Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells
Abstract
MicroRNAs (miRNAs) are 20-nt-long to 24-nt-long noncoding RNAs acting as post-transcriptional regulators of gene expression in animals and plants. In mammals, more than 50% of mRNAs are predicted to be the subject of miRNA-mediated control but mechanistic aspects of the regulation are not fully understood and different studies have produced often-contradictory results. miRNAs can affect both the translation and stability of mRNAs. In this report, we review current progress in understanding how miRNAs execute these effects in animals and we discuss some of the controversies regarding different modes of miRNA function.
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miRNAs direct translational repression by partial binding to the 3' UTR of mRNAs after incorporation into an RNA-induced silencing complex containing Argonaute-2 (Ago2).
“miRNAs direct translational repression by partial binding to the 3Ј UTR of mRNAs after first being incorporated into an RNA-induced silencing complex containing Argonaute-2 (Ago2) (Gregory et al., 2005;Chekulaeva and Filipowicz, 2009;Ha and Kim, 2014).”
From MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models (2017) · cites this paper as Chekulaeva and Filipowicz, 2009
Cites
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“Different degrees of destabilization appear to apply to the majority of mRNA targets, as demonstrated by microarray analyses of transcript levels in cells and organs in which the miRNA pathway was inhibited or in which miRNA levels were experimentally increased or decreased [26,54,58,60,61,64–69].”
BackgroundP-body formation is a consequence, not the cause, of RNA-mediated gene silencing
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Self-citationRegulation of mRNA Translation and Stability by microRNAs
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MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models
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- Authors
- Chekulaeva, M., & Filipowicz, W.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 21
- Issue
- 3
- Pages
- 452-460
- ISSN
- 0955-0674
- Cited by
- 595
- References
- 6
- Language
- en
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