Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation.
Abstract
Osteoblasts/stromal cells support the formation of osteoclast-like cells (OCL) from osteoclast progenitor cells via expressing a membrane-associated protein, osteoclast differentiation factor (ODF), in the presence of osteotropic factors, whereas the cells secrete a substantial amount of osteoclastogenesis inhibitory factor (OCIF) in the unstimulated state. There are both OCL formation-supporting and the nonsupporting cell lines in osteoblasts/stromal cell lineages. The mechanism that divides osteoblasts/stromal cell lines into the two types is not known. The present study reports that OCL formation-supporting cell line ST2 showed a greatly increased level of ODF mRNA, whereas their OCIF mRNA was drastically diminished in the presence of 1alpha, 25(OH)2-dihydroxyvitamin D3 or prostaglandin E2. In contrast, MC3T3-E1 cells lacking OCL formation-supporting ability did not show a decrease in OCIF mRNA in response to the factors, despite a similar increase in ODF mRNA as ST2 cells. However, inactivated MC3T3-E1 cells secreting nothing supported OCL formation in coculture with human promyelocytic cells, HL60. On the contrary, ST2 cells did not support OCL formation from HL60 cells when cocultured in medium conditioned by 1alpha, 25(OH)2 vitamin D3-treated MC3T3-E1. These findings indicate that reciprocal gene expression of ODF and OCIF in osteoblasts/stromal cells is essential for supporting OCL formation.
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Reciprocal regulation of RANKL and OPG is often observed and might amplify proresorptive signals.
“Reciprocal regulation of RANKL and OPG is often observed, a phenomenon that might serve to amplify proresorptive signals (82)(83)(84).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [82]
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130 · see citing works
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224 · see citing works
Yasuda, H., Shima, N., Nakagawa, N., Mochizuki, S.-I., Yano, K., Fujise, N., Sato, Y., Goto, M., Yamaguchi, K., Kuriyama, M., et al. (1998) · Endocrinology · doi:10.1210/endo.139.3.5837 · Cited by 1,201 · see citing works
Modulation of Osteoclast Differentiation
Suda, T., Takahashi, N., & Martin, T. J. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-1-66 · Cited by 996 · see citing works
OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION
Takahashi, N., Akatsu, T., Udagawa, N., Sasaki, T., Yamaguchi, A., Moseley, J. M., Martin, T. J., & Suda, T. (1988) · Endocrinology · doi:10.1210/endo-123-5-2600 · Cited by 934 · see citing works
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.
Tamura, T., Udagawa, N., Takahashi, N., Miyaura, C., Tanaka, S., Yamada, Y., Koishihara, Y., Ohsugi, Y., Kumaki, K., & Taga, T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11924 · Cited by 826 · see citing works
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.
Tsuda, E., Goto, M., Mochizuki, S.-I., Yano, K., Kobayashi, F., Morinaga, T., & Higashio, K. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6603 · Cited by 787 · see citing works
Takahashi, N., Yamana, H., Yoshiki, S., Roodman, G. D., Mundy, G. R., Jones, S. J., BOYDE, A., & Suda, T. (1988) · Endocrinology · doi:10.1210/endo-122-4-1373 · Cited by 731 · see citing works
Tanaka, S., Takahashi, N., Udagawa, N., Tamura, T., Akatsu, T., Stanley, E. R., Kurokawa, T., & Suda, T. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116179 · Cited by 573 · see citing works
Udagawa, N., Takahashi, N., Akatsu, T., Sasaki, T., Yamaguchi, A., KODAMA, H., Martin, T. J., & Suda, T. (1989) · Endocrinology · doi:10.1210/endo-125-4-1805 · Cited by 492 · see citing works
The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor
Wong, B. R., Josien, R., Lee, S. Y., Vologodskaia, M., Steinman, R. M., & Choi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28355 · Cited by 458 · see citing works
Interleukin-11: a new cytokine critical for osteoclast development.
