The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Scavenging of Peroxynitrite by Phycocyanin and Phycocyanobilin from Spirulina platensis: Protection against Oxidative Damage to DNA
Abstract
Peroxynitrite (ONOO(-)) is known to inactivate important cellular targets and also mediate oxidative damage in DNA. The present study has demonstrated that phycocyanin, a biliprotein from spirulina platensis and its chromophore, phycocyanobilin (PCB), efficiently scavenge ONOO(-), a potent physiological inorganic toxin. Scavenging of ONOO(-) by phycocyanin and PCB was established by studying their interaction with ONOO(-) and quantified by using competition kinetics of pyrogallol red bleaching assay. The relative antioxidant ratio and IC(50) value clearly indicate that phycocyanin is a more efficient ONOO(-) scavenger than PCB. The present study has also shown that PCB significantly inhibits the ONOO(-)-mediated single-strand breaks in supercoiled plasmid DNA in a dose-dependent manner with an IC(50) value of 2.9 +/- 0.6 microM. These results suggest that phycocyanin, has the ability to inhibit the ONOO(-)-mediated deleterious biological effects and hence has the potential to be used as a therapeutic agent.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“From a crew radiation mitigation perspective, some cyanobacteria such as those from the genus Arthrospira offer the unique benefit of producing phycocyanin and its chromophore phycocyanobilin (PCB). These molecules act as potent antioxidants which inhibit peroxynitrite (ONOO–) mediated oxidative damage in DNA [107].”
Citations
Cites
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Bilirubin Is an Antioxidant of Possible Physiological Importance
Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., & Ames, B. N. (1987) · Science · doi:10.1126/science.3029864 · Cited by 3,502
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Radí, R., Beckman, J. S., Bush, K. M., & Freeman, B. Α. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90224-7 · Cited by 2,201
Antioxidant activity of albumin-bound bilirubin.
Stocker, R., Glazer, A. N., & Ames, B. N. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5918 · Cited by 769
Kaur, H., & Halliwell, B. B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00722-5 · Cited by 706
The chemistry of DNA damage from nitric oxide and peroxynitrite
Burney, S., Caulfield, J. L., Niles, J. C., Wishnok, J. S., & Tannenbaum, S. R. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(99)00006-8 · Cited by 556
Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae
Romay, C., Armesto, J., Remirez, D., González, R., Ledon, N., & García, I. (1998) · Inflammation Research · doi:10.1007/s000110050256 · Cited by 511
Neužil, J., & Stocker, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89449-8 · Cited by 509
C-Phycocyanin: A potent peroxyl radical scavenger in Vivo and in Vitro
Bhat, V. B., & Madyastha, K. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3270 · Cited by 477
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Tamir, 1996, Biochem. Biophys. Acta, 1288, F31
Cited by
Sorted by citations
Biologically Active Metabolites Synthesized by Microalgae
de Morais, M. G., Vaz, B. D. S., de Morais, E. G., & Costa, J. A. V. (2015) · BioMed Research International · doi:10.1155/2015/835761 · Cited by 492
Phycobiliproteins from cyanobacteria: Chemistry and biotechnological applications
Pagels, F., Guedes, A. C., Amaro, H. M., Kijjoa, A., & Vasconcelos, V. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.02.010 · Cited by 426
Patel, A. B., Mishra, S., Pawar, R., & Ghosh, P. K. (2004) · Protein Expression and Purification · doi:10.1016/j.pep.2004.10.028 · Cited by 361
Nutraceutical properties of phycocyanin
Fernández-Rojas, B., Hernández‐Juárez, J., & Pedraza‐Chaverrí, J. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.10.011 · Cited by 301
Finamore, A., Palmery, M., Bensehaila, S., & Peluso, I. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3247528 · Cited by 256
Metadata
- Authors
- Bhat, V. B., & Madyastha, K. M.
- Affiliations
- Jawaharlal Nehru Centre for Advanced Scientific Research (IN)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 285
- Issue
- 2
- Pages
- 262-266
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2087459960
- Cited by
- 277
- References
- 39
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 14 · 2023: 10 · 2022: 27 · 2021: 21 · 2020: 15 · 2019: 14 · 2018: 15 · 2017: 10 · 2016: 10 · 2015: 13 · 2014: 11 · 2013: 8 · 2012: 13
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- NOT FOUND REPOSITORY (Indian Institute of Science Bangalore) (acceptedVersion)
- Funders
- Council of Scientific and Industrial Research, India
- Jawaharlal Nehru Centre for Advanced Scientific Research
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- peroxynitrite, phycocyanin, phycocyanobilin, Spirulina platensis, free radical scavenging, oxidative DNA damage, single-strand breaks, plasmid DNA, antioxidant activity, biliproteins
- MeSH terms
- Cyanobacteria, DNA Damage, DNA, Superhelical, Kinetics, Nitrates, Phycocyanin, Plasmids, Pyrroles, Spectrophotometry, Free Radical Scavengers, Tetrapyrroles, Phycobilins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
