Cell Ig Mucin-3 Reduces Inflammatory Heart Disease by Increasing CTLA-4 during Innate Immunity
Frisancho‐Kiss, S., Nyland, J. F., Davis, S. E., Barrett, M. A., Gatewood, S. J. L., Njoku, D. B., Čiháková, D., Silbergeld, E. K., Rose, N. R., & Fairweather, D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6411 · Cited by 132 · see citing works
Self-citation
A Novel Type I IFN-Producing Cell Subset in Murine Lupus
Lee, P. Y., Weinstein, J. S., Nacionales, D. C., Scumpia, P. O., Li, Y., Butfiloski, E. J., van Rooijen, N., Moldawer, L. L., Satoh, M., & Reeves, W. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.5101 · Cited by 128 · see citing works
Stage-Specific Sampling by Pattern Recognition Receptors during Candida albicans Phagocytosis
Heinsbroek, S. E. M., Taylor, P. R., Martínez, F. O., Martínez‐Pomares, L., Brown, G. D., & Gordon, S. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000218 · Cited by 124 · see citing works
Complement Component 3 Is Required for Optimal Expansion of CD8 T Cells During a Systemic Viral Infection
Suresh, M., Molina, H. D., Salvato, M. S., Mastellos, D. C., Lambris, J. D., & Sándor, M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.2.788 · Cited by 117 · see citing works
Animal Models of Multiple Sclerosis
Furlan, R., Cuomo, C., & Martino, G. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-931-4_11 · Cited by 116 · see citing works
Mast Cells and Innate Cytokines are Associated with Susceptibility to Autoimmune Heart Disease Following Coxsackievirus B3 Infection
Fairweather, D., Frisancho-Kiss, S., Gatewood, S., Njoku, D., Steele, R., Barrett, M., & Rose, N. R. (2004) · Autoimmunity · doi:10.1080/0891693042000196200 · Cited by 115 · see citing works
Self-citation
Toll like receptors and autoimmunity: A critical appraisal
Papadimitraki, E. D., Bertsias, G. K., & Boumpas, D. T. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.09.001 · Cited by 113 · see citing works
TIM Family of Genes in Immunity and Tolerance
Kuchroo, V. K., Meyers, J. H., Umetsu, D. T., & DeKruyff, R. H. (2006) · Advances in immunology · doi:10.1016/s0065-2776(06)91006-2 · Cited by 111 · see citing works
oxLDL uptake by dendritic cells induces upregulation of scavenger-receptors, maturation and differentiation
Nickel, T., Schmauß, D., Hanssen, H., Sicic, Z., Krebs, B., Jankl, S., Summo, C., Fraunberger, P., Walli, A. K., Pfeiler, S., et al. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.01.002 · Cited by 111 · see citing works
The role of the innate immune response in autoimmune disease
Lang, K. S., Burow, A., Kurrer, M. O., Lang, P. A., & Recher, M. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.07.018 · Cited by 106 · see citing works
Environmental epidemiology and risk factors for autoimmune disease
Dooley, M. A., & Hogan, S. L. (2003) · Current Opinion in Rheumatology · doi:10.1097/00002281-200303000-00002 · Cited by 102 · see citing works
Recent Advances and Opportunities in Research on Lupus: Environmental Influences and Mechanisms of Disease
Cooper, G. S., Gilbert, K. M., Greidinger, E. L., James, J. A., Pfau, J. C., Reinlib, L., Richardson, B. C., & Rose, N. R. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11092 · Cited by 99 · see citing works
Macrophages Are Mediators of Gastritis in Acute Helicobacter pylori Infection in C57BL/6 Mice
Kaparakis‐Liaskos, M., Walduck, A. K., Price, J. D., Pedersen, J. S., van Rooijen, N., Pearse, M. J., Wijburg, O. L. C., & Strugnell, R. A. (2008) · Infection and Immunity · doi:10.1128/iai.01481-07 · Cited by 95 · see citing works
Genetic complexity of autoimmune myocarditis
Li, H. S., Ligons, D. L., & Rose, N. R. (2007) · Autoimmunity Reviews · doi:10.1016/j.autrev.2007.11.010 · Cited by 94 · see citing works
Immunotoxicology and Immunopharmacology
(2006) · CRC Press eBooks · doi:10.1201/9781420005448 · Cited by 94 · see citing works
Transcriptional and inflammasome‐mediated pathways for the induction of IL‐1β production by Mycobacterium tuberculosis
Kleinnijenhuis, J., Joosten, L. A. B., van de Veerdonk, F. L., Savage, N. D. L., van Crevel, R., Kullberg, B. J., van der Ven, A. J. A. M., Ottenhoff, T. H. M., Dinarello, C. A., van der Meer, J. W. M., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200839115 · Cited by 91 · see citing works
Toll like receptors and viruses
Finberg, R. W., Wang, J. P., & Kurt‐Jones, E. A. (2007) · Reviews in Medical Virology · doi:10.1002/rmv.525 · Cited by 90 · see citing works
Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections
Sewell, D. L., Reinke, E. K., Hogan, L. H., Sándor, M., & Fábry, Z. (2002) · Immunology Letters · doi:10.1016/s0165-2478(02)00025-1 · Cited by 88 · see citing works
Th17 Cells in MS and Experimental Autoimmune Encephalomyelitis.
