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Meta‐analysis of clinical trials as a scientific discipline. I: Control of bias and comparison with large co‐operative trials

Chalmers, Thomas C., Levin, Howard, Sacks, Henry S., Reitman, Dinah, Berrier, Jayne, Nagalingam, Raguraman·1987·Statistics in Medicine
DOI 10.1002/sim.4780060320
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Abstract

Meta‐analysis is an important method of bridging the gap between undersized randomized control trials and the treatment of patients. However, as in any retrospective study, the opportunities for bias to distort the results are widespread. Attempts must be made to introduce the controls found in prospective studies by blinding the selection of papers and extraction of data and making blinded duplicate determinations. Informal and personalized methods of obtaining data are probably more liable to error and bias than employing only published data. Publication bias is a serious problem requiring further research. There also need to be more comparisons of meta‐analysed small studies with large co‐operative trials.

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Metadata

Authors
Chalmers, T. C., Levin, H., Sacks, H. S., Reitman, D., Berrier, J., & Nagalingam, R.
Venue
Statistics in Medicine
Publisher
Wiley
Published
1987-04
Volume
6
Issue
3
Pages
315-325
ISSN
  • 0277-6715 (ISSN-L)
  • 1097-0258
DOI
10.1002/sim.4780060320
OpenAlex
W2105494532
Cited by
246
References
5
FWCI
13.29
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7134 d)

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CoChat. (2026). Citation check: Meta‐analysis of clinical trials as a scientific discipline. I: Control of bias and comparison with large co‐operative trials. https://app.cochat.ai/papers/10.1002/sim.4780060320
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Chalmers, T. C., Levin, H., Sacks, H. S., Reitman, D., Berrier, J., & Nagalingam, R. (1987). Meta‐analysis of clinical trials as a scientific discipline. I: Control of bias and comparison with large co‐operative trials. Statistics in Medicine. https://doi.org/10.1002/sim.4780060320

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