Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity and inflammation in mice
Open accessAbstract
BACKGROUND: Results from epidemiological studies indicate that particulate air pollution constitutes a hazard for human health. Recent studies suggest that diesel exhaust possesses endocrine activity and therefore may affect reproductive outcome. This study in mice aimed to investigate whether exposure to diesel exhaust particles (DEP; NIST 2975) would affect gestation, postnatal development, activity, learning and memory, and biomarkers of transplacental toxicity. Pregnant mice (C57BL/6; BomTac) were exposed to 19 mg/m3 DEP (~1.106 particles/cm3; mass median diameter congruent with 240 nm) on gestational days 9-19, for 1 h/day. RESULTS: Gestational parameters were similar in control and diesel groups. Shortly after birth, body weights of DEP offspring were slightly lower than in controls. This difference increased during lactation, so by weaning the DEP exposed offspring weighed significantly less than the control progeny. Only slight effects of exposure were observed on cognitive function in female DEP offspring and on biomarkers of exposure to particles or genotoxic substances. CONCLUSION: In utero exposure to DEP decreased weight gain during lactation. Cognitive function and levels of biomarkers of exposure to particles or to genotoxic substances were generally similar in exposed and control offspring. The particle size and chemical composition of the DEP and differences in exposure methods (fresh, whole exhaust versus aged, resuspended DEP) may play a significant role on the biological effects observed in this compared to other studies.
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Other studies have confirmed early reductions in offspring birth weight following prenatal diesel exhaust particle exposure, which were sustained throughout lactation.
“Other studies have confirmed early reductions in offspring birth weight following prenatal diesel exhaust particle exposure, which were sustained throughout lactation [81].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [81]
The Results (Litter parameters) report that DEP-exposed offspring weighed slightly less shortly after birth, but the difference was not statistically significant. The difference increased during lactation and was significant by weaning. The paper therefore supports lower weight during lactation, but not a confirmed reduction in birth weight sustained throughout it. (LLM, conf=0.88)
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- Authors
- Hougaard, K. S., Jensen, K. A., Nordly, P., Taxvig, C., Vogel, U., Saber, A. T., & Wallin, H.
- Affiliations
- National Research Centre for the Working Environment (DK)
- University of Copenhagen (DK)
- Technical University of Denmark (DK)
- Venue
- Particle and Fibre Toxicology
- Published
- 2008
- Volume
- 5
- Issue
- 1
- Pages
- 3
- ISSN
- 1743-8977 (ISSN-L)
- PMC
- PMC2323399
- OpenAlex
- W2102523805
- Cited by
- 132
- References
- 54
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 13 · 2018: 10 · 2017: 11 · 2016: 5 · 2015: 11 · 2014: 6 · 2013: 10 · 2012: 7
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Particle and Fibre Toxicology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, other-oa)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- diesel exhaust particles, prenatal exposure, postnatal development, weight gain, lactation, cognitive function, learning and memory, genotoxicity, inflammation, particulate matter pollution, endocrine activity, gestation, mice
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