The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Nanoscale Radiotherapy with Hafnium Oxide Nanoparticles
Abstract
AIM: There is considerable interest in approaches that could improve the therapeutic window of radiotherapy. In this study, hafnium oxide nanoparticles were designed that concentrate in tumor cells to achieve intracellular high-energy dose deposit. MATERIALS & METHODS: Conventional methods were used, implemented in different ways, to explore interactions of these high-atomic-number nanoparticles and ionizing radiation with biological systems. RESULTS: Using the Monte Carlo simulation, these nanoparticles, when exposed to high-energy photons, were shown to demonstrate an approximately ninefold radiation dose enhancement compared with water. Importantly, the nanoparticles show satisfactory dispersion and persistence within the tumor and they form clusters in the cytoplasm of cancer cells. Marked antitumor activity is demonstrated in human cancer models. Safety is similar in treated and control animals as demonstrated by a broad program of toxicology evaluation. CONCLUSION: These findings, supported by good tolerance, provide the basis for developing this new type of nanoparticle as a promising anticancer approach in human patients.
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Understanding biophysicochemical interactions at the nano–bio interface
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Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells
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The use of gold nanoparticles to enhance radiotherapy in mice
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Gold nanoparticles: a new X-ray contrast agent
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(2020) · Penelope · doi:10.1787/9d2cc3d5-en · Cited by 1,275
Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas
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Gold Nanoparticles as Radiation Sensitizers in Cancer Therapy
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Cited by
Cancer nanomedicine: progress, challenges and opportunities
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Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
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Clinical Translation of Nanomedicine
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Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy
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Metadata
- Authors
- Maggiorella, L., Barouch, G., Devaux, C., Pottier, A., Deutsch, E., Bourhis, J., Borghi, E., & Levy, L.
- Venue
- Future Oncology
- Publisher
- Informa UK Limited
- Published
- 2012-09-30
- Volume
- 8
- Issue
- 9
- Pages
- 1167-1181
- ISSN
- 1479-6694 (ISSN-L)
- 1744-8301
- OpenAlex
- W2164918134
- Cited by
- 373
- References
- 28
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Maggiorella, L., Barouch, G., Devaux, C., Pottier, A., Deutsch, E., Bourhis, J., Borghi, E., & Levy, L. (2012). Nanoscale Radiotherapy with Hafnium Oxide Nanoparticles. Future Oncology. https://doi.org/10.2217/fon.12.96
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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