The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Electrical Stimulation Induces the Level of TGF-β1 mRNA in Osteoblastic Cells by a Mechanism Involving Calcium/Calmodulin Pathway
Open accessAbstract
It is well-known that electrical stimulation can prompt healing of bone fractures. However, the mechanism involved is less clear. In this study, we found that capacitively coupled electric field-induced proliferation of osteoblastic cells (MC3T3-E1) accompanied increased levels of transforming growth factor-beta 1 (TGF-beta1) mRNA determined by quantitative reverse transcription/polymerase chain reaction. Previous reports have shown that verapamil and W-7, both of which block voltage gated calcium channels and inhibit the activation of cytosolic calmodulin, respectively, blocked capacitively coupled electric field-induced proliferation of the osteoblast cells. Interestingly, we found that verapamil and W-7 can also block capacitively coupled electric field-induced elevation of TGF-beta1 mRNA. This result suggested that electrical stimulation induces the level of TGF-beta1 mRNA in osteoblastic cells by a mechanism involving calcium/calmodulin pathway. The potential roles of TGF-beta in the electrical signal-induced osteogenesis was discussed.
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Tibial nonunion treated with direct current, capacitive coupling, or bone graft
Brighton, C. T., Shaman, P., Bruce, R., Esterhai, J. L., Pollack, S. R., & Friedenberg, Z. B. (1995) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199512000-00034 · Cited by 116
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Cited by
Piezoelectric polymers as biomaterials for tissue engineering applications
Ribeiro, C., Sencadas, V., Correia, D. M., & Lanceros-Méndez, S. (2015) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2015.08.043 · Cited by 521
Piezoelectric smart biomaterials for bone and cartilage tissue engineering
Jacob, J., More, N., Kalia, K., & Kapusetti, G. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0059-8 · Cited by 454
Electrical Stimulation: A Novel Tool for Tissue Engineering
Balint, R., Cassidy, N. J., & Cartmell, S. H. (2013) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2012.0183 · Cited by 405
Cellular mechanisms of direct-current electric field effects: galvanotaxis and metastatic disease
Mycielska, M. E., & Djamgoz, M. B. A. (2004) · Journal of Cell Science · doi:10.1242/jcs.01125 · Cited by 375
Supronowicz, P. R., Ajayan, P. M., Ullmann, K. R., Arulanandam, B. P., Metzger, D. W., & Bizios, R. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.10015 · Cited by 366
Metadata
- Authors
- Zhuang, H., Wang, W., Seldes, R. M., Tahernia, A. D., Fan, H., & Brighton, C. T.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 237
- Issue
- 2
- Pages
- 225-229
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2048545216
- Cited by
- 213
- References
- 1
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Electrical Stimulation Induces the Level of TGF-β1 mRNA in Osteoblastic Cells by a Mechanism Involving Calcium/Calmodulin Pathway. https://app.cochat.ai/papers/10.1006/bbrc.1997.7118
- The paper
- Zhuang, H., Wang, W., Seldes, R. M., Tahernia, A. D., Fan, H., & Brighton, C. T. (1997). Electrical Stimulation Induces the Level of TGF-β1 mRNA in Osteoblastic Cells by a Mechanism Involving Calcium/Calmodulin Pathway. Biochemical and Biophysical Research Communications. https://doi.org/10.1006/bbrc.1997.7118
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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