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Cited by 24Cancer-related molecular mechanisms researchRNA Research and SplicingMicroRNA in disease regulation

Noncoding RNA mutations in cancer

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Zhou, Honghong, Hao, Xinpei, Zhang, Peng, He, Shunmin·2023·WIREs RNA
DOI 10.1002/wrna.1812
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Abstract

Cancer is driven by both germline and somatic genetic changes. Efforts have been devoted to characterizing essential genetic variations in cancer initiation and development. Most attention has been given to mutations in protein‐coding genes and associated regulatory elements such as promoters and enhancers. The development of sequencing technologies and in silico and experimental methods has allowed further exploration of cancer predisposition variants and important somatic mutations in noncoding RNAs, mainly for long noncoding RNAs and microRNAs. Association studies including GWAS have revealed hereditary variations including SNPs and indels in lncRNA or miRNA genes and regulatory regions. These mutations altered RNA secondary structures, expression levels, and target recognition and then conferred cancer predisposition to carriers. Whole‐exome/genome sequencing comparing cancer and normal tissues has revealed important somatic mutations in noncoding RNA genes. Mutation hotspots and somatic copy number alterations have been identified in various tumor‐associated noncoding RNAs. Increasing focus and effort have been devoted to studying the noncoding region of the genome. The complex genetic network of cancer initiation is being unveiled. This article is categorized under: RNA in Disease and Development > RNA in Disease

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  • Mutations in miRNA sequence bases may alter its secondary structure, expression levels, and target recognition.

    “Because mutations in the miRNA sequence bases may alter its secondary structure, expression levels, and target recognition [11].”

    From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [11]

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Cited by

Sorted by citations

Authors
Zhou, H., Hao, X., Zhang, P., & He, S.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics Chinese Academy of Sciences Beijing China
Corresponding author
He, Shunmin
ORCID
Venue
WIREs RNA
Publisher
Wiley
Published
2023-08-06
Volume
14
Issue
6
Pages
e1812-e1812
ISSN
  • 1757-7004 (ISSN-L)
  • 1757-7012
DOI
10.1002/wrna.1812
OpenAlex
W4385613978
Cited by
24
References
11
Citations by year
2026: 4 · 2025: 9 · 2024: 10 · 2023: 1
FWCI
0.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Wiley Interdisciplinary Reviews - RNA (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81902519, 91940306, 31871294, 81871898)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Keywords
long non-coding RNA, microRNA, somatic mutations, germline mutations, cancer susceptibility, copy number alterations, mutational hotspots, RNA secondary structure, miRNA target recognition, tumor initiation
MeSH terms
Humans, Mutation, Neoplasms, Genetic Predisposition to Disease, RNA, Untranslated, MicroRNAs, Gene Regulatory Networks, RNA, Long Noncoding

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