Basic fibroblast growth factor induces osteoclast formation by reciprocally regulating the production of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in mouse osteoblastic cells.
Abstract
Basic fibroblast growth factor (bFGF) induced osteoclast formation in co-cultures of mouse spleen cells and osteoblasts. Osteoclastogenesis inhibitory factor (OCIF) and a selective cyclooxygenase-2 (COX-2) inhibitor, NS-398, abolished bFGF-induced osteoclast formation. bFGF did not affect spleen cells, but it did affect osteoblasts, to stimulate osteoclast formation. Northern blot analysis revealed that bFGF up-regulated the expression of osteoclast differentiation factor (ODF) and COX-2 and down-regulated the expression of OCIF in primary osteoblastic cells. NS-398 abolished the increase of ODF mRNA, but it had no effect on the decrease of OCIF mRNA. NS-398 suppressed the binding of (125)I-labeled OCIF to osteoblastic cells treated with bFGF. Enzyme-linked immunosorbent assay showed that bFGF inhibited OCIF production by osteoblastic cells, and the inhibition was not affected by NS-398. We conclude that bFGF induces osteoclast formation by stimulating ODF production through COX-2-mediated prostaglandin synthesis and by suppressing OCIF production through a mechanism independent of prostaglandin synthesis.
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Reciprocal regulation of RANKL and OPG is often observed and might amplify proresorptive signals.
“Reciprocal regulation of RANKL and OPG is often observed, a phenomenon that might serve to amplify proresorptive signals (82)(83)(84).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [83]
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- Authors
- Nakagawa, N., Yasuda, H., Yano, K., Mochizuki, S.-I., Kobayashi, N., Fujimoto, H., Shima, N., Morinaga, T., Chikazu, D., Kawaguchi, H., & Higashio, K.
- Affiliations
- Megmilk Snow Brand (Japan) (JP)
- The University of Tokyo (JP)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 265
- Issue
- 1
- Pages
- 158-163
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2018303721
- Cited by
- 64
- References
- 48
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 3 · 2019: 4 · 2017: 1 · 2016: 1 · 2014: 4 · 2013: 4 · 2012: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- basic fibroblast growth factor, osteoclastogenesis, osteoclast differentiation factor, osteoprotegerin, osteoblasts, cyclooxygenase-2, prostaglandin synthesis, NS-398, splenocytes, bone remodeling
- MeSH terms
- Animals, Animals, Newborn, Carrier Proteins, Gene Expression Regulation, Glycoproteins, Humans, Isoenzymes, Membrane Glycoproteins, Membrane Proteins, Mice, Inbred Strains, Nitrobenzenes, Osteoclasts, Prostaglandin-Endoperoxide Synthases, Recombinant Proteins, Spleen, Sulfonamides, Transcription, Genetic, Fibroblast Growth Factor 2, Cyclooxygenase Inhibitors, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Coculture Techniques, Mice, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B
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