Hofstetter, H. H., Gold, R., & Hp, H. (2009) · PubMed · Cited by 87 · see citing works
Mycobacterium tuberculosis lipids regulate cytokines, TLR-2/4 and MHC class II expression in human macrophages
Lopez-Marin, L. M., Estrada‐García, I., Lopez-Marin, L. M., Segura, E., Mendez‐Aragón, P., van Soolingen, D., Torres-González, R., Chacón‐Salinas, R., Estrada-Parra, S. A., Maldonado‐Bernal, C., et al. (2008) · Tuberculosis · doi:10.1016/j.tube.2007.10.003 · Cited by 84 · see citing works
Complement Receptor 1 and 2 Deficiency Increases Coxsackievirus B3-Induced Myocarditis, Dilated Cardiomyopathy, and Heart Failure by Increasing Macrophages, IL-1β, and Immune Complex Deposition in the Heart
Fairweather, D., Frisancho-Kiss, S., Njoku, D. B., Nyland, J. F., Kaya, Z., Yusung, S. A., Davis, S. E., Frisancho, J. A., Barrett, M. A., & Rose, N. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3516 · Cited by 82 · see citing works
Self-citation
Regulatory T cells and Toll-like receptors: What is the missing link?
Dai, J., Liu, B., & Li, Z. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.01.027 · Cited by 71 · see citing works
Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection
Pecora, N., Fulton, S. A., Reba, S. M., Drage, M. G., Simmons, D. P., Urankar-Nagy, N., Boom, W. H., & Harding, C. V. (2008) · Cellular Immunology · doi:10.1016/j.cellimm.2008.07.002 · Cited by 60 · see citing works
Autoimmunity: From the mosaic to the kaleidoscope
Blank, M., & Gershwin, M. E. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.11.015 · Cited by 60 · see citing works
Inducible Nitric Oxide Synthase and Arginase Expression in Heart Tissue during AcuteTrypanosoma cruziInfection in Mice: Arginase I Is Expressed in Infiltrating CD68+Macrophages
Cuervo, H., Pineda, M. A., Aoki, M. P., Gea, S., Fresno, M., & Gironès, N. (2008) · The Journal of Infectious Diseases · doi:10.1086/529527 · Cited by 59 · see citing works
The secreted Helicobacter cysteine‐rich protein A causes adherence of human monocytes and differentiation into a macrophage‐like phenotype
Dumrese, C., Slomianka, L., Ziegler, U., Choi, S. S., Kalia, A., Fulurija, A., Lü, W., Berg, D. E., Benghezal, M., Marshall, B. J., et al. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.04.027 · Cited by 59 · see citing works
Toll-Like Receptors and Rheumatoid Arthritis
Brentano, F., Kyburz, D., & Gay, S. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-541-1_20 · Cited by 57 · see citing works
Human cytomegalovirus targets different subsets of antigen‐presenting cells with pathological consequences for host immunity: implications for immunosuppression, chronic inflammation and autoimmunity
Varani, S., Frascaroli, G., Landini, M. P., & Söderberg‐Nauclér, C. (2009) · Reviews in Medical Virology · doi:10.1002/rmv.609 · Cited by 55 · see citing works
IL-13-Mediated Gender Difference in Susceptibility to Autoimmune Encephalomyelitis
Sinha, S., Kaler, L. J., Proctor, T. M., Teuscher, C., Vandenbark, A. A., & Offner, H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2679 · Cited by 52 · see citing works
Treatment of Mice with the Neutrophil-Depleting Antibody RB6-8C5 Results in Early Development of Experimental Lyme Arthritis via the Recruitment of Gr-1 − Polymorphonuclear Leukocyte-Like Cells
Brown, C. R., Blaho, V. A., & Loiacono, C. M. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.4956-4965.2004 · Cited by 50 · see citing works
Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease
Cooper, G. S., Gilbert, K. M., Greidinger, E. L., James, J. A., Pfau, J. C., Reinlib, L., Richardson, B., & Rose, N. (2009) · Ciência & Saúde Coletiva · doi:10.1590/s1413-81232009000500028 · Cited by 49 · see citing works
Bone marrow transplantation, refractory autoimmunity and the contributions of Susumu Ikehara
Gershwin, M. E. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.12.006 · Cited by 46 · see citing works
The role of Toll-like receptor-4 in pertussis vaccine-induced immunity
Banus, S., Stenger, R. M., Gremmer, E. R., Dormans, J. A. M. A., Mooi, F. R., Kimman, T. G., & Vandebriel, R. J. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-21 · Cited by 45 · see citing works
Increased susceptibility of male BALB/c mice to coxsackievirus B3-induced myocarditis: role for CD1d
Huber, S. A. (2004) · Medical Microbiology and Immunology · doi:10.1007/s00430-004-0221-6 · Cited by 44 · see citing works
Novel Model of Constrictive Pericarditis Associated With Autoimmune Heart Disease in Interferon-γ–Knockout Mice
Afanasyeva, M., Georgakopoulos, D., Fairweather, D., Caturegli, P., Kass, D. A., & Rose, N. R. (2004) · Circulation · doi:10.1161/01.cir.0000147538.92263.3a · Cited by 42 · see citing works
