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Cited by 20Fibromyalgia and Chronic Fatigue Syndrome ResearchPsychosomatic Disorders and Their TreatmentsRheumatoid Arthritis Research and Therapies

Differences in depression, anxiety and stress disorders between fibromyalgia associated with rheumatoid arthritis and primary fibromyalgia

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Alciati, Alessandra, Cirillo, Mariateresa, Masala, Ignazio Francesco, Sarzi‐Puttini, Piercarlo, Atzeni, Fabiola·2021·Stress and Health
DOI 10.1002/smi.2992
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Abstract

Fibromyalgia (FM) was frequently observed in patients with rheumatoid arthritis (RA). We aimed to evaluate the differences in psychiatric comorbidities and life adversities between patients with Rheumatoid arthritis + FM (secondary fibromyalgia [SFM]) and people with primary FM (PFM). In a cross-sectional, observational study, patients with PFM and SFM underwent a structured interview for the lifetime diagnosis of major depression (MDD), panic disorder (PD) and post-traumatic stress disorder (PTSD) and were assessed for childhood/adulthood adversities and FM-related symptoms severity. Thirty patients with PFM and 40 with SFM were recruited. The univariate analysis showed that the lifetime rates of MDD were significantly higher in PFM versus SFM (76.7 % and 40%, respectively, p < 0.003), as well as the rates of PD (50 % and 15%, respectively, p < 0.003), whereas there was no difference in PTSD rates. The rates of sexual abuse and physical neglect were significantly higher in PFM patients versus SFM patients (p < 0.005 and p < 0.023). Life events occurring before FM onset were different in PFM and SFM groups. In the logistic regression model, lifetime PD and physical neglect remain independent risk factors for PFM. PFM and SFM differ in psychiatric comorbidities and environmental adversities, suggesting that common pathogenesis may develop through different pathways.

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  • Physical and psychological stressful events, including early life traumatic experience, are fibromyalgia predisposing factors.

    “there is strong evidence that physical and psychological stressful events, including early life traumatic experience, are FM predisposing factors [16,17].”

    From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [16]

  • The model is in tune with a bulk of data suggesting a role of HPA and HPG axes in FM pathogenesis.

    “Third, it is in tune with a bulk of data suggesting a role of HPA and HPG axes in FM pathogenesis [10–17]”

    From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [16]

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Authors
Alciati, A., Cirillo, M., Masala, I. F., Sarzi‐Puttini, P., & Atzeni, F.
Affiliations
  • IRCCS Humanitas Research Hospital (IT)
  • University of Messina (IT)
  • Santissima Trinità (IT)
  • ASST Fatebenefratelli Sacco (IT)
Corresponding author
Alciati, Alessandra
ORCID
Venue
Stress and Health
Publisher
Wiley
Published
2020-10-06
Volume
37
Issue
2
Pages
255-262
ISSN
  • 1532-2998 (ISSN-L)
  • 1532-3005
DOI
10.1002/smi.2992
OpenAlex
W3090978974
Cited by
20
References
44
Citations by year
2026: 1 · 2025: 8 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 2
FWCI
0.91
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Stress and Health (publishedVersion)
  • PubMed (publishedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords
fibromyalgia, rheumatoid arthritis, secondary fibromyalgia, primary fibromyalgia, major depressive disorder, panic disorder, post-traumatic stress disorder, childhood adversity, physical neglect, sexual abuse, life events, psychiatric comorbidity, risk factors
MeSH terms
Adult, Anxiety, Arthritis, Rheumatoid, Child, Cross-Sectional Studies, Depression, Fibromyalgia, Humans, Stress Disorders, Post-Traumatic

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