Decellularized nerve matrix hydrogel and glial‐derived neurotrophic factor modifications assisted nerve repair with decellularized nerve matrix scaffolds
Open accessAbstract
Nerve defects are challenging to address clinically without satisfactory treatments. As a reliable alternative to autografts, decellularized nerve matrix scaffolds (DNM-S) have been widely used in clinics for surgical nerve repair. However, DNM-S remain inferior to autografts in their ability to support nerve regeneration for long nerve defects. In this study, we systematically and clearly presented the nano-architecture of nerve-specific structures, including the endoneurium, basement membrane and perineurium/epineurium in DNM-S. Furthermore, we modified the DNM-S by supplementing decellularized nerve matrix hydrogel (DNMG) and glial-derived neurotrophic factor (GDNF) and then bridged a 50-mm sciatic nerve defect in a beagle model. Fifteen beagles were randomly divided into three groups (five per group): an autograft group, DNM-S group and GDNF-DNMG-modified DNM-S (DNM-S/GDNF@DNMG) group. DNM-S/GDNF@DNMG, as optimized nerve grafts, were used to bridge nerve defects in the same manner as in the DNM-S group. The repair outcome was evaluated by behavioural observations, electrophysiological assessments, regenerated nerve tissue histology and reinnervated target muscle examinations. Compared with the DNM-S group, limb function, electrophysiological responses and histological findings were improved in the DNM-S/GDNF@DNMG group 6 months after grafting, reflecting a narrower gap between the effects of DNM-S and autografts. In conclusion, modification of DNM-S with DNMG and GDNF enhanced nerve regeneration and functional recovery, indicating that noncellular modification of DNM-S is a promising method for treating long nerve defects.
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γ sterilization affects the scaffold's elasticity, subsequently affecting cell attachment, behavior, and viability.
“It has been reported that γ sterilization affects the scaffold's elasticity, subsequently affecting cell attachment, behavior, and viability [[180], [181], [182]].”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [181]
Cites
Matricellular proteins: extracellular modulators of cell function
BORNSTEIN, P. K., & Sage, E. H. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00361-7 · Cited by 966 · see citing works
Peripheral Nerve Conduit: Materials and Structures
Houshyar, S., Bhattacharyya, A., & Shanks, R. A. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00203 · Cited by 216 · see citing works
Next Generation Nerve Guides: Materials, Fabrication, Growth Factors, and Cell Delivery
Bell, J. H. A., & Haycock, J. W. (2011) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2011.0498 · Cited by 207 · see citing works
The nerve regenerative microenvironment: Early behavior and partnership of axons and Schwann cells
Webber, C. A., & Zochodne, D. W. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.05.037 · Cited by 194 · see citing works
Seif-Naraghi, S. B., Horn, D., Schup-Magoffin, P. J., & Christman, K. L. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.06.030 · Cited by 187 · see citing works
Heparin/heparan sulphate binding in the TGF-β cytokine superfamily
Rider, C. C. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340458 · Cited by 169 · see citing works
Decellularized myocardial matrix hydrogels: In basic research and preclinical studies
Wang, R. M., & Christman, K. L. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.06.002 · Cited by 165 · see citing works
Lin, T., Liu, S., Chen, S., Qiu, S., Rao, Z., Liu, J., Zhu, S., Yan, L., Mao, H., Zhu, Q., et al. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.04.001 · Cited by 165 · see citing works
Self-citationGlial cell line‐derived neurotrophic factor‐induced signaling in Schwann cells
Iwase, T., Jung, C., Bae, H.-S., Zhang, M., & Soliven, B. C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03290.x · Cited by 127 · see citing works
