The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Rapid and Superior Bacteria Killing of Carbon Quantum Dots/ZnO Decorated Injectable Folic Acid‐Conjugated PDA Hydrogel through Dual‐Light Triggered ROS and Membrane Permeability
Abstract
One of the most difficult challenges in the biomedical field is bacterial infection, which causes tremendous harm to human health. In this work, an injectable hydrogel is synthesized through rapid assembly of dopamine (DA) and folic acid (FA) cross‐linked by transition metal ions (TMIs, i.e., Zn 2+), which was named as DFT‐hydrogel. Both the two carboxyl groups in the FA molecule and catechol in polydopamine (PDA) easily chelates Zn 2+ to form metal–ligand coordination, thereby allowing this injectable hydrogel to match the shapes of wounds. In addition, PDA in the hydrogel coated around carbon quantum dot‐decorated ZnO (C/ZnO) nanoparticles (NPs) to rapidly generate reactive oxygen species (ROS) and heat under illumination with 660 and 808 nm light, endows this hybrid hydrogel with great antibacterial efficacy against Staphylococcus aureus (S. aureus, typical Gram‐positive bacteria) and Escherichia coli (E. coli, typical Gram‐negative bacteria). The antibacterial efficacy of the prepared DFT‐C/ZnO‐hydrogel against S. aureus and E. coli under dual‐light irradiation is 99.9%. Importantly, the hydrogels release zinc ions over 12 days, resulting in a sustained antimicrobial effect and promoted fibroblast growth. Thus, this hybrid hydrogel exhibits great potential for the reconstruction of bacteria‐infected tissues, especially exposed wounds.
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Multifunctional hydrogels for wound healing: Special focus on biomacromolecular based hydrogels
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Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing
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Research Progress of Polydopamine Hydrogel in the Prevention and Treatment of Oral Diseases
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Metadata
- Authors
- Xiang, Y., Mao, C., Liu, X., Cui, Z., Jing, D., Yang, X., Liang, Y., Li, Z., Zhu, S., Zheng, Y., Yeung, K. W. K., Zheng, D., Wang, X., & Wu, S.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2019-04-25
- Volume
- 15
- Issue
- 22
- Pages
- e1900322-e1900322
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2941492992
- Cited by
- 266
- References
- 49
- FWCI
- 20.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xiang, Y., Mao, C., Liu, X., Cui, Z., Jing, D., Yang, X., Liang, Y., Li, Z., Zhu, S., Zheng, Y., Yeung, K. W. K., Zheng, D., Wang, X., & Wu, S. (2019). Rapid and Superior Bacteria Killing of Carbon Quantum Dots/ZnO Decorated Injectable Folic Acid‐Conjugated PDA Hydrogel through Dual‐Light Triggered ROS and Membrane Permeability. Small. https://doi.org/10.1002/smll.201900322
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