Self-citation
Sex-related differences in the pattern of coxsackievirus B-3-induced immune spleen cell cytotoxicity against virus-infected myofibers
Huber, S. A., Job, L. P., & Woodruff, J. F. (1981) · Infection and Immunity · doi:10.1128/iai.32.1.68-73.1981 · Cited by 35 · see citing works
Genetic control of myeloproliferation in BXH-2 mice
Turcotte, K. (2003) · Blood · doi:10.1182/blood-2003-06-1852 · Cited by 33 · see citing works
A tribute to an outstanding immunologist – Ian Reay Mackay
Whittingham, S., Rowley, M. J., & Gershwin, M. E. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.04.004 · Cited by 33 · see citing works
Neutrophil and monocyte receptor expression in uncomplicated and complicated influenza A infection with pneumonia
Pauksens, K., Fjaertoft, G., Håkansson, L., & Venge, P. (2008) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540701646287 · Cited by 21 · see citing works
Th17 Cells Bounce off the Fungal Wall
Levitz, S. M. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.04.004 · Cited by 21 · see citing works
Animal Models of Multiple Sclerosis
Sato, F., Omura, S., Martinez, N. E., & Tsunoda, I. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-384913-7.00004-6 · Cited by 20 · see citing works
IP-10 protects while MIP-2 promotes experimental anesthetic hapten - induced hepatitis
Njoku, D. B., Li, Z., Mellerson, J. L., Sharma, R. B., Talor, M. V., Barat, N. C., & Rose, N. R. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.11.003 · Cited by 18 · see citing works
Antigen‐Specific Immunoregulation and Autoimmune Thyroiditisa
Rose, N. R., & Talor, E. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb33461.x · Cited by 11 · see citing works
Oral tolerance: Passing CD11b on the way to tolerance
Veldhoen, M. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100106 · Cited by 6 · see citing works
Complement regulatory proteins in other species
(1999) · Elsevier eBooks · doi:10.1016/b978-012506965-6/50010-6 · Cited by 2 · see citing works

Flagged first, then by citations

1 of the 124 references couldn’t be matched to a known paper.

Sorted by citations

Macrophages in Tumor Microenvironments and the Progression of Tumors
Hao, N.-B., Lü, M.-H., Fan, Y.-H., Cao, Y.-L., Zhang, Z.-R., & Yang, S.-M. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/948098 · Cited by 1,003 · see citing works
The role of immune dysfunction in the pathophysiology of autism
Onore, C., Careaga, M., & Ashwood, P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.08.007 · Cited by 635 · see citing works
Human Gingiva-Derived Mesenchymal Stem Cells Elicit Polarization of M2 Macrophages and Enhance Cutaneous Wound Healing
Zhang, Q.-Z., Su, W., Shi, S., Wilder-Smith, P. B. B., Xiang, A. P., Wong, A. K., Nguyen, A. L., Kwon, C. W., & Le, A. D. (2010) · Stem Cells · doi:10.1002/stem.503 · Cited by 620 · see citing works
ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages
Zhang, Y., Choksi, S., Chen, K., Pobezinskaya, E. L., Linnoila, I. R., & Liu, Z.-G. (2013) · Cell Research · doi:10.1038/cr.2013.75 · Cited by 575 · see citing works
Crosstalk between fibroblasts and inflammatory cells
Linthout, S. V., Miteva, K., & Tschöpe, C. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu062 · Cited by 572 · see citing works
Type 2 immunity in the skin and lungs
Akdiş, C. A., Arkwright, P. D., Brüggen, M., Busse, W. W., Gadina, M., Guttman‐Yassky, E., Kabashima, K., Mitamura, Y., Vian, L., Wu, J., et al. (2020) · Allergy · doi:10.1111/all.14318 · Cited by 559 · see citing works
Factor XIII: A Coagulation Factor With Multiple Plasmatic and Cellular Functions
Muszbek, L., Bereczky, Z., Bagoly, Z., Komáromi, I., & Katona, Ë. (2011) · Physiological Reviews · doi:10.1152/physrev.00016.2010 · Cited by 493 · see citing works
Comparison of polarization properties of human adult microglia and blood‐derived macrophages
Durafourt, B. A., Moore, C. S., Zammit, D., Johnson, T., Zaguia, F., Guiot, M., Bar‐Or, A., & Antel, J. P. (2012) · Glia · doi:10.1002/glia.22298 · Cited by 470 · see citing works
Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds
Garg, K., Pullen, N. A., Oskeritzian, C. A., Ryan, J. J., & Bowlin, G. L. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.065 · Cited by 457 · see citing works
Roles of microglia in brain development, tissue maintenance and repair
Michell‐Robinson, M. A., Touil, H., Healy, L. M., Owen, D. R., Durafourt, B. A., Bar‐Or, A., Antel, J. P., & Moore, C. S. (2015) · Brain · doi:10.1093/brain/awv066 · Cited by 421 · see citing works
MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing
He, X.-N., Dong, Z., Cao, Y.-N., Wang, H., Liu, S.-Y., Liao, L., Jin, Y., Yuan, L., & Li, B. (2019) · Stem Cells International · doi:10.1155/2019/7132708 · Cited by 372 · see citing works
Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy
Lee, D. E., Ayoub, N., & Agrawal, D. K. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0303-6 · Cited by 393 · see citing works
Type 2 immunity in allergic diseases
Öğülür, İ., Mitamura, Y., Yazıcı, D., Pat, Y., Ardıçlı, S., Li, M., D’Avino, P., Beha, C., Babayev, H., Zhao, B., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01261-2 · Cited by 413 · see citing works
MicroRNAs modulate the noncanonical transcription factor NF-κB pathway by regulating expression of the kinase IKKα during macrophage differentiation
Li, T., Morgan, M. J., Choksi, S., Zhang, Y., Kim, Y., & Liu, Z.-G. (2010) · Nature Immunology · doi:10.1038/ni.1918 · Cited by 339 · see citing works
MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS
Ponomarev, E. D., Veremeyko, T., & Weiner, H. L. (2012) · Glia · doi:10.1002/glia.22363 · Cited by 311 · see citing works
Induction of autophagy is essential for monocyte-macrophage differentiation
Zhang, Y., Morgan, M. J., Chen, K., Choksi, S., & Liu, Z.-G. (2012) · Blood · doi:10.1182/blood-2011-08-372383 · Cited by 291 · see citing works
Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer
Sato-Kaneko, F., Yao, S., Ahmadi, A., Zhang, S. S., Hosoya, T., Kaneda, M. M., Varner, J. A., Pu, M., Messer, K. S., Guiducci, C., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93397 · Cited by 283 · see citing works
Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections
Guilliams, M., Lambrecht, B. N., & Hammad, H. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.14 · Cited by 261 · see citing works
The Role of Macrophages and Dendritic Cells in the Initiation of Inflammation in IBD
Steinbach, E. C., & Plevy, S. E. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182a69dca · Cited by 250 · see citing works
Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13
Gao, S., Zhou, J., Liu, N., Wang, L., Gao, Q., Wu, Y. R., Zhao, Q., Liu, P. N., Wang, S., Liu, Y., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.025 · Cited by 240 · see citing works
Cardiac myosin-Th17 responses promote heart failure in human myocarditis
Myers, J. M., Cooper, L. T., Kem, D. C., Stavrakis, S., Kosanke, S. D., Shevach, E. M., Fairweather, D., Stoner, J. A., Cox, C. J., & Cunningham, M. W. (2016) · JCI Insight · doi:10.1172/jci.insight.85851 · Cited by 230 · see citing works
Self-citation
Salmonella Require the Fatty Acid Regulator PPARδ for the Establishment of a Metabolic Environment Essential for Long-Term Persistence
Eisele, N. A., Ruby, T., Jacobson, A. R., Manzanillo, P. S., Cox, J. S., Lam, L. H., Mukundan, L., Chawla, A., & Monack, D. M. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.010 · Cited by 226 · see citing works
Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice
Alexander, M. R., Moehle, C. W., Johnson, J. L., Yang, Z., Lee, J. K., Jackson, C. L., & Owens, G. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43713 · Cited by 218 · see citing works
Immune system: a double-edged sword in cancer
Lakshmi Narendra, B., Eshvendar Reddy, K., Shantikumar, S., & Ramakrishna, S. (2013) · Inflammation Research · doi:10.1007/s00011-013-0645-9 · Cited by 206 · see citing works
Inflammatory response of macrophages in infection
Zhang, L., & Wang, C.-C. (2014) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(14)60024-2 · Cited by 188 · see citing works
The Conserved Scavenger Receptor Cysteine-Rich Superfamily in Therapy and Diagnosis
Martínez, V. G., Moestrup, S. K., Holmskov, U., Mollenhauer, J., & Lozano, F. (2011) · Pharmacological Reviews · doi:10.1124/pr.111.004523 · Cited by 187 · see citing works
NADPH Oxidases Are Essential for Macrophage Differentiation
Xu, Q., Choksi, S., Qu, J., Jang, J., Choe, M., Bánfi, B., Engelhardt, J. F., & Liu, Z.-G. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.731216 · Cited by 184 · see citing works
MicroRNAs as Molecular Switches in Macrophage Activation
Curtale, G., Rubino, M., & Locati, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00799 · Cited by 182 · see citing works
Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis
Krysko, O., Holtappels, G., Zhang, N., Kubica, M., Deswarte, K., Derycke, L., Claeys, S., Hammad, H., Brusselle, G., Vandenabeele, P., et al. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02498.x · Cited by 181 · see citing works
Adenosine Deaminase in the Modulation of Immune System and its Potential as a Novel Target for Treatment of Inflammatory Disorders
Antonioli, L., Colucci, R., Motta, C. L., Tuccori, M., Awwad, O., Settimo, F. D., Blandizzi, C., & Fornai, M. (2012) · Current Drug Targets · doi:10.2174/138945012800564095 · Cited by 179 · see citing works