Chondroitinase treatment increases the effective length of acellular nerve grafts
Neubauer, D., GRAHAM, J., & Muir, D. C. G. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.006 · Cited by 123 · see citing works
Barras, F. M., Pasche, P., Bouche, N., Aebischer, P., & Zurn, A. D. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10434 · Cited by 117 · see citing works
Rusli, N. S., & Harith, S. (2020) · Journal of Nutrition Science · doi:10.35308/jns.v1i2.2757 · Cited by 115 · see citing works
Growth factor delivery systems and repair strategies for damaged peripheral nerves
Madduri, S., & Gander, B. A. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.11.036 · Cited by 106 · see citing works
Hydrogels as scaffolds and delivery systems to enhance axonal regeneration after injuries
Carballo-Molina, O. A., & Velasco, I. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00013 · Cited by 105 · see citing works
Peripheral Nerve‐Derived Matrix Hydrogel Promotes Remyelination and Inhibits Synapse Formation
Zou, J., Liu, S., Sun, J., Yang, W., Xu, Y., Rao, Z., Jiang, B., Zhu, Q., Liu, X., Wu, J., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201705739 · Cited by 105 · see citing works
Self-citationGarcı́a, R., Aguiar, J. A., Alberti, E., Cuétara, K., & Fuentes, N. P. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.111 · Cited by 104 · see citing works
Sonnenberg, S. B., Rane, A. A., Liu, C. J., Rao, N., Roth, G. A., Suarez, S. L., Wang, R. M., Muñoz, A., Bajaj, V., Zhang, S. X., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.12.021 · Cited by 100 · see citing works
Electrospun silk fibroin‐based neural scaffold for bridging a long sciatic nerve gap in dogs
Xue, C., Zhu, H., Tan, D., Ren, H., Gu, X., Zhao, Y., Zhang, P., Sun, Z., Yang, Y., Gu, J., et al. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2449 · Cited by 96 · see citing works
Decellularized Matrices As Cell-Instructive Scaffolds to Guide Tissue-Specific Regeneration
Robb, K. P., Shridhar, A., & Flynn, L. E. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00619 · Cited by 90 · see citing works
He, B., Zhu, Q., Chai, Y., Ding, X., Tang, J., Gu, L., Xiang, J., Yang, Y., Zhu, J., & Liu, X. (2013) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1707 · Cited by 88 · see citing works
Self-citationSlivka, P. F., Dearth, C. L., Keane, T. J., Meng, F. W., Medberry, C. J., Riggio, R. T., Reing, J. E., & Badylak, S. F. (2014) · Biomaterials Science · doi:10.1039/c4bm00189c · Cited by 77 · see citing works
Idé, C., Tohyama, K., Tajima, K., Endo, K., Sano, K.-I., Tamura, M., Mizoguchi, A., Kitada, M., Morihara, T., & Shirasu, M. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6921 · Cited by 77 · see citing works
Matrices, scaffolds, and carriers for protein and molecule delivery in peripheral nerve regeneration
Tajdaran, K., Chan, K. S., Gordon, T., & Borschel, G. H. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.014 · Cited by 69 · see citing works
Marquardt, L. M., Ee, X., Iyer, N. R., Hunter, D. A., Mackinnon, S. E., Wood, M. D., & Sakiyama‐Elbert, S. E. (2015) · Tissue Engineering Part A · doi:10.1089/ten.tea.2015.0311 · Cited by 67 · see citing works
Yu, H., Jiang, P., Guo, Q., Zhang, L., Li, Z., Zhao, B., Sui, X., Wang, Y., Xu, W., & Lu, S. (2009) · Microsurgery · doi:10.1002/micr.20635 · Cited by 62 · see citing works
Decellularized grafts with axially aligned channels for peripheral nerve regeneration
Sridharan, R., Reilly, R. B., & Buckley, C. T. (2014) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2014.10.002 · Cited by 61 · see citing works
Jahromi, M., Razavi, S., & Bakhtiari, A. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2945 · Cited by 59 · see citing works
Xing, M. M. Q., Zhuang, H., Bu, S., Hua, L., Darabi, M. A., & Cao, X. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s96324 · Cited by 51 · see citing works
