Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)

Stem Cell Properties of Human Dental Pulp Stem Cells

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Synthetic Matrix Metalloproteinase-Sensitive Hydrogels for the Conduction of Tissue Regeneration: Engineering Cell-Invasion Characteristics

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RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 FOR TREATMENT OF OPEN TIBIAL FRACTURES: A PROSPECTIVE, CONTROLLED, RANDOMIZED STUDY OF FOUR HUNDRED AND FIFTY PATIENTS

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Electrospun silk-BMP-2 scaffolds for bone tissue engineering

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Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends

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Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in the Treatment of Tibial Nonunions: A Prospective, Randomized Clinical Trial Comparing rhOP-1 with Fresh Bone Autograft*

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Repair of bone defects using synthetic mimetics of collagenous extracellular matrices

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Collagen sponges for bone regeneration with rhBMP-2

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Pore Size of Porous Hydroxyapatite as the Cell-Substratum Controls BMP-Induced Osteogenesis

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Use of Recombinant Human Bone Morphogenetic Protein-2 to Achieve Posterolateral Lumbar Spine Fusion in Humans: A Prospective, Randomized Clinical Pilot Trial 2002 Volvo Award in Clinical Studies

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A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE® Bone Graft)

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Chitosan-Based Particles as Controlled Drug Delivery Systems

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Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells

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BMP-Induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: Topology of osteogenesis

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Silk implants for the healing of critical size bone defects

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The Application of Tissue Engineering to Regeneration of Pulp and Dentin in Endodontics

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Controlled release of growth factors based on biodegradation of gelatin hydrogel

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Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells

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BONE MORPHOGENETIC PROTEINS IN CLINICAL APPLICATIONS

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Delivery of bone morphogenetic proteins for orthopedic tissue regeneration

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The application of recombinant human collagen in tissue engineering

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Nano- and micro-fiber combined scaffolds: A new architecture for bone tissue engineering

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Starch-based biodegradable hydrogels with potential biomedical applications as drug delivery systems

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Engineering bone‐like tissue in vitro using human bone marrow stem cells and silk scaffolds

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Delivering on the promise of bone morphogenetic proteins

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Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein

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Localized delivery of growth factors for bone repair

Luginbuehl, V., Meinel, L., Merkle, H. P., & Gander, B. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.03.004 · Cited by 332

Bone morphogenetic protein‐2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells

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Bone morphogenetic proteins: An update on basic biology and clinical relevance

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BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model

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Potential applications and delivery strategies for bone morphogenetic proteins

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The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres

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Induction of Dentin Formation on Canine Amputated Pulp by Recombinant Human Bone Morphogenetic Proteins (BMP)-2 and -4

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Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion

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Transcriptional Profiling of Bone Regeneration

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Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(l-lactic-co-glycolic acid) scaffold

Jeon, O., Song, S. J., Kang, S.-W., Putnam, A. J., & Kim, B.-S. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.02.023 · Cited by 261

Posterolateral Lumbar Intertransverse Process Spine Arthrodesis With Recombinant Human Bone Morphogenetic Protein 2/Hydroxyapatite–Tricalcium Phosphate After Laminectomy in the Nonhuman Primate

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Production and Characterization of Chitosan Fibers and 3‐D Fiber Mesh Scaffolds for Tissue Engineering Applications

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Osteochondral defects: present situation and tissue engineering approaches

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Alternative tissue engineering scaffolds based on starch: processing methodologies, morphology, degradation and mechanical properties

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Synthetic extracellular matrices for in situ tissue engineering

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Porous silk fibroin 3‐D scaffolds for delivery of bone morphogenetic protein‐2 in vitro and in vivo

Karageorgiou, V., Tomkins, M., Fajardo, R., Meinel, L., Snyder, B., Wade, K., Chen, J., Vunjak‐Novakovic, G., & Kaplan, D. L. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30728 · Cited by 213

