The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
G‐quadruplexes in RNA biology
Abstract
G‐quadruplexes are noncanonical structures formed by G‐rich DNA and RNA sequences that fold into a four‐stranded conformation. Experimental studies and computational predictions show that RNA G‐quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts. RNA G‐quadruplexes at these specific locations play important roles in key cellular functions, including telomere homeostasis and gene expression. Indeed, RNA G‐quadruplexes appear as important regulators of pre‐mRNA processing (splicing and polyadenylation), RNA turnover, mRNA targeting and translation. The regulatory mechanisms controlled by RNA G‐quadruplexes involve the binding of protein factors that modulate G‐quadruplex conformation and/or serve as a bridge to recruit additional protein regulators. In this review, we summarize the current knowledge on the role of G‐quadruplexes in RNA biology with particular emphasis on the molecular mechanisms underlying their specific function in RNA metabolism occurring in physiological or pathological conditions. WIREs RNA 2012, 3:495–507. doi: 10.1002/wrna.1113 This article is categorized under: RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
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Bochman, M. L., Paeschke, K., & Zakian, V. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3296 · Cited by 1,446
Re-evaluation of G-quadruplex propensity with G4Hunter
Bedrat, A., Lacroix, L., & Mergny, J.-L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw006 · Cited by 687
RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria
Guo, J. U., & Bartel, D. P. (2016) · Science · doi:10.1126/science.aaf5371 · Cited by 470
rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome
Kwok, C. K., Marsico, G., Sahakyan, A. B., Chambers, V. S., & Balasubramanian, S. (2016) · Nature Methods · doi:10.1038/nmeth.3965 · Cited by 438
Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery
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Metadata
- Authors
- Millevoi, S., Moine, H., & Vagner, S.
- Venue
- WIREs RNA
- Publisher
- Wiley
- Published
- 2012-04-04
- Volume
- 3
- Issue
- 4
- Pages
- 495-507
- ISSN
- 1757-7004 (ISSN-L)
- 1757-7012
- OpenAlex
- W2013646237
- Cited by
- 277
- References
- 114
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- closed
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