Lee, D. J., Fontaine, A. K., Meng, X., & Park, D. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00344 · Cited by 51 · see citing works
Tonda‐Turo, C., Audisio, C., Gnavi, S., Chiono, V., Gentile, P., Raimondo, S., Geuna, S., Perroteau, I., & Ciardelli, G. (2011) · Advanced Engineering Materials · doi:10.1002/adem.201080099 · Cited by 34 · see citing works
Shin, Y. H., Park, S. Y., & Kim, J. K. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2874 · Cited by 27 · see citing works
Yang, L., Liu, X., Zhu, Q., Zhang, Y., Xi, T., Hu, J. X., He, C., & Jiang, L. (2010) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.31719 · Cited by 26 · see citing works
Self-citationPedrini, F. A., Boriani, F., Bolognesi, F., Fazio, N., Marchetti, C., & Baldini, N. (2018) · Neurosurgery · doi:10.1093/neuros/nyy374 · Cited by 22 · see citing works
Boriani, F., Fazio, N., Bolognesi, F., Pedrini, F. A., Marchetti, C., & Baldini, N. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.10.195 · Cited by 22 · see citing works
Chu, T., Wang, L., Guo, A., Chan, V. W., Wong, C. W., & Wu, W. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01253.x · Cited by 22 · see citing works
Giusti, G., Lee, J., Kremer, T. L., Friedrich, P. F., Bishop, A. T., & Shin, A. Y. (2014) · Microsurgery · doi:10.1002/micr.22371 · Cited by 21 · see citing works
Huang, W., Zhang, Y., Zhang, H., & Katiella, K. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.137588 · Cited by 15 · see citing works
Li, L., Yang, J., Qin, B., Wang, H., Yang, Y., Fang, J., Chen, G., Liu, X., Tu, Z., & Gu, L. (2019) · Journal of neurosurgery · doi:10.3171/2019.2.jns182620 · Cited by 14 · see citing works
Self-citationBliley, J. M., Sivak, W. N., Minteer, D. M., Tompkins-Rhoades, C., Day, J., Williamson, G., Liao, H.-T., & Marra, K. G. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/ab5001518 · Cited by 8 · see citing works
Pollins, A. C., Boyer, R. B., Nussenbaum, M. E., & Thayer, W. P. (2018) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000001464 · Cited by 7 · see citing works
Flagged first, then by citations
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Sorted by citations
Zhang, X., Chen, X., Hong, H., Hu, R., Liu, J., & Liu, C. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.09.014 · Cited by 680 · see citing works
Brown, M., Li, J., Moraes, C., Tabrizian, M., & Li-Jessen, N. Y. K. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121786 · Cited by 282 · see citing works
Neishabouri, A., Soltani Khaboushan, A., Daghigh, F., Kajbafzadeh, A.-M., & Majidi Zolbin, M. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.805299 · Cited by 281 · see citing works
Yao, Z., Yuan, W., Xu, J., Tong, W., Mi, J., Ho, P., Chow, D. H. K., Li, Y., Yao, H., Li, X., et al. (2022) · Advanced Science · doi:10.1002/advs.202202102 · Cited by 147 · see citing works
Self-citationProgress in biomaterials inspired by the extracellular matrix
Chen, Z., Du, C., Liu, S., Liu, J., Yang, Y., Dong, L., Zhao, W., Huang, W., & Lei, Y. (2024) · Giant · doi:10.1016/j.giant.2024.100323 · Cited by 132 · see citing works
Tao, M., Ao, T., Mao, X., Yan, X., Javed, R., Hou, W., Wang, Y., Sun, C., Lin, S., Yu, T., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.02.010 · Cited by 119 · see citing works
Deng, R., Luo, Z., Rao, Z., Lin, Z., Chen, S., Zhou, J., Zhu, Q., Liu, X., Bai, Y., & Quan, D. (2022) · Advanced Fiber Materials · doi:10.1007/s42765-021-00124-5 · Cited by 93 · see citing works
Self-citationThe engineering and application of extracellular matrix hydrogels: a review
Zhang, Y.-T., Xu, Y., & Gao, J. (2023) · Biomaterials Science · doi:10.1039/d3bm00183k · Cited by 68 · see citing works
Self-citationYang, J., Hsu, C., Cao, T., Ye, H., Chen, J., & Li, Y.-Q. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.350212 · Cited by 57 · see citing works
Li, C., An, N., Song, Q., Hu, Y., Yin, W., Wang, Q., Le, Y., Pan, W., Yan, X., Wang, Y., et al. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01086-7 · Cited by 57 · see citing works