Use of Recombinant Human Bone Morphogenetic Protein-2 in Spinal Fusion Applications

McKay, B., & Sandhu, H. S. (2002) · Spine · doi:10.1097/00007632-200208151-00014 · Cited by 211

Alginate hydrogel linked with synthetic oligopeptide derived from BMP-2 allows ectopic osteoinductionin vivo

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Randomized Radiostereometric Study Comparing Osteogenic Protein-1 (BMP-7) and Autograft Bone in Human Noninstrumented Posterolateral Lumbar Fusion: 2002 Volvo Award in Clinical Studies

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Recombinant Protein-co-PEG Networks as Cell-Adhesive and Proteolytically Degradable Hydrogel Matrixes. Part II: Biofunctional Characteristics

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Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope

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Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2

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Retention and activity of BMP‐2 in hyaluronic acid‐based scaffolds in vitro

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Potentiation of the activity of bone morphogenetic protein-2 in bone regeneration by a PLA–PEG/hydroxyapatite composite

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A Pilot Study Evaluating the Safety and Efficacy of OP-1 Putty (rhBMP-7) as a Replacement for Iliac Crest Autograft in Posterolateral Lumbar Arthrodesis for Degenerative Spondylolisthesis

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Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein‐2 (rhBMP‐)

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Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: Comparison of adenovirus mediated gene transfer and protein delivery of BMP-2

Meinel, L., Hofmann, S., Betz, O. B., Fajardo, R., Merkle, H. P., Langer, R., Evans, C. H., Vunjak‐Novakovic, G., & Kaplan, D. L. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.05.021 · Cited by 179

BMP-silk composite matrices heal critically sized femoral defects

Kirker-Head, C., Karageorgiou, V., Hofmann, S., Fajardo, R., Betz, O., Merkle, H. P., Hilbe, M., von Rechenberg, B., McCool, J., Abrahamsen, L., et al. (2007) · Bone · doi:10.1016/j.bone.2007.04.186 · Cited by 177

Bone repair with a form of BMP‐2 engineered for incorporation into fibrin cell ingrowth matrices

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BMP-2 induces the expression of chondrocyte-specific genes in bovine synovium-derived progenitor cells cultured in three-dimensional alginate hydrogel

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Effects of geometry of hydroxyapatite as a cell substratum in BMP-induced ectopic bone formation

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Differential degradation rates in vivo and in vitro of biocompatible poly(lactic acid) and poly(glycolic acid) homo- and co-polymers for a polymeric drug-delivery microchip

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Healing of large segmental defects in rat femurs is aided by RhBMP‐2 in PLGA matrix

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Posterolateral lumbar spine fusion with INFUSE bone graft

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Immobilization of bone morphogenetic protein‐2 on a nanofibrous chitosan membrane for enhanced guided bone regeneration

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A new biotechnology for articular cartilage repair: subchondral implantation of a composite of interconnected porous hydroxyapatite, synthetic polymer (PLA-PEG), and bone morphogenetic protein-2 (rhBMP-2)

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BMPs: From bone morphogenetic proteins to body morphogenetic proteins

Reddi, A. H. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.04.003 · Cited by 154

New synthetic biodegradable polymers as BMP carriers for bone tissue engineering

Saito, N., & Takaoka, K. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00040-1 · Cited by 153

Controlled release of rhBMP-2 loaded poly(dl-lactic-co-glycolic acid)/calcium phosphate cement composites in vivo

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In vitro effects of combined and sequential delivery of two bone growth factors

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A Prospective Randomized Study of Posterolateral Lumbar Fusion Using Osteogenic Protein-1 (OP-1) Versus Local Autograft With Ceramic Bone Substitute

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Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites

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Bone Morphogenetic Protein 2 Incorporated into Biomimetic Coatings Retains Its Biological Activity

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Performance of hydroxyapatite bone repair scaffolds created via three‐dimensional fabrication techniques

