Poly(A) binding proteins: are they all created equal?

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

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Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

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MicroRNAs direct rapid deadenylation of mRNA

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Getting to the Root of miRNA-Mediated Gene Silencing

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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesPreprint

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Internal ribosome entry sites in eukaryotic mRNA moleculesPreprint

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The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

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miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

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Molecular mechanisms of translation initiation in eukaryotes

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A positive-feedback-based bistable ‘memory module’ that governs a cell fate decision.

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Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

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RNA-quality control by the exosome

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Binding of a novel SMG-1–Upf1–eRF1–eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decayPreprint

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Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression.

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Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells

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Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development

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Evidence for a Pioneer Round of mRNA Translation

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A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein

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Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases

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Recognition of Polyadenylate RNA by the Poly(A)-Binding Protein

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mRNA Polyadenylate-Binding Protein: Gene Isolation and Sequencing and Identification of a Ribonucleoprotein Consensus Sequence

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Deadenylation is a widespread effect of miRNA regulation

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Protein factors in pre-mRNA 3′-end processing

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A single domain of yeast poly(A)-binding protein is necessary and sufficient for RNA binding and cell viability.

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Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation

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Maskin Is a CPEB-Associated Factor that Transiently Interacts with eIF-4E

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Upf1 Senses 3′UTR Length to Potentiate mRNA Decay

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Nonsense-Mediated mRNA Decay in Mammalian Cells Involves Decapping, Deadenylating, and Exonucleolytic Activities

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A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: Domain structure and expression

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Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

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GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

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Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

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miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

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mRNA poly(A) tail, a 3' enhancer of translational initiation.

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A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

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The Poly(A)-Binding Protein Nuclear 1 Suppresses Alternative Cleavage and Polyadenylation Sites

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Eukaryotic translation initiation factors and regulators

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Symplekin and xGLD-2 Are Required for CPEB-Mediated Cytoplasmic Polyadenylation

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Rotavirus RNA‐binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F

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Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

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miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

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Structure and function of poly(A) binding proteins

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Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation

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Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay

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Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation.

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Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3′ Untranslated Region

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EJC-independent degradation of nonsense immunoglobulin-μ mRNA depends on 3′ UTR length

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Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.

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Translation Initiation Factors eIF-iso4G and eIF-4B Interact with the Poly(A)-binding Protein and Increase Its RNA Binding Activity

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The mRNA Poly(A)-Binding Protein: Localization, Abundance, and RNA-Binding Specificity

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eIF4G Dramatically Enhances the Binding of eIF4E to the mRNA 5′-Cap Structure

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The DAZL family proteins are PABP‐binding proteins that regulate translation in germ cells

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The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities.

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XenopusPoly(A) Binding Protein: Functional Domains in RNA Binding and Protein – Protein Interaction

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An NMD Pathway in Yeast Involving Accelerated Deadenylation and Exosome-Mediated 3′→5′ Degradation

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Dissolution of the maskin–eIF4E complex by cytoplasmic polyadenylation and poly(A)‐binding protein controls cyclin B1 mRNA translation and oocyte maturation

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mRNA quality control: An ancient machinery recognizes and degrades mRNAs with nonsense codons

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Translational Repression by a Novel Partner of Human Poly(A) Binding Protein, Paip2

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Poly(A) Tail Length Is Controlled by the Nuclear Poly(A)-binding Protein Regulating the Interaction between Poly(A) Polymerase and the Cleavage and Polyadenylation Specificity Factor

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Structure and function of the C-terminal PABC domain of human poly(A)-binding protein

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Ago–TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps

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Translational control by cytoplasmic polyadenylation in Xenopus oocytes

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The Silencing Domain of GW182 Interacts with PABPC1 To Promote Translational Repression and Degradation of MicroRNA Targets and Is Required for Target Release

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Cleavage of Poly(A)-Binding Protein by Poliovirus 3C Protease Inhibits Host Cell Translation: a Novel Mechanism for Host Translation Shutoff

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Possible Involvement of poly(A) in protein synthesks

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Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

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Human Proline-Rich Nuclear Receptor Coregulatory Protein 2 Mediates an Interaction between mRNA Surveillance Machinery and Decapping Complex

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Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells

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Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein

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Global Changes in Processing of mRNA 3′ Untranslated Regions Characterize Clinically Distinct Cancer Subtypes

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The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

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Paip1 Interacts with Poly(A) Binding Protein through Two Independent Binding Motifs

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CCR4-NOT Deadenylates mRNA Associated with RNA-Induced Silencing Complexes in Human Cells

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Cooperative modulation by eIF4G of eIF4E‐binding to the mRNA 5′ cap in yeast involves a site partially shared by p20

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Rapid Deadenylation Triggered by a Nonsense Codon Precedes Decay of the RNA Body in a Mammalian Cytoplasmic Nonsense-Mediated Decay Pathway

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Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression

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Wheat Germ Poly(A) Binding Protein Enhances the Binding Affinity of Eukaryotic Initiation Factor 4F and (iso)4F for Cap Analogues

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Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression

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Recognition and elimination of nonsense mRNA

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Biochemical characterisation of cap-poly(A) synergy in rabbit reticulocyte lysates: the eIF4G-PABP interaction increases the functional affinity of eIF4E for the capped mRNA 5'-end

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Regulation of Poly(A)-binding Protein through PABP-interacting ProteinsPreprint

