Cited by 141HIV Research and TreatmentHIV/AIDS drug development and treatmentT-cell and Retrovirus Studies

Cellular proteins detected in HIV‐1

Ott, David E.·2008·Reviews in Medical Virology

Abstract

It has been known for some time that HIV‐1 virions contain cellular proteins in addition to proteins encoded by the viral genome. Recent studies have vastly increased the number of host proteins detected in HIV‐1. This review summarises the current findings on several cellular proteins present in these virions, including some functional studies on their potential roles in the viral replication cycle and pathogenesis. Because retroviruses require extensive assistance from host proteins and pathways, the data from biochemical characterisations of HIV‐1 serve as an important starting point for understanding the role of cellular proteins that act in or influence the biology of HIV‐1. Additionally, a better understanding of the interactions between cellular proteins and viral components might provide more targets for anti‐HIV therapeutic intervention and provide for a better understanding of how HIV‐1 alters the immune system. The extensive study of HIV‐1 has already brought new insights to the fields of immunology and vaccine science. In the same way, knowledge of viral‐‐cellular protein interactions might assist our understanding of important cellular pathways. Copyright © 2008 John Wiley & Sons, Ltd.

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Crossref · 10.1002/rmv.570

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Authors
Ott, D. E.
Affiliations
National Cancer Institute (US)
Corresponding author
Ott, David E.
Venue
Reviews in Medical Virology
Publisher
Wiley
Published
2008-02-11
Volume
18
Issue
3
Pages
159-175
ISSN
  • 1052-9276 (ISSN-L)
  • 1099-1654
OpenAlex
W2017418049
Cited by
141
References
142
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 12 · 2017: 7 · 2016: 11 · 2015: 7 · 2014: 7 · 2013: 12 · 2012: 26
FWCI
1.15
Type
journal article
Language
en
Open access
closed
Locations
  • Reviews in Medical Virology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01co12400-79-0-22)
  • National Cancer Institute (N01CO12400)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords
HIV-1, host-virus interaction, retroviral replication, viral pathogenesis, immune system alterations
MeSH terms
Antigens, Surface, Humans, Membrane Proteins, Proteins, Virion, HIV-1, HIV Infections

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