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Porous starch-based drug delivery systems processed by a microwave route

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Clinical applications of BMP-7

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Bone morphogenetic proteins for spinal fusion

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New starch-based thermoplastic hydrogels for use as bone cements or drug-delivery carriers

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Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins

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Thermoreversible hydrogel scaffolds for articular cartilage engineering

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Bone healing in the rat and dog with nonglycosylated BMP‐2 demonstrating low solubility in fibrin matrices

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Enhanced Bone Regeneration at a Segmental Bone Defect by Controlled Release of Bone Morphogenetic Protein-2 from a Biodegradable Hydrogel

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Evaluation of Polylactic Acid Homopolymers as Carriers for Bone Morphogenetic Protein

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Novel glycidyl methacrylated dextran (Dex-GMA)/gelatin hydrogel scaffolds containing microspheres loaded with bone morphogenetic proteins: Formulation and characteristics

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N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage

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Hyaluronan Supports Recombinant Human Bone Morphogenetic Protein‐2 Induced Bone Reconstruction of Advanced Alveolar Ridge Defects in Dogs. A Pilot Study

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Maxillary Alveolar Cleft Repair in Dogs Using Recombinant Human Bone Morphogenetic Protein-2 and a Polymer Carrier

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Nanoparticle technology in bone tissue engineering

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Biological Activity of rhBMP-2 Released From PLGA Microspheres

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Recombinant Human Bone Morphogenetic Protein‐2 Potentiates the In Vivo Osteogenic Ability of Marrow/Hydroxyapatite Composites

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Comparison of Healos/Bone Marrow to INFUSE(rhBMP-2/ACS) With a Collagen-Ceramic Sponge Bulking Agent as Graft Substitutes for Lumbar Spine Fusion

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Repair of 20‐mm long rabbit radial bone defects using BMP‐derived peptide combined with an α‐tricalcium phosphate scaffold

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Skull Bone Regeneration in Nonhuman Primates by Controlled Release of Bone Morphogenetic Protein-2 from a Biodegradable Hydrogel

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Bone Regeneration in the Rat Mandible with Bone Morphogenetic Protein‐2: A Comparison of Two Carriers

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Biodegradable Poly-D,L-Lactic Acid-Polyethylene Glycol Block Copolymers as a BMP Delivery System for Inducing Bone

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The effect of a fibrin-fibronectin/β-tricalcium phosphate/recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects

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In vivo BMP-7 (OP-1) enhancement of osteoporotic vertebral bodies in an ovine model

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Chondrogenic Differentiation on Perlecan Domain I, Collagen II, and Bone Morphogenetic Protein-2–Based Matrices

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Comparison of BMP‐2 and ‐4 for rat mandibular bone regeneration at various doses1

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Fabrication and release behavior of a novel freeze-gelled chitosan/γ-PGA scaffold as a carrier for rhBMP-2

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A comparative histologic analysis of tissue-engineered bone using platelet-rich plasma and platelet-enriched fibrin glue

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Recombinant human bone morphogenetic protein 2 enhances bone healing in an experimental model of fractures at risk of non-union

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Effect of a Fibrin‐Fibronectin Sealing System as a Carrier for Recombinant Human Bone Morphogenetic Protein‐4 on Bone Formation in Rat Calvarial Defects

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Use of rhBMP-2 Activated Chitosan Films To Improve Osseointegration

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Bone regeneration using a naturally grown HA/TCP carrier loaded with rh BMP‐2 is independent of barrier‐membrane effects

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Cervical spine fusion with bioabsorbable cages

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Enhancement of bone ingrowth in a titanium fiber mesh implant by rhBMP-2 and hyaluronic acid

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Effect of polylactic acid on osteoinduction of demineralized bone: preliminary study of the usefulness of polylactic acid as a carrier of bone morphogenetic protein

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Untitled work

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Effects of protein dose and delivery system on BMP-mediated bone regeneration

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