The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
A Dual‐Cross‐Linked Hydrogel Patch for Promoting Diabetic Wound Healing
Open accessAbstract
Diabetic wound treatment faces significant challenges in clinical settings. Alternative treatment approaches are needed. Continuous bleeding, disordered inflammatory regulation, obstruction of cell proliferation, and disturbance of tissue remodeling are the main characteristics of diabetic wound healing. Hydrogels made of either naturally derived or synthetic materials can potentially be designed with a variety of functions for managing the healing process of chronic wounds. Here, a hemostatic and anti‐inflammatory hydrogel patch is designed for promoting diabetic wound healing. The hydrogel patch is derived from dual‐cross‐linked methacryloyl‐substituted Bletilla Striata polysaccharide (B) and gelatin (G) via ultraviolet (UV) light. It is demonstrated that the B–G hydrogel can effectively regulate the M1/M2 phenotype of macrophages, significantly promote the proliferation and migration of fibroblasts in vitro, and accelerate angiogenesis. It can boost wound closure by normalizing epidermal tissue regeneration and depositing collagen appropriately in vivo without exogenous cytokine supplementation. Overall, the B–G bioactive hydrogel can promote diabetic wound healing in a simple, economical, effective, and safe manner.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Yue, K., Trujillo-de Santiago, G., Alvarez, M. M., Tamayol, A., Annabi, N., & Khademhosseini, A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.045 · Cited by 3,146
Cell-laden microengineered gelatin methacrylate hydrogels
Nichol, J. W., Koshy, S. T., Bae, H., Hwang, C. M., Yamanlar, S., & Khademhosseini, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.064 · Cited by 2,377
Qu, J., Zhao, X., Liang, Y., Zhang, T., Ma, P. X., & Guo, B. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.044 · Cited by 1,809
Diabetes and Vascular Disease: Pathophysiology, Clinical Consequences, and Medical Therapy: Part I
Creager, M. A., Lüscher, T. F., of, P. W. T. A., Cosentino, F., & Beckman, J. A. (2003) · Circulation · doi:10.1161/01.cir.0000091257.27563.32 · Cited by 1,650
The effect of pore size on cell adhesion in collagen-GAG scaffolds
O’Brien, F. J., Harley, B. A., Yannas, I. V., & Gibson, L. J. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.02.052 · Cited by 1,329
Liang, Y., Zhao, X., Hu, T., Chen, B., Yin, Z., Ma, P. X., & Guo, B. (2019) · Small · doi:10.1002/smll.201900046 · Cited by 1,281
Patel, S., Srivastava, S., Singh, M. R., & Singh, D. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108615 · Cited by 1,049
Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing
Hesketh, M., Sahin, K. B., West, Z. E., & Murray, R. Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071545 · Cited by 852
Photocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering
Zhao, X., Lang, Q., Yildirimer, L., Lin, Z. Y., Cui, W., Annabi, N., Ng, K. W., Dokmeci, M. R., Ghaemmaghami, A. M., & Khademhosseini, A. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500005 · Cited by 832
Recent advance in surface modification for regulating cell adhesion and behaviors
Cai, S., Wu, C., Yang, W., Liang, W., Yu, H., & Liu, L. (2020) · Nanotechnology Reviews · doi:10.1515/ntrev-2020-0076 · Cited by 644
Cited by
Fu, M., Zhao, Y., Wang, Y., Li, Y., Wu, M., Liu, Q., Hou, Z., Lu, Z., Wu, K., & Guo, J. (2023) · Small · doi:10.1002/smll.202205489 · Cited by 107
Metadata
- Authors
- Liu, J., Qu, M., Wang, C., Xue, Y., Huang, H., Chen, Q., Sun, W., Zhou, X., Xu, G., & Jiang, X.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2022-03-23
- Volume
- 18
- Issue
- 17
- Pages
- e2106172-e2106172
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W4220841456
- Cited by
- 285
- References
- 65
- FWCI
- 21.87
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Dual‐Cross‐Linked Hydrogel Patch for Promoting Diabetic Wound Healing. https://app.cochat.ai/papers/10.1002/smll.202106172
- The paper
- Liu, J., Qu, M., Wang, C., Xue, Y., Huang, H., Chen, Q., Sun, W., Zhou, X., Xu, G., & Jiang, X. (2022). A Dual‐Cross‐Linked Hydrogel Patch for Promoting Diabetic Wound Healing. Small. https://doi.org/10.1002/smll.202106172
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
