International network of cancer genome projects
Open accessAbstract
Hundreds of individual human cancer genome sequences are expected to be published in 2010, and thousands per year after that. The International Cancer Genome Consortium (ICGC) was launched with the aim of keeping track of the data relating to large-scale cancer genome studies of all major cancers in adults and children — a total of 50 different cancer types and/or subtypes. In this issue the ICGC team ( http://www.icgc.org ) spells out the policies and planning for the project. The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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The human genome consists of approximately 3 billion base pairs, posing significant computational challenges such as execution time, memory usage, and management of genomic rearrangements.
“For instance, the human genome consists of approximately 3 billion base pairs, posing significant computational challenges such as execution time, memory usage, and management of genomic rearrangements [9].”
From Whole-Genome Alignment: Methods, Challenges, and Future Directions (2024) · cites this paper as [9]
The “ICGC in the Next Decade” section describes the difficulty of accurately assembling highly rearranged chromosomes in tumor cells, and “ICGC Datasets” describes storage difficulties caused by large datasets. Neither section gives the human genome’s size as approximately 3 billion base pairs or identifies execution time and memory usage as challenges. (LLM, conf=0.86)
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- Authors
- The International Cancer Genome Consortium
- Venue
- Nature
- Published
- 2010-04-15
- Volume
- 464
- Issue
- 7291
- Pages
- 993-998
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2902243
- OpenAlex
- W2121906867
- Cited by
- 2,299
- References
- 7
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- FWCI
- 42.57
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- journal article
- Language
- en
- Update notices
- erratum (2010-06-17)
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- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- National University of Singapore (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HAL (submittedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Wellcome Trust (077198, 088340, 093867)
- Japan Society for the Promotion of Science (20221009)
- National Heart, Lung, and Blood Institute (R01HL055268)
- National Human Genome Research Institute (R01HG001806)
- National Cancer Institute (P50CA127003, R21CA094510, P50CA102701, P01CA117969)
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK071329)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Reproductive Medicine › Science, Research, and Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- ICGC, cancer genome sequencing, oncogenic mutations, mutagenesis, tumor subtypes, epigenomics, transcriptomics, cancer therapy development
- MeSH terms
- DNA Mutational Analysis, Genetics, Medical, Humans, International Cooperation, Mutation, Neoplasms, Genome, Human, Intellectual Property, DNA Methylation, Genomics, Databases, Genetic, Genes, Neoplasm
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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