Sex Differences in Inflammation during Atherosclerosis
Fairweather, D. (2014) · Clinical Medicine Insights Cardiology · doi:10.4137/cmc.s17068 · Cited by 172 · see citing works
Self-citation
Modulation of macrophage activation and programming in immunity
Liu, G., & Yang, H. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24157 · Cited by 166 · see citing works
Periodontal disease immunology: ‘double indemnity’ in protecting the host
Ebersole, J. L., Dawson, D. R., Morford, L. A., Peyyala, R., Miller, C. S., & González, O. A. (2013) · Periodontology 2000 · doi:10.1111/prd.12005 · Cited by 167 · see citing works
Chronic Inflammation and Progressive Calcification as a Result of Fat Necrosis
Mineda, K., Kuno, S., D, H. K. M., Kinoshita, K., Doi, K., Hashimoto, I., Nakanishi, H., & Yoshimura, K. (2014) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000000097 · Cited by 161 · see citing works
The Development of Nasal Polyp Disease Involves Early Nasal Mucosal Inflammation and Remodelling
Meng, J., Zhou, P., Liu, Y., Liu, F., Yi, X., Liu, S., Holtappels, G., Bachert, C., & Zhang, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082373 · Cited by 153 · see citing works
The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPAR<i>γ</i>
Wang, X., Ji, Y., Feng, P., Liu, R., Li, G., Zheng, J., Xue, Y., Wei, Y., Ji, C., Chen, D., et al. (2021) · Advanced Science · doi:10.1002/advs.202100209 · Cited by 147 · see citing works
Iron levels in polarized macrophages: regulation of immunity and autoimmunity
Recalcati, S., Locati, M., Gammella, E., Invernizzi, P., & Cairo, G. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.03.003 · Cited by 150 · see citing works
The role of gender and organ specific autoimmunity
Nussinovitch, U., & Shoenfeld, Y. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.11.001 · Cited by 145 · see citing works
Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study
Durrenberger, P. F., Fernando, F. S., Kashefi, S. N., Bonnert, T. P., Seilhean, D., Nait‐Oumesmar, B., Schmitt, A., Gebicke‐Haerter, P. J., Falkai, P., Grünblatt, E., et al. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1293-0 · Cited by 139 · see citing works
Pathogenesis and diagnosis of myocarditis
ElAmm, C. A., Fairweather, D., & Cooper, L. T. (2012) · Heart · doi:10.1136/heartjnl-2012-301686 · Cited by 140 · see citing works
Self-citation
An overview of the immune mechanisms of viral myocarditis
Lasrado, N., & Reddy, J. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2131 · Cited by 140 · see citing works
Sex and Life Expectancy
Seifarth, J., McGowan, C. L. M., & Milne, K. J. (2012) · Gender Medicine · doi:10.1016/j.genm.2012.10.001 · Cited by 139 · see citing works
Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polyps
Takabayashi, T., Kato, A., Peters, A. T., Hulse, K. E., Suh, L. A., Carter, R., Norton, J., Grammer, L. C., Tan, B. K., Chandra, R. K., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.003 · Cited by 138 · see citing works
Mouse bone marrow-derived mesenchymal stem cells induce macrophage M2 polarization through the nuclear factor-κB and signal transducer and activator of transcription 3 pathways
Gao, S., Mao, F., Zhang, B., Zhang, L., Zhang, X., Wang, M., Yan, Y., Yang, T., Zhang, J., Zhu, W., et al. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370213518169 · Cited by 133 · see citing works
Attributes of alternatively activated (M2) macrophages
Shrivastava, R., & Shukla, N. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.03.062 · Cited by 130 · see citing works
Blood leukocytes and macrophages of various phenotypes have distinct abilities to form podosomes and to migrate in 3D environments
Cougoule, C., Goethem, E. V., Cabec, V. L., Lafouresse, F., Dupré, L., Mehraj, V., Mège, J., Lastrucci, C., & Maridonneau‐Parini, I. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2012.07.002 · Cited by 127 · see citing works
M1/M2-macrophage phenotypes regulate renal calcium oxalate crystal development
Taguchi, K., Okada, A., Hamamoto, S., Unno, R., Moritoki, Y., Ando, R., Mizuno, K., Tozawa, K., Kohri, K., & Yasui, T. (2016) · Scientific Reports · doi:10.1038/srep35167 · Cited by 127 · see citing works
mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis
Hallowell, R. W., Collins, S. L., Craig, J. M., Zhang, Y., Oh, M. H., Illei, P. B., Chan-Li, Y., Vigeland, C. L., Mitzner, W., Scott, A. L., et al. (2017) · Nature Communications · doi:10.1038/ncomms14208 · Cited by 126 · see citing works
Diabetes-impaired wound healing and altered macrophage activation: a possible pathophysiologic correlation