Li, T., Javed, R., & Ao, Q. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666201111103815 · Cited by 46 · see citing works
Advances in 3D printing combined with tissue engineering for nerve regeneration and repair
Liao, W., Shi, Y., Li, Z., & Yin, X. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-03052-9 · Cited by 43 · see citing works
Nerve regeneration using decellularized tissues: challenges and opportunities
Mahdian, M., Tabatabai, T. S., Abpeikar, Z., Rezakhani, L., & Khazaei, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1295563 · Cited by 41 · see citing works
Extracellular matrix grafts: From preparation to application (Review)
Jiang, Y., Li, R., Han, C., & Huang, L. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4818 · Cited by 36 · see citing works
Electrospinning porcine decellularized nerve matrix scaffold for peripheral nerve regeneration
Kong, Y., Xu, J., Han, Q., Zheng, T., Wu, L., Li, G., & Yang, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.04.161 · Cited by 36 · see citing works
Kellaway, S. C., Roberton, V. H., Jones, J. N., Loczenski, R., Phillips, J. B., & White, L. J. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.12.003 · Cited by 31 · see citing works
Yao, Z., Chen, Z., He, X. M., Wei, Y., Qian, J., Zong, Q., He, S., Song, L., Ma, L., Lin, S., et al. (2024) · Advanced Fiber Materials · doi:10.1007/s42765-024-00489-3 · Cited by 28 · see citing works
Self-citationHussein, K. H., Ahmadzada, B., Correa, J. C., Sultan, A., Wilken, S., Amiot, B., & Nyberg, S. L. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.06.001 · Cited by 28 · see citing works
Regulation of Schwann Cell and DRG Neurite Behaviors within Decellularized Peripheral Nerve Matrix
Xue, W. L., Kong, Y., Rafay, A., Roy, P., Huh, S., Kuss, M. A., Kumar, V., & Duan, B. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c20320 · Cited by 26 · see citing works
Chemical materials involved in neural tissue engineering scaffold techniques: a narrative review
Li, M., Zhou, J., Ning, Y., & Xiong, Y. (2024) · Advanced technology in neuroscience . · doi:10.4103/atn.atn-d-24-00017 · Cited by 20 · see citing works
Processing and post-processing of fish skin as a novel material in tissue engineering
Esmaeili, A., Rahimi, A., Abbasi, A., Hasannejad-Asl, B., Bagheri‐Mohammadi, S., Farjami, M., & Keshel, S. H. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102238 · Cited by 20 · see citing works
Application of decellularization-recellularization technique in plastic and reconstructive surgery
Shang, Y., Wang, G., Zhen, Y., Liu, N., Nie, F., Zhao, Z., Li, H., & An, Y. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002085 · Cited by 16 · see citing works
Shi, S., Yu, X., Ou, X., Zheng, C., Xie, F., & Huang, Y. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s547018 · Cited by 13 · see citing works
Broeren, B. O., Hundepool, C. A., Kumas, A. H., Duraku, L. S., Walbeehm, E. T., Hooijmans, C. R., Power, D., Zuidam, J. M., & de Jong, T. (2024) · PLoS ONE · doi:10.1371/journal.pone.0279324 · Cited by 13 · see citing works
Qiu, S., Deng, P., He, F.-L., Yan, L., Tu, Z.-H., Liu, X., Quan, D., Bai, Y., Zheng, C., & Zhu, Q. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.350213 · Cited by 13 · see citing works
Self-citationLi, Y., Chen, Z., Zhou, J., Guan, Y., Xing, J., Niu, Z., Zhang, B., Zeng, Q., Pei, X., Wang, Y., et al. (2022) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2022.130743 · Cited by 12 · see citing works
Luo, R., Hu, R.-N., Xu, J., Yu, P., Wu, X., Zhe, M., Liu, M., Xing, F., Xiang, Z., Zhou, C., et al. (2023) · Nanotechnology Reviews · doi:10.1515/ntrev-2023-0151 · Cited by 12 · see citing works
A comprehensive review of hydrogel strategies for repairing peripheral nerve injuries
Jia, S., Zhou, H., Chen, J., Lin, J., Zhu, X., Weng, J., Li, W., & Yu, F. (2025) · Brain‐X · doi:10.1002/brx2.70012 · Cited by 12 · see citing works
A comparative study of human and porcine-derived decellularised nerve matrices.
