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Cited by 549

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Graphical methods for assessing violations of the proportional hazards assumption in cox regression

Hess, Kenneth R.·1995·Statistics in Medicine

Abstract

A major assumption of the Cox proportional hazards model is that the effect of a given covariate does not change over time. If this assumption is violated, the simple Cox model is invalid, and more sophisticated analyses are required. This paper describes eight graphical methods for detecting violations of the proportional hazards assumption and demonstrates each on three published datasets with a single binary covariate. I discuss the relative merits of these methods. Smoothed plots of the scaled Schoenfeld residuals are recommended for assessing PH violations because they provide precise usable information about the time dependence of the covariate effects.

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Cites

Research works printed but not linked: 14

  1. Kay R., 1984, Goodness of fit methods for the proportional hazards regression model: A review, Revue d'Epidémiologie et Santé Publique, 32, 185
  2. Schumacher M., 1984, On a goodness‐of‐fit test for the proportional hazards model, EDV in Medizin und Biologie, 15, 19
  3. Harrell F. E., 1986, SUGI Supplemental Library User's Guide, Version 5
  4. 10.1002/bimj.4710340505 · doi:10.1002/bimj.4710340505
  5. 10.2307/2288262 · doi:10.2307/2288262
  6. Breslow N., 1972, Discussion on ‘Regression models and life tables’ by D. R. Cox, Journal of the Royal Statistical Society, Series B, 34, 216
  7. Breslow N., 1984, Methodologies for the Collection and Analysis of Mortality Data, 367
  8. Harrell F. E.andLee K. L.‘Verifying assumptions of the Cox proportional hazards model’ SUGI II: Proceedings of the Eleventh Annual SAS Users Group International Conference 823–828(1986).
  9. 10.3109/07357909009017550 · doi:10.3109/07357909009017550
  10. 10.3109/07357908309020278 · doi:10.3109/07357908309020278
  11. 10.2307/1403046 · doi:10.2307/1403046
  12. Kalbfleisch J. D., 1980, The Statistical Analysis of Failure Time Data, 214
  13. O'Quigley J., 1984, Testing the proportional hazards regression model against some general alternatives, Revue d' Épidémiologie et Santé Publique, 3, 199
  14. Kalbfleisch J. D., 1980, The Statistical Analysis of Failure Time Data, 134

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Metadata

Authors
Hess, K. R.
Venue
Statistics in Medicine
Publisher
Wiley
Published
1995-08-15
Volume
14
Issue
15
Pages
1707-1723
ISSN
  • 0277-6715 (ISSN-L)
  • 1097-0258
OpenAlex
W2053452241
Cited by
549
References
45
FWCI
5.21
Type
journal article
Language
en
Open access
closed

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