Miao, M., Niu, Y., Xie, T., Yuan, B., Qing, C., & Lu, S. (2012) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2012.00772.x · Cited by 125 · see citing works
Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response
Subbian, S., Tsenova, L., Yang, G., O’Brien, P. E., Parsons, S. D. C., Peixoto, B., Taylor, L., Fallows, D. A., & Kaplan, G. (2011) · Open Biology · doi:10.1098/rsob.110016 · Cited by 118 · see citing works
Selenium Levels Affect the IL-4–Induced Expression of Alternative Activation Markers in Murine Macrophages
Nelson, S. M., Lei, X. G., & Prabhu, K. S. (2011) · Journal of Nutrition · doi:10.3945/jn.111.141176 · Cited by 116 · see citing works
TIM-3 Regulates Innate Immune Cells To Induce Fetomaternal Tolerance
Chabtini, L., Mfarrej, B. G., Mounayar, M., Zhu, B., Batal, I., Dakle, P. J., Smith, B. D., Boenisch, O., Najafian, N., Akiba, H., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202176 · Cited by 112 · see citing works
Mesenchymal stem cells and extracellular matrix scaffold promote muscle regeneration by synergistically regulating macrophage polarization toward the M2 phenotype
Qiu, X., Liu, S., Zhang, H., Zhu, B., Su, Y., Zheng, C., Tian, R., Wang, M., Kuang, H., Zhao, X., et al. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0821-5 · Cited by 111 · see citing works
Cellular and Molecular Mechanisms of Autoimmune Disease
Bolon, B. N. (2011) · Toxicologic Pathology · doi:10.1177/0192623311428481 · Cited by 111 · see citing works
Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation
Adamson, S. E., Griffiths, R., Moravec, R., Subramanian, S., Montgomery, G., Chen, W., Han, J. E., Sharma, P. R., Mullins, G. R., Gorski, S. A., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci79590 · Cited by 105 · see citing works
Molecular definition of the pro‐tumorigenic phenotype of glioma‐activated microglia
Ellert‐Miklaszewska, A., Dąbrowski, M., Lipko, M. A., Sliwa, M., Maleszewska, M., & Kaminska, B. (2013) · Glia · doi:10.1002/glia.22510 · Cited by 104 · see citing works
Immunomodulatory Therapeutic Effects of Curcumin on M1/M2 Macrophage Polarization in Inflammatory Diseases
Azhdari, S., Moghaddam, A. S., Abdollahi, E., Johnston, T. P., Ghaneifar, Z., Vahedi, P., & Goleij, P. (2022) · Current Molecular Pharmacology · doi:10.2174/1874467215666220324114624 · Cited by 98 · see citing works
Clinical Impact of the Presence of Macrophages in Endomyocardial Biopsies of Patients with Dilated Cardiomyopathy
Nakayama, T., Sugano, Y., Yokokawa, T., Nagai, T., Matsuyama, T., Ohta‐Ogo, K., Ikeda, Y., Ishibashi‐Ueda, H., Nakatani, T., Ohte, N., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.767 · Cited by 96 · see citing works
Th2 Regulation of Viral Myocarditis in Mice: Different Roles for TLR3 versus TRIF in Progression to Chronic Disease
Abston, E. D., Coronado, M. J., Bucek, A., Bedja, D., Shin, J., Kim, J. B., Kim, E., Gabrielson, K. L., Georgakopoulos, D., Mitzner, W., et al. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/129486 · Cited by 94 · see citing works
Self-citation
Extracellular Hepatitis C Virus Core Protein Activates STAT3 in Human Monocytes/Macrophages/Dendritic Cells via an IL-6 Autocrine Pathway
Tacke, R., Tosello-Trampont, A., Nguyen, V., Mullins, D. W., & Hahn, Y. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.217653 · Cited by 94 · see citing works
Differential Macrophage Polarization Promotes Tissue Remodeling and Repair in a Model of Ischemic Retinopathy
Marchetti, V., Yanes, Ó., Aguilar, E., Wang, M., Friedlander, D. F., Moreno, S. K., Storm, K., Zhan, M., Naccache, S. N., Nemerow, G. R., et al. (2011) · Scientific Reports · doi:10.1038/srep00076 · Cited by 92 · see citing works
Regulation of inflammation during wound healing: the function of mesenchymal stem cells and strategies for therapeutic enhancement
Gao, M., Guo, H., Dong, X., Wang, Z., Yang, Z., Shang, Q., & Wang, Q. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1345779 · Cited by 102 · see citing works
Macrophage polarization in response to wear particles in vitro
Antonios, J. K., Yao, Z., Li, C., Rao, A. J., & Goodman, S. B. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2013.39 · Cited by 90 · see citing works
Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells
Maisonneuve, C., Tsang, D. K. L., Foerster, E. G., Robert, L. M., Mukherjee, T., Prescott, D., Tattoli, I., Lemire, P., Winer, D. A., Winer, S., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108677 · Cited by 89 · see citing works
Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization
Shan, K., Feng, N., Cui, J., Wang, S., Qu, H., Fu, G., Li, J., Chen, H., Wang, X., Wang, R., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15436 · Cited by 85 · see citing works