Girasole, G., Passeri, G., Jilka, R. L., & Manolagas, S. C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117130 · Cited by 395 · see citing works
Modulation of osteoclast differentiation by local factors
Suda, T., Udagawa, N., Nakamura, I., Miyaura, C., & Takahashi, N. (1995) · Bone · doi:10.1016/8756-3282(95)00185-g · Cited by 314 · see citing works
Role of prostaglandins in interleukin-1-induced bone resorption in mice in vitro
Akatsu, T., Takahashi, N., Udagawa, N., Imamura, K., Yamaguchi, A., Sato, K., Nagata, N., & Suda, T. (1991) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650060212 · Cited by 235 · see citing works
[20] Role of 1α,25-dihydroxyvitamin D3 in osteoclast differentiation and function
Suda, T., Jimi, E., Nakamura, I., & Takahashi, N. (1997) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(97)82110-6 · Cited by 186 · see citing works
Takahashi, N., Udagawa, N., Akatsu, T., Tanaka, H., Isogai, Y., & Suda, T. (1991) · Endocrinology · doi:10.1210/endo-128-4-1792 · Cited by 154 · see citing works
Chambers, T. J., Owens, J., Hattersley, G., Jat, P., & Noble, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5578 · Cited by 143 · see citing works
Akatsu, T., Takahashi, N., Udagawa, N., et al. (1989) · Endocrinology · doi:10.1210/endo-125-1-20 · Cited by 97 · see citing works
Cloning of an osteoblastic cell line involved in the formation of osteoclast‐like cells
Yamashita, T., ASANO, K., Takahashi, N., Akatsu, T., Udagawa, N., Sasaki, T., Martin, T. J., & Suda, T. (1990) · Journal of Cellular Physiology · doi:10.1002/jcp.1041450327 · Cited by 87 · see citing works
Differentiation of HL-60 Cells into Cells with the Osteoclast Phenotype*
Yoneda, T., ALSINA, M. M., Garcia, J., et al. (1991) · Endocrinology · doi:10.1210/endo-129-2-683 · Cited by 55 · see citing works
Marks, S. C., MacKay, C. A., Jackson, M. E., Larson, E. K., Cielinski, M. J., Stanley, E. R., & Aukerman, S. L. (1993) · Bone · doi:10.1016/8756-3282(93)90091-n · Cited by 51 · see citing works
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Kearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824 · see citing works
Role of receptor activator of nuclear factor-κB ligand and osteoprotegerin in bone cell biology
Hofbauer, L. C., & Heufelder, A. E. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100226 · Cited by 586 · see citing works
Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism
Malone, A. M. D., Anderson, C. T., Tummala, P., Kwon, R. Y., Johnston, T. R., Stearns, T., & Jacobs, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700636104 · Cited by 477 · see citing works
Collin-Osdoby, P., Rothe, L., Anderson, F., Nelson, M., Maloney, W., & Osdoby, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010153200 · Cited by 398 · see citing works
Saika, M., Inoue, D., Kido, S., & Matsumoto, T. (2001) · Endocrinology · doi:10.1210/endo.142.6.8220 · Cited by 194 · see citing works
- Authors
- Nagai, M., & Sato, N.
- Affiliations
- Iwate Medical University (JP)
- Corresponding author
- Nagai, Masazumi
- ORCID
- Nagai, Masazumi
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 257
- Issue
- 3
- Pages
- 719-723
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2074007657
- Cited by
- 111
- References
- 23
- Citations by year
- 2024: 1 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 8 · 2012: 4
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Promotion and Mutual Aid Corporation for Private Schools of Japan
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- osteoprotegerin, osteoclast differentiation factor, osteoclastogenesis, osteoblasts, stromal cells, 1,25-dihydroxyvitamin D3, prostaglandin E2, osteoclast progenitor cells, HL-60 cells, MC3T3-E1 cells, ST2 cells, bone remodeling
- MeSH terms
- Animals, Calcitriol, Carrier Proteins, Cell Differentiation, Cell Line, Cell Membrane, Dexamethasone, Gene Expression Regulation, Glycoproteins, Humans, Membrane Glycoproteins, Osteoblasts, Osteoclasts, RNA, Messenger, Stem Cells, Dinoprostone, Tissue Fixation, Culture Media, Conditioned, Stromal Cells, Receptors, Calcitonin, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Coculture Techniques, HL-60 Cells, Mice, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B
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