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Cited by 549

The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.

Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)

Open access
Bessa, P. C., Casal, M., Reis, R. L.·2008·Journal of Tissue Engineering and Regenerative Medicine

Abstract

Bone morphogenetic proteins (BMPs) are cytokines with a strong effect on bone and cartilage growth and with important roles during embryonic patterning and early skeletal formation. BMPs have promising potential for clinical bone and cartilage repair, working as powerful bone-inducing components in diverse tissue-engineering products. Synthetic polymers, natural origin polymers, inorganic materials and composites may be used as carriers for the delivery of BMPs. Carriers range from nanoparticles to complex three-dimensional (3D) scaffolds, membranes for tissue-guided regeneration, biomimetic surfaces and smart thermosensitive hydrogels. Current clinical uses include spinal fusion, healing of long bone defects and craniofacial and periodontal applications, amongst others. BMP-2 and BMP-7 have recently received approval by the US Food and Drug Administration (FDA) for specific clinical cases, delivered in absorbable collagen sponges. Considering the expanding number of publications in the field of BMPs, there are prospects of a brilliant future in the field of regenerative medicine of bone and cartilage with the use of BMPs.

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Metadata

Authors
Bessa, P. C., Casal, M., & Reis, R. L.
Venue
Journal of Tissue Engineering and Regenerative Medicine
Published
2008
Volume
2
Issue
2-3
Pages
81-96
ISSN
  • 1932-6254 (ISSN-L)
  • 1932-7005
OpenAlex
W2027116665
Cited by
549
References
141
FWCI
20.04
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). https://app.cochat.ai/papers/10.1002/term.74
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Bessa, P. C., Casal, M., & Reis, R. L. (2008). Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). Journal of Tissue Engineering and Regenerative Medicine. https://doi.org/10.1002/term.74

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.