Myeloid-Derived Suppressor Cells Infiltrate the Heart in Acute Trypanosoma cruzi Infection
Cuervo, H., Guerrero, N. A., Carbajosa, S., Beschin, A., BAETSELIER, P. D., Gironès, N., & Fresno, M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002928 · Cited by 84 · see citing works
Lesional Accumulation of CD163+ Macrophages/microglia in Rat Traumatic Brain Injury
Zhang, Z., Zhang, Z.-Y., Wu, Y., & Schluesener, H. J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.038 · Cited by 83 · see citing works
Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders
Koushki, K., Shahbaz, S. K., Keshavarz, M., Bezsonov, E. E., Sathyapalan, T., & Sahebkar, A. (2021) · Biomolecules · doi:10.3390/biom11091289 · Cited by 82 · see citing works
Sex differences in pulmonary arterial hypertension: role of infection and autoimmunity in the pathogenesis of disease
Batton, K. A., Austin, C. O., Bruno, K. A., Burger, C. D., Shapiro, B. P., & Fairweather, D. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0176-8 · Cited by 81 · see citing works
Self-citation
Fibroblast autophagy in fibrotic disorders
Principe, D. D., Lista, P., Malorni, W., & Giammarioli, A. M. (2012) · The Journal of Pathology · doi:10.1002/path.4115 · Cited by 81 · see citing works
Mechanisms of protein aggregation in the retinal pigment epithelial cells
Kaarniranta, K. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e198 · Cited by 78 · see citing works
Autoimmune heart disease: role of sex hormones and autoantibodies in disease pathogenesis
Fairweather, D., Petri, M., Coronado, M. J., & Cooperr, L. T. (2012) · Expert Review of Clinical Immunology · doi:10.1586/eci.12.10 · Cited by 74 · see citing works
Self-citation
Tumor-Associated Macrophage-Mediated Targeted Therapy of Triple-Negative Breast Cancer
Niu, M., Valdes, S. A., Naguib, Y. W., Hursting, S. D., & Cui, Z. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00987 · Cited by 76 · see citing works
Sex differences in spontaneous versus induced animal models of autoimmunity
Lee, T., & Chiang, B. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.11.020 · Cited by 75 · see citing works
The worldwide gradient of autoimmune conditions
Selmi, C. F. (2010) · Autoimmunity Reviews · doi:10.1016/j.autrev.2010.02.004 · Cited by 75 · see citing works
Cutaneous Granulomas in Ataxia Telangiectasia and Other Primary Immunodeficiencies: Reflection of Inappropriate Immune Regulation?
Chiam, L., Verhagen, M., Haraldsson, Á., Wulffraat, N. M., Driessen, G. J., Netea, M., Weemaes, C., Seyger, M., & van Deuren, M. (2011) · Dermatology · doi:10.1159/000330335 · Cited by 69 · see citing works
The Therapeutic Potential of Epigenetics in Autoimmune Diseases
Santis, M. D., & Selmi, C. F. (2011) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-011-8293-8 · Cited by 75 · see citing works
Alternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages
Soldano, S., Pizzorni, C., Paolino, S., Trombetta, A., Montagna, P., Brizzolara, R., Ruaro, B., Sulli, A., & Cutolo, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166433 · Cited by 65 · see citing works
B cell depletion therapy exacerbates murine primary biliary cirrhosis
Dhirapong, A., Lleò, A., Yang, G., Tsuneyama, K., Dunn, R., Kehry, M. R., Packard, T. A., Cambier, J. C., Liu, F., Lindor, K. D., et al. (2010) · Hepatology · doi:10.1002/hep.24044 · Cited by 70 · see citing works
Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo
Aviello, G., Borrelli, F., Guida, F., Romano, B., Lewellyn, K., Chiaro, M. D., Luongo, L., Zjawiony, J. K., Maione, S., Izzo, A. A., et al. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0752-4 · Cited by 70 · see citing works
Pore size-mediated macrophage M1-to-M2 transition influences new vessel formation within the compartment of a scaffold
Yin, Y., He, X., Wang, J., Wu, R., Xu, X., Hong, Y., Tian, B., & Chen, F. (2019) · Applied Materials Today · doi:10.1016/j.apmt.2019.100466 · Cited by 70 · see citing works
Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game
Través, P. G., Luque, A., & Hortelano, S. (2012) · Mediators of Inflammation · doi:10.1155/2012/568783 · Cited by 68 · see citing works
Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis
Gaddis, D. E., Maynard, C. L., Weaver, C. T., Michalek, S. M., & Katz, J. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0512220 · Cited by 66 · see citing works
Temporal phenotypic features distinguish polarized macrophagesin vitro
Melton, D. W., McManus, L. M., Gelfond, J., & Shireman, P. K. (2015) · Autoimmunity · doi:10.3109/08916934.2015.1027816 · Cited by 65 · see citing works
Soluble macrophage-derived CD163 is a marker of disease activity and progression in early rheumatoid arthritis.
