The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
TPGS‐Functionalized Polydopamine‐Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance
Abstract
A nanocarrier system of d‐a‐tocopheryl polyethylene glycol 1000 succinate (TPGS)‐functionalized polydopamine‐coated mesoporous silica nanoparticles (NPs) is developed for sustainable and pH‐responsive delivery of doxorubicin (DOX) as a model drug for the treatment of drug‐resistant nonsmall cell lung cancer. Such nanoparticles are of desired particle size, drug loading, and drug release profile. The surface morphology, surface charge, and surface chemical properties are also successfully characterized by a series of techniques such as transmission electron microscopy (TEM), X‐ray photoelectron spectroscopy (XPS), Brunauer‐Emmett‐Teller (BET) method, thermal gravimetric analysis (TGA), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FTIR). The normal A549 cells and drug‐resistant A549 cells are employed to access the cytotoxicity and cellular uptake of the NPs. The therapeutic effects of TPGS‐conjugated nanoparticles are evaluated in vitro and in vivo. Compared with free DOX and DOX‐loaded NPs without TPGS ligand modification, MSNs‐DOX@PDA‐TPGS exhibits outstanding capacity to overcome multidrug resistance and shows better in vivo therapeutic efficacy. This splendid drug delivery platform can also be sued to deliver other hydrophilic and hydrophobic drugs.
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Cites
Yin Win, K., & Feng, S.-S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.07.050 · Cited by 1,452
Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers
Park, J., Brust, T. F., Lee, H. J., Lee, S. C., Watts, V. J., & Yeo, Y. (2014) · ACS Nano · doi:10.1021/nn405809c · Cited by 407
New developments in ordered mesoporous materials for drug delivery
Manzano, M., & Vallet-Regí, M. (2010) · Journal of Materials Chemistry · doi:10.1039/b922651f · Cited by 359
Scientific Advances in Lung Cancer 2015
Tsao, A. S., Scagliotti, G. V., Bunn, P. A., Carbone, D. P., Warren, G. W., Bai, C., de Koning, H. J., Yousaf-Khan, A. U., McWilliams, A., Tsao, M. S., et al. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.03.012 · Cited by 284
Cited by
Recent progress in drug delivery
Li, C., Wang, J., Wang, Y., Gao, H., Wei, G., Huang, Y., Yu, H., Gan, Y., Wang, Y., Mei, L., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.08.003 · Cited by 818
Self-citationPhenolic-enabled nanotechnology: versatile particle engineering for biomedicine
Wu, D., Zhou, J., Creyer, M. N., Yim, W., Chen, Z., Messersmith, P. B., & Jokerst, J. V. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00908c · Cited by 317
Cheng, W., Nie, J., Gao, N., Liu, G., Tao, W., Xiao, X., Jiang, L., Liu, Z., Zeng, X., & Mei, L. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201704135 · Cited by 304
Self-citationZeng, W., Zhang, H., Deng, Y., Jiang, A., Bao, X., Guo, M., Li, Z., Wu, M., Ji, X., Zeng, X., et al. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124494 · Cited by 256
Self-citationKankala, R. K., Liu, C.-G., Yang, D.-Y., Wang, S.-B., & Chen, A.-Z. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.123138 · Cited by 157
Metadata
- Authors
- Cheng, W., Liang, C., Xu, L., Liu, G., Gao, N., Tao, W., Luo, L., Zuo, Y., Wang, X., Zhang, X., Zeng, X., & Mei, L.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2017-06-08
- Volume
- 13
- Issue
- 29
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2621849512
- Cited by
- 269
- References
- 4
- FWCI
- 13.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cheng, W., Liang, C., Xu, L., Liu, G., Gao, N., Tao, W., Luo, L., Zuo, Y., Wang, X., Zhang, X., Zeng, X., & Mei, L. (2017). TPGS‐Functionalized Polydopamine‐Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance. Small. https://doi.org/10.1002/smll.201700623
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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