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Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl

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Structural basis of ligand recognition by PABC, a highly specific peptide‐binding domain found in poly(A)‐binding protein and a HECT ubiquitin ligase

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The DAZL and PABP families: RNA-binding proteins with interrelated roles in translational control in oocytes

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PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding

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Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

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Differential effects of aromatic and charged residue substitutions in the RNA binding domains of the yeast Poly(A)-binding protein

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Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish

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The eIF4E/eIF4G Interaction Inhibitor 4EGI-1 Augments TRAIL-Mediated Apoptosis through c-FLIP Down-regulation and DR5 Induction Independent of Inhibition of Cap-Dependent Protein Translation

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The Phosphorylation State of Poly(A)-binding Protein Specifies Its Binding to Poly(A) RNA and Its Interaction with Eukaryotic Initiation Factor (eIF) 4F, eIFiso4F, and eIF4B

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Multiple elements in the eIF4G1 N‐terminus promote assembly of eIF4G1•PABP mRNPs in vivo

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Poly(A)-binding protein (PABP): a common viral target

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Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs

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Identification of a C-terminal Poly(A)-binding Protein (PABP)-PABP Interaction Domain

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Negative Control of the Poly(A)-binding Protein mRNA Translation Is Mediated by the Adenine-rich Region of Its 5′-Untranslated Region

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X-ray structure of the human hyperplastic discs protein: An ortholog of the C-terminal domain of poly(A)-binding protein

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Interaction between Ski7p and Upf1p is required for nonsense‐mediated 3′‐to‐5′ mRNA decay in yeast

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Ubiquitination and Proteasome-dependent Degradation of Human Eukaryotic Translation Initiation Factor 4E

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Unexpected Complexity of Poly(A)-Binding Protein Gene Families in Flowering Plants: Three Conserved Lineages That Are at Least 200 Million Years Old and Possible Auto- and Cross-Regulation

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The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice

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Crossing the borders: Poly(A)-binding proteins working on both sides of the fence

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Wheat Germ Poly(A)-binding Protein Increases the ATPase and the RNA Helicase Activity of Translation Initiation Factors eIF4A, eIF4B, and eIF-iso4F

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Rrp6p Controls mRNA Poly(A) Tail Length and Its Decoration with Poly(A) Binding Proteins

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PABP is not essential for microRNA‐mediated translational repression and deadenylation in vitro

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Sequential waves of polyadenylation and deadenylation define a translation circuit that drives meiotic progression

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Arabidopsis thaliana class II poly(A)-binding proteins are required for efficient multiplication of turnip mosaic virus

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Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression

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Poly(A)-binding proteins are functionally distinct and have essential roles during vertebrate development

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Embryonic Poly(A)-Binding Protein Stimulates Translation in Germ Cells

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Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL

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Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B

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Poly(A)-Binding Protein 1 Partially Relocalizes to the Nucleus during Herpes Simplex Virus Type 1 Infection in an ICP27-Independent Manner and Does Not Inhibit Virus Replication

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The multifunctional poly(A)-binding protein (PABP) 1 is subject to extensive dynamic post-translational modification, which molecular modelling suggests plays an important role in co-ordinating its activities

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Translational Control of Poly(A)‐Binding Protein Expression

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mRNA-specific regulation of translation by poly(A)-binding proteins

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Recognition of nonsense mRNA: towards a unified model

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Expression of poly(A)‐binding protein is upregulated during recovery from heat shock in HeLa cells

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East of EDEN was a poly(A) tail

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Pabp binds to the osk 3′UTR and specifically contributes to osk mRNA stability and oocyte accumulation

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Homeostasis in mRNA Initiation

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Solution Structure of the Orphan PABC Domain fromSaccharomyces cerevisiae Poly(A)-binding Protein

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Nanopore Detachment Kinetics of Poly(A) Binding Proteins from RNA Molecules Reveals the Critical Role of C-Terminus Interactions

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Identification and characterization of proteins that interact with the carboxy terminus of poly(A)-binding protein and inhibit translation in vitro

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Kinetic Mechanism for the Binding of eIF4F and Tobacco Etch Virus Internal Ribosome Entry Site RNA

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Poly(A)-Binding Protein Increases the Binding Affinity and Kinetic Rates of Interaction of Viral Protein Linked to Genome with Translation Initiation Factors eIFiso4F and eIFiso4F·4B Complex

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Effects of poly(A)-binding protein on the interactions of translation initiation factor eIF4F and eIF4F·4B with internal ribosome entry site (IRES) of tobacco etch virus RNA

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Solution Structure of the PABC Domain from Wheat Poly (A)-Binding Protein: An Insight into RNA Metabolic and Translational Control in Plants

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Poly(A) tail affects equilibrium and thermodynamic behavior of tobacco etch virus mRNA with translation initiation factors eIF4F, eIF4B and PABP

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Sequence diversity and conservation of the poly(A)-binding protein in plants

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A PASport to Cellular Proliferation

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Advances in COVID-19 mRNA vaccine development

Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601 · see citing works

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

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Identifying RBP Targets with RIP-seq

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Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast.Preprint

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Evidence that Poly(A) Binding Protein C1 Binds Nuclear Pre-mRNA Poly(A) Tails

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Specificity factors in cytoplasmic polyadenylation

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The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein QuakingPreprint

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