The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Dual‐Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor Based on an O2 Self‐Sufficient Nanoplatform
Abstract
Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome‐based nanoparticle (designated as LipoMB/CaO 2) with O 2 self‐sufficient property for dual‐stage light‐driven PDT is demonstrated to address this problem. Through a short time irradiation, 1 O 2 activated by the photosensitizer methylene blue (MB) can induce lipid peroxidation to break the liposome, and enlarge the contact area of CaO 2 with H 2 O, resulting in accelerated O 2 production. Accelerated O 2 level further regulates hypoxic tumor microenvironment and in turn improves 1 O 2 generation by MB under another long time irradiation. In vitro and in vivo experiments also demonstrate the superior competence of LipoMB/CaO 2 to alleviate tumor hypoxia, suppress tumor growth and antitumor metastasis with low side‐effect. The O 2 self‐sufficient LipoMB/CaO 2 nanoplatform with dual‐stage light manipulation is a successful attempt for PDT against hypoxic tumor.
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Cites
1 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309
RetractedTargeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
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Exploiting tumour hypoxia in cancer treatment
Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828
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Improvement of Tumor Response by Manipulation of Tumor Oxygenation During Photodynamic Therapy¶
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Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy
Lin, H., Chen, Y., & Shi, J. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00471k · Cited by 803
Conquering the Hypoxia Limitation for Photodynamic Therapy
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202103978 · Cited by 705
Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation
Zhu, P., Chen, Y., & Shi, J. (2018) · ACS Nano · doi:10.1021/acsnano.8b00999 · Cited by 572
Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles
Zhang, M., Song, R., Liu, Y., Yi, Z., Meng, X., Zhang, J., Tang, Z., Yao, Z., Liu, Y., Liu, X., et al. (2019) · Chem · doi:10.1016/j.chempr.2019.06.003 · Cited by 527
The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors
Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506
Metadata
- Authors
- Liu, L., Zhang, Y., Qiu, W., Zhang, L., Gao, F., Li, B., Xu, L., Fan, J., Li, Z., & Zhang, X.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2017-08-07
- Volume
- 13
- Issue
- 37
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2745249303
- Cited by
- 240
- References
- 9
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, L., Zhang, Y., Qiu, W., Zhang, L., Gao, F., Li, B., Xu, L., Fan, J., Li, Z., & Zhang, X. (2017). Dual‐Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor Based on an O2 Self‐Sufficient Nanoplatform. Small. https://doi.org/10.1002/smll.201701621
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