Diesel exhaust affects immunological action in the placentas of mice
Abstract
We investigated the effect of diesel exhaust (DE) on pregnancy and fetal development in mice at day 14 postcoitum (pc) with a special focus on the placenta. The number of absorbed fetuses increased in groups exposed to DE, and congestion was observed in histological sections of placentas. During placental absorption expression of CYP1A1 mRNA decreased to undetectable levels, whereas expression of TNF alpha mRNA increased approximately twofold over that of the control. Levels of CYP1A1 mRNA in normal placentas from DE-exposed mice were unchanged. mRNA levels of inflammatory cytokines IL-2, IL-5, IL-12 alpha, IL-12 beta, and GM-CSF increased in placentas exposed to DE (0.3 and 3.0 mg diesel exhaust particles (DEP)/m3). Expression of IL-5 mRNA was markedly increased in DE-exposed placentas, although levels were barely detectable in control placentas. IL-6 mRNA expression was increased approximately 10-fold in placentas exposed to DE (3.0 mg DEP/m3). It has been reported that expression of mRNA encoding proteins involved in immune function in the placenta is increased during fetal absorption in mice. In the present study, expression of such mRNA by the placenta was increased by DE exposure. Because it is believed that expression of mRNA in the placenta also affects fetal development, DE may promote fetal absorption. These findings suggest that in mice exposure to DE affects fetal absorption and placental function by modifying expression of immune-related genes during early gestat…
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DE exposure increased placental expression of multiple inflammatory cytokines, especially IL-5 and IL-6 (<tenfold).
“In another mouse model, DE exposure increased placental expression of multiple inflammatory cytokines, especially IL-5 and IL-6 (<tenfold) [168].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [168]
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- Authors
- Fujimoto, A., Tsukue, N., Watanabe, M., Sugawara, I., Yanagisawa, R., Takano, H., Yoshida, S., & Takeda, K.
- Affiliations
- Tokyo University of Science (JP)
- Japan Science and Technology Agency (JP)
- National Institute for Environmental Studies (JP)
- Corresponding author
- Takeda, Ken
- Venue
- Environmental Toxicology
- Publisher
- Wiley
- Published
- 2005
- Volume
- 20
- Issue
- 4
- Pages
- 431-440
- ISSN
- 1520-4081 (ISSN-L)
- 1522-7278
- OpenAlex
- W1969801887
- Cited by
- 60
- References
- 42
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 4 · 2019: 2 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- diesel exhaust, diesel exhaust particles, placenta, pregnancy, fetal development, placental immunity, CYP1A1, TNF-α, inflammatory cytokines, IL-5, interleukin-6, GM-CSF, IL-12, air pollution exposure
- MeSH terms
- Animals, Vehicle Emissions, Dose-Response Relationship, Drug, Female, Litter Size, Male, Mice, Inbred ICR, Placenta, Pregnancy, RNA, Messenger, Sex Ratio, Cytokines, Gene Expression Regulation, Developmental, Fetal Development, Mice
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