Li, R., Qiu, S., Yang, W., Rao, Z., Chen, J., Yang, Y., Zhu, Q., Liu, X., Bai, Y., & Quan, D. (2023) · PubMed Central · doi:10.12336/biomatertransl.2023.03.006 · Cited by 11 · see citing works
Self-citationAdvances in tissue engineering of peripheral nerve and tissue innervation – a systematic review
Sueters, J., van Heiningen, R., de Vries, R., Güler, Z., Huirne, J. A. F., & Smit, T. H. (2025) · Journal of Tissue Engineering · doi:10.1177/20417314251316918 · Cited by 10 · see citing works
Ma, F., Wang, H., Yang, X., Wu, Y., Liao, C., Xie, B., Li, Y., & Zhang, W. (2021) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37327 · Cited by 9 · see citing works
Kuna, V. K., Lundgren, A., Anerillas, L. O., Kelk, P., Brohlin, M., Wiberg, M., Kingham, P. J., Novikova, L. N., Andersson, G., & Novikov, L. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158746 · Cited by 8 · see citing works
Karimi, F., Alizadeh, M., Bitaraf, F. S., & Shirshahi, V. (2024) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35448 · Cited by 7 · see citing works
Nerve tissue engineering on degradable scaffold
Chandy, T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824064-9.00011-3 · Cited by 2 · see citing works
Modili, F., Zandi, M., Farahmandghavi, F., Pezeshki‐Modaress, M., & Tabatabaei, M. H. (2025) · Iranian Polymer Journal · doi:10.1007/s13726-025-01565-0 · Cited by 1 · see citing works
He, F., Li, Z., Liao, F., Wang, S., Huang, X., Sun, J., Huang, A., LinFang, S., Lin, T., Rao, Z., et al. (2026) · Regenerative Biomaterials · doi:10.1093/rb/rbag047 · Cited by 1 · see citing works
Self-citationMultiscale biomimetic design for peripheral nerve repair: Beyond passive bridging
Sun, M., He, Z. Y., Luo, Y., Qin, L., Jin, B., Li, S., Fan, X., Zhang, J., Feng, X. X., Peng, L., et al. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103433 · Cited by 1 · see citing works
Suga, N., Taniguchi, K., Sawamura, H., Ikeda, Y., Matsuda, S., & Yoshikawa, S. (2023) · Nature Cell and Science · doi:10.61474/ncs.2023.00002
Matrize dezelularizatuak eta zelula amak ehun ingeniaritzan
Luzuriaga, J., Ibarretxe, G., & Aranguren, U. (2024) · EKAIA Euskal Herriko Unibertsitateko Zientzi eta Teknologi Aldizkaria · doi:10.1387/ekaia.25202
Shevchenko, Y. V., Liadova, T. I., Hladkykh, F. V., Matvieienko, M. S., Chyzh, M., & Komorovsky, R. (2024) · Ukrainian journal of cardiovascular surgery · doi:10.30702/ujcvs/24.32(04)/shl061-7890
- Authors
- Qiu, S., Rao, Z., He, F., Wang, T., Xu, Y., Du, Z., Yao, Z., Lin, T., Yan, L., Quan, D., Zhu, Q., & Liu, X.
- Affiliations
- Sun Yat-sen University (CN)
- Department of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated HospitalSun Yat‐sen University Guangzhou China
- Corresponding author
- Quan, Daping
- Zhu, Qingtang
- Liu, Xiaolin
- ORCID
- Venue
- Journal of Tissue Engineering and Regenerative Medicine
- Publisher
- Wiley
- Published
- 2020-05-30
- Volume
- 14
- Issue
- 7
- Pages
- 931-943
- ISSN
- 1932-6254 (ISSN-L)
- 1932-7005
- OpenAlex
- W3020147187
- Cited by
- 40
- References
- 41
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 12 · 2021: 3 · 2020: 2
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Tissue Engineering and Regenerative Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Guangzhou Science and Technology Program key projects (201807070082, 201803010091, 201807010082)
- National Natural Science Foundation of China (31670986)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- nerve regeneration, glial cell line-derived neurotrophic factor, sciatic nerve defect, peripheral nerve repair, autograft alternative, perineurium, endoneurium, basement membrane, functional recovery
- MeSH terms
- Animals, Dogs, Extracellular Matrix, Male, Nerve Regeneration, Sciatic Nerve, Hydrogels, Glial Cell Line-Derived Neurotrophic Factor, Tissue Scaffolds
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