The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Enhancement of Radiation Cytotoxicity in Breast‐Cancer Cells by Localized Attachment of Gold Nanoparticles
Abstract
Gold nanoparticles (GNPs) and modified GNPs having two kinds of functional molecules, cysteamine (AET) and thioglucose (Glu), are synthesized. Cell uptake and radiation cytotoxicity enhancement in a breast‐cancer cell line (MCF‐7) versus a nonmalignant breast‐cell line (MCF‐10A) are studied. Transmission electron microscopy (TEM) results show that cancer cells take up functional Glu‐GNPs significantly more than naked GNPs. The TEM results also indicate that AET‐capped GNPs are mostly bound to the MCF‐7 cell membrane, while Glu‐GNPs enter the cells and are distributed in the cytoplasm. After MCF‐7 cell uptake of Glu‐GNPs, or binding of AET‐GNPs, the in vitro cytotoxicity effects are observed at 24, 48, and 72 hours. The results show that these functional GNPs have little or no toxicity to these cells. To validate the enhanced killing effect on cancer cells, various forms of radiation are applied such as 200 kVp X‐rays and γ‐rays, to the cells, both with and without functional GNPs. By comparison with irradiation alone, the results show that GNPs significantly enhance cancer killing.
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Metadata
- Authors
- Kong, T., Zeng, J., Wang, X., Yang, X., Yang, J., McQuarrie, S., McEwan, A., Roa, W., Chen, J., & Xing, J. Z.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2008-09
- Volume
- 4
- Issue
- 9
- Pages
- 1537-1543
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2143021230
- Cited by
- 339
- References
- 13
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kong, T., Zeng, J., Wang, X., Yang, X., Yang, J., McQuarrie, S., McEwan, A., Roa, W., Chen, J., & Xing, J. Z. (2008). Enhancement of Radiation Cytotoxicity in Breast‐Cancer Cells by Localized Attachment of Gold Nanoparticles. Small. https://doi.org/10.1002/smll.200700794
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