Cited by 278Antioxidant Activity and Oxidative StressPhytochemicals and Antioxidant ActivitiesFree Radicals and Antioxidants

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Scavenging of Peroxynitrite by Phycocyanin and Phycocyanobilin from Spirulina platensis: Protection against Oxidative Damage to DNA

Bhat, Vadiraja B., Madyastha, K.M.·2001·Biochemical and Biophysical Research Communications

DOI 10.1006/bbrc.2001.5195

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Abstract

Peroxynitrite (ONOO(-)) is known to inactivate important cellular targets and also mediate oxidative damage in DNA. The present study has demonstrated that phycocyanin, a biliprotein from spirulina platensis and its chromophore, phycocyanobilin (PCB), efficiently scavenge ONOO(-), a potent physiological inorganic toxin. Scavenging of ONOO(-) by phycocyanin and PCB was established by studying their interaction with ONOO(-) and quantified by using competition kinetics of pyrogallol red bleaching assay. The relative antioxidant ratio and IC(50) value clearly indicate that phycocyanin is a more efficient ONOO(-) scavenger than PCB. The present study has also shown that PCB significantly inhibits the ONOO(-)-mediated single-strand breaks in supercoiled plasmid DNA in a dose-dependent manner with an IC(50) value of 2.9 +/- 0.6 microM. These results suggest that phycocyanin, has the ability to inhibit the ONOO(-)-mediated deleterious biological effects and hence has the potential to be used as a therapeutic agent.

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Authors: Bhat, V. B., & Madyastha, K. M.
Affiliations: Jawaharlal Nehru Centre for Advanced Scientific Research (IN)
Venue: Biochemical and Biophysical Research Communications
Publisher: Elsevier BV
Published: 2001-07
Volume: 285
Issue: 2
Pages: 262-266
ISSN: 0006-291X (ISSN-L)
DOI: 10.1006/bbrc.2001.5195
OpenAlex: W2087459960
Cited by: 277
References: 39
Citations by year: 2026: 5 · 2025: 11 · 2024: 14 · 2023: 10 · 2022: 27 · 2021: 21 · 2020: 15 · 2019: 14 · 2018: 15 · 2017: 10 · 2016: 10 · 2015: 13 · 2014: 11 · 2013: 8 · 2012: 13
FWCI: 2.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biochemical and Biophysical Research Communications (publishedVersion)
PubMed (publishedVersion)
NOT FOUND REPOSITORY (Indian Institute of Science Bangalore) (acceptedVersion)
Funders: Council of Scientific and Industrial Research, India
Jawaharlal Nehru Centre for Advanced Scientific Research
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords: peroxynitrite, phycocyanin, phycocyanobilin, Spirulina platensis, free radical scavenging, oxidative DNA damage, single-strand breaks, plasmid DNA, antioxidant activity, biliproteins
MeSH terms: Cyanobacteria, DNA Damage, DNA, Superhelical, Kinetics, Nitrates, Phycocyanin, Plasmids, Pyrroles, Spectrophotometry, Free Radical Scavengers, Tetrapyrroles, Phycobilins

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Scavenging of Peroxynitrite by Phycocyanin and Phycocyanobilin from Spirulina platensis: Protection against Oxidative Damage to DNA

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