Greisen, S. R., Møller, H. J., Stengaard‐Pedersen, K., Hetland, M. L., Hørslev-Petersen, K., Jørgensen, A., Hvid, M., & Deleuran, B. W. (2011) · PubMed · Cited by 61 · see citing works
MicroRNAs in the Diagnosis and Treatment of Cancer
Mansoori, B., Mohammadi, A., Shirjang, S., & Baradaran, B. (2017) · Immunological Investigations · doi:10.1080/08820139.2017.1377407 · Cited by 57 · see citing works
Influences of age-related changes in mesenchymal stem cells on macrophages during in-vitro culture
Yin, Y., Wu, R., He, X., Xu, X., Wang, J., & Chen, F. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0608-0 · Cited by 61 · see citing works
Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ
Hucke, S., Floßdorf, J., Grützke, B., Dunay, I. R., Frenzel, K., Jungverdorben, J., Linnartz‐Gerlach, B., Mack, M., Peitz, M., Brüstle, O., et al. (2012) · Brain · doi:10.1093/brain/aws058 · Cited by 57 · see citing works
Lactoferrin-Containing Immunocomplexes Drive the Conversion of Human Macrophages from M2- into M1-like Phenotype
Gao, C., Dong, H., Li, T., & Gao, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00037 · Cited by 57 · see citing works
Macrophage-based therapeutic approaches for cardiovascular diseases
Sansonetti, M., Soodi, B. A., Thum, T., & Jung, M. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-023-01027-9 · Cited by 57 · see citing works
Noninvasive Imaging of Myocardial Inflammation in Myocarditis using 68Ga-tagged Mannosylated Human Serum Albumin Positron Emission Tomography
Lee, S., Im, H., Kang, S., Chung, S., Cho, Y. S., Kang, H., Park, H. S., Hwang, D.-W., Park, J., Paeng, J.-C., et al. (2017) · Theranostics · doi:10.7150/thno.15712 · Cited by 56 · see citing works
Macrophage diversity in cardiac inflammation: A review
Barin, J. G., Rose, N. R., & Čiháková, D. (2012) · Immunobiology · doi:10.1016/j.imbio.2011.06.009 · Cited by 56 · see citing works
Functional Macrophage Heterogeneity in a Mouse Model of Autoimmune Central Nervous System Pathology
London, A., Benhar, I., Mattapallil, M. J., Mack, M., Caspi, R. R., & Schwartz, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202076 · Cited by 55 · see citing works
Allergic Aspergillus Rhinosinusitis
Chakrabarti, A., & Kaur, H. (2016) · Journal of Fungi · doi:10.3390/jof2040032 · Cited by 55 · see citing works
Chronic Rhinosinusitis and the Coagulation System
Kim, D., Cho, S., Takabayashi, T., & Schleimer, R. P. (2015) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2015.7.5.421 · Cited by 55 · see citing works
Stochiometric quantification of the thiol redox proteome of macrophages reveals subcellular compartmentalization and susceptibility to oxidative perturbations
Duan, J., Zhang, T., Gaffrey, M. J., Weitz, K., Moore, R. J., Li, X., Xian, M., Thrall, B. D., & Qian, W. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101649 · Cited by 54 · see citing works
Periodontal ligament stem cells promote polarization of M2 macrophages
Liu, J., Wang, H., Zhang, L., Li, X., Ding, X., Ding, G., & Wei, F. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ma1220-853rr · Cited by 53 · see citing works
Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
The Role of Activated Microglia and Resident Macrophages in the Neurovascular Unit during Cerebral Ischemia: Is the Jury Still Out?
Barakat, R., & Redzic, Z. B. (2015) · Medical Principles and Practice · doi:10.1159/000435858 · Cited by 49 · see citing works
Mesenchymal stem cells promote macrophage polarization toward M2b-like cells
Kudlik, G., Hegyi, B., Czibula, Á., Monostori, É., Buday, L., & Uher, F. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.08.022 · Cited by 48 · see citing works

Immune Functions of the M2 Macrophages: Host Defense, Self-tolerance, and Autoimmunity
Rőszer, T. (2020) · Progress in inflammation research · doi:10.1007/978-3-030-50480-9_6 · Cited by 2 · see citing works
Macrophages : As central inflammatory mediators and as targets for therapeutic interventions
Andersson, Å. (2006) · Figshare
M2 macrophages and their role in rheumatic diseases
Bhattacharya, S., & Aggarwal, A. (2018) · Rheumatology International · doi:10.1007/s00296-018-4120-3 · Cited by 56 · see citing works
Alternative activation of macrophages: immune function and cellular biology
Varin, A., & Gordon, S. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.009 · Cited by 361 · see citing works
Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases
Benedetto, P. D., Ruscitti, P., Vadasz, Z., Toubi, E., & Giacomelli, R. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102369 · Cited by 139 · see citing works

Authors: Fairweather, D., & Cihakova, D.
Affiliations: Johns Hopkins University (US)
Corresponding author: Fairweather, DeLisa
ORCID: Fairweather, DeLisa
Venue: Journal of Autoimmunity
Publisher: Elsevier BV
Published: 2009-11
Volume: 33
Issue: 3-4
Pages: 222-230
ISSN: 0896-8411 (ISSN-L)
DOI: 10.1016/j.jaut.2009.09.012
PMC: PMC2783278
OpenAlex: W2083198686
Cited by: 290
References: 124
Citations by year: 2026: 4 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 4 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 16 · 2017: 20 · 2016: 26 · 2015: 18 · 2014: 26 · 2013: 32 · 2012: 36
FWCI: 12.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Autoimmunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Myocarditis Foundation
National Institutes of Health
National Heart, Lung, and Blood Institute (HL 67290, R01HL087033, R01HL067290, HL 70729, R01HL070729, HL087033)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: M2 macrophages, autoimmunity, infection, Th2 immune response, Th1 response, immune evasion, fibrosis, experimental autoimmune myocarditis, viral infection, estrogen, sex differences, CD206, scavenger receptor A
MeSH terms: Animals, Autoimmune Diseases, Complement System Proteins, Female, Humans, Immunity, Cellular, Infections, Macrophage Activation, Macrophages, Male, Sex Factors, Gonadal Steroid Hormones, Cytokines, Immunity, Humoral

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alternatively activated macrophages in infection and autoimmunity

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks