Osteoclastogenesis inhibitory factor (OCIF) directly inhibits bone-resorbing activity of isolated mature osteoclasts.
Abstract
Osteoclastogenesis inhibitory factor (OCIF) was previously reported to specifically inhibit osteoclast development by interrupting the action of osteoclast differentiation factor (ODF), which is expressed in stromal cells and plays an important role in osteoclastogenesis. Here we report the direct action of OCIF on isolated rabbit mature osteoclasts to inhibit their functional bone-resorbing activity. The cell population employed in this study consisted of mature osteoclasts with more than 95% of purity. The inhibition by OCIF was dose dependent and observed as early as 6 h after the OCIF addition. An OCIF-binding protein of 140 kDa was detected on the plasma membrane of osteoclasts. ODF with a Mr of 40 kDa was recently isolated as a ligand for OCIF and shows to be identical to TRANCE/RANKL. However, ODF was not detected in osteoclasts. OCIF did not have any impact on the mRNA levels of cathepsin K/OC2 and carbonic anhydrase II responsible for degradation of organic and inorganic bone matrices, respectively, or on osteoclast apoptosis. However, OCIF reduced or disrupted the formation of F-actin ring in isolated osteoclasts, the cytoskeletal structure of which is correlated with bone resorption. These findings demonstrate that OCIF directly inhibits osteoclast function through an ODF-independent mechanism besides blocking the generation of osteoclasts.
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OPG/OCIF suppresses osteoclastogenesis in vitro and also suppresses osteoclast activity, survival, and adhesion to bone surfaces.
“This molecule was referred to as osteoclastogenesis inhibitory factor (OCIF) based on its ability to suppress osteoclastogenesis in vitro (5).OPG/OCIF was shown soon thereafter to also suppress osteoclast activity (7)(8)(9), survival (10,11), and adhesion to bone surfaces (12,13).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [8]
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444 · see citing works
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439 · see citing works
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130 · see citing works
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224 · see citing works
Self-citationA homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290 · see citing works
(2019) · Elsevier eBooks · doi:10.1016/c2015-1-01622-2 · Cited by 1,690 · see citing works
Compston, J. E. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.2431019.x · Cited by 1,383 · see citing works
Yasuda, H., Shima, N., Nakagawa, N., Mochizuki, S.-I., Yano, K., Fujise, N., Sato, Y., Goto, M., Yamaguchi, K., Kuriyama, M., et al. (1998) · Endocrinology · doi:10.1210/endo.139.3.5837 · Cited by 1,201 · see citing works
Self-citationWong, B. R., Rho, J., Arron, J. R., Robinson, E. A., Orlinick, J. R., Chao, M. V., Kalachikov, S. M., Cayani, E., Bartlett, F. S., Frankel, W. N., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25190 · Cited by 1,042 · see citing works
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.
Tsuda, E., Goto, M., Mochizuki, S.-I., Yano, K., Kobayashi, F., Morinaga, T., & Higashio, K. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6603 · Cited by 787 · see citing works
Self-citationEstrogen Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts
Kameda, T., Mano, H., Yuasa, T., Mori, Y., Miyazawa, K., Shiokawa, M., Nakamaru, Y., 広井, 恵., Hiura, K., Kameda, A., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.4.489 · Cited by 519 · see citing works
Self-citationKinetics of the osteoclast cytoskeleton during the resorption cycle in vitro
Lakkakorpi, P. T., & Väänänen, K. (1991) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650060806 · Cited by 248 · see citing works
Identification of osteopontin in isolated rabbit osteoclasts
Tezuka, K.-I., Sato, T., Kamioka, H., Nijweide, P. J., Tanaka, K., Matsuo, T., Ohta, M., Kurihara, N., Hakeda, Y., & Kumegawa, M. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90832-6 · Cited by 209 · see citing works
Self-citationZambonin-Zallone, A., Teti, A. M., Grano, M., Rubinacci, A., Abbadini, M., Gaboli, M. P., & Marchisio, P. C. (1989) · Experimental Cell Research · doi:10.1016/0014-4827(89)90266-8 · Cited by 201 · see citing works
Characterization of Structural Domains of Human Osteoclastogenesis Inhibitory Factor
Yamaguchi, K., Kinosaki, M., Goto, M., Kobayashi, F., Tsuda, E., Morinaga, T., & Higashio, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5117 · Cited by 200 · see citing works
Self-citationLee, K. (1994) · Endocrinology · doi:10.1210/en.134.1.441 · Cited by 183 · see citing works
Lee, K., Deeds, J. D., Chiba, S., UN-NO, M., Bond, A., & Segre, G. V. (1994) · Endocrinology · doi:10.1210/endo.134.1.8275957 · Cited by 135 · see citing works
Suzuki, H., Nakamura, I., Takahashi, N., Ikuhara, T., Matsuzaki, K., Isogai, Y., Hori, M., & Suda, T. (1996) · Endocrinology · doi:10.1210/endo.137.11.8895334 · Cited by 114 · see citing works
Mammalian Mature Osteoclasts as Estrogen Target Cells
Mano, H., Yuasa, T., Kameda, T., Miyazawa, K., Nakamaru, Y., Shiokawa, M., Mori, Y., Yamada, T., Miyata, K., Shindo, H., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0947 · Cited by 97 · see citing works
Self-citationA simple method to assess osteoclast-mediated bone resorption using unfractionated bone cells
Takada, Y., Kusuda, M., Hiura, K., Sato, T., Mochizuki, H., Nagao, Y., Tomura, M., YAHIRO, M., Hakeda, Y., KAWASHIMA, H., et al. (1992) · Bone and Mineral · doi:10.1016/0169-6009(92)90785-c · Cited by 97 · see citing works
Self-citationVitamin D and the hematolymphopoietic tissue: a 1994 update.
Manolagas, S. C., Yu, X., Girasole, G., & Bellido, T. (1994) · PubMed · Cited by 96 · see citing works
Characterization of monomeric and homodimeric forms of osteoclastogenesis inhibitory factor.
Tomoyasu, A., Goto, M., Fujise, N., Mochizuki, S.-I., Yasuda, H., Morinaga, T., Tsuda, E., & Higashio, K. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8443 · Cited by 83 · see citing works
Self-citationDetection and Characterization of Apoptosis in Osteoclasts in Vitro
Kameda, T., Ishikawa, H., & Tsutsui, T. W. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1251 · Cited by 62 · see citing works
Teti, A. M., Taranta, A., Migliaccio, S., Degiorgi, A., Santandrea, E., Villanova, I., Faraggiana, T., Chellaiah, M., & Hruska, K. A. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.1.50 · Cited by 43 · see citing works
Kakudo, S., Miyazawa, K., Kameda, T., Mano, H., Mori, Y., Yuasa, T., Nakamaru, Y., Shiokawa, M., Nagahira, K., Tokunaga, S., et al. (1996) · Journal of Bone and Mineral Metabolism · doi:10.1007/bf02239480 · Cited by 43 · see citing works
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Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Boyle, W. J., & Riggs, B. L. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.1.2 · Cited by 1,167 · see citing works
IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology
Tat, S. K., Marc, P., Théoleyre, S., Heymann, D., & Fortun, Y. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2003.10.005 · Cited by 959 · see citing works
Kearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824 · see citing works
Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond
Walsh, M. C., & Choi, Y. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00511 · Cited by 599 · see citing works
Role of receptor activator of nuclear factor-κB ligand and osteoprotegerin in bone cell biology
Hofbauer, L. C., & Heufelder, A. E. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100226 · Cited by 586 · see citing works
Cell biology of the osteoclast
Roodman, G. D. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(99)00061-2 · Cited by 570 · see citing works
The effect of a single dose of osteoprotegerin in postmenopausal women.
Bekker, P. J., Holloway, D., Nakanishi, A., Arrighi, M., Leese, P. T., & Dunstan, C. R. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.2.348 · Cited by 484 · see citing works
Kikuchi, T., Matsuguchi, T., Tsuboi, N., Mitani, A., Tanaka, S., Matsuoka, M., Yamamoto, G., Hishikawa, T., Noguchi, T., & Yoshikai, Y. (2001) · Journal of Immunology · doi:10.4049/jimmunol.166.5.3574 · Cited by 265 · see citing works
Transforming Growth Factor β Affects Osteoclast Differentiation via Direct and Indirect Actions
Quinn, J. M. W., Itoh, K., Udagawa, N., Häusler, K., Yasuda, H., Shima, N., Mizuno, A., Higashio, K., Takahashi, N., Suda, T., et al. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.10.1787 · Cited by 278 · see citing works
Self-citationWalsh, M. C., & Choi, Y. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00027-3 · Cited by 199 · see citing works
Teraoka, S. N., Malone, K. E., Doody, D. R., Suter, N. M., Ostrander, E. A., Daling, J. R., & CONCANNON, P. J. (2001) · Cancer · doi:10.1002/1097-0142(20010801)92:3 · Cited by 111 · see citing works
The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis
Haynes, D. R., Crotti, T. N., Potter, A. E., Loric, M., Atkins, G. J., Howie, D. W., & Findlay, D. M. (2001) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.83b6.10905 · Cited by 186 · see citing works
Thirunavukkarasu, K., Halladay, D., Miles, R. R., Yang, X., Galvin, R. J. S., Chandrasekhar, S., Martin, T. J., & Onyia, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000322200 · Cited by 181 · see citing works
Kazama, J. J., Shigematsu, T., Yano, K., Tsuda, E., Miura, M., Iwasaki, Y., Kawaguchi, Y., Gejyo, F., Kurokawa, K., & Fukagawa, M. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.31402 · Cited by 169 · see citing works
Self-citationHofbauer, L. C., & Heufelder, A. E. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6702 · Cited by 175 · see citing works
Pettit, A. R., Walsh, N. C., Manning, C., Goldring, S. R., & Gravallese, E. M. (2006) · Rheumatology · doi:10.1093/rheumatology/kel045 · Cited by 151 · see citing works
Wada, N., Maeda, H., Yoshimine, Y., & Akamine, A. (2004) · Bone · doi:10.1016/j.bone.2004.04.023 · Cited by 145 · see citing works
Stimulation of Osteoprotegerin (OPG) Gene Expression by Transforming Growth Factor-β (TGF-β)
Thirunavukkarasu, K., Miles, R. R., Halladay, D., Yang, X., Galvin, R. J. S., Chandrasekhar, S., Martin, T. J., & Onyia, J. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104319200 · Cited by 138 · see citing works
Lee, C. A., & Einhorn, T. A. (2001) · Elsevier eBooks · doi:10.1016/b978-012470862-4/50002-7 · Cited by 135 · see citing works
Hofbauer, L. C. (1999) · European Journal of Endocrinology · doi:10.1530/eje.0.1410195 · Cited by 120 · see citing works
Osteoclast formation and resorption
Lerner, U. H. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00052-4 · Cited by 114 · see citing works
New Perspective in Osteoarthritis: The OPG and RANKL System as a Potential Therapeutic Target?
Tat, S. K., Pelletier, J.-P., Velasco, C. R., Padrines, M., & Martel-Pelletier, J. (2009) · The Keio Journal of Medicine · doi:10.2302/kjm.58.29 · Cited by 112 · see citing works
Osteoprotegerin in the Inner Ear May Inhibit Bone Remodeling in the Otic Capsule
Zehnder, A. F., Kristiansen, A. G., Adams, J. C., Merchant, S. N., & McKenna, M. J. (2005) · The Laryngoscope · doi:10.1097/01.mlg.0000150702.28451.35 · Cited by 112 · see citing works
Arko, B., Preželj, J., Komel, R., Kocijancic, A., Hudler, P., & Marc, J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020124 · Cited by 105 · see citing works
Transcriptional Mechanisms of Bone Morphogenetic Protein-induced Osteoprotegrin Gene Expression
Wan, M., Shi, X., Feng, X., & Cao, X. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006918200 · Cited by 104 · see citing works
Capparelli, C., Morony, S., Warmington, K., Adamu, S., Lacey, D., Dunstan, C. R., Stouch, B., Martin, S., & Kostenuik, P. J. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.5.852 · Cited by 103 · see citing works
Dexamethasone promotes osteoclastogenesis by inhibiting osteoprotegerin through multiple levels
Kondo, T., Kitazawa, R., Yamaguchi, A., & Kitazawa, S. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21414 · Cited by 103 · see citing works
Regulation of osteoclast activity
Greenfield, E. M., Bi, Y., & Miyauchi, A. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00156-3 · Cited by 97 · see citing works
Makhluf, H. A., Mueller, S. M., Mizuno, S., & Glowacki, J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2182 · Cited by 96 · see citing works
Théoleyre, S., Tat, S. K., Vusio, P., Blanchard, F., Gallagher, J. T., Ricard‐Blum, S., Fortun, Y., Padrines, M., Rédiní, F., & Heymann, D. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.06.120 · Cited by 94 · see citing works
High serum osteoprotegerin and low RANKL in primary biliary cirrhosis
Szalay, F., Hegedüs, D., Lakatos, P. L., Tornai, I., Bajnok, É., Dunkel, K., & Lakatos, P. L. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00435-x · Cited by 91 · see citing works
Yamada, Y., Ito, A., Kojima, H., Sakane, M., Miyakawa, S., Uemura, T., & LeGeros, R. Z. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31265 · Cited by 76 · see citing works
1α,25 Dihydroxyvitamin D3 Rapidly Regulates the Mouse Osteoprotegerin Gene Through Dual Pathways
Kondo, T., Kitazawa, R., Maeda, S., & Kitazawa, S. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040604 · Cited by 76 · see citing works
A Novel Osteoblast-derived C-type Lectin That Inhibits Osteoclast Formation
Zhou, H., Kartsogiannis, V., Hu, Y. S., Elliott, J., Quinn, J. M. W., McKinstry, W. J., Gillespie, M. T., & Ng, K. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011554200 · Cited by 74 · see citing works
Arko, B., Preželj, J., Kocijančič, A., Komel, R., & Marc, J. (2004) · Maturitas · doi:10.1016/j.maturitas.2004.08.006 · Cited by 71 · see citing works
Sultana, F., Neog, M. K., & Rasool, M. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.04.046 · Cited by 63 · see citing works
Fahrleitner-Pammer, A., Dobnig, H., Piswanger-Soelkner, C., Bonelli, C., Dimai, H.-P., Leb, G., & Obermayer-Pietsch, B. (2003) · Wiener Klinische Wochenschrift · doi:10.1007/bf03040334 · Cited by 62 · see citing works
Osteoprotegerin differentially regulates protease expression in osteoclast cultures
Wittrant, Y., Couillaud, S., Théoleyre, S., Dunstan, C. R., Heymann, D., & Rédiní, F. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00179-1 · Cited by 61 · see citing works
Role of the RANK/RANKL pathway in breast cancer
Kiesel, L., & Kohl, A. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.01.001 · Cited by 61 · see citing works
Mundy, G. R., Oyajobi, B. O., Gutierrez, G. E., Sterling, J. A. R., Padalecki, S. S., Elefteriou, F., & Zhao, M. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50020-3 · Cited by 59 · see citing works
Gao, L., & Zhang, S. (2022) · Pharmaceuticals · doi:10.3390/ph15040397 · Cited by 58 · see citing works
Yamada, Y. (2003) · Molecular Genetics and Metabolism · doi:10.1016/s1096-7192(03)00125-2 · Cited by 57 · see citing works
Sobue, T., Hakeda, Y., Kobayashi, Y., Hayakawa, H., Yamashita, K., Aoki, T., Kumegawa, M., Noguchi, T., & Hayakawa, T. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.12.2205 · Cited by 57 · see citing works
Self-citationOsteoprotegerin, an endogenous antiosteoclast factor for protecting bone in rheumatoid arthritis
Bolon, B. N., Shalhoub, V., Kostenuik, P. J., Campagnuolo, G., Morony, S., Boyle, W. J., Zack, D. J., & Feige, U. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10680 · Cited by 57 · see citing works
Wittrant, Y., Théoleyre, S., Couillaud, S., Dunstan, C. R., Heymann, D., & Rédiní, F. (2003) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.10.016 · Cited by 55 · see citing works
O’Brien, E. A., Williams, J. H. H., & Marshall, M. J. E. (2001) · Bone · doi:10.1016/s8756-3282(00)00431-2 · Cited by 54 · see citing works
Sun, J., Li, J., Liu, X., Wei, L., Wang, G., & Meng, F. (2009) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2009.01.007 · Cited by 51 · see citing works
Théoleyre, S., Wittrant, Y., Couillaud, S., Vusio, P., Berreur, M., Dunstan, C. R., Blanchard, F., Rédiní, F., & Heymann, D. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2003.10.005 · Cited by 49 · see citing works
Buckley, K. A., & Fraser, W. D. (2002) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456320203900602 · Cited by 45 · see citing works
Effects of cod bone gelatin on bone metabolism and bone microarchitecture in ovariectomized rats.
Han, X., Xu, Y.-J., Wang, J.-B., Pei, X.-R., Yang, R.-Y., Li, N., & Li, Y. (2009) · Bone · doi:10.1016/j.bone.2008.12.005 · Cited by 41 · see citing works
The TNF Receptor Superfamily: Role in Immune Inflammation and Bone Formation
Cheng, X., Kinosaki, M., Murali, R., & Greene, M. I. (2003) · Immunologic Research · doi:10.1385/ir:27:2-3:287 · Cited by 42 · see citing works
Retardation in Bone Resorption after Bone Marrow Ablation in Klotho Mutant Mice1
Yamashita, T., Yoshitake, H., Tsuji, K., Kawaguchi, N., Nabeshima, Y., & Noda, M. (2000) · Endocrinology · doi:10.1210/endo.141.1.7252 · Cited by 40 · see citing works
Li, L., Yu, J., Wang, Y., & Ding, Y. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.070437 · Cited by 38 · see citing works
Seck, T. L., Diel, I., Bismar, H., Ziegler, R., & Pfeilschifter, J. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1450199 · Cited by 34 · see citing works
Poulsen, R. C., Wolber, F. M., Moughan, P. J., & Kruger, M. C. (2007) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2007.10.004 · Cited by 33 · see citing works
Oh, K. W., Rhee, E., Lee, W., Kim, S. W., Oh, E. S., Baek, K. H., Kang, M. I., Choi, M. G., Yoo, H. J., & Park, S. W. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02090.x · Cited by 34 · see citing works
Takizawa, M., Suzuki, K., Matsubayashi, T., Kikuyama, M., Suzuki, H., Takahashi, K., Katsuta, H., Mitsuhashi, J., Nishida, S., Yamaguchi, S., et al. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.07.008 · Cited by 31 · see citing works
In Vitro Generation of Mature Human Osteoclasts
Hemingway, F., Cheng, X., Knowles, H. J., Martínez, F. O., Gordon, S., & Athanasou, N. A. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9530-0 · Cited by 30 · see citing works
Caetano‐Lopes, J., Henke, K., Urso, K., Duryea, J. W., Charles, J. F., Warman, M. L., & Harris, M. P. (2020) · Development · doi:10.1242/dev.181834 · Cited by 29 · see citing works
Bone formation in rabbit cancellous bone explant culture model is enhanced by mechanical load
ming, W. Z., Yu, L. J., xin, L. R., Hao, L., Yong, G., Liu, L., chang, Z. X., & Zhang, Z. (2013) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-12-35 · Cited by 28 · see citing works
Osteoprotegerin Enhances Osteogenesis of Human Mesenchymal Stem Cells
Palumbo, S. L., & Li, W. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0550 · Cited by 28 · see citing works
Doumouchtsis, K., Kostakis, A., Doumouchtsis, S. K., Tziamalis, M. P., Tsigris, C., Kostaki, M., & Perrea, D. N. (2007) · Journal of Endocrinological Investigation · doi:10.1007/bf03350814 · Cited by 25 · see citing works
Mancini, L., Moradi‐Bidhendi, N., Brandi, M. L., Perretti, M., & MacIntyre, I. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3953 · Cited by 25 · see citing works
Mochizuki, S.-I., Fujise, N., Higashio, K., & Tsuda, E. (2002) · Journal of Bone and Mineral Metabolism · doi:10.1007/s774-002-8441-x · Cited by 24 · see citing works
Self-citationDoran, P. M., Turner, R. T., Chen, D., Facteau, S. M., Ludvigson, J. M., Khosla, S., Riggs, B. L., & Russell, S. J. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.01.006 · Cited by 22 · see citing works
Feige, U. (2001) · Annals of the Rheumatic Diseases · doi:10.1136/ard.60.90003.iii81 · Cited by 21 · see citing works
Preželj, J., Ostanek, B., Logar, D. B., Marc, J., Hawa, G., & Kocjan, T. (2008) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181271873 · Cited by 20 · see citing works
Neves, J. D. S., Salmon, C. R., Omar, N. F., Narvaes, E. A. O., Gomes, J. R., & Novaes, P. D. (2009) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2009.04.001 · Cited by 20 · see citing works
Alteration of bone cell function by RANKL and OPG in different in vitro models
Lin, J., Callon, K. E., Lin, C. Q.-X., Bava, U., Zheng, M., Reid, I. R., & Cornish, J. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01800.x · Cited by 20 · see citing works
Localization of Osteoprotegerin (OPG) on Bone Surfaces and Cement Lines in Rat Tibia
Nakamura, H., Tsuji, T., Hirata, A., & Yamamoto, T. (2002) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540205000708 · Cited by 20 · see citing works
Is Heparin Effective for the Controlled Delivery of High-Dose Bone Morphogenetic Protein-2?
Kim, R. Y., Lee, B., Park, S.-N., Ko, J.-H., Kim, I. S., & Hwang, S. J. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2015.0537 · Cited by 19 · see citing works
Mutations within the TNF-Like Core Domain of RANKL Impair Osteoclast Differentiation and Activation
Cheng, T., Pavlos, N. J., Wang, C., Tan, J. W.-Y., Lin, J., Cornish, J., Zheng, M., & Xu, J. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0465 · Cited by 19 · see citing works
Kudo, O., Sabokbar, A., Pocock, A., Itonaga, I., & Athanasou, N. A. (2002) · Calcified Tissue International · doi:10.1007/s00223-001-2128-1 · Cited by 19 · see citing works
Breakthrough in bone: the molecular mechanism of osteoclast/osteoblast coupling revealed
Schwarz, E. M., & O’Keefe, R. J. (2000) · Current Opinion in Orthopedics · doi:10.1097/00001433-200010000-00001 · Cited by 17 · see citing works
Zhao, H., Liu, X., Zou, H., Dai, N., Yao, L., Zhang, X., Gao, Q., Liu, W. X., Gu, J., Yuan, Y., et al. (2016) · Cell Adhesion & Migration · doi:10.1080/19336918.2015.1129480 · Cited by 16 · see citing works
Fu, Y., Gu, J., Zhang, Y., Tong, X., Zhao, H., Yuan, Y., Liu, X., Bian, J., & Liu, Z. (2013) · Journal of Veterinary Science · doi:10.4142/jvs.2013.14.4.405 · Cited by 15 · see citing works
Gaudio, A., Lasco, A., Morabito, N., Atteritano, M., Vergara, C., Catalano, A., Fries, W., Trifiletti, A., & Frisina, N. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03347549 · Cited by 15 · see citing works
蕨, 信., Tachibana, Y., Kumegawa, M., & Hakeda, Y. (2001) · Cytotechnology · doi:10.1023/a:1008159332152 · Cited by 14 · see citing works
Self-citationHou, L., Hou, J., Yao, J., & Zhou, Z. (2011) · Acta veterinaria Scandinavica · doi:10.1186/1751-0147-53-21 · Cited by 14 · see citing works
Zang, L., Ma, M., Hu, J., Qiu, H., Huang, B. S., & Chu, T. (2015) · Scientific Reports · doi:10.1038/srep18324 · Cited by 12 · see citing works
Mori, K., Miyamoto, N., Higuchi, Y., Nanba, K., Ito, M., Tsurudome, M., Nishio, M., Kawano, M., Uchida, A., & Ito, Y. (2001) · Cellular Immunology · doi:10.1006/cimm.2000.1748 · Cited by 12 · see citing works
Yang, X., Halladay, D., Onyia, J. E., Martin, T. J., & Chandrasekhar, S. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6176 · Cited by 12 · see citing works
Fu, Y., Gu, J., Wang, Y., Yuan, Y., Liu, X., Bian, J., & Liu, Z. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4284 · Cited by 10 · see citing works
Mundy, G. R., Oyajobi, B. O., Traianedes, K., Dallas, S. L., & Chen, D. (2001) · Elsevier eBooks · doi:10.1016/b978-012470862-4/50014-3 · Cited by 8 · see citing works
Grzegorzewska, A. E., & Młot-Michalska, M. (2005) · PubMed · Cited by 7 · see citing works
Owen, S., Sanders, A. J., MASON, M. D., & Jiang, W. G. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3339 · Cited by 7 · see citing works
Serum markers of bone turnover in dialyzed patients separated according to age
Grzegorzewska, A. E., & Młot-Michalska, M. (2006) · International Urology and Nephrology · doi:10.1007/s11255-006-0079-1 · Cited by 7 · see citing works
A role for TNF in bone resorption of deciduous molars in human beings
Ureles, S. D., Chrzan, J. M., Norton, L. A., & Rossomando, E. F. (2000) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1067/mod.2000.105249 · Cited by 5 · see citing works
Wang, L., Sheng, Z., & Yao, T. (2023) · Journal of orthopaedic surgery · doi:10.1177/10225536231219637 · Cited by 3 · see citing works
Régulation ostéoblastique de la survie des ostéoclastes : effets du calcitriol
Mentaverri, R., Lorget, F., Wattel, A., Maamer, M., Kamel, S., & Brazier, M. (2000) · Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie · doi:10.1016/s0764-4469(00)01249-x · Cited by 1 · see citing works
Hwang, Y.-S., Jeon, H.-J., Shin, S. H., Chung, I., Kim, G., Kim, C. H., & Kim, U. (2011) · 대한구강악안면외과학회지 · doi:10.5125/jkaoms.2011.37.5.386 · Cited by 1 · see citing works
Oh, K. W., Yun, E. J., Rhee, E., Lee, W., Baek, K. H., Kang, M. I., Park, C., Ihm, S. H., Choi, M. G., Yoo, H. J., et al. (2005) · Journal of Korean Endocrine Society · doi:10.3803/jkes.2005.20.3.204 · Cited by 1 · see citing works
Mundy, G. R., Oyajobi, B. O., Gutierrez, G., Sterling, J. A. R., Padalecki, S. S., Elefteriou, F., & Zhao, M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375098-3.50019-6 · Cited by 1 · see citing works
Abdullah, D. N. A. (2013) · IIUM Medical Journal Malaysia · doi:10.31436/imjm.v12i1.1997 · Cited by 1 · see citing works
OPG, RANK and RANKL in Bone Metastasis and Cancer-Associated Osteolysis
Kostenuik, P. J. (2004) · Cancer metastasis · doi:10.1007/978-1-4020-2036-0_11 · Cited by 1 · see citing works
Bolon, B. N., Shalhoub, V., Kostenuik, P. J., Zack, D. J., & Feige, U. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7883-8_10
Bedeutung von RANK-Ligand und Osteoprotegerin für den Knochenstoffwechsel
Hofbauer, L. C., & Schoppet, M. (2006) · Springer eBooks · doi:10.1007/3-540-28782-5_21
Mardock, M. A. (2003) · VTechWorks (Virginia Tech)
- Authors
- Hakeda, Y., Kobayashi, Y., Yamaguchi, K., Yasuda, H., Tsuda, E., Higashio, K., Miyata, T., & Kumegawa, M.
- Affiliations
- Meikai University (JP)
- Megmilk Snow Brand (Japan) (JP)
- Corresponding author
- Hakeda, Yoshiyuki
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 251
- Issue
- 3
- Pages
- 796-801
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2112216791
- Cited by
- 107
- References
- 27
- Citations by year
- 2023: 2 · 2022: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- osteoprotegerin, osteoclasts, bone resorption, osteoclast differentiation factor, F-actin ring, cathepsin K, carbonic anhydrase II, osteoclast apoptosis
- MeSH terms
- Actins, Animals, Bone Resorption, Carbonic Anhydrases, Cathepsins, Cell Separation, Dose-Response Relationship, Drug, Glycoproteins, Osteoclasts, Protein Binding, Rabbits, RNA, Messenger, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Osteoprotegerin, Cathepsin K
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