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Cited by 36Hydrogels: synthesis, properties, applicationsPolymer Surface Interaction StudiesDental materials and restorations

Research Progress of Polydopamine Hydrogel in the Prevention and Treatment of Oral Diseases

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Zhou, Yuqi, Yang, Yuanmeng, Liu, Rongpu, Zhou, Qin, Lu, Haixia, Zhang, Wenjie·2023·International Journal of Nanomedicine
DOI 10.2147/ijn.s407044PMC PMC10199686
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Abstract

Oral diseases represent one of the most prevalent diseases globally and are associated with serious health and economic burdens, greatly altering the quality of life of affected individuals. Various biomaterials play important roles in the treatment of oral diseases. To some extent, the development of biomaterials has promoted progress in clinically available oral medicines. Hydrogels have unique tunable advantages that make them useful in the next generation of regenerative strategies and have been widely applied in both oral soft and hard tissues repair. However, most hydrogels lack self-adhesive properties, which may result in low repair efficacy. Polydopamine (PDA), the primary adhesive component, has attracted increasing attention in recent years. PDA-modified hydrogels exhibit reliable and suitable adherence to tissues and easily integrate into tissues to promote repair efficiency. This paper reviews the latest research progress on PDA hydrogels and elaborates on the mechanism of the reaction between PDA functional groups and hydrogels, and summarizes the biological properties and the applications of PDA hydrogels in the prevention and treatment of the field of oral diseases. It is also proposed that in future research we should simulate the complex microenvironment of the oral cavity as much as possible, coordinate and plan various biological events rationally, and realize the translation from scientific research to clinical practice.

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  • Covalent immobilization of BMP-2 onto PDA-coated implant surfaces ensures stable localization of BMP-2 at the implant-bone interface, prevents rapid diffusion and loss, enables sustained localized release of osteogenic cues, and thereby enhances recruitment and activation of osteoprogenitor cells and accelerates new bone formation around the implant.

    “This strategy ensures stable localization of BMP-2 at the implant–bone interface, effectively preventing rapid diffusion and loss while enabling sustained, localized release of osteogenic cues.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [7]

    Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

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  • PDA adheres to material surfaces through multiple mechanisms: coordination bonds with inorganic substrates such as metal oxides and ceramics, hydrogen bonding with hydroxyl- or amine-rich surfaces, covalent coupling with amine- or thiol-containing organic substrates via Schiff base formation or Michael addition, and π-π stacking and hydrophobic interactions on aromatic or hydrophobic surfaces.

    “Specifically, PDA can form coordination bonds with inorganic substrates such as metal oxides and ceramics; establish hydrogen bonding interactions with surfaces rich in hydroxyl or amine groups; and undergo covalent coupling with organic substrates containing amine or thiol groups via Schiff base formation or Michael addition reactions.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [7]

    Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

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  • PDA exhibits exceptionally strong and substrate-independent adhesion owing to the abundant catechol moieties within its molecular structure.

    “Owing to the abundant catechol moieties within its molecular structure, PDA exhibits exceptionally strong and substrate-independent adhesion.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [7]

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Authors
Zhou, Y., Yang, Y., Liu, R., Zhou, Q., Lu, H., & Zhang, W.
Affiliations
Shanghai Jiao Tong University (CN)
Corresponding author
  • Lu, Haixia
  • Zhang, Wenjie
ORCID
Venue
International Journal of Nanomedicine
Publisher
Informa UK Limited
Published
2023-05
Volume
Volume 18
Pages
2623-2645
ISSN
  • 1176-9114 (ISSN-L)
  • 1178-2013
DOI
10.2147/ijn.s407044
PMC
PMC10199686
OpenAlex
W4376955676
Cited by
36
References
121
Citations by year
2026: 15 · 2025: 9 · 2024: 7 · 2023: 5
FWCI
0.68
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Nanomedicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
  • National Natural Science Foundation of China (32071361, 82022015)
  • Shanghai Rising-Star Program (20QA1405700)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
Keywords
polydopamine, hydrogels, oral diseases, self-adhesion, tissue repair, biomaterials, clinical translation
MeSH terms
Adhesives, Biocompatible Materials, Humans, Indoles, Polymers, Quality of Life, Hydrogels

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